CRAL-TRIO domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HKB4_LEIBR

TriTrypDb:

LbrM.32.1420 , LBRM2903_320020100

Length:

493

Annotations

LeishMANIAdb annotations

Carries a conserved CRAL-TRIO domain. Its didtant homologs are cytoplasmic and are involved in antiviral response.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKB4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKB4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	436	440	PF00656	0.689
CLV_NRD_NRD_1	53	55	PF00675	0.343
CLV_NRD_NRD_1	63	65	PF00675	0.276
CLV_PCSK_KEX2_1	234	236	PF00082	0.327
CLV_PCSK_KEX2_1	300	302	PF00082	0.326
CLV_PCSK_KEX2_1	52	54	PF00082	0.370
CLV_PCSK_PC1ET2_1	234	236	PF00082	0.405
CLV_PCSK_PC1ET2_1	300	302	PF00082	0.162
CLV_PCSK_SKI1_1	205	209	PF00082	0.369
CLV_PCSK_SKI1_1	241	245	PF00082	0.301
CLV_PCSK_SKI1_1	285	289	PF00082	0.239
CLV_PCSK_SKI1_1	325	329	PF00082	0.367
CLV_PCSK_SKI1_1	441	445	PF00082	0.528
CLV_PCSK_SKI1_1	53	57	PF00082	0.241
CLV_PCSK_SKI1_1	59	63	PF00082	0.215
CLV_Separin_Metazoa	166	170	PF03568	0.342
DEG_SCF_TRCP1_1	369	375	PF00400	0.254
DOC_MAPK_gen_1	358	365	PF00069	0.295
DOC_MAPK_gen_1	435	445	PF00069	0.594
DOC_MAPK_MEF2A_6	179	186	PF00069	0.266
DOC_MAPK_RevD_3	220	235	PF00069	0.162
DOC_PP1_RVXF_1	478	485	PF00149	0.410
DOC_PP1_RVXF_1	75	82	PF00149	0.219
DOC_PP2B_LxvP_1	261	264	PF13499	0.321
DOC_USP7_MATH_1	135	139	PF00917	0.212
DOC_USP7_UBL2_3	230	234	PF12436	0.456
DOC_WW_Pin1_4	172	177	PF00397	0.222
DOC_WW_Pin1_4	342	347	PF00397	0.709
DOC_WW_Pin1_4	390	395	PF00397	0.351
LIG_14-3-3_CanoR_1	134	144	PF00244	0.278
LIG_14-3-3_CanoR_1	403	411	PF00244	0.636
LIG_Actin_WH2_2	192	210	PF00022	0.162
LIG_BRCT_BRCA1_1	388	392	PF00533	0.314
LIG_deltaCOP1_diTrp_1	88	97	PF00928	0.376
LIG_FHA_1	163	169	PF00498	0.406
LIG_FHA_1	217	223	PF00498	0.248
LIG_FHA_1	335	341	PF00498	0.636
LIG_FHA_1	349	355	PF00498	0.436
LIG_FHA_1	440	446	PF00498	0.529
LIG_FHA_1	463	469	PF00498	0.255
LIG_FHA_2	125	131	PF00498	0.384
LIG_FHA_2	431	437	PF00498	0.525
LIG_FHA_2	8	14	PF00498	0.414
LIG_LIR_Gen_1	138	146	PF02991	0.244
LIG_LIR_Gen_1	375	383	PF02991	0.407
LIG_LIR_Nem_3	130	136	PF02991	0.377
LIG_LIR_Nem_3	138	143	PF02991	0.302
LIG_LIR_Nem_3	194	200	PF02991	0.300
LIG_LIR_Nem_3	228	232	PF02991	0.302
LIG_LIR_Nem_3	265	270	PF02991	0.333
LIG_LIR_Nem_3	375	379	PF02991	0.351
LIG_LIR_Nem_3	405	411	PF02991	0.693
LIG_LIR_Nem_3	88	93	PF02991	0.279
LIG_LYPXL_yS_3	251	254	PF13949	0.208
LIG_Pex14_2	374	378	PF04695	0.458
LIG_Pex14_2	388	392	PF04695	0.298
LIG_Pex14_2	93	97	PF04695	0.331
LIG_REV1ctd_RIR_1	264	272	PF16727	0.333
LIG_SH2_CRK	133	137	PF00017	0.400
LIG_SH2_CRK	271	275	PF00017	0.339
LIG_SH2_CRK	326	330	PF00017	0.433
LIG_SH2_CRK	58	62	PF00017	0.315
LIG_SH2_GRB2like	140	143	PF00017	0.266
LIG_SH2_GRB2like	191	194	PF00017	0.194
LIG_SH2_NCK_1	326	330	PF00017	0.388
LIG_SH2_PTP2	140	143	PF00017	0.337
LIG_SH2_SRC	140	143	PF00017	0.262
LIG_SH2_STAT5	140	143	PF00017	0.333
LIG_SH2_STAT5	198	201	PF00017	0.205
LIG_SH2_STAT5	42	45	PF00017	0.489
LIG_SH3_3	181	187	PF00018	0.321
LIG_SH3_3	408	414	PF00018	0.563
LIG_SH3_3	420	426	PF00018	0.683
LIG_SUMO_SIM_anti_2	180	186	PF11976	0.353
LIG_SUMO_SIM_anti_2	442	448	PF11976	0.283
LIG_SUMO_SIM_par_1	218	223	PF11976	0.314
LIG_SUMO_SIM_par_1	442	448	PF11976	0.283
LIG_SUMO_SIM_par_1	464	469	PF11976	0.377
LIG_TRAF2_1	19	22	PF00917	0.272
LIG_TRAF2_1	24	27	PF00917	0.229
LIG_TYR_ITIM	195	200	PF00017	0.321
MOD_CDK_SPxxK_3	172	179	PF00069	0.321
MOD_CK1_1	109	115	PF00069	0.434
MOD_CK1_1	415	421	PF00069	0.568
MOD_CK1_1	430	436	PF00069	0.532
MOD_CK2_1	274	280	PF00069	0.262
MOD_CK2_1	430	436	PF00069	0.529
MOD_CK2_1	7	13	PF00069	0.371
MOD_GlcNHglycan	369	372	PF01048	0.505
MOD_GlcNHglycan	399	402	PF01048	0.587
MOD_GlcNHglycan	404	407	PF01048	0.554
MOD_GlcNHglycan	414	417	PF01048	0.536
MOD_GSK3_1	330	337	PF00069	0.597
MOD_GSK3_1	350	357	PF00069	0.452
MOD_GSK3_1	386	393	PF00069	0.264
MOD_GSK3_1	397	404	PF00069	0.440
MOD_GSK3_1	412	419	PF00069	0.528
MOD_GSK3_1	427	434	PF00069	0.526
MOD_GSK3_1	454	461	PF00069	0.346
MOD_GSK3_1	462	469	PF00069	0.225
MOD_N-GLC_1	439	444	PF02516	0.346
MOD_NEK2_1	136	141	PF00069	0.236
MOD_NEK2_1	177	182	PF00069	0.358
MOD_NEK2_1	207	212	PF00069	0.414
MOD_NEK2_1	216	221	PF00069	0.296
MOD_NEK2_1	312	317	PF00069	0.279
MOD_NEK2_1	466	471	PF00069	0.278
MOD_NEK2_2	57	62	PF00069	0.207
MOD_PKA_2	402	408	PF00069	0.704
MOD_PKA_2	430	436	PF00069	0.482
MOD_Plk_1	439	445	PF00069	0.336
MOD_Plk_1	75	81	PF00069	0.322
MOD_Plk_2-3	124	130	PF00069	0.456
MOD_Plk_2-3	372	378	PF00069	0.273
MOD_Plk_4	106	112	PF00069	0.314
MOD_Plk_4	136	142	PF00069	0.292
MOD_Plk_4	177	183	PF00069	0.349
MOD_Plk_4	262	268	PF00069	0.296
MOD_Plk_4	454	460	PF00069	0.354
MOD_ProDKin_1	172	178	PF00069	0.222
MOD_ProDKin_1	342	348	PF00069	0.701
MOD_ProDKin_1	390	396	PF00069	0.365
MOD_SUMO_rev_2	103	107	PF00179	0.383
MOD_SUMO_rev_2	304	309	PF00179	0.284
TRG_ENDOCYTIC_2	133	136	PF00928	0.286
TRG_ENDOCYTIC_2	140	143	PF00928	0.297
TRG_ENDOCYTIC_2	197	200	PF00928	0.327
TRG_ENDOCYTIC_2	251	254	PF00928	0.227
TRG_ENDOCYTIC_2	271	274	PF00928	0.343
TRG_ENDOCYTIC_2	58	61	PF00928	0.283
TRG_ER_diArg_1	52	54	PF00400	0.366
TRG_NLS_Bipartite_1	52	68	PF00514	0.225
TRG_NLS_MonoExtN_4	62	68	PF00514	0.232
TRG_Pf-PMV_PEXEL_1	205	209	PF00026	0.335
TRG_Pf-PMV_PEXEL_1	241	245	PF00026	0.336
TRG_Pf-PMV_PEXEL_1	301	305	PF00026	0.216
TRG_PTS1	490	493	PF00515	0.384

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6D4	Leptomonas seymouri	23%	94%
A0A0N0P991	Leptomonas seymouri	28%	100%
A0A0N0P9K9	Leptomonas seymouri	54%	100%
A0A0N1I2J8	Leptomonas seymouri	27%	100%
A0A0N1PCS4	Leptomonas seymouri	25%	100%
A0A0S4J7N0	Bodo saltans	29%	100%
A0A0S4KJL3	Bodo saltans	28%	100%
A0A1X0NUH5	Trypanosomatidae	30%	85%
A0A1X0NUJ5	Trypanosomatidae	39%	100%
A0A3Q8IGQ2	Leishmania donovani	24%	100%
A0A3R7MUL5	Trypanosoma rangeli	27%	89%
A0A3S7X4P4	Leishmania donovani	27%	95%
A0A3S7X4R1	Leishmania donovani	24%	100%
A0A422P1E3	Trypanosoma rangeli	36%	100%
A4HJI7	Leishmania braziliensis	27%	100%
A4HJI8	Leishmania braziliensis	24%	100%
A4HJI9	Leishmania braziliensis	26%	100%
A4HKB3	Leishmania braziliensis	23%	100%
A4I6Y2	Leishmania infantum	27%	95%
A4I6Y3	Leishmania infantum	24%	100%
A4I6Y4	Leishmania infantum	29%	100%
A4I7U3	Leishmania infantum	24%	100%
B5MCN3	Homo sapiens	24%	100%
E9B204	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	95%
E9B205	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9B206	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9B2Q1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
O76054	Homo sapiens	24%	100%
P58875	Bos taurus	24%	100%
Q16KN5	Aedes aegypti	23%	76%
Q4Q5F6	Leishmania major	25%	98%
Q4Q656	Leishmania major	25%	100%
Q4Q657	Leishmania major	26%	100%
Q8R0F9	Mus musculus	22%	100%
Q99J08	Mus musculus	25%	100%
Q99MS0	Rattus norvegicus	25%	100%
Q9SCU1	Arabidopsis thaliana	23%	100%
Q9UDX3	Homo sapiens	22%	100%
Q9UDX4	Homo sapiens	26%	100%
Q9Z1J8	Rattus norvegicus	27%	100%
V5BL84	Trypanosoma cruzi	36%	100%
V5BQT0	Trypanosoma cruzi	28%	89%