Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HKD2_LEIBR

TriTrypDb:

LbrM.32.1610 , LBRM2903_320022200

Length:

161

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4HKD2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKD2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	9	11	PF00675	0.621
CLV_PCSK_FUR_1	10	14	PF00082	0.693
CLV_PCSK_KEX2_1	12	14	PF00082	0.629
CLV_PCSK_KEX2_1	9	11	PF00082	0.617
CLV_PCSK_PC1ET2_1	12	14	PF00082	0.697
DEG_Nend_UBRbox_1	1	4	PF02207	0.396
DOC_PP2B_LxvP_1	147	150	PF13499	0.537
DOC_WW_Pin1_4	11	16	PF00397	0.409
DOC_WW_Pin1_4	112	117	PF00397	0.646
DOC_WW_Pin1_4	151	156	PF00397	0.663
LIG_14-3-3_CanoR_1	107	117	PF00244	0.645
LIG_AP2alpha_1	65	69	PF02296	0.437
LIG_BRCT_BRCA1_1	82	86	PF00533	0.404
LIG_deltaCOP1_diTrp_1	74	80	PF00928	0.268
LIG_FHA_1	109	115	PF00498	0.646
LIG_FHA_2	125	131	PF00498	0.583
LIG_FHA_2	41	47	PF00498	0.415
LIG_LIR_Gen_1	133	144	PF02991	0.631
LIG_LIR_Gen_1	74	85	PF02991	0.239
LIG_LIR_Nem_3	133	139	PF02991	0.636
LIG_LIR_Nem_3	74	80	PF02991	0.265
LIG_LIR_Nem_3	84	90	PF02991	0.265
LIG_MLH1_MIPbox_1	83	87	PF16413	0.335
LIG_Pex14_2	65	69	PF04695	0.382
LIG_Pex14_2	87	91	PF04695	0.334
LIG_SH2_PTP2	138	141	PF00017	0.573
LIG_SH2_STAT5	138	141	PF00017	0.573
LIG_SH2_STAT5	21	24	PF00017	0.426
LIG_SH3_1	12	18	PF00018	0.427
LIG_SH3_3	12	18	PF00018	0.409
LIG_SH3_3	149	155	PF00018	0.557
LIG_SH3_3	44	50	PF00018	0.397
LIG_SH3_4	49	56	PF00018	0.398
LIG_SH3_5	116	120	PF00018	0.658
LIG_TRAF2_1	126	129	PF00917	0.569
MOD_CK1_1	109	115	PF00069	0.567
MOD_CK1_1	40	46	PF00069	0.559
MOD_CK2_1	124	130	PF00069	0.483
MOD_GlcNHglycan	25	28	PF01048	0.441
MOD_GSK3_1	108	115	PF00069	0.523
MOD_GSK3_1	36	43	PF00069	0.613
MOD_NEK2_1	106	111	PF00069	0.510
MOD_NEK2_1	8	13	PF00069	0.699
MOD_NEK2_1	80	85	PF00069	0.289
MOD_NEK2_2	75	80	PF00069	0.271
MOD_PIKK_1	40	46	PF00454	0.399
MOD_PKA_2	106	112	PF00069	0.466
MOD_PKA_2	8	14	PF00069	0.514
MOD_Plk_1	40	46	PF00069	0.490
MOD_Plk_1	73	79	PF00069	0.271
MOD_Plk_2-3	124	130	PF00069	0.484
MOD_Plk_4	81	87	PF00069	0.351
MOD_ProDKin_1	11	17	PF00069	0.514
MOD_ProDKin_1	112	118	PF00069	0.561
MOD_ProDKin_1	151	157	PF00069	0.590
MOD_SUMO_rev_2	119	127	PF00179	0.509
TRG_ENDOCYTIC_2	138	141	PF00928	0.462
TRG_ENDOCYTIC_2	92	95	PF00928	0.382
TRG_ER_diArg_1	8	10	PF00400	0.591

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P9K3	Leptomonas seymouri	72%	100%
A0A0S4J7V8	Bodo saltans	52%	90%
A0A1X0NUF1	Trypanosomatidae	64%	98%
A0A3Q8IGR1	Leishmania donovani	80%	100%
A0A422NIA9	Trypanosoma rangeli	57%	100%
A4I7W2	Leishmania infantum	80%	100%
D0AA25	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	99%
E9B2S0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4Q5D7	Leishmania major	80%	100%