CRAL-TRIO domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CRAL/TRIO domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HKB5_LEIBR

TriTrypDb:

LbrM.32.1430 , LBRM2903_320020200

Length:

760

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKB5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKB5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	65	69	PF00656	0.542
CLV_NRD_NRD_1	116	118	PF00675	0.462
CLV_NRD_NRD_1	260	262	PF00675	0.701
CLV_NRD_NRD_1	302	304	PF00675	0.628
CLV_NRD_NRD_1	311	313	PF00675	0.636
CLV_NRD_NRD_1	448	450	PF00675	0.324
CLV_NRD_NRD_1	507	509	PF00675	0.236
CLV_NRD_NRD_1	666	668	PF00675	0.448
CLV_NRD_NRD_1	688	690	PF00675	0.335
CLV_NRD_NRD_1	713	715	PF00675	0.393
CLV_PCSK_KEX2_1	116	118	PF00082	0.465
CLV_PCSK_KEX2_1	260	262	PF00082	0.704
CLV_PCSK_KEX2_1	302	304	PF00082	0.628
CLV_PCSK_KEX2_1	311	313	PF00082	0.636
CLV_PCSK_KEX2_1	448	450	PF00082	0.385
CLV_PCSK_KEX2_1	507	509	PF00082	0.266
CLV_PCSK_KEX2_1	657	659	PF00082	0.311
CLV_PCSK_KEX2_1	688	690	PF00082	0.380
CLV_PCSK_KEX2_1	712	714	PF00082	0.416
CLV_PCSK_PC1ET2_1	657	659	PF00082	0.311
CLV_PCSK_PC7_1	112	118	PF00082	0.495
CLV_PCSK_PC7_1	444	450	PF00082	0.356
CLV_PCSK_SKI1_1	124	128	PF00082	0.516
CLV_PCSK_SKI1_1	275	279	PF00082	0.490
CLV_PCSK_SKI1_1	512	516	PF00082	0.342
CLV_PCSK_SKI1_1	650	654	PF00082	0.435
CLV_PCSK_SKI1_1	658	662	PF00082	0.413
CLV_PCSK_SKI1_1	689	693	PF00082	0.355
CLV_PCSK_SKI1_1	94	98	PF00082	0.435
CLV_Separin_Metazoa	531	535	PF03568	0.229
DEG_APCC_DBOX_1	274	282	PF00400	0.494
DEG_Nend_Nbox_1	1	3	PF02207	0.534
DEG_SCF_FBW7_1	188	194	PF00400	0.535
DEG_SPOP_SBC_1	219	223	PF00917	0.622
DEG_SPOP_SBC_1	293	297	PF00917	0.553
DOC_CKS1_1	188	193	PF01111	0.569
DOC_CKS1_1	355	360	PF01111	0.467
DOC_CYCLIN_RxL_1	647	655	PF00134	0.495
DOC_CYCLIN_yCln2_LP_2	510	516	PF00134	0.302
DOC_MAPK_gen_1	311	322	PF00069	0.529
DOC_MAPK_gen_1	488	498	PF00069	0.229
DOC_MAPK_gen_1	558	566	PF00069	0.356
DOC_MAPK_gen_1	662	671	PF00069	0.451
DOC_MAPK_gen_1	686	693	PF00069	0.342
DOC_MAPK_gen_1	94	103	PF00069	0.435
DOC_MAPK_MEF2A_6	743	750	PF00069	0.349
DOC_MAPK_NFAT4_5	743	751	PF00069	0.400
DOC_PP1_RVXF_1	561	567	PF00149	0.353
DOC_PP1_RVXF_1	665	672	PF00149	0.382
DOC_PP1_RVXF_1	687	694	PF00149	0.354
DOC_PP2B_LxvP_1	146	149	PF13499	0.413
DOC_PP2B_LxvP_1	461	464	PF13499	0.229
DOC_USP7_MATH_1	106	110	PF00917	0.345
DOC_USP7_MATH_1	218	222	PF00917	0.526
DOC_USP7_MATH_1	247	251	PF00917	0.665
DOC_USP7_MATH_1	293	297	PF00917	0.672
DOC_USP7_MATH_1	610	614	PF00917	0.498
DOC_USP7_MATH_1	66	70	PF00917	0.542
DOC_USP7_MATH_1	663	667	PF00917	0.381
DOC_WW_Pin1_4	187	192	PF00397	0.631
DOC_WW_Pin1_4	214	219	PF00397	0.620
DOC_WW_Pin1_4	252	257	PF00397	0.676
DOC_WW_Pin1_4	289	294	PF00397	0.602
DOC_WW_Pin1_4	295	300	PF00397	0.570
DOC_WW_Pin1_4	3	8	PF00397	0.590
DOC_WW_Pin1_4	354	359	PF00397	0.601
DOC_WW_Pin1_4	415	420	PF00397	0.315
DOC_WW_Pin1_4	459	464	PF00397	0.247
DOC_WW_Pin1_4	475	480	PF00397	0.226
LIG_14-3-3_CanoR_1	275	281	PF00244	0.591
LIG_14-3-3_CanoR_1	285	293	PF00244	0.635
LIG_14-3-3_CanoR_1	302	307	PF00244	0.623
LIG_14-3-3_CanoR_1	523	528	PF00244	0.460
LIG_14-3-3_CanoR_1	561	567	PF00244	0.481
LIG_14-3-3_CanoR_1	667	672	PF00244	0.522
LIG_14-3-3_CanoR_1	743	749	PF00244	0.423
LIG_Actin_WH2_2	35	52	PF00022	0.414
LIG_APCC_ABBA_1	748	753	PF00400	0.319
LIG_BIR_III_2	421	425	PF00653	0.356
LIG_BIR_III_4	162	166	PF00653	0.515
LIG_BRCT_BRCA1_1	580	584	PF00533	0.229
LIG_BRCT_BRCA1_1	693	697	PF00533	0.333
LIG_Clathr_ClatBox_1	280	284	PF01394	0.502
LIG_Clathr_ClatBox_1	436	440	PF01394	0.356
LIG_deltaCOP1_diTrp_1	678	683	PF00928	0.359
LIG_deltaCOP1_diTrp_1	733	741	PF00928	0.412
LIG_eIF4E_1	15	21	PF01652	0.516
LIG_eIF4E_1	509	515	PF01652	0.302
LIG_eIF4E_1	527	533	PF01652	0.302
LIG_FHA_1	23	29	PF00498	0.429
LIG_FHA_1	295	301	PF00498	0.594
LIG_FHA_1	334	340	PF00498	0.609
LIG_FHA_1	37	43	PF00498	0.381
LIG_FHA_1	378	384	PF00498	0.290
LIG_FHA_1	431	437	PF00498	0.444
LIG_FHA_1	480	486	PF00498	0.266
LIG_FHA_1	540	546	PF00498	0.356
LIG_FHA_2	198	204	PF00498	0.549
LIG_FHA_2	416	422	PF00498	0.356
LIG_FHA_2	573	579	PF00498	0.337
LIG_FHA_2	59	65	PF00498	0.606
LIG_LIR_Apic_2	526	530	PF02991	0.229
LIG_LIR_Gen_1	182	191	PF02991	0.636
LIG_LIR_Gen_1	276	283	PF02991	0.618
LIG_LIR_Gen_1	314	322	PF02991	0.607
LIG_LIR_Gen_1	433	442	PF02991	0.461
LIG_LIR_Gen_1	546	557	PF02991	0.302
LIG_LIR_Gen_1	690	700	PF02991	0.490
LIG_LIR_Nem_3	182	188	PF02991	0.624
LIG_LIR_Nem_3	272	277	PF02991	0.567
LIG_LIR_Nem_3	314	319	PF02991	0.603
LIG_LIR_Nem_3	433	437	PF02991	0.353
LIG_LIR_Nem_3	526	532	PF02991	0.448
LIG_LIR_Nem_3	546	552	PF02991	0.202
LIG_LIR_Nem_3	690	696	PF02991	0.481
LIG_LIR_Nem_3	87	93	PF02991	0.356
LIG_MYND_1	129	133	PF01753	0.285
LIG_Pex14_2	693	697	PF04695	0.391
LIG_REV1ctd_RIR_1	738	747	PF16727	0.415
LIG_SH2_CRK	185	189	PF00017	0.552
LIG_SH2_CRK	399	403	PF00017	0.375
LIG_SH2_CRK	434	438	PF00017	0.401
LIG_SH2_CRK	511	515	PF00017	0.302
LIG_SH2_CRK	93	97	PF00017	0.360
LIG_SH2_GRB2like	185	188	PF00017	0.546
LIG_SH2_STAP1	185	189	PF00017	0.590
LIG_SH2_STAP1	362	366	PF00017	0.490
LIG_SH2_STAP1	434	438	PF00017	0.356
LIG_SH2_STAT5	399	402	PF00017	0.327
LIG_SH2_STAT5	445	448	PF00017	0.297
LIG_SH2_STAT5	509	512	PF00017	0.302
LIG_SH2_STAT5	537	540	PF00017	0.302
LIG_SH2_STAT5	549	552	PF00017	0.302
LIG_SH2_STAT5	722	725	PF00017	0.392
LIG_SH2_STAT5	90	93	PF00017	0.404
LIG_SH2_STAT5	95	98	PF00017	0.289
LIG_SH3_3	349	355	PF00018	0.577
LIG_SUMO_SIM_anti_2	276	282	PF11976	0.567
LIG_SUMO_SIM_anti_2	494	500	PF11976	0.260
LIG_SUMO_SIM_par_1	318	324	PF11976	0.532
LIG_SUMO_SIM_par_1	373	380	PF11976	0.355
LIG_SUMO_SIM_par_1	435	440	PF11976	0.476
LIG_SUMO_SIM_par_1	494	500	PF11976	0.302
LIG_TRFH_1	415	419	PF08558	0.302
LIG_TYR_ITIM	91	96	PF00017	0.407
LIG_UBA3_1	127	135	PF00899	0.286
LIG_UBA3_1	551	558	PF00899	0.229
MOD_CDK_SPxxK_3	295	302	PF00069	0.561
MOD_CDK_SPxxK_3	459	466	PF00069	0.229
MOD_CK1_1	197	203	PF00069	0.597
MOD_CK1_1	210	216	PF00069	0.592
MOD_CK1_1	22	28	PF00069	0.480
MOD_CK1_1	223	229	PF00069	0.698
MOD_CK1_1	241	247	PF00069	0.541
MOD_CK1_1	255	261	PF00069	0.685
MOD_CK1_1	267	273	PF00069	0.585
MOD_CK1_1	276	282	PF00069	0.643
MOD_CK1_1	292	298	PF00069	0.532
MOD_CK1_1	305	311	PF00069	0.602
MOD_CK1_1	318	324	PF00069	0.544
MOD_CK1_1	478	484	PF00069	0.295
MOD_CK1_1	56	62	PF00069	0.547
MOD_CK1_1	613	619	PF00069	0.532
MOD_CK1_1	624	630	PF00069	0.642
MOD_CK1_1	726	732	PF00069	0.312
MOD_CK1_1	739	745	PF00069	0.352
MOD_CK2_1	197	203	PF00069	0.547
MOD_CK2_1	231	237	PF00069	0.608
MOD_CK2_1	29	35	PF00069	0.351
MOD_CK2_1	324	330	PF00069	0.547
MOD_CK2_1	572	578	PF00069	0.293
MOD_CK2_1	59	65	PF00069	0.543
MOD_GlcNHglycan	196	199	PF01048	0.555
MOD_GlcNHglycan	239	243	PF01048	0.753
MOD_GlcNHglycan	269	272	PF01048	0.569
MOD_GlcNHglycan	323	326	PF01048	0.623
MOD_GlcNHglycan	467	470	PF01048	0.287
MOD_GlcNHglycan	55	58	PF01048	0.513
MOD_GlcNHglycan	607	610	PF01048	0.636
MOD_GlcNHglycan	612	615	PF01048	0.743
MOD_GlcNHglycan	68	71	PF01048	0.549
MOD_GlcNHglycan	693	696	PF01048	0.372
MOD_GlcNHglycan	698	701	PF01048	0.443
MOD_GSK3_1	106	113	PF00069	0.356
MOD_GSK3_1	15	22	PF00069	0.492
MOD_GSK3_1	187	194	PF00069	0.625
MOD_GSK3_1	202	209	PF00069	0.529
MOD_GSK3_1	210	217	PF00069	0.639
MOD_GSK3_1	219	226	PF00069	0.565
MOD_GSK3_1	269	276	PF00069	0.591
MOD_GSK3_1	285	292	PF00069	0.782
MOD_GSK3_1	301	308	PF00069	0.623
MOD_GSK3_1	311	318	PF00069	0.556
MOD_GSK3_1	320	327	PF00069	0.652
MOD_GSK3_1	474	481	PF00069	0.333
MOD_GSK3_1	49	56	PF00069	0.501
MOD_GSK3_1	539	546	PF00069	0.314
MOD_GSK3_1	565	572	PF00069	0.353
MOD_GSK3_1	599	606	PF00069	0.494
MOD_GSK3_1	60	67	PF00069	0.525
MOD_GSK3_1	609	616	PF00069	0.618
MOD_GSK3_1	621	628	PF00069	0.598
MOD_GSK3_1	632	639	PF00069	0.670
MOD_GSK3_1	663	670	PF00069	0.400
MOD_GSK3_1	722	729	PF00069	0.330
MOD_GSK3_1	732	739	PF00069	0.244
MOD_LATS_1	313	319	PF00433	0.550
MOD_LATS_1	687	693	PF00433	0.302
MOD_N-GLC_1	152	157	PF02516	0.504
MOD_N-GLC_1	264	269	PF02516	0.578
MOD_N-GLC_1	293	298	PF02516	0.637
MOD_N-GLC_1	539	544	PF02516	0.356
MOD_N-GLC_1	578	583	PF02516	0.225
MOD_N-GLC_1	610	615	PF02516	0.486
MOD_N-GLC_2	175	177	PF02516	0.493
MOD_NEK2_1	1	6	PF00069	0.657
MOD_NEK2_1	20	25	PF00069	0.316
MOD_NEK2_1	273	278	PF00069	0.631
MOD_NEK2_1	286	291	PF00069	0.547
MOD_NEK2_1	320	325	PF00069	0.556
MOD_NEK2_1	344	349	PF00069	0.432
MOD_NEK2_1	430	435	PF00069	0.353
MOD_NEK2_1	49	54	PF00069	0.479
MOD_NEK2_1	517	522	PF00069	0.302
MOD_NEK2_1	556	561	PF00069	0.279
MOD_NEK2_1	615	620	PF00069	0.628
MOD_NEK2_1	652	657	PF00069	0.340
MOD_NEK2_1	732	737	PF00069	0.305
MOD_NEK2_2	744	749	PF00069	0.390
MOD_PIKK_1	241	247	PF00454	0.598
MOD_PIKK_1	625	631	PF00454	0.642
MOD_PIKK_1	636	642	PF00454	0.542
MOD_PK_1	118	124	PF00069	0.364
MOD_PK_1	315	321	PF00069	0.529
MOD_PKA_1	118	124	PF00069	0.364
MOD_PKA_1	302	308	PF00069	0.599
MOD_PKA_1	311	317	PF00069	0.585
MOD_PKA_1	50	56	PF00069	0.564
MOD_PKA_1	667	673	PF00069	0.434
MOD_PKA_2	111	117	PF00069	0.369
MOD_PKA_2	206	212	PF00069	0.534
MOD_PKA_2	301	307	PF00069	0.587
MOD_PKA_2	311	317	PF00069	0.641
MOD_PKA_2	465	471	PF00069	0.288
MOD_PKA_2	663	669	PF00069	0.435
MOD_Plk_1	610	616	PF00069	0.488
MOD_Plk_1	689	695	PF00069	0.313
MOD_Plk_2-3	138	144	PF00069	0.312
MOD_Plk_4	220	226	PF00069	0.630
MOD_Plk_4	269	275	PF00069	0.640
MOD_Plk_4	276	282	PF00069	0.638
MOD_Plk_4	315	321	PF00069	0.655
MOD_Plk_4	357	363	PF00069	0.505
MOD_Plk_4	705	711	PF00069	0.422
MOD_Plk_4	736	742	PF00069	0.370
MOD_ProDKin_1	187	193	PF00069	0.632
MOD_ProDKin_1	214	220	PF00069	0.621
MOD_ProDKin_1	252	258	PF00069	0.677
MOD_ProDKin_1	289	295	PF00069	0.604
MOD_ProDKin_1	3	9	PF00069	0.588
MOD_ProDKin_1	354	360	PF00069	0.600
MOD_ProDKin_1	415	421	PF00069	0.315
MOD_ProDKin_1	459	465	PF00069	0.247
MOD_ProDKin_1	475	481	PF00069	0.226
TRG_ENDOCYTIC_2	185	188	PF00928	0.627
TRG_ENDOCYTIC_2	389	392	PF00928	0.396
TRG_ENDOCYTIC_2	399	402	PF00928	0.335
TRG_ENDOCYTIC_2	434	437	PF00928	0.401
TRG_ENDOCYTIC_2	511	514	PF00928	0.302
TRG_ENDOCYTIC_2	549	552	PF00928	0.469
TRG_ENDOCYTIC_2	93	96	PF00928	0.349
TRG_ER_diArg_1	448	451	PF00400	0.356
TRG_ER_diArg_1	506	508	PF00400	0.229
TRG_ER_diArg_1	711	714	PF00400	0.418
TRG_NLS_MonoCore_2	487	492	PF00514	0.229
TRG_NLS_MonoExtN_4	116	121	PF00514	0.385
TRG_Pf-PMV_PEXEL_1	140	144	PF00026	0.321
TRG_Pf-PMV_PEXEL_1	159	164	PF00026	0.499
TRG_Pf-PMV_PEXEL_1	202	206	PF00026	0.582

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P992	Leptomonas seymouri	44%	100%
A0A3S5H7R8	Leishmania donovani	62%	99%
A0A3S7X4P4	Leishmania donovani	22%	100%
A4HJI7	Leishmania braziliensis	22%	100%
A4I6Y2	Leishmania infantum	22%	100%
A4I7U4	Leishmania infantum	62%	99%
E9B204	Leishmania mexicana (strain MHOM/GT/2001/U1103)	21%	100%
E9B2Q2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	99%
Q4Q5F5	Leishmania major	62%	100%
Q4Q657	Leishmania major	22%	100%