Cleavage and polyadenylation specificity factor-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cleavage and polyadenylation specificity factor- like protein

Species:

Leishmania braziliensis

UniProt:

A4HKC2_LEIBR

TriTrypDb:

LbrM.32.1500 , LBRM2903_320021100

Length:

1536

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11

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Expansion

Sequence features

A4HKC2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

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Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006378	mRNA polyadenylation	7	1
GO:0006396	RNA processing	6	1
GO:0006397	mRNA processing	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0005488	binding	1	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	367	371	PF00656	0.515
CLV_C14_Caspase3-7	682	686	PF00656	0.386
CLV_NRD_NRD_1	1456	1458	PF00675	0.221
CLV_NRD_NRD_1	1507	1509	PF00675	0.342
CLV_NRD_NRD_1	619	621	PF00675	0.304
CLV_NRD_NRD_1	642	644	PF00675	0.249
CLV_NRD_NRD_1	670	672	PF00675	0.363
CLV_NRD_NRD_1	763	765	PF00675	0.282
CLV_NRD_NRD_1	955	957	PF00675	0.428
CLV_NRD_NRD_1	979	981	PF00675	0.459

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P988	Leptomonas seymouri	70%	100%
A0A1X0NUH0	Trypanosomatidae	39%	100%
A0A3Q8IJ77	Leishmania donovani	85%	100%
A0A422P1D6	Trypanosoma rangeli	39%	100%
A4I7V5	Leishmania infantum	85%	100%
D0AA09	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9B2Q9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q1E5B0	Coccidioides immitis (strain RS)	20%	100%
Q4Q5E8	Leishmania major	85%	100%
Q9V726	Drosophila melanogaster	21%	100%

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