Putative ubiquitin hydrolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquitin hydrolase, putative

Species:

Leishmania braziliensis

UniProt:

A4HKB2_LEIBR

TriTrypDb:

LbrM.32.1400 , LBRM2903_320019900

Length:

409

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKB2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKB2

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	12
GO:0006511	ubiquitin-dependent protein catabolic process	7	10
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	10
GO:0009057	macromolecule catabolic process	4	10
GO:0009987	cellular process	1	10
GO:0016579	protein deubiquitination	6	12
GO:0019538	protein metabolic process	3	12
GO:0019941	modification-dependent protein catabolic process	6	10
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0043632	modification-dependent macromolecule catabolic process	5	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	12
GO:0044248	cellular catabolic process	3	10
GO:0044260	obsolete cellular macromolecule metabolic process	3	10
GO:0044265	obsolete cellular macromolecule catabolic process	4	10
GO:0051603	proteolysis involved in protein catabolic process	5	10
GO:0070646	protein modification by small protein removal	5	12
GO:0070647	protein modification by small protein conjugation or removal	5	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901575	organic substance catabolic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004843	cysteine-type deubiquitinase activity	5	12
GO:0008233	peptidase activity	3	12
GO:0008234	cysteine-type peptidase activity	4	12
GO:0016787	hydrolase activity	2	12
GO:0019783	ubiquitin-like protein peptidase activity	4	12
GO:0101005	deubiquitinase activity	5	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	155	159	PF00656	0.223
CLV_C14_Caspase3-7	314	318	PF00656	0.239
CLV_NRD_NRD_1	281	283	PF00675	0.333
CLV_PCSK_KEX2_1	281	283	PF00082	0.329
CLV_PCSK_KEX2_1	301	303	PF00082	0.365
CLV_PCSK_PC1ET2_1	301	303	PF00082	0.410
CLV_PCSK_SKI1_1	261	265	PF00082	0.311
CLV_PCSK_SKI1_1	301	305	PF00082	0.425
CLV_PCSK_SKI1_1	47	51	PF00082	0.203
CLV_PCSK_SKI1_1	79	83	PF00082	0.182
DEG_Nend_UBRbox_3	1	3	PF02207	0.326
DEG_SCF_FBW7_1	141	147	PF00400	0.182
DEG_SPOP_SBC_1	146	150	PF00917	0.299
DOC_CKS1_1	141	146	PF01111	0.182
DOC_CYCLIN_RxL_1	299	309	PF00134	0.338
DOC_CYCLIN_yClb5_NLxxxL_5	261	267	PF00134	0.395
DOC_MAPK_DCC_7	268	277	PF00069	0.319
DOC_MAPK_gen_1	177	184	PF00069	0.338
DOC_MAPK_gen_1	212	221	PF00069	0.326
DOC_MAPK_gen_1	261	269	PF00069	0.350
DOC_MAPK_MEF2A_6	214	223	PF00069	0.424
DOC_MAPK_MEF2A_6	225	233	PF00069	0.389
DOC_MAPK_MEF2A_6	268	277	PF00069	0.319
DOC_MAPK_RevD_3	267	282	PF00069	0.389
DOC_PP2B_LxvP_1	304	307	PF13499	0.304
DOC_USP7_MATH_1	134	138	PF00917	0.329
DOC_USP7_MATH_1	144	148	PF00917	0.360
DOC_USP7_MATH_1	385	389	PF00917	0.244
DOC_USP7_UBL2_3	177	181	PF12436	0.361
DOC_USP7_UBL2_3	261	265	PF12436	0.308
DOC_USP7_UBL2_3	393	397	PF12436	0.424
DOC_WW_Pin1_4	140	145	PF00397	0.338
DOC_WW_Pin1_4	161	166	PF00397	0.421
DOC_WW_Pin1_4	348	353	PF00397	0.390
DOC_WW_Pin1_4	369	374	PF00397	0.429
DOC_WW_Pin1_4	79	84	PF00397	0.362
LIG_14-3-3_CanoR_1	218	222	PF00244	0.383
LIG_14-3-3_CanoR_1	324	329	PF00244	0.416
LIG_14-3-3_CanoR_1	59	65	PF00244	0.328
LIG_BIR_III_4	158	162	PF00653	0.182
LIG_BIR_III_4	189	193	PF00653	0.356
LIG_BIR_III_4	334	338	PF00653	0.182
LIG_Clathr_ClatBox_1	118	122	PF01394	0.424
LIG_Clathr_ClatBox_1	291	295	PF01394	0.338
LIG_FHA_1	249	255	PF00498	0.363
LIG_FHA_1	264	270	PF00498	0.313
LIG_FHA_1	320	326	PF00498	0.235
LIG_FHA_1	341	347	PF00498	0.341
LIG_FHA_1	349	355	PF00498	0.328
LIG_FHA_1	376	382	PF00498	0.401
LIG_Integrin_RGD_1	332	334	PF01839	0.424
LIG_LIR_Apic_2	224	230	PF02991	0.424
LIG_LIR_Gen_1	105	114	PF02991	0.316
LIG_LIR_Gen_1	21	29	PF02991	0.408
LIG_LIR_Nem_3	21	25	PF02991	0.408
LIG_LIR_Nem_3	224	229	PF02991	0.310
LIG_LIR_Nem_3	320	326	PF02991	0.312
LIG_LIR_Nem_3	398	404	PF02991	0.298
LIG_MYND_1	65	69	PF01753	0.450
LIG_NRBOX	106	112	PF00104	0.361
LIG_Pex14_1	48	52	PF04695	0.319
LIG_Pex14_1	53	57	PF04695	0.319
LIG_Pex14_2	18	22	PF04695	0.338
LIG_SH2_CRK	227	231	PF00017	0.450
LIG_SH2_CRK	323	327	PF00017	0.338
LIG_SH2_STAT5	208	211	PF00017	0.182
LIG_SH2_STAT5	227	230	PF00017	0.426
LIG_SH2_STAT5	341	344	PF00017	0.304
LIG_SH2_STAT5	401	404	PF00017	0.304
LIG_SH3_3	138	144	PF00018	0.182
LIG_SH3_3	66	72	PF00018	0.450
LIG_SUMO_SIM_anti_2	217	224	PF11976	0.393
LIG_SUMO_SIM_par_1	116	123	PF11976	0.223
LIG_TRAF2_1	98	101	PF00917	0.338
LIG_TYR_ITSM	397	404	PF00017	0.424
LIG_WRC_WIRS_1	19	24	PF05994	0.409
LIG_WRC_WIRS_1	42	47	PF05994	0.182
MOD_CK1_1	120	126	PF00069	0.284
MOD_CK1_1	145	151	PF00069	0.393
MOD_CK2_1	120	126	PF00069	0.321
MOD_CK2_1	254	260	PF00069	0.381
MOD_CK2_1	95	101	PF00069	0.324
MOD_DYRK1A_RPxSP_1	140	144	PF00069	0.182
MOD_GlcNHglycan	136	139	PF01048	0.320
MOD_GlcNHglycan	144	147	PF01048	0.381
MOD_GlcNHglycan	165	168	PF01048	0.250
MOD_GlcNHglycan	27	30	PF01048	0.190
MOD_GlcNHglycan	79	82	PF01048	0.405
MOD_GlcNHglycan	84	87	PF01048	0.411
MOD_GSK3_1	128	135	PF00069	0.328
MOD_GSK3_1	136	143	PF00069	0.390
MOD_GSK3_1	144	151	PF00069	0.448
MOD_GSK3_1	23	30	PF00069	0.416
MOD_GSK3_1	312	319	PF00069	0.349
MOD_GSK3_1	75	82	PF00069	0.233
MOD_N-GLC_1	161	166	PF02516	0.318
MOD_N-GLC_1	385	390	PF02516	0.428
MOD_N-GLC_2	5	7	PF02516	0.319
MOD_NEK2_1	196	201	PF00069	0.386
MOD_NEK2_1	245	250	PF00069	0.304
MOD_NEK2_1	25	30	PF00069	0.120
MOD_NEK2_1	263	268	PF00069	0.319
MOD_NEK2_1	60	65	PF00069	0.402
MOD_NEK2_1	8	13	PF00069	0.318
MOD_NEK2_1	95	100	PF00069	0.330
MOD_PIKK_1	88	94	PF00454	0.377
MOD_PK_1	324	330	PF00069	0.450
MOD_PKA_2	139	145	PF00069	0.328
MOD_PKA_2	217	223	PF00069	0.450
MOD_Plk_1	237	243	PF00069	0.319
MOD_Plk_1	245	251	PF00069	0.193
MOD_Plk_1	312	318	PF00069	0.298
MOD_Plk_1	319	325	PF00069	0.300
MOD_Plk_1	385	391	PF00069	0.424
MOD_Plk_2-3	117	123	PF00069	0.335
MOD_Plk_4	120	126	PF00069	0.182
MOD_Plk_4	196	202	PF00069	0.397
MOD_Plk_4	204	210	PF00069	0.359
MOD_Plk_4	217	223	PF00069	0.307
MOD_Plk_4	324	330	PF00069	0.362
MOD_Plk_4	340	346	PF00069	0.335
MOD_Plk_4	375	381	PF00069	0.389
MOD_Plk_4	396	402	PF00069	0.424
MOD_Plk_4	8	14	PF00069	0.416
MOD_ProDKin_1	140	146	PF00069	0.338
MOD_ProDKin_1	161	167	PF00069	0.421
MOD_ProDKin_1	348	354	PF00069	0.390
MOD_ProDKin_1	369	375	PF00069	0.429
MOD_ProDKin_1	79	85	PF00069	0.362
TRG_DiLeu_BaEn_2	397	403	PF01217	0.389
TRG_DiLeu_BaEn_4	116	122	PF01217	0.450
TRG_DiLeu_BaLyEn_6	321	326	PF01217	0.424
TRG_ENDOCYTIC_2	226	229	PF00928	0.424
TRG_ENDOCYTIC_2	323	326	PF00928	0.304
TRG_ENDOCYTIC_2	401	404	PF00928	0.304
TRG_ER_diArg_1	280	282	PF00400	0.350

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMP3	Leptomonas seymouri	65%	80%
A0A0S4IXL6	Bodo saltans	32%	75%
A0A1X0NUI1	Trypanosomatidae	43%	92%
A0A3S7X5G6	Leishmania donovani	78%	97%
A0A422P1B8	Trypanosoma rangeli	41%	93%
A4I7U2	Leishmania infantum	78%	76%
D0AA02	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	93%
E9B2Q0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
O94269	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	80%
Q4Q5F7	Leishmania major	78%	100%
Q9FPS3	Arabidopsis thaliana	25%	74%
V5DHM6	Trypanosoma cruzi	40%	100%