G5-interacting protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

G5-interacting protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HKC5_LEIBR

TriTrypDb:

LbrM.32.1530 , LBRM2903_320021400

Length:

781

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKC5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKC5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	664	668	PF00656	0.455
CLV_C14_Caspase3-7	766	770	PF00656	0.494
CLV_NRD_NRD_1	419	421	PF00675	0.297
CLV_NRD_NRD_1	739	741	PF00675	0.410
CLV_PCSK_KEX2_1	265	267	PF00082	0.537
CLV_PCSK_KEX2_1	458	460	PF00082	0.640
CLV_PCSK_KEX2_1	739	741	PF00082	0.410
CLV_PCSK_PC1ET2_1	265	267	PF00082	0.529
CLV_PCSK_PC1ET2_1	458	460	PF00082	0.520
CLV_PCSK_PC7_1	454	460	PF00082	0.466
CLV_PCSK_SKI1_1	312	316	PF00082	0.521
CLV_PCSK_SKI1_1	317	321	PF00082	0.549
CLV_PCSK_SKI1_1	458	462	PF00082	0.474
CLV_PCSK_SKI1_1	534	538	PF00082	0.497
DOC_CKS1_1	216	221	PF01111	0.526
DOC_CKS1_1	490	495	PF01111	0.321
DOC_CYCLIN_RxL_1	454	464	PF00134	0.488
DOC_CYCLIN_yClb5_NLxxxL_5	513	522	PF00134	0.473
DOC_MAPK_FxFP_2	646	649	PF00069	0.413
DOC_MAPK_gen_1	420	428	PF00069	0.407
DOC_MAPK_gen_1	653	660	PF00069	0.356
DOC_MAPK_gen_1	729	737	PF00069	0.534
DOC_MAPK_MEF2A_6	240	247	PF00069	0.315
DOC_MAPK_MEF2A_6	346	355	PF00069	0.265
DOC_MAPK_MEF2A_6	653	660	PF00069	0.356
DOC_MAPK_NFAT4_5	346	354	PF00069	0.341
DOC_PIKK_1	399	407	PF02985	0.405
DOC_PP1_RVXF_1	365	372	PF00149	0.533
DOC_PP2B_LxvP_1	226	229	PF13499	0.663
DOC_PP4_FxxP_1	630	633	PF00568	0.350
DOC_PP4_FxxP_1	646	649	PF00568	0.413
DOC_PP4_FxxP_1	756	759	PF00568	0.493
DOC_USP7_MATH_1	168	172	PF00917	0.680
DOC_USP7_MATH_1	181	185	PF00917	0.723
DOC_USP7_MATH_1	189	193	PF00917	0.632
DOC_USP7_MATH_1	285	289	PF00917	0.460
DOC_USP7_MATH_1	310	314	PF00917	0.405
DOC_USP7_MATH_1	452	456	PF00917	0.446
DOC_USP7_MATH_1	770	774	PF00917	0.301
DOC_USP7_UBL2_3	252	256	PF12436	0.515
DOC_USP7_UBL2_3	318	322	PF12436	0.473
DOC_USP7_UBL2_3	373	377	PF12436	0.468
DOC_USP7_UBL2_3	721	725	PF12436	0.620
DOC_USP7_UBL2_3	727	731	PF12436	0.585
DOC_WW_Pin1_4	185	190	PF00397	0.639
DOC_WW_Pin1_4	215	220	PF00397	0.753
DOC_WW_Pin1_4	239	244	PF00397	0.516
DOC_WW_Pin1_4	273	278	PF00397	0.463
DOC_WW_Pin1_4	300	305	PF00397	0.470
DOC_WW_Pin1_4	489	494	PF00397	0.321
DOC_WW_Pin1_4	74	79	PF00397	0.531
DOC_WW_Pin1_4	743	748	PF00397	0.521
LIG_14-3-3_CanoR_1	224	229	PF00244	0.677
LIG_14-3-3_CanoR_1	367	372	PF00244	0.529
LIG_BIR_II_1	1	5	PF00653	0.684
LIG_BRCT_BRCA1_1	590	594	PF00533	0.408
LIG_BRCT_BRCA1_2	590	596	PF00533	0.422
LIG_Clathr_ClatBox_1	553	557	PF01394	0.375
LIG_deltaCOP1_diTrp_1	667	672	PF00928	0.397
LIG_eIF4E_1	339	345	PF01652	0.455
LIG_FHA_1	240	246	PF00498	0.370
LIG_FHA_1	360	366	PF00498	0.322
LIG_FHA_1	490	496	PF00498	0.385
LIG_FHA_1	653	659	PF00498	0.418
LIG_FHA_1	704	710	PF00498	0.454
LIG_FHA_2	439	445	PF00498	0.479
LIG_FHA_2	464	470	PF00498	0.476
LIG_HP1_1	243	247	PF01393	0.359
LIG_LIR_Apic_2	429	435	PF02991	0.439
LIG_LIR_Apic_2	464	470	PF02991	0.445
LIG_LIR_Gen_1	100	109	PF02991	0.686
LIG_LIR_Gen_1	267	277	PF02991	0.504
LIG_LIR_Gen_1	475	483	PF02991	0.377
LIG_LIR_Gen_1	507	518	PF02991	0.375
LIG_LIR_Nem_3	100	105	PF02991	0.748
LIG_LIR_Nem_3	267	272	PF02991	0.441
LIG_LIR_Nem_3	475	479	PF02991	0.359
LIG_LIR_Nem_3	507	513	PF02991	0.370
LIG_LIR_Nem_3	514	519	PF02991	0.344
LIG_LIR_Nem_3	591	597	PF02991	0.473
LIG_LIR_Nem_3	619	624	PF02991	0.486
LIG_LIR_Nem_3	637	641	PF02991	0.488
LIG_LIR_Nem_3	671	675	PF02991	0.340
LIG_PTB_Apo_2	53	60	PF02174	0.736
LIG_PTB_Apo_2	642	649	PF02174	0.473
LIG_PTB_Phospho_1	53	59	PF10480	0.738
LIG_PTB_Phospho_1	642	648	PF10480	0.492
LIG_Rb_LxCxE_1	550	569	PF01857	0.387
LIG_RPA_C_Insects	571	586	PF08784	0.262
LIG_SH2_CRK	102	106	PF00017	0.743
LIG_SH2_CRK	129	133	PF00017	0.777
LIG_SH2_CRK	141	145	PF00017	0.634
LIG_SH2_CRK	516	520	PF00017	0.331
LIG_SH2_GRB2like	102	105	PF00017	0.746
LIG_SH2_GRB2like	54	57	PF00017	0.719
LIG_SH2_NCK_1	141	145	PF00017	0.629
LIG_SH2_NCK_1	467	471	PF00017	0.459
LIG_SH2_PTP2	271	274	PF00017	0.372
LIG_SH2_PTP2	510	513	PF00017	0.337
LIG_SH2_SRC	54	57	PF00017	0.663
LIG_SH2_STAP1	463	467	PF00017	0.586
LIG_SH2_STAP1	679	683	PF00017	0.538
LIG_SH2_STAT5	122	125	PF00017	0.656
LIG_SH2_STAT5	271	274	PF00017	0.372
LIG_SH2_STAT5	339	342	PF00017	0.332
LIG_SH2_STAT5	343	346	PF00017	0.356
LIG_SH2_STAT5	432	435	PF00017	0.419
LIG_SH2_STAT5	463	466	PF00017	0.573
LIG_SH2_STAT5	472	475	PF00017	0.330
LIG_SH2_STAT5	476	479	PF00017	0.289
LIG_SH2_STAT5	489	492	PF00017	0.253
LIG_SH2_STAT5	510	513	PF00017	0.315
LIG_SH2_STAT5	566	569	PF00017	0.358
LIG_SH2_STAT5	675	678	PF00017	0.426
LIG_SH3_1	432	438	PF00018	0.409
LIG_SH3_3	151	157	PF00018	0.724
LIG_SH3_3	209	215	PF00018	0.689
LIG_SH3_3	219	225	PF00018	0.666
LIG_SH3_3	3	9	PF00018	0.725
LIG_SH3_3	432	438	PF00018	0.399
LIG_SH3_3	542	548	PF00018	0.448
LIG_SH3_3	80	86	PF00018	0.680
LIG_SH3_3	92	98	PF00018	0.682
LIG_SH3_CIN85_PxpxPR_1	219	224	PF14604	0.613
LIG_SUMO_SIM_anti_2	393	401	PF11976	0.429
LIG_SUMO_SIM_anti_2	498	504	PF11976	0.300
LIG_SUMO_SIM_par_1	695	702	PF11976	0.486
LIG_TRAF2_1	528	531	PF00917	0.447
LIG_UBA3_1	518	523	PF00899	0.340
LIG_UBA3_1	532	537	PF00899	0.460
LIG_UBA3_1	570	575	PF00899	0.366
LIG_ULM_U2AF65_1	739	744	PF00076	0.466
LIG_WRC_WIRS_1	669	674	PF05994	0.465
LIG_WRC_WIRS_1	734	739	PF05994	0.416
MOD_CDK_SPK_2	239	244	PF00069	0.575
MOD_CDK_SPK_2	273	278	PF00069	0.319
MOD_CDK_SPxxK_3	217	224	PF00069	0.750
MOD_CDK_SPxxK_3	300	307	PF00069	0.481
MOD_CK1_1	185	191	PF00069	0.676
MOD_CK1_1	236	242	PF00069	0.632
MOD_CK1_1	599	605	PF00069	0.476
MOD_CK1_1	687	693	PF00069	0.516
MOD_CK1_1	763	769	PF00069	0.499
MOD_CK1_1	773	779	PF00069	0.541
MOD_CK2_1	285	291	PF00069	0.639
MOD_CK2_1	300	306	PF00069	0.523
MOD_CK2_1	360	366	PF00069	0.479
MOD_CK2_1	438	444	PF00069	0.526
MOD_CK2_1	463	469	PF00069	0.538
MOD_CK2_1	535	541	PF00069	0.448
MOD_Cter_Amidation	315	318	PF01082	0.308
MOD_GlcNHglycan	174	177	PF01048	0.665
MOD_GlcNHglycan	208	211	PF01048	0.781
MOD_GlcNHglycan	287	290	PF01048	0.581
MOD_GlcNHglycan	312	315	PF01048	0.369
MOD_GlcNHglycan	414	418	PF01048	0.467
MOD_GlcNHglycan	453	457	PF01048	0.442
MOD_GlcNHglycan	481	484	PF01048	0.483
MOD_GlcNHglycan	541	545	PF01048	0.504
MOD_GlcNHglycan	599	602	PF01048	0.496
MOD_GlcNHglycan	730	734	PF01048	0.426
MOD_GlcNHglycan	83	86	PF01048	0.810
MOD_GSK3_1	142	149	PF00069	0.644
MOD_GSK3_1	168	175	PF00069	0.700
MOD_GSK3_1	181	188	PF00069	0.533
MOD_GSK3_1	251	258	PF00069	0.511
MOD_GSK3_1	367	374	PF00069	0.616
MOD_GSK3_1	461	468	PF00069	0.445
MOD_GSK3_1	683	690	PF00069	0.475
MOD_GSK3_1	699	706	PF00069	0.307
MOD_GSK3_1	7	14	PF00069	0.763
MOD_GSK3_1	721	728	PF00069	0.569
MOD_GSK3_1	729	736	PF00069	0.406
MOD_GSK3_1	769	776	PF00069	0.520
MOD_N-GLC_1	182	187	PF02516	0.545
MOD_N-GLC_2	121	123	PF02516	0.656
MOD_NEK2_1	371	376	PF00069	0.571
MOD_NEK2_1	386	391	PF00069	0.359
MOD_NEK2_1	479	484	PF00069	0.416
MOD_NEK2_1	590	595	PF00069	0.500
MOD_NEK2_1	684	689	PF00069	0.490
MOD_NEK2_1	719	724	PF00069	0.524
MOD_NEK2_2	652	657	PF00069	0.265
MOD_PIKK_1	142	148	PF00454	0.642
MOD_PIKK_1	16	22	PF00454	0.529
MOD_PIKK_1	182	188	PF00454	0.541
MOD_PIKK_1	196	202	PF00454	0.698
MOD_PIKK_1	547	553	PF00454	0.427
MOD_PIKK_1	746	752	PF00454	0.472
MOD_PIKK_1	97	103	PF00454	0.696
MOD_PK_1	224	230	PF00069	0.666
MOD_PKA_1	317	323	PF00069	0.377
MOD_PKA_2	687	693	PF00069	0.521
MOD_Plk_1	359	365	PF00069	0.416
MOD_Plk_1	413	419	PF00069	0.386
MOD_Plk_1	452	458	PF00069	0.483
MOD_Plk_1	556	562	PF00069	0.361
MOD_Plk_1	729	735	PF00069	0.535
MOD_Plk_2-3	360	366	PF00069	0.443
MOD_Plk_4	233	239	PF00069	0.731
MOD_Plk_4	360	366	PF00069	0.500
MOD_Plk_4	498	504	PF00069	0.343
MOD_Plk_4	556	562	PF00069	0.380
MOD_Plk_4	763	769	PF00069	0.461
MOD_ProDKin_1	185	191	PF00069	0.639
MOD_ProDKin_1	215	221	PF00069	0.752
MOD_ProDKin_1	239	245	PF00069	0.500
MOD_ProDKin_1	273	279	PF00069	0.464
MOD_ProDKin_1	300	306	PF00069	0.469
MOD_ProDKin_1	489	495	PF00069	0.321
MOD_ProDKin_1	74	80	PF00069	0.532
MOD_ProDKin_1	743	749	PF00069	0.520
MOD_SUMO_for_1	264	267	PF00179	0.445
MOD_SUMO_for_1	402	405	PF00179	0.468
MOD_SUMO_for_1	536	539	PF00179	0.497
MOD_SUMO_rev_2	399	404	PF00179	0.474
MOD_SUMO_rev_2	607	616	PF00179	0.384
MOD_SUMO_rev_2	650	655	PF00179	0.451
TRG_DiLeu_BaEn_1	360	365	PF01217	0.432
TRG_DiLeu_BaEn_2	428	434	PF01217	0.422
TRG_DiLeu_BaLyEn_6	456	461	PF01217	0.318
TRG_DiLeu_BaLyEn_6	601	606	PF01217	0.462
TRG_ENDOCYTIC_2	102	105	PF00928	0.690
TRG_ENDOCYTIC_2	122	125	PF00928	0.656
TRG_ENDOCYTIC_2	129	132	PF00928	0.588
TRG_ENDOCYTIC_2	141	144	PF00928	0.540
TRG_ENDOCYTIC_2	271	274	PF00928	0.485
TRG_ENDOCYTIC_2	476	479	PF00928	0.357
TRG_ENDOCYTIC_2	510	513	PF00928	0.329
TRG_ENDOCYTIC_2	516	519	PF00928	0.361
TRG_ENDOCYTIC_2	621	624	PF00928	0.484
TRG_ER_diArg_1	656	659	PF00400	0.449
TRG_NLS_MonoExtC_3	533	539	PF00514	0.496

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P989	Leptomonas seymouri	58%	98%
A0A0S4IM67	Bodo saltans	23%	100%
A0A1X0NUG5	Trypanosomatidae	37%	100%
A0A3S7X5G1	Leishmania donovani	84%	99%
A0A422NI97	Trypanosoma rangeli	37%	100%
A4I7V2	Leishmania infantum	84%	99%
D0AA13	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9B2R2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	98%
Q4Q5E5	Leishmania major	84%	99%