Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HKC0_LEIBR

TriTrypDb:

LbrM.32.1480 , LBRM2903_320020900

Length:

552

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKC0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKC0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	130	134	PF00656	0.525
CLV_NRD_NRD_1	255	257	PF00675	0.611
CLV_NRD_NRD_1	347	349	PF00675	0.512
CLV_NRD_NRD_1	522	524	PF00675	0.465
CLV_NRD_NRD_1	534	536	PF00675	0.476
CLV_PCSK_FUR_1	345	349	PF00082	0.586
CLV_PCSK_KEX2_1	254	256	PF00082	0.632
CLV_PCSK_KEX2_1	347	349	PF00082	0.512
CLV_PCSK_KEX2_1	504	506	PF00082	0.465
CLV_PCSK_KEX2_1	522	524	PF00082	0.372
CLV_PCSK_PC1ET2_1	504	506	PF00082	0.483
CLV_PCSK_SKI1_1	141	145	PF00082	0.549
CLV_PCSK_SKI1_1	297	301	PF00082	0.429
CLV_PCSK_SKI1_1	465	469	PF00082	0.503
CLV_PCSK_SKI1_1	49	53	PF00082	0.441
CLV_PCSK_SKI1_1	493	497	PF00082	0.583
CLV_PCSK_SKI1_1	79	83	PF00082	0.422
DEG_APCC_DBOX_1	521	529	PF00400	0.373
DEG_Nend_UBRbox_1	1	4	PF02207	0.463
DEG_SCF_FBW7_2	397	404	PF00400	0.441
DOC_CDC14_PxL_1	378	386	PF14671	0.483
DOC_CKS1_1	183	188	PF01111	0.562
DOC_CYCLIN_RxL_1	74	86	PF00134	0.479
DOC_CYCLIN_yCln2_LP_2	246	252	PF00134	0.519
DOC_CYCLIN_yCln2_LP_2	265	271	PF00134	0.510
DOC_PP2B_LxvP_1	144	147	PF13499	0.551
DOC_PP2B_LxvP_1	250	253	PF13499	0.757
DOC_PP2B_LxvP_1	45	48	PF13499	0.458
DOC_USP7_MATH_1	170	174	PF00917	0.590
DOC_USP7_MATH_1	190	194	PF00917	0.683
DOC_USP7_MATH_1	3	7	PF00917	0.458
DOC_USP7_MATH_1	380	384	PF00917	0.564
DOC_USP7_MATH_1	506	510	PF00917	0.427
DOC_WW_Pin1_4	182	187	PF00397	0.695
DOC_WW_Pin1_4	192	197	PF00397	0.837
DOC_WW_Pin1_4	397	402	PF00397	0.445
LIG_14-3-3_CanoR_1	232	238	PF00244	0.581
LIG_14-3-3_CanoR_1	256	262	PF00244	0.763
LIG_14-3-3_CanoR_1	360	365	PF00244	0.412
LIG_14-3-3_CanoR_1	505	511	PF00244	0.365
LIG_14-3-3_CanoR_1	66	70	PF00244	0.590
LIG_BIR_III_2	107	111	PF00653	0.502
LIG_EVH1_2	155	159	PF00568	0.563
LIG_EVH1_2	323	327	PF00568	0.530
LIG_FHA_1	178	184	PF00498	0.626
LIG_FHA_1	274	280	PF00498	0.502
LIG_FHA_1	293	299	PF00498	0.373
LIG_FHA_1	324	330	PF00498	0.531
LIG_FHA_1	398	404	PF00498	0.517
LIG_FHA_1	451	457	PF00498	0.554
LIG_FHA_2	122	128	PF00498	0.495
LIG_FHA_2	497	503	PF00498	0.461
LIG_FHA_2	53	59	PF00498	0.541
LIG_FHA_2	542	548	PF00498	0.463
LIG_FHA_2	66	72	PF00498	0.330
LIG_KLC1_Yacidic_2	498	502	PF13176	0.392
LIG_LIR_Gen_1	16	25	PF02991	0.371
LIG_LIR_Gen_1	242	252	PF02991	0.580
LIG_LIR_Gen_1	426	435	PF02991	0.471
LIG_LIR_Nem_3	16	22	PF02991	0.367
LIG_LIR_Nem_3	240	244	PF02991	0.682
LIG_LIR_Nem_3	308	313	PF02991	0.494
LIG_LIR_Nem_3	35	40	PF02991	0.516
LIG_LIR_Nem_3	426	432	PF02991	0.471
LIG_LIR_Nem_3	77	81	PF02991	0.595
LIG_PDZ_Class_2	547	552	PF00595	0.611
LIG_Pex14_1	429	433	PF04695	0.540
LIG_SH2_CRK	37	41	PF00017	0.445
LIG_SH2_GRB2like	19	22	PF00017	0.430
LIG_SH2_SRC	500	503	PF00017	0.366
LIG_SH2_STAP1	294	298	PF00017	0.513
LIG_SH2_STAT5	19	22	PF00017	0.430
LIG_SH2_STAT5	269	272	PF00017	0.649
LIG_SH2_STAT5	294	297	PF00017	0.415
LIG_SH2_STAT5	46	49	PF00017	0.497
LIG_SH2_STAT5	500	503	PF00017	0.468
LIG_SH2_STAT5	67	70	PF00017	0.400
LIG_SH3_1	145	151	PF00018	0.693
LIG_SH3_3	143	149	PF00018	0.609
LIG_SH3_3	260	266	PF00018	0.626
LIG_SH3_CIN85_PxpxPR_1	106	111	PF14604	0.411
LIG_SH3_CIN85_PxpxPR_1	249	254	PF14604	0.530
LIG_SUMO_SIM_anti_2	57	66	PF11976	0.499
LIG_TRAF2_1	172	175	PF00917	0.559
LIG_TRAF2_1	434	437	PF00917	0.588
LIG_UBA3_1	44	49	PF00899	0.476
LIG_UBA3_1	528	536	PF00899	0.369
MOD_CK1_1	292	298	PF00069	0.693
MOD_CK1_1	330	336	PF00069	0.532
MOD_CK1_1	383	389	PF00069	0.493
MOD_CK1_1	5	11	PF00069	0.450
MOD_CK2_1	125	131	PF00069	0.748
MOD_CK2_1	239	245	PF00069	0.524
MOD_CK2_1	360	366	PF00069	0.453
MOD_CK2_1	370	376	PF00069	0.583
MOD_CK2_1	496	502	PF00069	0.439
MOD_CK2_1	52	58	PF00069	0.535
MOD_CK2_1	541	547	PF00069	0.447
MOD_CK2_1	65	71	PF00069	0.323
MOD_GlcNHglycan	152	155	PF01048	0.665
MOD_GlcNHglycan	310	313	PF01048	0.668
MOD_GlcNHglycan	489	492	PF01048	0.525
MOD_GlcNHglycan	506	509	PF01048	0.359
MOD_GSK3_1	121	128	PF00069	0.719
MOD_GSK3_1	198	205	PF00069	0.763
MOD_GSK3_1	208	215	PF00069	0.604
MOD_GSK3_1	257	264	PF00069	0.602
MOD_GSK3_1	289	296	PF00069	0.446
MOD_GSK3_1	308	315	PF00069	0.580
MOD_GSK3_1	323	330	PF00069	0.549
MOD_GSK3_1	393	400	PF00069	0.523
MOD_GSK3_1	52	59	PF00069	0.462
MOD_GSK3_1	70	77	PF00069	0.287
MOD_LATS_1	494	500	PF00433	0.466
MOD_NEK2_1	325	330	PF00069	0.530
MOD_NEK2_1	487	492	PF00069	0.532
MOD_PIKK_1	198	204	PF00454	0.730
MOD_PIKK_1	231	237	PF00454	0.706
MOD_PIKK_1	239	245	PF00454	0.599
MOD_PIKK_1	257	263	PF00454	0.702
MOD_PKA_1	504	510	PF00069	0.364
MOD_PKA_2	231	237	PF00069	0.768
MOD_PKA_2	292	298	PF00069	0.517
MOD_PKA_2	308	314	PF00069	0.481
MOD_PKA_2	504	510	PF00069	0.459
MOD_PKA_2	65	71	PF00069	0.393
MOD_PKB_1	72	80	PF00069	0.485
MOD_Plk_1	239	245	PF00069	0.585
MOD_Plk_1	289	295	PF00069	0.618
MOD_Plk_2-3	127	133	PF00069	0.615
MOD_Plk_2-3	541	547	PF00069	0.429
MOD_Plk_4	496	502	PF00069	0.397
MOD_Plk_4	506	512	PF00069	0.368
MOD_ProDKin_1	182	188	PF00069	0.696
MOD_ProDKin_1	192	198	PF00069	0.838
MOD_ProDKin_1	397	403	PF00069	0.444
MOD_SUMO_for_1	409	412	PF00179	0.434
MOD_SUMO_rev_2	430	439	PF00179	0.525
MOD_SUMO_rev_2	498	506	PF00179	0.523
MOD_SUMO_rev_2	86	94	PF00179	0.472
TRG_DiLeu_BaEn_1	60	65	PF01217	0.496
TRG_DiLeu_BaLyEn_6	462	467	PF01217	0.490
TRG_ENDOCYTIC_2	19	22	PF00928	0.354
TRG_ENDOCYTIC_2	244	247	PF00928	0.681
TRG_ENDOCYTIC_2	37	40	PF00928	0.450
TRG_ER_diArg_1	110	113	PF00400	0.437
TRG_ER_diArg_1	253	256	PF00400	0.628
TRG_ER_diArg_1	344	347	PF00400	0.592
TRG_Pf-PMV_PEXEL_1	103	107	PF00026	0.520
TRG_Pf-PMV_PEXEL_1	256	261	PF00026	0.596
TRG_Pf-PMV_PEXEL_1	372	376	PF00026	0.573

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IKZ7	Leishmania donovani	69%	100%
A4I7U9	Leishmania infantum	69%	100%
D0AA07	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	97%
E9B2Q7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
Q4Q5F0	Leishmania major	68%	100%