HECT domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HKC7_LEIBR

TriTrypDb:

LbrM.32.1550 , LBRM2903_320021600

Length:

773

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKC7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKC7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	200	204	PF00656	0.364
CLV_C14_Caspase3-7	58	62	PF00656	0.558
CLV_NRD_NRD_1	179	181	PF00675	0.555
CLV_NRD_NRD_1	401	403	PF00675	0.454
CLV_NRD_NRD_1	52	54	PF00675	0.707
CLV_NRD_NRD_1	703	705	PF00675	0.804
CLV_NRD_NRD_1	712	714	PF00675	0.652
CLV_PCSK_FUR_1	710	714	PF00082	0.545
CLV_PCSK_KEX2_1	179	181	PF00082	0.558
CLV_PCSK_KEX2_1	333	335	PF00082	0.525
CLV_PCSK_KEX2_1	52	54	PF00082	0.708
CLV_PCSK_KEX2_1	703	705	PF00082	0.804
CLV_PCSK_KEX2_1	712	714	PF00082	0.652
CLV_PCSK_KEX2_1	8	10	PF00082	0.672
CLV_PCSK_PC1ET2_1	333	335	PF00082	0.525
CLV_PCSK_PC1ET2_1	8	10	PF00082	0.672
CLV_PCSK_SKI1_1	229	233	PF00082	0.439
CLV_PCSK_SKI1_1	291	295	PF00082	0.548
CLV_PCSK_SKI1_1	329	333	PF00082	0.521
CLV_PCSK_SKI1_1	535	539	PF00082	0.418
CLV_PCSK_SKI1_1	543	547	PF00082	0.466
DEG_APCC_DBOX_1	178	186	PF00400	0.594
DEG_MDM2_SWIB_1	295	302	PF02201	0.517
DEG_Nend_Nbox_1	1	3	PF02207	0.700
DEG_SCF_FBW7_1	368	375	PF00400	0.532
DOC_ANK_TNKS_1	51	58	PF00023	0.742
DOC_CYCLIN_RxL_1	223	236	PF00134	0.448
DOC_CYCLIN_RxL_1	400	410	PF00134	0.543
DOC_MAPK_gen_1	693	702	PF00069	0.781
DOC_MAPK_gen_1	710	720	PF00069	0.500
DOC_MAPK_MEF2A_6	713	722	PF00069	0.607
DOC_PP1_RVXF_1	299	305	PF00149	0.572
DOC_PP2B_LxvP_1	405	408	PF13499	0.558
DOC_PP2B_LxvP_1	437	440	PF13499	0.594
DOC_PP4_FxxP_1	673	676	PF00568	0.774
DOC_USP7_MATH_1	147	151	PF00917	0.670
DOC_USP7_MATH_1	164	168	PF00917	0.489
DOC_USP7_MATH_1	351	355	PF00917	0.446
DOC_USP7_MATH_1	429	433	PF00917	0.410
DOC_USP7_MATH_1	450	454	PF00917	0.571
DOC_USP7_MATH_1	55	59	PF00917	0.609
DOC_USP7_MATH_1	576	580	PF00917	0.537
DOC_USP7_MATH_1	739	743	PF00917	0.752
DOC_USP7_UBL2_3	256	260	PF12436	0.314
DOC_USP7_UBL2_3	329	333	PF12436	0.468
DOC_WW_Pin1_4	113	118	PF00397	0.810
DOC_WW_Pin1_4	18	23	PF00397	0.666
DOC_WW_Pin1_4	368	373	PF00397	0.582
DOC_WW_Pin1_4	419	424	PF00397	0.514
DOC_WW_Pin1_4	455	460	PF00397	0.687
DOC_WW_Pin1_4	62	67	PF00397	0.697
DOC_WW_Pin1_4	734	739	PF00397	0.671
DOC_WW_Pin1_4	767	772	PF00397	0.736
LIG_14-3-3_CanoR_1	334	343	PF00244	0.515
LIG_14-3-3_CanoR_1	402	406	PF00244	0.546
LIG_14-3-3_CanoR_1	433	440	PF00244	0.509
LIG_14-3-3_CanoR_1	467	475	PF00244	0.622
LIG_14-3-3_CanoR_1	535	541	PF00244	0.473
LIG_14-3-3_CanoR_1	703	711	PF00244	0.789
LIG_14-3-3_CanoR_1	9	18	PF00244	0.644
LIG_APCC_ABBAyCdc20_2	658	664	PF00400	0.520
LIG_BRCT_BRCA1_1	509	513	PF00533	0.476
LIG_BRCT_BRCA1_1	683	687	PF00533	0.619
LIG_CtBP_PxDLS_1	383	387	PF00389	0.529
LIG_EH1_1	224	232	PF00400	0.488
LIG_eIF4E_1	326	332	PF01652	0.498
LIG_FHA_1	10	16	PF00498	0.601
LIG_FHA_1	184	190	PF00498	0.421
LIG_FHA_1	222	228	PF00498	0.522
LIG_FHA_1	241	247	PF00498	0.290
LIG_FHA_1	369	375	PF00498	0.664
LIG_FHA_1	416	422	PF00498	0.598
LIG_FHA_1	433	439	PF00498	0.387
LIG_FHA_1	560	566	PF00498	0.478
LIG_FHA_1	567	573	PF00498	0.495
LIG_FHA_1	663	669	PF00498	0.705
LIG_FHA_2	116	122	PF00498	0.791
LIG_FHA_2	125	131	PF00498	0.670
LIG_FHA_2	243	249	PF00498	0.332
LIG_FHA_2	439	445	PF00498	0.564
LIG_LIR_Apic_2	417	423	PF02991	0.493
LIG_LIR_Apic_2	671	676	PF02991	0.770
LIG_LIR_Gen_1	21	31	PF02991	0.367
LIG_LIR_Gen_1	296	305	PF02991	0.508
LIG_LIR_Gen_1	490	500	PF02991	0.409
LIG_LIR_Gen_1	558	567	PF02991	0.296
LIG_LIR_Gen_1	85	95	PF02991	0.493
LIG_LIR_Nem_3	21	26	PF02991	0.391
LIG_LIR_Nem_3	296	302	PF02991	0.500
LIG_LIR_Nem_3	490	495	PF02991	0.403
LIG_LIR_Nem_3	510	516	PF02991	0.200
LIG_LIR_Nem_3	558	564	PF02991	0.467
LIG_LIR_Nem_3	684	690	PF02991	0.608
LIG_LIR_Nem_3	742	746	PF02991	0.678
LIG_LIR_Nem_3	85	91	PF02991	0.515
LIG_MLH1_MIPbox_1	509	513	PF16413	0.473
LIG_MYND_1	372	376	PF01753	0.469
LIG_NRBOX	184	190	PF00104	0.475
LIG_NRBOX	86	92	PF00104	0.507
LIG_PCNA_yPIPBox_3	199	211	PF02747	0.311
LIG_Pex14_2	235	239	PF04695	0.533
LIG_Pex14_2	295	299	PF04695	0.459
LIG_Pex14_2	304	308	PF04695	0.301
LIG_Pex14_2	512	516	PF04695	0.334
LIG_PTB_Apo_2	745	752	PF02174	0.656
LIG_Rb_LxCxE_1	358	377	PF01857	0.565
LIG_REV1ctd_RIR_1	325	333	PF16727	0.450
LIG_SH2_PTP2	420	423	PF00017	0.514
LIG_SH2_PTP2	699	702	PF00017	0.718
LIG_SH2_SRC	699	702	PF00017	0.599
LIG_SH2_STAP1	336	340	PF00017	0.601
LIG_SH2_STAT5	23	26	PF00017	0.594
LIG_SH2_STAT5	324	327	PF00017	0.422
LIG_SH2_STAT5	356	359	PF00017	0.465
LIG_SH2_STAT5	38	41	PF00017	0.518
LIG_SH2_STAT5	420	423	PF00017	0.514
LIG_SH2_STAT5	563	566	PF00017	0.469
LIG_SH2_STAT5	699	702	PF00017	0.664
LIG_SH2_STAT5	79	82	PF00017	0.518
LIG_SH3_3	708	714	PF00018	0.795
LIG_SUMO_SIM_anti_2	396	402	PF11976	0.390
LIG_SUMO_SIM_anti_2	422	428	PF11976	0.513
LIG_SUMO_SIM_par_1	392	399	PF11976	0.375
LIG_TRAF2_1	442	445	PF00917	0.568
LIG_TRAF2_1	632	635	PF00917	0.595
LIG_TRFH_1	479	483	PF08558	0.616
LIG_UBA3_1	397	403	PF00899	0.491
LIG_WRC_WIRS_1	188	193	PF05994	0.425
LIG_WRC_WIRS_1	678	683	PF05994	0.535
LIG_WRC_WIRS_1	743	748	PF05994	0.652
MOD_CDK_SPK_2	455	460	PF00069	0.593
MOD_CK1_1	115	121	PF00069	0.841
MOD_CK1_1	21	27	PF00069	0.635
MOD_CK1_1	278	284	PF00069	0.557
MOD_CK1_1	396	402	PF00069	0.314
MOD_CK1_1	41	47	PF00069	0.341
MOD_CK1_1	432	438	PF00069	0.418
MOD_CK1_1	458	464	PF00069	0.663
MOD_CK1_1	605	611	PF00069	0.485
MOD_CK1_1	65	71	PF00069	0.650
MOD_CK1_1	682	688	PF00069	0.693
MOD_CK1_1	742	748	PF00069	0.653
MOD_CK2_1	100	106	PF00069	0.628
MOD_CK2_1	115	121	PF00069	0.722
MOD_CK2_1	124	130	PF00069	0.814
MOD_CK2_1	359	365	PF00069	0.443
MOD_CK2_1	438	444	PF00069	0.551
MOD_CK2_1	645	651	PF00069	0.462
MOD_GlcNHglycan	154	158	PF01048	0.801
MOD_GlcNHglycan	164	167	PF01048	0.715
MOD_GlcNHglycan	213	216	PF01048	0.471
MOD_GlcNHglycan	252	255	PF01048	0.328
MOD_GlcNHglycan	277	280	PF01048	0.528
MOD_GlcNHglycan	338	341	PF01048	0.505
MOD_GlcNHglycan	462	465	PF01048	0.647
MOD_GlcNHglycan	509	512	PF01048	0.511
MOD_GlcNHglycan	551	554	PF01048	0.567
MOD_GlcNHglycan	613	616	PF01048	0.516
MOD_GlcNHglycan	653	656	PF01048	0.497
MOD_GlcNHglycan	687	690	PF01048	0.712
MOD_GlcNHglycan	704	707	PF01048	0.613
MOD_GlcNHglycan	714	717	PF01048	0.749
MOD_GlcNHglycan	755	758	PF01048	0.764
MOD_GSK3_1	111	118	PF00069	0.787
MOD_GSK3_1	183	190	PF00069	0.484
MOD_GSK3_1	193	200	PF00069	0.461
MOD_GSK3_1	242	249	PF00069	0.541
MOD_GSK3_1	289	296	PF00069	0.495
MOD_GSK3_1	368	375	PF00069	0.662
MOD_GSK3_1	415	422	PF00069	0.537
MOD_GSK3_1	451	458	PF00069	0.637
MOD_GSK3_1	499	506	PF00069	0.483
MOD_GSK3_1	576	583	PF00069	0.396
MOD_GSK3_1	590	597	PF00069	0.477
MOD_GSK3_1	601	608	PF00069	0.466
MOD_GSK3_1	677	684	PF00069	0.701
MOD_GSK3_1	9	16	PF00069	0.429
MOD_N-GLC_1	183	188	PF02516	0.436
MOD_N-GLC_1	260	265	PF02516	0.305
MOD_N-GLC_1	549	554	PF02516	0.321
MOD_N-GLC_1	62	67	PF02516	0.556
MOD_N-GLC_2	518	520	PF02516	0.282
MOD_NEK2_1	191	196	PF00069	0.476
MOD_NEK2_1	239	244	PF00069	0.522
MOD_NEK2_1	250	255	PF00069	0.510
MOD_NEK2_1	275	280	PF00069	0.560
MOD_NEK2_1	294	299	PF00069	0.298
MOD_NEK2_1	413	418	PF00069	0.506
MOD_NEK2_1	451	456	PF00069	0.462
MOD_NEK2_1	507	512	PF00069	0.474
MOD_NEK2_1	566	571	PF00069	0.321
MOD_NEK2_1	602	607	PF00069	0.494
MOD_NEK2_1	611	616	PF00069	0.549
MOD_NEK2_1	640	645	PF00069	0.601
MOD_NEK2_1	681	686	PF00069	0.694
MOD_NEK2_1	753	758	PF00069	0.716
MOD_NEK2_2	536	541	PF00069	0.528
MOD_PIKK_1	147	153	PF00454	0.565
MOD_PIKK_1	193	199	PF00454	0.511
MOD_PIKK_1	240	246	PF00454	0.514
MOD_PIKK_1	294	300	PF00454	0.545
MOD_PIKK_1	415	421	PF00454	0.492
MOD_PIKK_1	452	458	PF00454	0.613
MOD_PKA_1	712	718	PF00069	0.533
MOD_PKA_1	8	14	PF00069	0.449
MOD_PKA_2	401	407	PF00069	0.482
MOD_PKA_2	432	438	PF00069	0.500
MOD_PKA_2	651	657	PF00069	0.681
MOD_PKA_2	662	668	PF00069	0.584
MOD_PKA_2	682	688	PF00069	0.715
MOD_PKA_2	692	698	PF00069	0.702
MOD_PKA_2	702	708	PF00069	0.463
MOD_PKA_2	712	718	PF00069	0.695
MOD_PKA_2	8	14	PF00069	0.449
MOD_PKB_1	710	718	PF00069	0.535
MOD_Plk_1	493	499	PF00069	0.459
MOD_Plk_1	503	509	PF00069	0.482
MOD_Plk_1	591	597	PF00069	0.577
MOD_Plk_4	124	130	PF00069	0.660
MOD_Plk_4	268	274	PF00069	0.422
MOD_Plk_4	393	399	PF00069	0.416
MOD_Plk_4	401	407	PF00069	0.482
MOD_Plk_4	503	509	PF00069	0.504
MOD_Plk_4	536	542	PF00069	0.418
MOD_Plk_4	566	572	PF00069	0.569
MOD_Plk_4	576	582	PF00069	0.388
MOD_Plk_4	83	89	PF00069	0.525
MOD_ProDKin_1	113	119	PF00069	0.809
MOD_ProDKin_1	18	24	PF00069	0.658
MOD_ProDKin_1	368	374	PF00069	0.586
MOD_ProDKin_1	419	425	PF00069	0.512
MOD_ProDKin_1	455	461	PF00069	0.689
MOD_ProDKin_1	62	68	PF00069	0.690
MOD_ProDKin_1	734	740	PF00069	0.672
MOD_ProDKin_1	767	773	PF00069	0.740
MOD_SUMO_for_1	442	445	PF00179	0.390
MOD_SUMO_for_1	725	728	PF00179	0.655
TRG_DiLeu_BaEn_1	447	452	PF01217	0.427
TRG_DiLeu_BaLyEn_6	226	231	PF01217	0.424
TRG_DiLeu_BaLyEn_6	369	374	PF01217	0.601
TRG_ENDOCYTIC_2	23	26	PF00928	0.382
TRG_ENDOCYTIC_2	322	325	PF00928	0.414
TRG_ENDOCYTIC_2	563	566	PF00928	0.289
TRG_ENDOCYTIC_2	699	702	PF00928	0.718
TRG_ENDOCYTIC_2	743	746	PF00928	0.623
TRG_ER_diArg_1	52	54	PF00400	0.665
TRG_ER_diArg_1	702	704	PF00400	0.803
TRG_ER_diArg_1	710	713	PF00400	0.669
TRG_NES_CRM1_1	216	228	PF08389	0.338
TRG_NES_CRM1_1	490	504	PF08389	0.429
TRG_NES_CRM1_1	601	613	PF08389	0.556
TRG_Pf-PMV_PEXEL_1	229	233	PF00026	0.499

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2J2	Leptomonas seymouri	54%	100%
A0A1X0NUI7	Trypanosomatidae	29%	100%
A0A3S7X5F7	Leishmania donovani	74%	100%
A4I7V6	Leishmania infantum	74%	100%
E9B2R4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q4Q5E3	Leishmania major	74%	97%