Kynurenine formamidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative cyclase, putative

Species:

Leishmania braziliensis

UniProt:

A4HKC9_LEIBR

TriTrypDb:

LbrM.32.1570 , LBRM2903_320021800

Length:

410

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A4HKC9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKC9

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	10
GO:0006520	amino acid metabolic process	3	10
GO:0006568	tryptophan metabolic process	5	10
GO:0006569	tryptophan catabolic process	5	10
GO:0006576	biogenic amine metabolic process	5	10
GO:0006586	indolalkylamine metabolic process	5	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009056	catabolic process	2	10
GO:0009063	amino acid catabolic process	4	10
GO:0009072	aromatic amino acid metabolic process	4	10
GO:0009074	aromatic amino acid family catabolic process	5	10
GO:0009308	amine metabolic process	4	10
GO:0009987	cellular process	1	10
GO:0016054	organic acid catabolic process	4	10
GO:0019439	aromatic compound catabolic process	4	10
GO:0019441	tryptophan catabolic process to kynurenine	5	10
GO:0019752	carboxylic acid metabolic process	5	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0042180	cellular ketone metabolic process	3	10
GO:0042430	indole-containing compound metabolic process	4	10
GO:0042436	indole-containing compound catabolic process	5	10
GO:0042537	benzene-containing compound metabolic process	4	10
GO:0043436	oxoacid metabolic process	4	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044248	cellular catabolic process	3	10
GO:0044270	cellular nitrogen compound catabolic process	4	10
GO:0044281	small molecule metabolic process	2	10
GO:0044282	small molecule catabolic process	3	10
GO:0046395	carboxylic acid catabolic process	5	10
GO:0046483	heterocycle metabolic process	3	10
GO:0046700	heterocycle catabolic process	4	10
GO:0070189	kynurenine metabolic process	4	10
GO:0071704	organic substance metabolic process	2	10
GO:1901360	organic cyclic compound metabolic process	3	10
GO:1901361	organic cyclic compound catabolic process	4	10
GO:1901564	organonitrogen compound metabolic process	3	10
GO:1901565	organonitrogen compound catabolic process	4	10
GO:1901575	organic substance catabolic process	3	10
GO:1901605	alpha-amino acid metabolic process	4	10
GO:1901606	alpha-amino acid catabolic process	5	10

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004061	arylformamidase activity	5	10
GO:0016787	hydrolase activity	2	10
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	10
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	4	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	168	172	PF00656	0.329
CLV_NRD_NRD_1	105	107	PF00675	0.437
CLV_NRD_NRD_1	12	14	PF00675	0.539
CLV_NRD_NRD_1	136	138	PF00675	0.527
CLV_PCSK_KEX2_1	105	107	PF00082	0.432
CLV_PCSK_KEX2_1	136	138	PF00082	0.527
CLV_PCSK_KEX2_1	19	21	PF00082	0.582
CLV_PCSK_KEX2_1	341	343	PF00082	0.644
CLV_PCSK_PC1ET2_1	19	21	PF00082	0.603
CLV_PCSK_PC1ET2_1	341	343	PF00082	0.527
CLV_PCSK_SKI1_1	100	104	PF00082	0.401
CLV_PCSK_SKI1_1	157	161	PF00082	0.508
CLV_PCSK_SKI1_1	20	24	PF00082	0.617
CLV_PCSK_SKI1_1	243	247	PF00082	0.446
CLV_PCSK_SKI1_1	270	274	PF00082	0.455
DEG_ODPH_VHL_1	210	222	PF01847	0.191
DEG_SCF_FBW7_1	65	72	PF00400	0.270
DEG_SPOP_SBC_1	293	297	PF00917	0.191
DOC_CKS1_1	66	71	PF01111	0.439
DOC_CYCLIN_RxL_1	105	117	PF00134	0.493
DOC_CYCLIN_RxL_1	239	248	PF00134	0.257
DOC_CYCLIN_RxL_1	267	277	PF00134	0.191
DOC_MAPK_gen_1	19	30	PF00069	0.450
DOC_MAPK_gen_1	267	275	PF00069	0.209
DOC_PP4_FxxP_1	306	309	PF00568	0.329
DOC_USP7_MATH_1	118	122	PF00917	0.355
DOC_USP7_MATH_1	22	26	PF00917	0.457
DOC_USP7_MATH_1	294	298	PF00917	0.322
DOC_USP7_MATH_1	300	304	PF00917	0.272
DOC_USP7_MATH_1	372	376	PF00917	0.342
DOC_USP7_MATH_1	75	79	PF00917	0.320
DOC_USP7_UBL2_3	19	23	PF12436	0.434
DOC_USP7_UBL2_3	225	229	PF12436	0.298
DOC_WW_Pin1_4	144	149	PF00397	0.315
DOC_WW_Pin1_4	296	301	PF00397	0.253
DOC_WW_Pin1_4	326	331	PF00397	0.297
DOC_WW_Pin1_4	48	53	PF00397	0.462
DOC_WW_Pin1_4	65	70	PF00397	0.375
LIG_14-3-3_CanoR_1	105	114	PF00244	0.650
LIG_14-3-3_CanoR_1	136	144	PF00244	0.420
LIG_14-3-3_CanoR_1	157	162	PF00244	0.191
LIG_14-3-3_CanoR_1	178	185	PF00244	0.352
LIG_14-3-3_CanoR_1	258	268	PF00244	0.307
LIG_14-3-3_CanoR_1	342	349	PF00244	0.302
LIG_14-3-3_CanoR_1	398	403	PF00244	0.367
LIG_Actin_WH2_2	346	362	PF00022	0.379
LIG_BIR_II_1	1	5	PF00653	0.359
LIG_BIR_III_4	396	400	PF00653	0.361
LIG_BRCT_BRCA1_1	120	124	PF00533	0.355
LIG_BRCT_BRCA1_1	302	306	PF00533	0.191
LIG_BRCT_BRCA1_1	400	404	PF00533	0.325
LIG_BRCT_BRCA1_1	77	81	PF00533	0.342
LIG_Clathr_ClatBox_1	272	276	PF01394	0.191
LIG_Clathr_ClatBox_1	324	328	PF01394	0.329
LIG_CtBP_PxDLS_1	27	31	PF00389	0.426
LIG_deltaCOP1_diTrp_1	298	306	PF00928	0.191
LIG_FHA_1	106	112	PF00498	0.590
LIG_FHA_1	217	223	PF00498	0.227
LIG_FHA_1	264	270	PF00498	0.198
LIG_FHA_1	35	41	PF00498	0.400
LIG_FHA_1	56	62	PF00498	0.359
LIG_FHA_1	66	72	PF00498	0.336
LIG_FHA_1	84	90	PF00498	0.280
LIG_FHA_2	166	172	PF00498	0.263
LIG_FHA_2	293	299	PF00498	0.253
LIG_FHA_2	4	10	PF00498	0.390
LIG_LIR_Apic_2	303	309	PF02991	0.191
LIG_LIR_Gen_1	121	132	PF02991	0.402
LIG_LIR_Gen_1	139	148	PF02991	0.470
LIG_LIR_Gen_1	303	312	PF02991	0.330
LIG_LIR_Gen_1	4	11	PF02991	0.455
LIG_LIR_Gen_1	51	61	PF02991	0.391
LIG_LIR_Nem_3	121	127	PF02991	0.344
LIG_LIR_Nem_3	139	144	PF02991	0.475
LIG_LIR_Nem_3	298	304	PF02991	0.331
LIG_LIR_Nem_3	362	368	PF02991	0.375
LIG_LIR_Nem_3	4	8	PF02991	0.466
LIG_LIR_Nem_3	51	56	PF02991	0.382
LIG_LIR_Nem_3	78	84	PF02991	0.351
LIG_LYPXL_yS_3	132	135	PF13949	0.421
LIG_MYND_1	48	52	PF01753	0.413
LIG_PCNA_yPIPBox_3	57	66	PF02747	0.280
LIG_PDZ_Class_3	405	410	PF00595	0.355
LIG_PTB_Apo_2	355	362	PF02174	0.315
LIG_PTB_Phospho_1	355	361	PF10480	0.318
LIG_SH2_CRK	361	365	PF00017	0.354
LIG_SH2_GRB2like	141	144	PF00017	0.407
LIG_SH2_SRC	185	188	PF00017	0.329
LIG_SH2_SRC	394	397	PF00017	0.371
LIG_SH2_STAP1	361	365	PF00017	0.247
LIG_SH2_STAT5	314	317	PF00017	0.246
LIG_SH2_STAT5	361	364	PF00017	0.350
LIG_SH2_STAT5	67	70	PF00017	0.273
LIG_SH3_3	145	151	PF00018	0.263
LIG_SH3_3	209	215	PF00018	0.319
LIG_SH3_3	329	335	PF00018	0.288
LIG_SH3_3	400	406	PF00018	0.258
LIG_SH3_3	63	69	PF00018	0.297
LIG_SUMO_SIM_anti_2	219	224	PF11976	0.329
LIG_SUMO_SIM_par_1	214	219	PF11976	0.359
LIG_SUMO_SIM_par_1	243	248	PF11976	0.263
LIG_SUMO_SIM_par_1	85	90	PF11976	0.369
LIG_TYR_ITIM	359	364	PF00017	0.344
LIG_WW_3	279	283	PF00397	0.209
MOD_CK1_1	251	257	PF00069	0.295
MOD_CK1_1	292	298	PF00069	0.272
MOD_CK1_1	344	350	PF00069	0.292
MOD_CK1_1	383	389	PF00069	0.345
MOD_CK1_1	70	76	PF00069	0.297
MOD_CK2_1	136	142	PF00069	0.460
MOD_CK2_1	143	149	PF00069	0.329
MOD_CK2_1	257	263	PF00069	0.342
MOD_CK2_1	292	298	PF00069	0.256
MOD_CMANNOS	104	107	PF00535	0.295
MOD_GlcNHglycan	116	119	PF01048	0.326
MOD_GlcNHglycan	190	193	PF01048	0.532
MOD_GlcNHglycan	24	27	PF01048	0.638
MOD_GlcNHglycan	289	292	PF01048	0.496
MOD_GlcNHglycan	380	383	PF01048	0.576
MOD_GlcNHglycan	77	80	PF01048	0.488
MOD_GSK3_1	114	121	PF00069	0.490
MOD_GSK3_1	157	164	PF00069	0.273
MOD_GSK3_1	22	29	PF00069	0.426
MOD_GSK3_1	245	252	PF00069	0.288
MOD_GSK3_1	254	261	PF00069	0.342
MOD_GSK3_1	283	290	PF00069	0.343
MOD_GSK3_1	292	299	PF00069	0.348
MOD_GSK3_1	65	72	PF00069	0.311
MOD_GSK3_1	83	90	PF00069	0.272
MOD_N-GLC_1	142	147	PF02516	0.600
MOD_N-GLC_1	249	254	PF02516	0.391
MOD_N-GLC_1	388	393	PF02516	0.606
MOD_NEK2_1	114	119	PF00069	0.268
MOD_NEK2_1	159	164	PF00069	0.280
MOD_NEK2_1	176	181	PF00069	0.246
MOD_NEK2_1	245	250	PF00069	0.262
MOD_NEK2_1	359	364	PF00069	0.337
MOD_NEK2_1	388	393	PF00069	0.387
MOD_NEK2_1	87	92	PF00069	0.471
MOD_PIKK_1	136	142	PF00454	0.443
MOD_PIKK_1	372	378	PF00454	0.316
MOD_PIKK_1	388	394	PF00454	0.359
MOD_PIKK_1	60	66	PF00454	0.362
MOD_PK_1	398	404	PF00069	0.364
MOD_PKA_1	105	111	PF00069	0.623
MOD_PKA_1	136	142	PF00069	0.321
MOD_PKA_1	341	347	PF00069	0.275
MOD_PKA_2	105	111	PF00069	0.592
MOD_PKA_2	136	142	PF00069	0.429
MOD_PKA_2	257	263	PF00069	0.336
MOD_PKA_2	341	347	PF00069	0.275
MOD_PKA_2	359	365	PF00069	0.373
MOD_PKB_1	129	137	PF00069	0.394
MOD_Plk_1	249	255	PF00069	0.267
MOD_Plk_1	283	289	PF00069	0.191
MOD_Plk_1	34	40	PF00069	0.304
MOD_Plk_2-3	328	334	PF00069	0.263
MOD_Plk_4	118	124	PF00069	0.406
MOD_Plk_4	334	340	PF00069	0.352
MOD_Plk_4	344	350	PF00069	0.263
MOD_Plk_4	380	386	PF00069	0.320
MOD_Plk_4	398	404	PF00069	0.319
MOD_Plk_4	83	89	PF00069	0.329
MOD_ProDKin_1	144	150	PF00069	0.315
MOD_ProDKin_1	296	302	PF00069	0.253
MOD_ProDKin_1	326	332	PF00069	0.297
MOD_ProDKin_1	48	54	PF00069	0.460
MOD_ProDKin_1	65	71	PF00069	0.378
MOD_SUMO_rev_2	17	25	PF00179	0.413
TRG_DiLeu_BaEn_2	148	154	PF01217	0.246
TRG_DiLeu_BaLyEn_6	107	112	PF01217	0.578
TRG_DiLeu_BaLyEn_6	240	245	PF01217	0.263
TRG_DiLeu_BaLyEn_6	363	368	PF01217	0.404
TRG_ENDOCYTIC_2	132	135	PF00928	0.374
TRG_ENDOCYTIC_2	141	144	PF00928	0.412
TRG_ENDOCYTIC_2	304	307	PF00928	0.356
TRG_ENDOCYTIC_2	361	364	PF00928	0.354
TRG_ER_diArg_1	104	106	PF00400	0.669
TRG_ER_diArg_1	128	131	PF00400	0.320
TRG_ER_diArg_1	135	137	PF00400	0.322
TRG_NES_CRM1_1	263	278	PF08389	0.235
TRG_Pf-PMV_PEXEL_1	126	130	PF00026	0.514

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9C3	Leptomonas seymouri	52%	100%
A0A0S4J7K0	Bodo saltans	28%	100%
A0A1X0NW41	Trypanosomatidae	36%	100%
A0A3S7X5K2	Leishmania donovani	73%	100%
A0A422NIA6	Trypanosoma rangeli	29%	100%
A4I7V8	Leishmania infantum	73%	100%
E9B2R6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q4Q5E1	Leishmania major	73%	100%