WLM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WLM domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HKB9_LEIBR

TriTrypDb:

LbrM.32.1470 , LBRM2903_320020800

Length:

381

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKB9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKB9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	130	132	PF00675	0.368
CLV_NRD_NRD_1	14	16	PF00675	0.430
CLV_NRD_NRD_1	200	202	PF00675	0.376
CLV_NRD_NRD_1	224	226	PF00675	0.408
CLV_NRD_NRD_1	234	236	PF00675	0.574
CLV_PCSK_KEX2_1	130	132	PF00082	0.368
CLV_PCSK_KEX2_1	14	16	PF00082	0.430
CLV_PCSK_KEX2_1	190	192	PF00082	0.394
CLV_PCSK_KEX2_1	200	202	PF00082	0.365
CLV_PCSK_KEX2_1	224	226	PF00082	0.408
CLV_PCSK_KEX2_1	233	235	PF00082	0.358
CLV_PCSK_PC1ET2_1	190	192	PF00082	0.249
CLV_PCSK_PC7_1	220	226	PF00082	0.501
CLV_PCSK_SKI1_1	220	224	PF00082	0.444
CLV_PCSK_SKI1_1	371	375	PF00082	0.653
CLV_PCSK_SKI1_1	9	13	PF00082	0.376
DEG_APCC_DBOX_1	219	227	PF00400	0.501
DEG_Nend_UBRbox_2	1	3	PF02207	0.514
DEG_SCF_FBW7_1	111	118	PF00400	0.249
DEG_SPOP_SBC_1	138	142	PF00917	0.249
DOC_ANK_TNKS_1	45	52	PF00023	0.430
DOC_MAPK_gen_1	127	137	PF00069	0.249
DOC_MAPK_gen_1	14	21	PF00069	0.411
DOC_MAPK_gen_1	52	59	PF00069	0.430
DOC_MAPK_MEF2A_6	28	37	PF00069	0.376
DOC_MAPK_MEF2A_6	333	340	PF00069	0.543
DOC_MAPK_MEF2A_6	91	100	PF00069	0.430
DOC_PP4_FxxP_1	47	50	PF00568	0.376
DOC_SPAK_OSR1_1	46	50	PF12202	0.430
DOC_USP7_MATH_1	115	119	PF00917	0.436
DOC_USP7_MATH_1	138	142	PF00917	0.337
DOC_USP7_MATH_1	189	193	PF00917	0.299
DOC_WW_Pin1_4	111	116	PF00397	0.398
DOC_WW_Pin1_4	183	188	PF00397	0.420
LIG_14-3-3_CanoR_1	180	187	PF00244	0.404
LIG_14-3-3_CanoR_1	342	352	PF00244	0.726
LIG_APCC_ABBA_1	56	61	PF00400	0.430
LIG_BIR_III_4	152	156	PF00653	0.249
LIG_BRCT_BRCA1_1	191	195	PF00533	0.501
LIG_BRCT_BRCA1_1	307	311	PF00533	0.646
LIG_CtBP_PxDLS_1	337	341	PF00389	0.535
LIG_deltaCOP1_diTrp_1	290	299	PF00928	0.450
LIG_DLG_GKlike_1	28	35	PF00625	0.311
LIG_FHA_1	132	138	PF00498	0.249
LIG_FHA_1	242	248	PF00498	0.756
LIG_FHA_1	347	353	PF00498	0.680
LIG_FHA_2	351	357	PF00498	0.757
LIG_FHA_2	365	371	PF00498	0.723
LIG_LIR_Nem_3	54	59	PF02991	0.342
LIG_LIR_Nem_3	81	86	PF02991	0.378
LIG_LYPXL_S_1	107	111	PF13949	0.501
LIG_LYPXL_yS_3	108	111	PF13949	0.501
LIG_Pex14_1	83	87	PF04695	0.430
LIG_PTB_Apo_2	81	88	PF02174	0.430
LIG_PTB_Phospho_1	81	87	PF10480	0.430
LIG_SH2_CRK	87	91	PF00017	0.378
LIG_SH2_STAT5	113	116	PF00017	0.260
LIG_SH3_3	132	138	PF00018	0.249
LIG_SH3_3	233	239	PF00018	0.551
LIG_SH3_3	24	30	PF00018	0.249
LIG_SH3_3	7	13	PF00018	0.420
LIG_TYR_ITIM	85	90	PF00017	0.501
MOD_CDK_SPxxK_3	183	190	PF00069	0.249
MOD_CK1_1	118	124	PF00069	0.434
MOD_CK1_1	183	189	PF00069	0.354
MOD_CK1_1	241	247	PF00069	0.651
MOD_CK1_1	346	352	PF00069	0.701
MOD_CK2_1	350	356	PF00069	0.550
MOD_CK2_1	364	370	PF00069	0.738
MOD_Cter_Amidation	128	131	PF01082	0.467
MOD_Cter_Amidation	198	201	PF01082	0.376
MOD_Cter_Amidation	50	53	PF01082	0.430
MOD_GlcNHglycan	141	144	PF01048	0.432
MOD_GlcNHglycan	187	190	PF01048	0.451
MOD_GlcNHglycan	204	207	PF01048	0.271
MOD_GlcNHglycan	240	243	PF01048	0.746
MOD_GlcNHglycan	37	40	PF01048	0.249
MOD_GSK3_1	111	118	PF00069	0.402
MOD_GSK3_1	163	170	PF00069	0.321
MOD_GSK3_1	174	181	PF00069	0.334
MOD_GSK3_1	185	192	PF00069	0.331
MOD_GSK3_1	248	255	PF00069	0.760
MOD_GSK3_1	288	295	PF00069	0.601
MOD_GSK3_1	344	351	PF00069	0.678
MOD_N-GLC_1	257	262	PF02516	0.644
MOD_N-GLC_1	35	40	PF02516	0.249
MOD_N-GLC_1	78	83	PF02516	0.311
MOD_NEK2_1	116	121	PF00069	0.171
MOD_NEK2_1	202	207	PF00069	0.400
MOD_NEK2_1	338	343	PF00069	0.536
MOD_NEK2_1	35	40	PF00069	0.249
MOD_NEK2_1	96	101	PF00069	0.387
MOD_PIKK_1	120	126	PF00454	0.487
MOD_PIKK_1	259	265	PF00454	0.642
MOD_PIKK_1	73	79	PF00454	0.249
MOD_PKA_1	190	196	PF00069	0.249
MOD_PKA_2	179	185	PF00069	0.430
MOD_PKA_2	190	196	PF00069	0.175
MOD_PKA_2	292	298	PF00069	0.486
MOD_Plk_1	109	115	PF00069	0.286
MOD_Plk_1	131	137	PF00069	0.249
MOD_Plk_1	257	263	PF00069	0.704
MOD_Plk_1	338	344	PF00069	0.549
MOD_Plk_1	78	84	PF00069	0.360
MOD_Plk_1	96	102	PF00069	0.503
MOD_Plk_4	209	215	PF00069	0.249
MOD_Plk_4	248	254	PF00069	0.646
MOD_Plk_4	28	34	PF00069	0.430
MOD_Plk_4	96	102	PF00069	0.390
MOD_ProDKin_1	111	117	PF00069	0.398
MOD_ProDKin_1	183	189	PF00069	0.420
TRG_DiLeu_BaEn_1	370	375	PF01217	0.533
TRG_ENDOCYTIC_2	108	111	PF00928	0.501
TRG_ENDOCYTIC_2	113	116	PF00928	0.419
TRG_ENDOCYTIC_2	86	89	PF00928	0.376
TRG_ER_diArg_1	13	15	PF00400	0.430
TRG_ER_diArg_1	200	202	PF00400	0.376
TRG_ER_diArg_1	223	225	PF00400	0.408
TRG_ER_diArg_1	233	235	PF00400	0.350
TRG_ER_diArg_1	7	10	PF00400	0.436
TRG_Pf-PMV_PEXEL_1	225	229	PF00026	0.404

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAV8	Leptomonas seymouri	46%	89%
A0A0S4JA65	Bodo saltans	29%	89%
A0A3Q8IFF9	Leishmania donovani	65%	100%
A4I7U8	Leishmania infantum	66%	100%
E9B2Q6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	99%
Q4Q5F1	Leishmania major	66%	100%