LicD_family_-_putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

LicD family, putative

Species:

Leishmania braziliensis

UniProt:

A4HKC3_LEIBR

TriTrypDb:

LbrM.32.1510 , LBRM2903_320021200

Length:

488

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HKC3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKC3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	152	156	PF00656	0.544
CLV_C14_Caspase3-7	413	417	PF00656	0.308
CLV_C14_Caspase3-7	51	55	PF00656	0.507
CLV_C14_Caspase3-7	67	71	PF00656	0.618
CLV_MEL_PAP_1	235	241	PF00089	0.301
CLV_NRD_NRD_1	101	103	PF00675	0.614
CLV_NRD_NRD_1	237	239	PF00675	0.435
CLV_NRD_NRD_1	281	283	PF00675	0.556
CLV_NRD_NRD_1	417	419	PF00675	0.411
CLV_NRD_NRD_1	86	88	PF00675	0.450
CLV_PCSK_KEX2_1	236	238	PF00082	0.449
CLV_PCSK_KEX2_1	281	283	PF00082	0.556
CLV_PCSK_KEX2_1	86	88	PF00082	0.467
CLV_PCSK_SKI1_1	269	273	PF00082	0.489
CLV_PCSK_SKI1_1	483	487	PF00082	0.443
CLV_PCSK_SKI1_1	87	91	PF00082	0.481
DEG_Nend_UBRbox_3	1	3	PF02207	0.592
DEG_SCF_FBW7_1	167	172	PF00400	0.600
DEG_SPOP_SBC_1	175	179	PF00917	0.711
DEG_SPOP_SBC_1	441	445	PF00917	0.341
DOC_CKS1_1	466	471	PF01111	0.379
DOC_CYCLIN_RxL_1	242	254	PF00134	0.422
DOC_CYCLIN_yCln2_LP_2	451	454	PF00134	0.354
DOC_MAPK_gen_1	333	343	PF00069	0.290
DOC_MAPK_gen_1	36	46	PF00069	0.463
DOC_MAPK_MEF2A_6	212	220	PF00069	0.471
DOC_PP1_RVXF_1	147	154	PF00149	0.545
DOC_PP1_RVXF_1	246	253	PF00149	0.375
DOC_PP2B_LxvP_1	197	200	PF13499	0.673
DOC_PP2B_LxvP_1	312	315	PF13499	0.424
DOC_PP2B_LxvP_1	451	454	PF13499	0.354
DOC_PP2B_PxIxI_1	215	221	PF00149	0.468
DOC_PP4_FxxP_1	450	453	PF00568	0.342
DOC_PP4_FxxP_1	97	100	PF00568	0.567
DOC_USP7_MATH_1	156	160	PF00917	0.627
DOC_USP7_MATH_1	30	34	PF00917	0.538
DOC_USP7_MATH_1	60	64	PF00917	0.781
DOC_USP7_MATH_2	161	167	PF00917	0.483
DOC_USP7_UBL2_3	483	487	PF12436	0.520
DOC_WW_Pin1_4	165	170	PF00397	0.724
DOC_WW_Pin1_4	465	470	PF00397	0.403
LIG_14-3-3_CanoR_1	236	246	PF00244	0.446
LIG_14-3-3_CanoR_1	6	16	PF00244	0.644
LIG_Actin_WH2_2	71	88	PF00022	0.413
LIG_APCC_ABBA_1	286	291	PF00400	0.263
LIG_APCC_ABBAyCdc20_2	17	23	PF00400	0.551
LIG_BIR_III_2	310	314	PF00653	0.419
LIG_BRCT_BRCA1_1	123	127	PF00533	0.515
LIG_BRCT_BRCA1_1	79	83	PF00533	0.623
LIG_Clathr_ClatBox_1	217	221	PF01394	0.475
LIG_deltaCOP1_diTrp_1	92	97	PF00928	0.553
LIG_FHA_1	178	184	PF00498	0.761
LIG_FHA_1	212	218	PF00498	0.770
LIG_FHA_1	220	226	PF00498	0.585
LIG_FHA_1	245	251	PF00498	0.402
LIG_FHA_1	298	304	PF00498	0.246
LIG_FHA_1	36	42	PF00498	0.519
LIG_FHA_1	441	447	PF00498	0.577
LIG_FHA_1	473	479	PF00498	0.456
LIG_FHA_1	77	83	PF00498	0.409
LIG_FHA_2	139	145	PF00498	0.549
LIG_FHA_2	369	375	PF00498	0.333
LIG_FHA_2	430	436	PF00498	0.357
LIG_LIR_Apic_2	448	453	PF02991	0.283
LIG_LIR_Apic_2	464	469	PF02991	0.450
LIG_LIR_Gen_1	124	135	PF02991	0.566
LIG_LIR_Gen_1	144	154	PF02991	0.658
LIG_LIR_Gen_1	344	355	PF02991	0.328
LIG_LIR_Nem_3	124	130	PF02991	0.548
LIG_LIR_Nem_3	144	150	PF02991	0.596
LIG_LIR_Nem_3	185	191	PF02991	0.594
LIG_LIR_Nem_3	230	234	PF02991	0.427
LIG_LIR_Nem_3	283	289	PF02991	0.297
LIG_LIR_Nem_3	344	350	PF02991	0.426
LIG_LIR_Nem_3	481	485	PF02991	0.368
LIG_LYPXL_yS_3	379	382	PF13949	0.403
LIG_PCNA_yPIPBox_3	331	345	PF02747	0.459
LIG_Pex14_1	407	411	PF04695	0.398
LIG_Pex14_1	93	97	PF04695	0.606
LIG_SH2_CRK	335	339	PF00017	0.454
LIG_SH2_NCK_1	412	416	PF00017	0.391
LIG_SH2_STAP1	131	135	PF00017	0.546
LIG_SH2_STAP1	289	293	PF00017	0.306
LIG_SH2_STAP1	299	303	PF00017	0.416
LIG_SH2_STAP1	4	8	PF00017	0.465
LIG_SH2_STAT5	134	137	PF00017	0.497
LIG_SH2_STAT5	234	237	PF00017	0.413
LIG_SH2_STAT5	299	302	PF00017	0.351
LIG_SH2_STAT5	457	460	PF00017	0.320
LIG_SH2_STAT5	474	477	PF00017	0.386
LIG_SH3_3	188	194	PF00018	0.554
LIG_SH3_3	205	211	PF00018	0.430
LIG_SUMO_SIM_par_1	254	261	PF11976	0.425
LIG_TRAF2_1	141	144	PF00917	0.565
LIG_TRAF2_1	182	185	PF00917	0.484
LIG_TYR_ITIM	297	302	PF00017	0.303
LIG_TYR_ITIM	377	382	PF00017	0.344
MOD_CDK_SPK_2	465	470	PF00069	0.372
MOD_CK1_1	165	171	PF00069	0.673
MOD_CK1_1	318	324	PF00069	0.666
MOD_CK1_1	394	400	PF00069	0.312
MOD_CK1_1	445	451	PF00069	0.421
MOD_CK1_1	58	64	PF00069	0.635
MOD_CK2_1	104	110	PF00069	0.553
MOD_CK2_1	138	144	PF00069	0.627
MOD_CK2_1	407	413	PF00069	0.332
MOD_CK2_1	429	435	PF00069	0.447
MOD_CK2_1	470	476	PF00069	0.418
MOD_CK2_1	7	13	PF00069	0.506
MOD_CK2_1	78	84	PF00069	0.536
MOD_GlcNHglycan	106	109	PF01048	0.553
MOD_GlcNHglycan	123	126	PF01048	0.593
MOD_GlcNHglycan	32	35	PF01048	0.639
MOD_GlcNHglycan	320	323	PF01048	0.581
MOD_GlcNHglycan	387	390	PF01048	0.632
MOD_GlcNHglycan	447	450	PF01048	0.520
MOD_GlcNHglycan	57	60	PF01048	0.594
MOD_GlcNHglycan	9	12	PF01048	0.489
MOD_GSK3_1	104	111	PF00069	0.660
MOD_GSK3_1	163	170	PF00069	0.638
MOD_GSK3_1	258	265	PF00069	0.254
MOD_GSK3_1	381	388	PF00069	0.352
MOD_GSK3_1	40	47	PF00069	0.665
MOD_GSK3_1	441	448	PF00069	0.452
MOD_GSK3_1	58	65	PF00069	0.702
MOD_N-GLC_1	121	126	PF02516	0.533
MOD_N-GLC_1	76	81	PF02516	0.422
MOD_NEK2_1	341	346	PF00069	0.453
MOD_NEK2_1	367	372	PF00069	0.433
MOD_NEK2_1	382	387	PF00069	0.473
MOD_NEK2_2	108	113	PF00069	0.470
MOD_NEK2_2	407	412	PF00069	0.459
MOD_PIKK_1	156	162	PF00454	0.526
MOD_PIKK_1	262	268	PF00454	0.215
MOD_PKA_1	237	243	PF00069	0.313
MOD_PKA_2	2	8	PF00069	0.578
MOD_PKA_2	237	243	PF00069	0.400
MOD_Plk_1	138	144	PF00069	0.654
MOD_Plk_1	162	168	PF00069	0.489
MOD_Plk_1	202	208	PF00069	0.614
MOD_Plk_1	394	400	PF00069	0.312
MOD_Plk_1	435	441	PF00069	0.272
MOD_Plk_1	69	75	PF00069	0.708
MOD_Plk_2-3	138	144	PF00069	0.423
MOD_Plk_2-3	391	397	PF00069	0.345
MOD_Plk_4	108	114	PF00069	0.499
MOD_Plk_4	230	236	PF00069	0.437
MOD_Plk_4	258	264	PF00069	0.257
MOD_Plk_4	394	400	PF00069	0.497
MOD_Plk_4	407	413	PF00069	0.396
MOD_Plk_4	70	76	PF00069	0.694
MOD_Plk_4	78	84	PF00069	0.445
MOD_ProDKin_1	165	171	PF00069	0.725
MOD_ProDKin_1	465	471	PF00069	0.410
MOD_SUMO_rev_2	33	41	PF00179	0.624
MOD_SUMO_rev_2	476	485	PF00179	0.382
TRG_DiLeu_BaEn_2	400	406	PF01217	0.508
TRG_DiLeu_BaLyEn_6	213	218	PF01217	0.469
TRG_DiLeu_BaLyEn_6	333	338	PF01217	0.421
TRG_ENDOCYTIC_2	299	302	PF00928	0.382
TRG_ENDOCYTIC_2	335	338	PF00928	0.402
TRG_ENDOCYTIC_2	379	382	PF00928	0.360
TRG_ENDOCYTIC_2	4	7	PF00928	0.452
TRG_ER_diArg_1	235	238	PF00400	0.512
TRG_ER_diArg_1	85	87	PF00400	0.507
TRG_Pf-PMV_PEXEL_1	456	460	PF00026	0.456
TRG_Pf-PMV_PEXEL_1	96	101	PF00026	0.427

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMW8	Leptomonas seymouri	45%	100%
A0A1X0NUG9	Trypanosomatidae	31%	100%
A0A3S7X5H6	Leishmania donovani	71%	99%
A0A422P1A8	Trypanosoma rangeli	36%	100%
A4I7V4	Leishmania infantum	71%	99%
D0AA10	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9B2R0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	99%
Q4Q5E7	Leishmania major	69%	100%
V5B178	Trypanosoma cruzi	35%	100%