Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein kinase domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HKB7_LEIBR

TriTrypDb:

LbrM.32.1450 , LBRM2903_320020600

Length:

560

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKB7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKB7

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016310	phosphorylation	5	11
GO:0019538	protein metabolic process	3	11
GO:0036211	protein modification process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0004672	protein kinase activity	3	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016301	kinase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0140096	catalytic activity, acting on a protein	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	139	143	PF00656	0.633
CLV_C14_Caspase3-7	457	461	PF00656	0.394
CLV_C14_Caspase3-7	90	94	PF00656	0.530
CLV_NRD_NRD_1	106	108	PF00675	0.738
CLV_NRD_NRD_1	130	132	PF00675	0.735
CLV_NRD_NRD_1	412	414	PF00675	0.408
CLV_NRD_NRD_1	536	538	PF00675	0.535
CLV_NRD_NRD_1	543	545	PF00675	0.477
CLV_PCSK_KEX2_1	129	131	PF00082	0.552
CLV_PCSK_KEX2_1	412	414	PF00082	0.408
CLV_PCSK_KEX2_1	536	538	PF00082	0.573
CLV_PCSK_KEX2_1	543	545	PF00082	0.482
CLV_PCSK_KEX2_1	558	560	PF00082	0.589
CLV_PCSK_PC7_1	554	560	PF00082	0.411
CLV_PCSK_SKI1_1	328	332	PF00082	0.387
CLV_PCSK_SKI1_1	502	506	PF00082	0.475
CLV_PCSK_SKI1_1	544	548	PF00082	0.518
CLV_Separin_Metazoa	104	108	PF03568	0.522
CLV_Separin_Metazoa	519	523	PF03568	0.531
DEG_APCC_DBOX_1	174	182	PF00400	0.356
DEG_SCF_FBW7_1	399	406	PF00400	0.447
DOC_CYCLIN_yCln2_LP_2	527	533	PF00134	0.290
DOC_MAPK_gen_1	214	222	PF00069	0.313
DOC_MAPK_MEF2A_6	266	274	PF00069	0.494
DOC_PP2B_LxvP_1	256	259	PF13499	0.379
DOC_PP2B_LxvP_1	272	275	PF13499	0.382
DOC_PP4_FxxP_1	243	246	PF00568	0.657
DOC_PP4_FxxP_1	80	83	PF00568	0.761
DOC_USP7_MATH_1	230	234	PF00917	0.528
DOC_USP7_MATH_1	339	343	PF00917	0.412
DOC_USP7_MATH_1	38	42	PF00917	0.544
DOC_USP7_MATH_1	403	407	PF00917	0.426
DOC_USP7_UBL2_3	206	210	PF12436	0.537
DOC_WW_Pin1_4	115	120	PF00397	0.533
DOC_WW_Pin1_4	191	196	PF00397	0.543
DOC_WW_Pin1_4	238	243	PF00397	0.680
DOC_WW_Pin1_4	399	404	PF00397	0.359
DOC_WW_Pin1_4	418	423	PF00397	0.335
DOC_WW_Pin1_4	467	472	PF00397	0.427
LIG_14-3-3_CanoR_1	130	136	PF00244	0.728
LIG_14-3-3_CanoR_1	332	340	PF00244	0.469
LIG_14-3-3_CanoR_1	522	527	PF00244	0.501
LIG_14-3-3_CanoR_1	543	547	PF00244	0.284
LIG_BIR_II_1	1	5	PF00653	0.752
LIG_BRCT_BRCA1_1	239	243	PF00533	0.720
LIG_CSL_BTD_1	192	195	PF09270	0.446
LIG_deltaCOP1_diTrp_1	431	435	PF00928	0.447
LIG_deltaCOP1_diTrp_1	548	555	PF00928	0.323
LIG_eIF4E_1	251	257	PF01652	0.502
LIG_FHA_1	192	198	PF00498	0.460
LIG_FHA_1	406	412	PF00498	0.227
LIG_FHA_1	449	455	PF00498	0.406
LIG_FHA_1	516	522	PF00498	0.339
LIG_FHA_2	372	378	PF00498	0.355
LIG_FHA_2	442	448	PF00498	0.335
LIG_FHA_2	543	549	PF00498	0.540
LIG_Integrin_RGD_1	61	63	PF01839	0.511
LIG_LIR_Apic_2	240	246	PF02991	0.679
LIG_LIR_Gen_1	248	259	PF02991	0.486
LIG_LIR_Gen_1	395	403	PF02991	0.335
LIG_LIR_Nem_3	145	151	PF02991	0.642
LIG_LIR_Nem_3	205	211	PF02991	0.382
LIG_LIR_Nem_3	248	254	PF02991	0.508
LIG_LIR_Nem_3	334	340	PF02991	0.441
LIG_LIR_Nem_3	395	399	PF02991	0.335
LIG_LIR_Nem_3	529	535	PF02991	0.443
LIG_LYPXL_S_1	26	30	PF13949	0.531
LIG_LYPXL_yS_3	27	30	PF13949	0.531
LIG_MYND_1	242	246	PF01753	0.669
LIG_NRP_CendR_1	558	560	PF00754	0.447
LIG_REV1ctd_RIR_1	78	82	PF16727	0.519
LIG_SH2_CRK	251	255	PF00017	0.510
LIG_SH2_STAP1	314	318	PF00017	0.496
LIG_SH2_STAT5	293	296	PF00017	0.718
LIG_SH2_STAT5	373	376	PF00017	0.451
LIG_SH3_3	174	180	PF00018	0.552
LIG_SH3_3	70	76	PF00018	0.622
LIG_TRAF2_1	245	248	PF00917	0.579
LIG_UBA3_1	504	510	PF00899	0.378
MOD_CDK_SPxK_1	401	407	PF00069	0.480
MOD_CK1_1	110	116	PF00069	0.520
MOD_CK1_1	133	139	PF00069	0.721
MOD_CK1_1	144	150	PF00069	0.628
MOD_CK1_1	201	207	PF00069	0.564
MOD_CK1_1	221	227	PF00069	0.502
MOD_CK1_1	238	244	PF00069	0.372
MOD_CK1_1	308	314	PF00069	0.507
MOD_CK1_1	401	407	PF00069	0.449
MOD_CK1_1	41	47	PF00069	0.755
MOD_CK1_1	418	424	PF00069	0.447
MOD_CK1_1	429	435	PF00069	0.362
MOD_CK1_1	490	496	PF00069	0.333
MOD_CK1_1	94	100	PF00069	0.755
MOD_CK2_1	115	121	PF00069	0.784
MOD_CK2_1	181	187	PF00069	0.507
MOD_CK2_1	213	219	PF00069	0.461
MOD_CK2_1	242	248	PF00069	0.606
MOD_CK2_1	277	283	PF00069	0.488
MOD_CK2_1	522	528	PF00069	0.493
MOD_CK2_1	542	548	PF00069	0.208
MOD_CK2_1	68	74	PF00069	0.504
MOD_GlcNHglycan	1	4	PF01048	0.738
MOD_GlcNHglycan	109	112	PF01048	0.749
MOD_GlcNHglycan	328	331	PF01048	0.498
MOD_GlcNHglycan	346	349	PF01048	0.493
MOD_GlcNHglycan	428	431	PF01048	0.227
MOD_GlcNHglycan	50	53	PF01048	0.748
MOD_GSK3_1	109	116	PF00069	0.675
MOD_GSK3_1	130	137	PF00069	0.726
MOD_GSK3_1	187	194	PF00069	0.603
MOD_GSK3_1	218	225	PF00069	0.513
MOD_GSK3_1	238	245	PF00069	0.631
MOD_GSK3_1	28	35	PF00069	0.674
MOD_GSK3_1	297	304	PF00069	0.674
MOD_GSK3_1	367	374	PF00069	0.447
MOD_GSK3_1	39	46	PF00069	0.725
MOD_GSK3_1	399	406	PF00069	0.388
MOD_GSK3_1	414	421	PF00069	0.442
MOD_GSK3_1	487	494	PF00069	0.443
MOD_GSK3_1	64	71	PF00069	0.741
MOD_N-GLC_1	131	136	PF02516	0.741
MOD_N-GLC_1	277	282	PF02516	0.504
MOD_N-GLC_1	308	313	PF02516	0.653
MOD_N-GLC_1	32	37	PF02516	0.549
MOD_NEK2_1	135	140	PF00069	0.544
MOD_NEK2_1	181	186	PF00069	0.507
MOD_NEK2_1	198	203	PF00069	0.441
MOD_NEK2_1	222	227	PF00069	0.514
MOD_NEK2_1	305	310	PF00069	0.750
MOD_NEK2_1	326	331	PF00069	0.535
MOD_NEK2_1	398	403	PF00069	0.406
MOD_NEK2_2	277	282	PF00069	0.499
MOD_NEK2_2	542	547	PF00069	0.481
MOD_NEK2_2	56	61	PF00069	0.522
MOD_PIKK_1	487	493	PF00454	0.317
MOD_PKA_1	107	113	PF00069	0.738
MOD_PKA_1	130	136	PF00069	0.728
MOD_PKA_2	130	136	PF00069	0.661
MOD_PKA_2	168	174	PF00069	0.433
MOD_PKA_2	213	219	PF00069	0.391
MOD_PKA_2	230	236	PF00069	0.665
MOD_PKA_2	331	337	PF00069	0.527
MOD_PKA_2	542	548	PF00069	0.285
MOD_PKB_1	129	137	PF00069	0.550
MOD_Plk_1	131	137	PF00069	0.631
MOD_Plk_1	198	204	PF00069	0.445
MOD_Plk_1	218	224	PF00069	0.494
MOD_Plk_1	277	283	PF00069	0.421
MOD_Plk_1	318	324	PF00069	0.567
MOD_Plk_1	32	38	PF00069	0.525
MOD_Plk_4	110	116	PF00069	0.778
MOD_Plk_4	168	174	PF00069	0.433
MOD_Plk_4	218	224	PF00069	0.513
MOD_Plk_4	289	295	PF00069	0.446
MOD_Plk_4	522	528	PF00069	0.537
MOD_Plk_4	64	70	PF00069	0.650
MOD_ProDKin_1	115	121	PF00069	0.534
MOD_ProDKin_1	191	197	PF00069	0.550
MOD_ProDKin_1	238	244	PF00069	0.668
MOD_ProDKin_1	399	405	PF00069	0.359
MOD_ProDKin_1	418	424	PF00069	0.335
MOD_ProDKin_1	467	473	PF00069	0.417
MOD_SUMO_rev_2	13	21	PF00179	0.486
TRG_DiLeu_BaEn_1	268	273	PF01217	0.530
TRG_DiLeu_BaEn_1	500	505	PF01217	0.509
TRG_DiLeu_BaEn_2	354	360	PF01217	0.480
TRG_DiLeu_BaEn_2	527	533	PF01217	0.543
TRG_DiLeu_BaEn_4	528	534	PF01217	0.510
TRG_DiLeu_BaLyEn_6	177	182	PF01217	0.393
TRG_DiLeu_BaLyEn_6	459	464	PF01217	0.578
TRG_ENDOCYTIC_2	251	254	PF00928	0.422
TRG_ENDOCYTIC_2	27	30	PF00928	0.689
TRG_ENDOCYTIC_2	337	340	PF00928	0.451
TRG_ER_diArg_1	129	131	PF00400	0.552
TRG_ER_diArg_1	411	413	PF00400	0.410
TRG_ER_diArg_1	535	537	PF00400	0.561
TRG_ER_diArg_1	558	560	PF00400	0.559
TRG_Pf-PMV_PEXEL_1	502	506	PF00026	0.470
TRG_Pf-PMV_PEXEL_1	82	86	PF00026	0.774

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEH1	Leptomonas seymouri	66%	100%
A0A1X0NUL0	Trypanosomatidae	38%	100%
A0A3S7X5E9	Leishmania donovani	73%	99%
A0A422P1A6	Trypanosoma rangeli	39%	100%
A4I7U6	Leishmania infantum	72%	100%
D0AA04	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9B2Q4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	99%
Q4Q5F3	Leishmania major	71%	100%
V5BGP5	Trypanosoma cruzi	39%	100%