Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HKC6_LEIBR

TriTrypDb:

LbrM.32.1540 , LBRM2903_320021500

Length:

352

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKC6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKC6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	273	277	PF00656	0.539
CLV_NRD_NRD_1	188	190	PF00675	0.617
CLV_NRD_NRD_1	262	264	PF00675	0.632
CLV_NRD_NRD_1	336	338	PF00675	0.412
CLV_NRD_NRD_1	342	344	PF00675	0.522
CLV_NRD_NRD_1	6	8	PF00675	0.507
CLV_PCSK_KEX2_1	188	190	PF00082	0.617
CLV_PCSK_KEX2_1	262	264	PF00082	0.668
CLV_PCSK_KEX2_1	336	338	PF00082	0.412
CLV_PCSK_KEX2_1	342	344	PF00082	0.522
CLV_PCSK_KEX2_1	36	38	PF00082	0.619
CLV_PCSK_KEX2_1	6	8	PF00082	0.511
CLV_PCSK_PC1ET2_1	36	38	PF00082	0.378
CLV_PCSK_SKI1_1	342	346	PF00082	0.469
CLV_PCSK_SKI1_1	7	11	PF00082	0.467
DEG_COP1_1	147	154	PF00400	0.552
DEG_Nend_UBRbox_2	1	3	PF02207	0.603
DEG_SCF_FBW7_1	174	180	PF00400	0.561
DEG_SPOP_SBC_1	146	150	PF00917	0.559
DOC_CDC14_PxL_1	163	171	PF14671	0.509
DOC_CKS1_1	151	156	PF01111	0.549
DOC_CKS1_1	174	179	PF01111	0.560
DOC_CKS1_1	249	254	PF01111	0.532
DOC_CKS1_1	54	59	PF01111	0.568
DOC_CYCLIN_yClb1_LxF_4	69	75	PF00134	0.485
DOC_CYCLIN_yCln2_LP_2	162	168	PF00134	0.649
DOC_CYCLIN_yCln2_LP_2	310	316	PF00134	0.705
DOC_MAPK_gen_1	262	269	PF00069	0.658
DOC_MAPK_gen_1	6	12	PF00069	0.495
DOC_MAPK_MEF2A_6	88	95	PF00069	0.538
DOC_PP2B_LxvP_1	169	172	PF13499	0.752
DOC_PP2B_LxvP_1	345	348	PF13499	0.489
DOC_PP4_FxxP_1	268	271	PF00568	0.501
DOC_USP7_MATH_1	146	150	PF00917	0.766
DOC_USP7_MATH_1	152	156	PF00917	0.567
DOC_USP7_MATH_1	177	181	PF00917	0.556
DOC_USP7_MATH_1	91	95	PF00917	0.696
DOC_WW_Pin1_4	150	155	PF00397	0.743
DOC_WW_Pin1_4	161	166	PF00397	0.600
DOC_WW_Pin1_4	173	178	PF00397	0.788
DOC_WW_Pin1_4	182	187	PF00397	0.619
DOC_WW_Pin1_4	200	205	PF00397	0.679
DOC_WW_Pin1_4	248	253	PF00397	0.731
DOC_WW_Pin1_4	309	314	PF00397	0.683
DOC_WW_Pin1_4	53	58	PF00397	0.501
DOC_WW_Pin1_4	94	99	PF00397	0.777
LIG_14-3-3_CanoR_1	144	154	PF00244	0.558
LIG_14-3-3_CanoR_1	202	211	PF00244	0.697
LIG_APCC_ABBA_1	10	15	PF00400	0.599
LIG_Clathr_ClatBox_1	22	26	PF01394	0.518
LIG_eIF4E_1	157	163	PF01652	0.689
LIG_FHA_1	102	108	PF00498	0.556
LIG_FHA_1	224	230	PF00498	0.630
LIG_FHA_1	249	255	PF00498	0.668
LIG_FHA_1	90	96	PF00498	0.735
LIG_FHA_2	271	277	PF00498	0.492
LIG_LIR_Apic_2	155	160	PF02991	0.694
LIG_LIR_Apic_2	71	76	PF02991	0.479
LIG_LIR_Gen_1	276	285	PF02991	0.601
LIG_LIR_Nem_3	276	282	PF02991	0.671
LIG_LIR_Nem_3	28	34	PF02991	0.603
LIG_MYND_1	167	171	PF01753	0.499
LIG_SH2_CRK	157	161	PF00017	0.693
LIG_SH2_CRK	32	36	PF00017	0.362
LIG_SH2_NCK_1	279	283	PF00017	0.455
LIG_SH2_SRC	242	245	PF00017	0.561
LIG_SH2_STAT5	13	16	PF00017	0.540
LIG_SH2_STAT5	157	160	PF00017	0.582
LIG_SH2_STAT5	242	245	PF00017	0.743
LIG_SH3_3	148	154	PF00018	0.747
LIG_SH3_3	162	168	PF00018	0.454
LIG_SH3_3	171	177	PF00018	0.681
LIG_SH3_3	205	211	PF00018	0.631
LIG_SH3_3	212	218	PF00018	0.630
LIG_SH3_3	246	252	PF00018	0.661
LIG_SH3_3	73	79	PF00018	0.496
LIG_SH3_3	92	98	PF00018	0.452
LIG_SUMO_SIM_anti_2	226	231	PF11976	0.576
LIG_SUMO_SIM_par_1	224	231	PF11976	0.576
LIG_SUMO_SIM_par_1	89	97	PF11976	0.541
LIG_TRAF2_1	322	325	PF00917	0.585
LIG_TRFH_1	344	348	PF08558	0.486
LIG_UBA3_1	22	30	PF00899	0.516
LIG_WW_3	77	81	PF00397	0.452
MOD_CDC14_SPxK_1	185	188	PF00782	0.586
MOD_CDK_SPxK_1	182	188	PF00069	0.586
MOD_CDK_SPxxK_3	182	189	PF00069	0.674
MOD_CK1_1	147	153	PF00069	0.696
MOD_CK1_1	155	161	PF00069	0.580
MOD_CK1_1	173	179	PF00069	0.560
MOD_CK1_1	203	209	PF00069	0.647
MOD_CK1_1	94	100	PF00069	0.629
MOD_CK2_1	314	320	PF00069	0.654
MOD_GlcNHglycan	122	126	PF01048	0.707
MOD_GlcNHglycan	130	133	PF01048	0.625
MOD_GlcNHglycan	179	182	PF01048	0.669
MOD_GlcNHglycan	2	6	PF01048	0.668
MOD_GlcNHglycan	223	226	PF01048	0.604
MOD_GlcNHglycan	256	259	PF01048	0.731
MOD_GlcNHglycan	307	310	PF01048	0.651
MOD_GSK3_1	146	153	PF00069	0.756
MOD_GSK3_1	173	180	PF00069	0.619
MOD_GSK3_1	305	312	PF00069	0.691
MOD_GSK3_1	315	322	PF00069	0.514
MOD_NEK2_1	1	6	PF00069	0.580
MOD_NEK2_1	121	126	PF00069	0.590
MOD_NEK2_1	145	150	PF00069	0.560
MOD_NEK2_1	254	259	PF00069	0.557
MOD_PIKK_1	203	209	PF00454	0.772
MOD_PK_1	82	88	PF00069	0.558
MOD_PKA_2	127	133	PF00069	0.655
MOD_Plk_1	275	281	PF00069	0.655
MOD_Plk_1	319	325	PF00069	0.531
MOD_Plk_2-3	270	276	PF00069	0.492
MOD_Plk_4	136	142	PF00069	0.812
MOD_Plk_4	152	158	PF00069	0.481
MOD_Plk_4	170	176	PF00069	0.620
MOD_Plk_4	270	276	PF00069	0.492
MOD_Plk_4	68	74	PF00069	0.477
MOD_Plk_4	82	88	PF00069	0.657
MOD_ProDKin_1	150	156	PF00069	0.744
MOD_ProDKin_1	161	167	PF00069	0.596
MOD_ProDKin_1	173	179	PF00069	0.790
MOD_ProDKin_1	182	188	PF00069	0.622
MOD_ProDKin_1	200	206	PF00069	0.679
MOD_ProDKin_1	248	254	PF00069	0.733
MOD_ProDKin_1	309	315	PF00069	0.681
MOD_ProDKin_1	53	59	PF00069	0.510
MOD_ProDKin_1	94	100	PF00069	0.782
TRG_DiLeu_BaEn_1	136	141	PF01217	0.698
TRG_DiLeu_BaEn_2	339	345	PF01217	0.450
TRG_DiLeu_BaLyEn_6	158	163	PF01217	0.675
TRG_DiLeu_BaLyEn_6	18	23	PF01217	0.649
TRG_ENDOCYTIC_2	242	245	PF00928	0.792
TRG_ENDOCYTIC_2	279	282	PF00928	0.570
TRG_ENDOCYTIC_2	32	35	PF00928	0.584
TRG_ENDOCYTIC_2	84	87	PF00928	0.532
TRG_ER_diArg_1	159	162	PF00400	0.672
TRG_ER_diArg_1	188	191	PF00400	0.573
TRG_ER_diArg_1	261	263	PF00400	0.767
TRG_ER_diArg_1	335	337	PF00400	0.409
TRG_ER_diArg_1	342	344	PF00400	0.522
TRG_Pf-PMV_PEXEL_1	21	26	PF00026	0.522
TRG_Pf-PMV_PEXEL_1	290	295	PF00026	0.559
TRG_Pf-PMV_PEXEL_1	336	340	PF00026	0.417
TRG_Pf-PMV_PEXEL_1	36	40	PF00026	0.533

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMP1	Leptomonas seymouri	36%	85%
A0A3S7X5H0	Leishmania donovani	55%	100%
A4I7V1	Leishmania infantum	55%	100%
E9B2R3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	100%
Q4Q5E4	Leishmania major	56%	95%