PPPDE domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PPPDE putative peptidase domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HKC1_LEIBR

TriTrypDb:

LbrM.32.1490 , LBRM2903_320021000

Length:

629

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HKC1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKC1

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0070646	protein modification by small protein removal	5	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008233	peptidase activity	3	12
GO:0016787	hydrolase activity	2	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	491	493	PF00675	0.517
CLV_PCSK_KEX2_1	21	23	PF00082	0.747
CLV_PCSK_KEX2_1	358	360	PF00082	0.537
CLV_PCSK_KEX2_1	491	493	PF00082	0.517
CLV_PCSK_PC1ET2_1	21	23	PF00082	0.592
CLV_PCSK_PC1ET2_1	358	360	PF00082	0.584
CLV_PCSK_SKI1_1	18	22	PF00082	0.665
CLV_PCSK_SKI1_1	229	233	PF00082	0.483
CLV_PCSK_SKI1_1	236	240	PF00082	0.497
CLV_PCSK_SKI1_1	278	282	PF00082	0.559
CLV_PCSK_SKI1_1	359	363	PF00082	0.487
CLV_PCSK_SKI1_1	402	406	PF00082	0.529
CLV_PCSK_SKI1_1	468	472	PF00082	0.248
CLV_PCSK_SKI1_1	537	541	PF00082	0.388
CLV_PCSK_SKI1_1	550	554	PF00082	0.292
DEG_APCC_DBOX_1	467	475	PF00400	0.507
DEG_SCF_FBW7_1	415	422	PF00400	0.218
DEG_SPOP_SBC_1	528	532	PF00917	0.276
DOC_ANK_TNKS_1	461	468	PF00023	0.583
DOC_CKS1_1	182	187	PF01111	0.258
DOC_CKS1_1	416	421	PF01111	0.222
DOC_CYCLIN_RxL_1	275	285	PF00134	0.231
DOC_CYCLIN_RxL_1	355	363	PF00134	0.360
DOC_MAPK_gen_1	358	364	PF00069	0.340
DOC_MAPK_gen_1	45	54	PF00069	0.530
DOC_MAPK_gen_1	491	500	PF00069	0.337
DOC_MAPK_JIP1_4	350	356	PF00069	0.329
DOC_MAPK_MEF2A_6	156	164	PF00069	0.278
DOC_MAPK_MEF2A_6	45	54	PF00069	0.532
DOC_MAPK_NFAT4_5	47	55	PF00069	0.450
DOC_PP2B_LxvP_1	110	113	PF13499	0.378
DOC_PP2B_LxvP_1	127	130	PF13499	0.501
DOC_USP7_MATH_1	104	108	PF00917	0.544
DOC_USP7_MATH_1	568	572	PF00917	0.573
DOC_USP7_UBL2_3	374	378	PF12436	0.291
DOC_WW_Pin1_4	149	154	PF00397	0.288
DOC_WW_Pin1_4	181	186	PF00397	0.258
DOC_WW_Pin1_4	415	420	PF00397	0.316
DOC_WW_Pin1_4	6	11	PF00397	0.501
LIG_14-3-3_CanoR_1	236	241	PF00244	0.218
LIG_14-3-3_CanoR_1	550	555	PF00244	0.583
LIG_14-3-3_CanoR_1	560	568	PF00244	0.558
LIG_14-3-3_CanoR_1	581	590	PF00244	0.490
LIG_14-3-3_CanoR_1	74	82	PF00244	0.575
LIG_14-3-3_CanoR_1	94	98	PF00244	0.472
LIG_Actin_WH2_2	104	122	PF00022	0.372
LIG_Actin_WH2_2	457	475	PF00022	0.518
LIG_APCC_ABBA_1	197	202	PF00400	0.339
LIG_APCC_ABBA_1	485	490	PF00400	0.294
LIG_BRCT_BRCA1_1	594	598	PF00533	0.609
LIG_Clathr_ClatBox_1	179	183	PF01394	0.339
LIG_FHA_1	103	109	PF00498	0.388
LIG_FHA_1	114	120	PF00498	0.371
LIG_FHA_1	182	188	PF00498	0.258
LIG_FHA_1	21	27	PF00498	0.401
LIG_FHA_1	219	225	PF00498	0.281
LIG_FHA_1	342	348	PF00498	0.362
LIG_FHA_1	367	373	PF00498	0.214
LIG_FHA_1	387	393	PF00498	0.366
LIG_FHA_1	394	400	PF00498	0.393
LIG_FHA_1	551	557	PF00498	0.479
LIG_FHA_2	152	158	PF00498	0.356
LIG_FHA_2	281	287	PF00498	0.243
LIG_FHA_2	381	387	PF00498	0.390
LIG_FHA_2	621	627	PF00498	0.567
LIG_GBD_Chelix_1	356	364	PF00786	0.520
LIG_GBD_Chelix_1	551	559	PF00786	0.321
LIG_IRF3_LxIS_1	115	122	PF10401	0.373
LIG_LIR_Gen_1	495	505	PF02991	0.289
LIG_LIR_Gen_1	569	580	PF02991	0.558
LIG_LIR_Nem_3	232	238	PF02991	0.338
LIG_LIR_Nem_3	250	254	PF02991	0.347
LIG_LIR_Nem_3	422	426	PF02991	0.312
LIG_LIR_Nem_3	459	463	PF02991	0.548
LIG_LIR_Nem_3	495	500	PF02991	0.308
LIG_LIR_Nem_3	569	575	PF02991	0.607
LIG_MYND_1	10	14	PF01753	0.434
LIG_MYND_1	461	465	PF01753	0.567
LIG_NRBOX	550	556	PF00104	0.508
LIG_NRBOX	616	622	PF00104	0.512
LIG_PCNA_yPIPBox_3	573	581	PF02747	0.515
LIG_PDZ_Class_2	624	629	PF00595	0.477
LIG_Pex14_1	423	427	PF04695	0.354
LIG_PTB_Apo_2	439	446	PF02174	0.350
LIG_REV1ctd_RIR_1	232	240	PF16727	0.291
LIG_SH2_CRK	132	136	PF00017	0.324
LIG_SH2_CRK	251	255	PF00017	0.304
LIG_SH2_NCK_1	132	136	PF00017	0.324
LIG_SH2_STAP1	547	551	PF00017	0.564
LIG_SH2_STAP1	602	606	PF00017	0.531
LIG_SH2_STAT3	171	174	PF00017	0.179
LIG_SH2_STAT5	171	174	PF00017	0.323
LIG_SH2_STAT5	200	203	PF00017	0.331
LIG_SH2_STAT5	219	222	PF00017	0.165
LIG_SH2_STAT5	279	282	PF00017	0.286
LIG_SH2_STAT5	367	370	PF00017	0.295
LIG_SH2_STAT5	407	410	PF00017	0.300
LIG_SH2_STAT5	514	517	PF00017	0.289
LIG_SH2_STAT5	592	595	PF00017	0.549
LIG_SH3_3	109	115	PF00018	0.487
LIG_SUMO_SIM_anti_2	105	112	PF11976	0.374
LIG_SUMO_SIM_anti_2	451	456	PF11976	0.321
LIG_SUMO_SIM_anti_2	495	502	PF11976	0.238
LIG_TRAF2_1	384	387	PF00917	0.220
LIG_TRAF2_1	58	61	PF00917	0.523
LIG_WW_1	129	132	PF00397	0.381
LIG_WW_3	71	75	PF00397	0.521
LIG_WW_3	91	95	PF00397	0.495
MOD_CDK_SPxxK_3	149	156	PF00069	0.423
MOD_CK1_1	134	140	PF00069	0.482
MOD_CK1_1	331	337	PF00069	0.462
MOD_CK1_1	496	502	PF00069	0.323
MOD_CK1_1	531	537	PF00069	0.285
MOD_CK1_1	611	617	PF00069	0.481
MOD_CK2_1	380	386	PF00069	0.489
MOD_CK2_1	50	56	PF00069	0.735
MOD_GlcNHglycan	136	139	PF01048	0.605
MOD_GlcNHglycan	189	192	PF01048	0.298
MOD_GlcNHglycan	272	275	PF01048	0.379
MOD_GlcNHglycan	330	333	PF01048	0.421
MOD_GlcNHglycan	389	392	PF01048	0.301
MOD_GlcNHglycan	47	50	PF01048	0.498
MOD_GlcNHglycan	509	512	PF01048	0.356
MOD_GlcNHglycan	531	534	PF01048	0.295
MOD_GSK3_1	1	8	PF00069	0.702
MOD_GSK3_1	102	109	PF00069	0.591
MOD_GSK3_1	236	243	PF00069	0.241
MOD_GSK3_1	337	344	PF00069	0.470
MOD_GSK3_1	411	418	PF00069	0.447
MOD_GSK3_1	444	451	PF00069	0.417
MOD_GSK3_1	527	534	PF00069	0.381
MOD_GSK3_1	81	88	PF00069	0.637
MOD_LATS_1	446	452	PF00433	0.388
MOD_N-GLC_1	2	7	PF02516	0.530
MOD_N-GLC_1	611	616	PF02516	0.367
MOD_NEK2_1	119	124	PF00069	0.764
MOD_NEK2_1	224	229	PF00069	0.291
MOD_NEK2_1	270	275	PF00069	0.355
MOD_NEK2_1	300	305	PF00069	0.526
MOD_NEK2_1	328	333	PF00069	0.474
MOD_NEK2_1	33	38	PF00069	0.651
MOD_NEK2_1	505	510	PF00069	0.438
MOD_NEK2_1	620	625	PF00069	0.372
MOD_NEK2_1	86	91	PF00069	0.754
MOD_NEK2_2	93	98	PF00069	0.470
MOD_PIKK_1	537	543	PF00454	0.426
MOD_PIKK_1	86	92	PF00454	0.706
MOD_PK_1	322	328	PF00069	0.506
MOD_PK_1	448	454	PF00069	0.339
MOD_PKA_2	119	125	PF00069	0.565
MOD_PKA_2	240	246	PF00069	0.314
MOD_PKA_2	349	355	PF00069	0.465
MOD_PKA_2	493	499	PF00069	0.337
MOD_PKA_2	93	99	PF00069	0.641
MOD_Plk_1	537	543	PF00069	0.498
MOD_Plk_2-3	56	62	PF00069	0.629
MOD_Plk_4	28	34	PF00069	0.736
MOD_Plk_4	306	312	PF00069	0.301
MOD_Plk_4	411	417	PF00069	0.352
MOD_Plk_4	448	454	PF00069	0.374
MOD_Plk_4	493	499	PF00069	0.336
MOD_Plk_4	550	556	PF00069	0.325
MOD_ProDKin_1	149	155	PF00069	0.342
MOD_ProDKin_1	181	187	PF00069	0.303
MOD_ProDKin_1	415	421	PF00069	0.388
MOD_ProDKin_1	6	12	PF00069	0.637
MOD_SUMO_for_1	288	291	PF00179	0.350
MOD_SUMO_for_1	372	375	PF00179	0.288
MOD_SUMO_rev_2	394	404	PF00179	0.303
TRG_DiLeu_BaEn_1	613	618	PF01217	0.357
TRG_DiLeu_BaEn_2	263	269	PF01217	0.350
TRG_DiLeu_BaLyEn_6	356	361	PF01217	0.414
TRG_DiLeu_BaLyEn_6	459	464	PF01217	0.453
TRG_ENDOCYTIC_2	132	135	PF00928	0.394
TRG_ENDOCYTIC_2	17	20	PF00928	0.686
TRG_ENDOCYTIC_2	251	254	PF00928	0.334
TRG_ENDOCYTIC_2	407	410	PF00928	0.330
TRG_ENDOCYTIC_2	602	605	PF00928	0.364
TRG_ER_diArg_1	212	215	PF00400	0.334
TRG_ER_diArg_1	315	318	PF00400	0.537
TRG_ER_diArg_1	491	493	PF00400	0.386
TRG_ER_diArg_1	559	562	PF00400	0.408
TRG_NLS_MonoExtC_3	17	22	PF00514	0.478
TRG_Pf-PMV_PEXEL_1	318	323	PF00026	0.523
TRG_Pf-PMV_PEXEL_1	359	363	PF00026	0.406
TRG_Pf-PMV_PEXEL_1	462	466	PF00026	0.491

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ICK7	Leptomonas seymouri	62%	100%
A0A0S4J986	Bodo saltans	31%	100%
A0A1X0NUY4	Trypanosomatidae	39%	100%
A0A3Q8IFV8	Leishmania donovani	75%	100%
A0A3R7KQA7	Trypanosoma rangeli	35%	100%
A4I7V0	Leishmania infantum	75%	100%
D0AA08	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9B2Q8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q4Q5E9	Leishmania major	75%	100%
V5BQT4	Trypanosoma cruzi	36%	100%