Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HKD1_LEIBR

TriTrypDb:

LbrM.32.1600 , LBRM2903_320022100

Length:

147

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKD1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKD1

PDB structure(s): 7aih_BC , 7ane_BC

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	51	53	PF00675	0.425
CLV_PCSK_KEX2_1	51	53	PF00082	0.399
CLV_PCSK_KEX2_1	7	9	PF00082	0.383
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.431
CLV_PCSK_PC7_1	47	53	PF00082	0.398
CLV_Separin_Metazoa	44	48	PF03568	0.447
DEG_APCC_KENBOX_2	62	66	PF00400	0.328
DEG_Nend_UBRbox_3	1	3	PF02207	0.398
DOC_MAPK_gen_1	33	40	PF00069	0.515
DOC_MAPK_gen_1	51	58	PF00069	0.415
DOC_MAPK_MEF2A_6	33	40	PF00069	0.515
DOC_MAPK_MEF2A_6	51	58	PF00069	0.415
DOC_MAPK_NFAT4_5	33	41	PF00069	0.512
DOC_MAPK_NFAT4_5	51	59	PF00069	0.416
DOC_MAPK_RevD_3	36	52	PF00069	0.455
DOC_USP7_MATH_1	115	119	PF00917	0.475
DOC_WW_Pin1_4	90	95	PF00397	0.396
LIG_14-3-3_CanoR_1	51	55	PF00244	0.422
LIG_14-3-3_CanoR_1	8	18	PF00244	0.462
LIG_FHA_1	115	121	PF00498	0.523
LIG_FHA_1	67	73	PF00498	0.311
LIG_FHA_1	94	100	PF00498	0.464
LIG_Integrin_isoDGR_2	49	51	PF01839	0.420
LIG_LIR_Gen_1	12	19	PF02991	0.393
LIG_LIR_Nem_3	12	18	PF02991	0.391
LIG_RPA_C_Fungi	80	92	PF08784	0.360
LIG_SH2_STAP1	5	9	PF00017	0.371
LIG_SUMO_SIM_par_1	53	59	PF11976	0.318
MOD_CK1_1	21	27	PF00069	0.504
MOD_CK2_1	130	136	PF00069	0.472
MOD_Cter_Amidation	49	52	PF01082	0.406
MOD_GlcNHglycan	82	85	PF01048	0.402
MOD_N-GLC_1	113	118	PF02516	0.322
MOD_NEK2_1	105	110	PF00069	0.449
MOD_NEK2_1	18	23	PF00069	0.495
MOD_NEK2_1	66	71	PF00069	0.409
MOD_NEK2_1	9	14	PF00069	0.502
MOD_NEK2_2	10	15	PF00069	0.373
MOD_PIKK_1	107	113	PF00454	0.544
MOD_PIKK_1	115	121	PF00454	0.468
MOD_PIKK_1	26	32	PF00454	0.378
MOD_PIKK_1	93	99	PF00454	0.413
MOD_PKA_2	50	56	PF00069	0.384
MOD_Plk_2-3	130	136	PF00069	0.568
MOD_Plk_4	10	16	PF00069	0.403
MOD_Plk_4	21	27	PF00069	0.373
MOD_ProDKin_1	90	96	PF00069	0.399
MOD_SUMO_for_1	41	44	PF00179	0.510
TRG_DiLeu_BaEn_4	136	142	PF01217	0.420
TRG_DiLeu_BaLyEn_6	52	57	PF01217	0.399
TRG_DiLeu_LyEn_5	136	141	PF01217	0.413

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I494	Leptomonas seymouri	83%	100%
A0A0S4J787	Bodo saltans	62%	100%
A0A1X0NUE5	Trypanosomatidae	76%	100%
A0A3Q8IGY2	Leishmania donovani	90%	100%
A0A3S5IR91	Trypanosoma rangeli	73%	100%
A4I7W1	Leishmania infantum	89%	100%
D0AA24	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	100%
E9B2R9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q5D8	Leishmania major	88%	100%