Peptide deformylase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Peptide deformylase

Gene product:

polypeptide deformylase-like protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HKB8_LEIBR

TriTrypDb:

LbrM.32.1460 , LBRM2903_320020700

Length:

271

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HKB8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKB8

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	12
GO:0006518	peptide metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	12
GO:0009059	macromolecule biosynthetic process	4	12
GO:0009987	cellular process	1	12
GO:0019538	protein metabolic process	3	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	12
GO:0043043	peptide biosynthetic process	5	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043603	amide metabolic process	3	12
GO:0043604	amide biosynthetic process	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0044271	cellular nitrogen compound biosynthetic process	4	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901566	organonitrogen compound biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018206	peptidyl-methionine modification	6	1
GO:0031365	N-terminal protein amino acid modification	5	1
GO:0036211	protein modification process	4	1
GO:0043412	macromolecule modification	4	1
GO:0043686	co-translational protein modification	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0016787	hydrolase activity	2	12
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	12
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	4	12
GO:0042586	peptide deformylase activity	5	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	2	4	PF00675	0.657
CLV_PCSK_KEX2_1	2	4	PF00082	0.655
CLV_PCSK_SKI1_1	197	201	PF00082	0.376
CLV_PCSK_SKI1_1	59	63	PF00082	0.328
DEG_Nend_UBRbox_1	1	4	PF02207	0.719
DOC_PP4_FxxP_1	97	100	PF00568	0.344
DOC_USP7_MATH_1	57	61	PF00917	0.385
DOC_WW_Pin1_4	72	77	PF00397	0.363
LIG_14-3-3_CanoR_1	162	168	PF00244	0.418
LIG_BRCT_BRCA1_1	31	35	PF00533	0.696
LIG_BRCT_BRCA1_1	74	78	PF00533	0.421
LIG_FHA_1	152	158	PF00498	0.413
LIG_FHA_1	243	249	PF00498	0.409
LIG_FHA_1	60	66	PF00498	0.392
LIG_FHA_1	68	74	PF00498	0.397
LIG_FHA_2	22	28	PF00498	0.642
LIG_LIR_Apic_2	121	126	PF02991	0.315
LIG_LIR_Apic_2	96	100	PF02991	0.344
LIG_LIR_Gen_1	229	239	PF02991	0.411
LIG_LIR_Nem_3	229	234	PF02991	0.421
LIG_Pex14_1	221	225	PF04695	0.427
LIG_SH2_PTP2	231	234	PF00017	0.421
LIG_SH2_STAP1	120	124	PF00017	0.475
LIG_SH2_STAP1	256	260	PF00017	0.493
LIG_SH2_STAT5	231	234	PF00017	0.379
LIG_SH2_STAT5	241	244	PF00017	0.386
LIG_SH3_3	123	129	PF00018	0.344
LIG_SH3_3	154	160	PF00018	0.328
LIG_SH3_3	229	235	PF00018	0.440
LIG_SH3_3	244	250	PF00018	0.342
LIG_SUMO_SIM_par_1	107	113	PF11976	0.373
LIG_TRAF2_2	235	240	PF00917	0.376
LIG_UBA3_1	82	86	PF00899	0.243
MOD_CK1_1	149	155	PF00069	0.475
MOD_CK1_1	26	32	PF00069	0.679
MOD_CK2_1	21	27	PF00069	0.688
MOD_GlcNHglycan	226	229	PF01048	0.476
MOD_GlcNHglycan	97	100	PF01048	0.344
MOD_GSK3_1	23	30	PF00069	0.749
MOD_GSK3_1	68	75	PF00069	0.385
MOD_N-GLC_1	243	248	PF02516	0.500
MOD_NEK2_1	110	115	PF00069	0.365
MOD_NEK2_1	195	200	PF00069	0.370
MOD_NEK2_1	208	213	PF00069	0.324
MOD_NEK2_1	77	82	PF00069	0.341
MOD_NEK2_1	95	100	PF00069	0.218
MOD_NEK2_2	31	36	PF00069	0.433
MOD_PIKK_1	44	50	PF00454	0.560
MOD_PIKK_1	68	74	PF00454	0.420
MOD_PKA_2	161	167	PF00069	0.449
MOD_Plk_1	243	249	PF00069	0.494
MOD_Plk_4	195	201	PF00069	0.328
MOD_Plk_4	243	249	PF00069	0.492
MOD_Plk_4	78	84	PF00069	0.421
MOD_ProDKin_1	72	78	PF00069	0.363
MOD_SUMO_rev_2	34	43	PF00179	0.605
MOD_SUMO_rev_2	80	88	PF00179	0.223
TRG_DiLeu_BaEn_1	190	195	PF01217	0.441
TRG_DiLeu_BaLyEn_6	13	18	PF01217	0.673
TRG_ENDOCYTIC_2	231	234	PF00928	0.417
TRG_ER_diArg_1	1	3	PF00400	0.695
TRG_ER_diArg_1	182	185	PF00400	0.316
TRG_Pf-PMV_PEXEL_1	16	20	PF00026	0.755
TRG_Pf-PMV_PEXEL_1	185	190	PF00026	0.344

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4A0	Leptomonas seymouri	70%	99%
A0A0S4KJX6	Bodo saltans	53%	98%
A0A1X0NUS7	Trypanosomatidae	66%	100%
A0A3R7P233	Trypanosoma rangeli	65%	100%
A0A3S7X5G9	Leishmania donovani	84%	100%
A4I7U7	Leishmania infantum	84%	100%
D0AA05	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	100%
E9B2Q5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q5F2	Leishmania major	84%	100%
V5B173	Trypanosoma cruzi	64%	100%