LeishMANIAdb
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CRAL-TRIO domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
CRAL-TRIO domain-containing protein
Gene product:
CRAL/TRIO domain containing protein, putative
Species:
Leishmania braziliensis
UniProt:
A4HKB3_LEIBR
TriTrypDb:
LbrM.32.1410 , LBRM2903_320020000
Length:
479

Annotations

LeishMANIAdb annotations

Carries a conserved CRAL-TRIO domain. Its didtant homologs are cytoplasmic and are involved in antiviral response.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 34
NetGPI no yes: 0, no: 34
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HKB3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKB3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 149 151 PF00675 0.407
CLV_NRD_NRD_1 168 170 PF00675 0.185
CLV_NRD_NRD_1 221 223 PF00675 0.281
CLV_PCSK_KEX2_1 149 151 PF00082 0.407
CLV_PCSK_KEX2_1 21 23 PF00082 0.424
CLV_PCSK_KEX2_1 221 223 PF00082 0.281
CLV_PCSK_KEX2_1 404 406 PF00082 0.357
CLV_PCSK_KEX2_1 417 419 PF00082 0.594
CLV_PCSK_PC1ET2_1 21 23 PF00082 0.469
CLV_PCSK_PC1ET2_1 404 406 PF00082 0.357
CLV_PCSK_PC1ET2_1 417 419 PF00082 0.623
CLV_PCSK_SKI1_1 131 135 PF00082 0.289
CLV_PCSK_SKI1_1 169 173 PF00082 0.353
CLV_PCSK_SKI1_1 21 25 PF00082 0.444
CLV_PCSK_SKI1_1 241 245 PF00082 0.337
CLV_PCSK_SKI1_1 35 39 PF00082 0.461
CLV_PCSK_SKI1_1 414 418 PF00082 0.646
DOC_CYCLIN_yCln2_LP_2 11 17 PF00134 0.334
DOC_MAPK_gen_1 169 177 PF00069 0.352
DOC_MAPK_gen_1 221 229 PF00069 0.290
DOC_MAPK_gen_1 404 412 PF00069 0.571
DOC_MAPK_MEF2A_6 169 177 PF00069 0.420
DOC_MAPK_MEF2A_6 404 412 PF00069 0.571
DOC_PP1_RVXF_1 290 296 PF00149 0.308
DOC_PP4_FxxP_1 295 298 PF00568 0.383
DOC_SPAK_OSR1_1 387 391 PF12202 0.467
DOC_USP7_MATH_1 304 308 PF00917 0.424
DOC_USP7_MATH_1 99 103 PF00917 0.394
DOC_USP7_UBL2_3 360 364 PF12436 0.397
DOC_WW_Pin1_4 124 129 PF00397 0.345
DOC_WW_Pin1_4 134 139 PF00397 0.469
DOC_WW_Pin1_4 95 100 PF00397 0.233
LIG_14-3-3_CanoR_1 131 137 PF00244 0.444
LIG_14-3-3_CanoR_1 22 30 PF00244 0.455
LIG_14-3-3_CanoR_1 387 391 PF00244 0.416
LIG_14-3-3_CanoR_1 418 426 PF00244 0.514
LIG_14-3-3_CanoR_1 465 475 PF00244 0.502
LIG_AP2alpha_1 88 92 PF02296 0.224
LIG_BRCT_BRCA1_1 334 338 PF00533 0.539
LIG_BRCT_BRCA1_1 388 392 PF00533 0.417
LIG_deltaCOP1_diTrp_1 372 378 PF00928 0.308
LIG_FHA_1 124 130 PF00498 0.462
LIG_FHA_1 135 141 PF00498 0.501
LIG_FHA_1 162 168 PF00498 0.438
LIG_FHA_1 22 28 PF00498 0.446
LIG_FHA_1 224 230 PF00498 0.318
LIG_FHA_1 349 355 PF00498 0.403
LIG_FHA_1 48 54 PF00498 0.545
LIG_FHA_2 177 183 PF00498 0.325
LIG_FHA_2 417 423 PF00498 0.571
LIG_GBD_Chelix_1 154 162 PF00786 0.192
LIG_LIR_Apic_2 294 298 PF02991 0.383
LIG_LIR_Apic_2 436 441 PF02991 0.518
LIG_LIR_Gen_1 182 193 PF02991 0.407
LIG_LIR_Gen_1 255 266 PF02991 0.316
LIG_LIR_Gen_1 351 358 PF02991 0.411
LIG_LIR_Gen_1 385 394 PF02991 0.446
LIG_LIR_Nem_3 182 188 PF02991 0.307
LIG_LIR_Nem_3 235 239 PF02991 0.359
LIG_LIR_Nem_3 255 261 PF02991 0.403
LIG_LIR_Nem_3 351 356 PF02991 0.397
LIG_Pex14_2 100 104 PF04695 0.336
LIG_Pex14_2 184 188 PF04695 0.221
LIG_Pex14_2 388 392 PF04695 0.346
LIG_Pex14_2 88 92 PF04695 0.394
LIG_SH2_CRK 278 282 PF00017 0.374
LIG_SH2_CRK 65 69 PF00017 0.338
LIG_SH2_NCK_1 109 113 PF00017 0.293
LIG_SH2_PTP2 353 356 PF00017 0.507
LIG_SH2_SRC 202 205 PF00017 0.266
LIG_SH2_STAP1 65 69 PF00017 0.437
LIG_SH2_STAT3 393 396 PF00017 0.480
LIG_SH2_STAT5 353 356 PF00017 0.391
LIG_SH3_3 265 271 PF00018 0.368
LIG_SUMO_SIM_par_1 225 230 PF11976 0.359
LIG_TRAF2_1 339 342 PF00917 0.623
LIG_TYR_ITIM 154 159 PF00017 0.376
LIG_TYR_ITIM 234 239 PF00017 0.405
LIG_TYR_ITSM 349 356 PF00017 0.400
LIG_WRC_WIRS_1 314 319 PF05994 0.172
MOD_CDK_SPxxK_3 124 131 PF00069 0.314
MOD_CK1_1 102 108 PF00069 0.493
MOD_CK2_1 176 182 PF00069 0.343
MOD_CK2_1 416 422 PF00069 0.562
MOD_Cter_Amidation 358 361 PF01082 0.476
MOD_GlcNHglycan 101 104 PF01048 0.462
MOD_GlcNHglycan 282 285 PF01048 0.337
MOD_GlcNHglycan 306 309 PF01048 0.459
MOD_GlcNHglycan 334 337 PF01048 0.580
MOD_GlcNHglycan 35 38 PF01048 0.326
MOD_GSK3_1 276 283 PF00069 0.300
MOD_GSK3_1 328 335 PF00069 0.467
MOD_GSK3_1 348 355 PF00069 0.455
MOD_GSK3_1 377 384 PF00069 0.419
MOD_GSK3_1 48 55 PF00069 0.544
MOD_GSK3_1 95 102 PF00069 0.462
MOD_N-GLC_2 223 225 PF02516 0.407
MOD_NEK2_1 122 127 PF00069 0.439
MOD_NEK2_1 244 249 PF00069 0.344
MOD_NEK2_1 276 281 PF00069 0.324
MOD_NEK2_1 378 383 PF00069 0.356
MOD_PIKK_1 53 59 PF00454 0.322
MOD_PKA_1 21 27 PF00069 0.450
MOD_PKA_1 417 423 PF00069 0.555
MOD_PKA_2 21 27 PF00069 0.457
MOD_PKA_2 386 392 PF00069 0.451
MOD_PKA_2 417 423 PF00069 0.530
MOD_PKA_2 47 53 PF00069 0.418
MOD_Plk_4 163 169 PF00069 0.324
MOD_Plk_4 223 229 PF00069 0.334
MOD_Plk_4 26 32 PF00069 0.378
MOD_Plk_4 276 282 PF00069 0.320
MOD_Plk_4 313 319 PF00069 0.368
MOD_Plk_4 434 440 PF00069 0.437
MOD_Plk_4 452 458 PF00069 0.343
MOD_ProDKin_1 124 130 PF00069 0.342
MOD_ProDKin_1 134 140 PF00069 0.466
MOD_ProDKin_1 95 101 PF00069 0.232
TRG_ENDOCYTIC_2 130 133 PF00928 0.445
TRG_ENDOCYTIC_2 156 159 PF00928 0.351
TRG_ENDOCYTIC_2 236 239 PF00928 0.378
TRG_ENDOCYTIC_2 278 281 PF00928 0.374
TRG_ENDOCYTIC_2 353 356 PF00928 0.409
TRG_ENDOCYTIC_2 65 68 PF00928 0.333
TRG_ER_diArg_1 220 222 PF00400 0.277
TRG_ER_diArg_1 408 411 PF00400 0.612
TRG_NLS_MonoExtC_3 168 173 PF00514 0.221
TRG_Pf-PMV_PEXEL_1 241 245 PF00026 0.380

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6D4 Leptomonas seymouri 29% 91%
A0A0N0P991 Leptomonas seymouri 67% 100%
A0A0N0P9K9 Leptomonas seymouri 28% 100%
A0A0N1I2J8 Leptomonas seymouri 32% 100%
A0A0N1PCS4 Leptomonas seymouri 31% 100%
A0A0S4J7N0 Bodo saltans 24% 100%
A0A0S4KJL3 Bodo saltans 32% 100%
A0A1X0NUH5 Trypanosomatidae 24% 82%
A0A1X0NUJ5 Trypanosomatidae 28% 100%
A0A3Q8ICN0 Leishmania donovani 30% 96%
A0A3Q8IGQ2 Leishmania donovani 83% 100%
A0A3R7MUL5 Trypanosoma rangeli 24% 87%
A0A3S7X4P4 Leishmania donovani 29% 92%
A0A3S7X4R1 Leishmania donovani 32% 98%
A0A422P1E3 Trypanosoma rangeli 27% 100%
A4HJI7 Leishmania braziliensis 29% 100%
A4HJI8 Leishmania braziliensis 29% 100%
A4HJI9 Leishmania braziliensis 31% 100%
A4HKB4 Leishmania braziliensis 23% 97%
A4I6Y2 Leishmania infantum 30% 92%
A4I6Y3 Leishmania infantum 31% 98%
A4I6Y4 Leishmania infantum 30% 100%
A4I7U3 Leishmania infantum 83% 100%
A8Y5H7 Mus musculus 23% 67%
E9B204 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 92%
E9B205 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 98%
E9B206 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9B2Q1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 81% 100%
Q0V9N0 Xenopus tropicalis 23% 68%
Q4Q5F6 Leishmania major 82% 100%
Q4Q655 Leishmania major 29% 100%
Q4Q656 Leishmania major 31% 100%
Q4Q657 Leishmania major 28% 100%
Q99MS0 Rattus norvegicus 22% 100%
V5BL84 Trypanosoma cruzi 27% 100%
V5BQT0 Trypanosoma cruzi 24% 86%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS