Putative ADP-ribosylation factor GTPase activating protein 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ADP-ribosylation factor GTPase activating protein 1, putative

Species:

Leishmania braziliensis

UniProt:

A4HKB0_LEIBR

TriTrypDb:

LbrM.32.1380 , LBRM2903_320019100

Length:

408

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000139	Golgi membrane	5	1
GO:0016020	membrane	2	1
GO:0031090	organelle membrane	3	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HKB0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKB0

Function

Biological processes
Term	Name	Level	Count
GO:0006901	vesicle coating	6	1
GO:0006996	organelle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0016050	vesicle organization	5	1
GO:0048200	Golgi transport vesicle coating	7	1
GO:0048205	COPI coating of Golgi vesicle	8	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0005096	GTPase activator activity	4	12
GO:0008047	enzyme activator activity	3	12
GO:0030234	enzyme regulator activity	2	12
GO:0030695	GTPase regulator activity	4	12
GO:0060589	nucleoside-triphosphatase regulator activity	3	12
GO:0098772	molecular function regulator activity	1	12
GO:0140677	molecular function activator activity	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	68	72	PF00656	0.363
CLV_NRD_NRD_1	90	92	PF00675	0.329
CLV_PCSK_KEX2_1	90	92	PF00082	0.344
DEG_SPOP_SBC_1	297	301	PF00917	0.535
DEG_SPOP_SBC_1	65	69	PF00917	0.363
DOC_CDC14_PxL_1	110	118	PF14671	0.534
DOC_MAPK_gen_1	77	86	PF00069	0.322
DOC_MAPK_gen_1	90	96	PF00069	0.413
DOC_MAPK_MEF2A_6	56	64	PF00069	0.344
DOC_PP1_RVXF_1	91	97	PF00149	0.413
DOC_USP7_MATH_1	149	153	PF00917	0.673
DOC_USP7_MATH_1	215	219	PF00917	0.716
DOC_USP7_MATH_1	23	27	PF00917	0.364
DOC_USP7_MATH_1	233	237	PF00917	0.643
DOC_USP7_MATH_1	296	300	PF00917	0.663
DOC_USP7_MATH_1	323	327	PF00917	0.744
DOC_USP7_MATH_1	338	342	PF00917	0.750
DOC_USP7_MATH_1	343	347	PF00917	0.773
DOC_USP7_MATH_2	296	302	PF00917	0.535
DOC_WW_Pin1_4	147	152	PF00397	0.541
DOC_WW_Pin1_4	284	289	PF00397	0.711
DOC_WW_Pin1_4	319	324	PF00397	0.760
DOC_WW_Pin1_4	32	37	PF00397	0.417
DOC_WW_Pin1_4	349	354	PF00397	0.662
DOC_WW_Pin1_4	5	10	PF00397	0.620
LIG_14-3-3_CanoR_1	225	229	PF00244	0.661
LIG_14-3-3_CanoR_1	276	284	PF00244	0.755
LIG_14-3-3_CanoR_1	310	314	PF00244	0.541
LIG_14-3-3_CanoR_1	66	71	PF00244	0.363
LIG_APCC_ABBAyCdc20_2	91	97	PF00400	0.413
LIG_BRCT_BRCA1_1	25	29	PF00533	0.458
LIG_CaM_NSCaTE_8	141	148	PF13499	0.607
LIG_CAP-Gly_1	404	408	PF01302	0.481
LIG_deltaCOP1_diTrp_1	133	141	PF00928	0.438
LIG_deltaCOP1_diTrp_1	71	76	PF00928	0.328
LIG_eIF4E_1	329	335	PF01652	0.510
LIG_FHA_1	211	217	PF00498	0.633
LIG_FHA_1	342	348	PF00498	0.769
LIG_FHA_2	319	325	PF00498	0.513
LIG_LIR_Apic_2	133	139	PF02991	0.435
LIG_LIR_Apic_2	352	358	PF02991	0.771
LIG_LIR_Apic_2	5	9	PF02991	0.566
LIG_LIR_Gen_1	12	23	PF02991	0.368
LIG_LIR_Gen_1	188	195	PF02991	0.561
LIG_LIR_Gen_1	196	205	PF02991	0.530
LIG_LIR_Gen_1	35	46	PF02991	0.449
LIG_LIR_Nem_3	12	18	PF02991	0.466
LIG_LIR_Nem_3	188	194	PF02991	0.544
LIG_LIR_Nem_3	196	201	PF02991	0.510
LIG_LIR_Nem_3	292	297	PF02991	0.735
LIG_LIR_Nem_3	35	41	PF02991	0.430
LIG_LIR_Nem_3	45	49	PF02991	0.371
LIG_PDZ_Class_3	403	408	PF00595	0.733
LIG_SH2_CRK	142	146	PF00017	0.539
LIG_SH2_CRK	191	195	PF00017	0.610
LIG_SH2_PTP2	6	9	PF00017	0.580
LIG_SH2_STAP1	118	122	PF00017	0.428
LIG_SH2_STAP1	191	195	PF00017	0.700
LIG_SH2_STAP1	242	246	PF00017	0.595
LIG_SH2_STAT5	6	9	PF00017	0.580
LIG_SH2_STAT5	95	98	PF00017	0.344
LIG_SH3_2	102	107	PF14604	0.496
LIG_SH3_2	393	398	PF14604	0.504
LIG_SH3_3	314	320	PF00018	0.766
LIG_SH3_3	362	368	PF00018	0.623
LIG_SH3_3	374	380	PF00018	0.812
LIG_SH3_3	390	396	PF00018	0.678
LIG_SH3_3	99	105	PF00018	0.328
MOD_CDC14_SPxK_1	357	360	PF00782	0.767
MOD_CDK_SPxK_1	354	360	PF00069	0.806
MOD_CK1_1	152	158	PF00069	0.707
MOD_CK1_1	181	187	PF00069	0.642
MOD_CK1_1	196	202	PF00069	0.440
MOD_CK1_1	299	305	PF00069	0.575
MOD_CK1_1	309	315	PF00069	0.569
MOD_CK1_1	322	328	PF00069	0.782
MOD_CK1_1	341	347	PF00069	0.515
MOD_CK1_1	349	355	PF00069	0.759
MOD_CK1_1	387	393	PF00069	0.674
MOD_CK2_1	147	153	PF00069	0.495
MOD_CK2_1	318	324	PF00069	0.671
MOD_CK2_1	334	340	PF00069	0.781
MOD_CMANNOS	73	76	PF00535	0.328
MOD_GlcNHglycan	157	160	PF01048	0.701
MOD_GlcNHglycan	180	183	PF01048	0.680
MOD_GlcNHglycan	191	194	PF01048	0.525
MOD_GlcNHglycan	195	198	PF01048	0.498
MOD_GlcNHglycan	217	220	PF01048	0.696
MOD_GlcNHglycan	235	238	PF01048	0.595
MOD_GlcNHglycan	252	255	PF01048	0.661
MOD_GlcNHglycan	336	339	PF01048	0.739
MOD_GlcNHglycan	340	343	PF01048	0.742
MOD_GlcNHglycan	384	389	PF01048	0.729
MOD_GlcNHglycan	51	54	PF01048	0.348
MOD_GSK3_1	181	188	PF00069	0.643
MOD_GSK3_1	189	196	PF00069	0.551
MOD_GSK3_1	199	206	PF00069	0.496
MOD_GSK3_1	233	240	PF00069	0.568
MOD_GSK3_1	296	303	PF00069	0.566
MOD_GSK3_1	318	325	PF00069	0.719
MOD_GSK3_1	334	341	PF00069	0.620
MOD_GSK3_1	343	350	PF00069	0.727
MOD_GSK3_1	363	370	PF00069	0.743
MOD_GSK3_1	60	67	PF00069	0.328
MOD_N-GLC_1	2	7	PF02516	0.431
MOD_N-GLC_1	363	368	PF02516	0.764
MOD_N-GLC_1	399	404	PF02516	0.496
MOD_N-GLC_1	49	54	PF02516	0.449
MOD_NEK2_1	250	255	PF00069	0.500
MOD_NEK2_1	334	339	PF00069	0.717
MOD_NEK2_1	42	47	PF00069	0.344
MOD_NEK2_1	49	54	PF00069	0.284
MOD_NEK2_1	64	69	PF00069	0.320
MOD_PIKK_1	199	205	PF00454	0.604
MOD_PKA_2	224	230	PF00069	0.690
MOD_PKA_2	309	315	PF00069	0.635
MOD_PKA_2	65	71	PF00069	0.363
MOD_PKB_1	107	115	PF00069	0.431
MOD_Plk_1	2	8	PF00069	0.588
MOD_Plk_1	363	369	PF00069	0.737
MOD_Plk_1	399	405	PF00069	0.591
MOD_Plk_2-3	399	405	PF00069	0.591
MOD_Plk_4	2	8	PF00069	0.487
MOD_Plk_4	42	48	PF00069	0.430
MOD_Plk_4	60	66	PF00069	0.185
MOD_ProDKin_1	147	153	PF00069	0.553
MOD_ProDKin_1	284	290	PF00069	0.712
MOD_ProDKin_1	319	325	PF00069	0.760
MOD_ProDKin_1	32	38	PF00069	0.417
MOD_ProDKin_1	349	355	PF00069	0.664
MOD_ProDKin_1	5	11	PF00069	0.608
TRG_ENDOCYTIC_2	110	113	PF00928	0.395
TRG_ENDOCYTIC_2	118	121	PF00928	0.389
TRG_ENDOCYTIC_2	142	145	PF00928	0.452
TRG_ENDOCYTIC_2	191	194	PF00928	0.606
TRG_ENDOCYTIC_2	294	297	PF00928	0.745
TRG_ER_diArg_1	106	109	PF00400	0.376
TRG_ER_diArg_1	90	93	PF00400	0.341
TRG_Pf-PMV_PEXEL_1	332	336	PF00026	0.760

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMX1	Leptomonas seymouri	56%	100%
A0A0S4KJM8	Bodo saltans	42%	73%
A0A1X0NUZ4	Trypanosomatidae	50%	100%
A0A3Q8IGX3	Leishmania donovani	72%	100%
A0A422P1B3	Trypanosoma rangeli	52%	100%
A4I7U0	Leishmania infantum	72%	100%
D0AA00	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9B2P8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%
Q4Q5F9	Leishmania major	71%	98%
V5BGP1	Trypanosoma cruzi	50%	100%