DUF4709 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HKA9_LEIBR

TriTrypDb:

LbrM.32.1370 , LBRM2903_320019000

Length:

797

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKA9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKA9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	161	165	PF00656	0.546
CLV_C14_Caspase3-7	728	732	PF00656	0.670
CLV_NRD_NRD_1	104	106	PF00675	0.430
CLV_NRD_NRD_1	155	157	PF00675	0.600
CLV_NRD_NRD_1	17	19	PF00675	0.604
CLV_NRD_NRD_1	252	254	PF00675	0.338
CLV_NRD_NRD_1	320	322	PF00675	0.406
CLV_NRD_NRD_1	361	363	PF00675	0.642
CLV_NRD_NRD_1	593	595	PF00675	0.445
CLV_NRD_NRD_1	715	717	PF00675	0.470
CLV_NRD_NRD_1	763	765	PF00675	0.607
CLV_NRD_NRD_1	771	773	PF00675	0.673
CLV_PCSK_KEX2_1	104	106	PF00082	0.430
CLV_PCSK_KEX2_1	16	18	PF00082	0.586
CLV_PCSK_KEX2_1	252	254	PF00082	0.338
CLV_PCSK_KEX2_1	269	271	PF00082	0.548
CLV_PCSK_KEX2_1	361	363	PF00082	0.583
CLV_PCSK_KEX2_1	471	473	PF00082	0.650
CLV_PCSK_KEX2_1	593	595	PF00082	0.445
CLV_PCSK_KEX2_1	715	717	PF00082	0.543
CLV_PCSK_KEX2_1	771	773	PF00082	0.671
CLV_PCSK_PC1ET2_1	269	271	PF00082	0.439
CLV_PCSK_PC1ET2_1	471	473	PF00082	0.510
CLV_PCSK_PC1ET2_1	771	773	PF00082	0.653
CLV_PCSK_SKI1_1	143	147	PF00082	0.552
CLV_PCSK_SKI1_1	157	161	PF00082	0.532
CLV_PCSK_SKI1_1	185	189	PF00082	0.534
CLV_PCSK_SKI1_1	253	257	PF00082	0.517
CLV_PCSK_SKI1_1	259	263	PF00082	0.529
CLV_PCSK_SKI1_1	322	326	PF00082	0.398
CLV_PCSK_SKI1_1	346	350	PF00082	0.531
CLV_PCSK_SKI1_1	523	527	PF00082	0.475
CLV_PCSK_SKI1_1	559	563	PF00082	0.497
CLV_PCSK_SKI1_1	679	683	PF00082	0.399
CLV_PCSK_SKI1_1	691	695	PF00082	0.355
CLV_PCSK_SKI1_1	76	80	PF00082	0.500
CLV_PCSK_SKI1_1	781	785	PF00082	0.538
CLV_Separin_Metazoa	358	362	PF03568	0.495
CLV_Separin_Metazoa	413	417	PF03568	0.504
DEG_APCC_DBOX_1	155	163	PF00400	0.615
DEG_APCC_DBOX_1	282	290	PF00400	0.389
DEG_APCC_DBOX_1	345	353	PF00400	0.525
DEG_APCC_DBOX_1	558	566	PF00400	0.384
DEG_SCF_FBW7_1	478	485	PF00400	0.513
DEG_SIAH_1	508	516	PF03145	0.532
DEG_SPOP_SBC_1	415	419	PF00917	0.624
DOC_ANK_TNKS_1	726	733	PF00023	0.586
DOC_CKS1_1	479	484	PF01111	0.513
DOC_CKS1_1	506	511	PF01111	0.531
DOC_CYCLIN_RxL_1	320	328	PF00134	0.518
DOC_CYCLIN_RxL_1	547	557	PF00134	0.408
DOC_CYCLIN_RxL_1	559	571	PF00134	0.504
DOC_MAPK_gen_1	185	194	PF00069	0.341
DOC_MAPK_gen_1	321	329	PF00069	0.397
DOC_MAPK_gen_1	361	367	PF00069	0.576
DOC_MAPK_MEF2A_6	321	329	PF00069	0.397
DOC_MAPK_NFAT4_5	322	330	PF00069	0.393
DOC_PP1_RVXF_1	232	238	PF00149	0.531
DOC_PP1_RVXF_1	689	695	PF00149	0.457
DOC_PP1_RVXF_1	8	14	PF00149	0.475
DOC_USP7_MATH_1	31	35	PF00917	0.575
DOC_USP7_MATH_1	414	418	PF00917	0.706
DOC_USP7_MATH_1	42	46	PF00917	0.561
DOC_USP7_MATH_1	420	424	PF00917	0.725
DOC_USP7_MATH_1	442	446	PF00917	0.514
DOC_USP7_MATH_1	527	531	PF00917	0.546
DOC_USP7_MATH_1	604	608	PF00917	0.559
DOC_USP7_MATH_1	615	619	PF00917	0.568
DOC_USP7_UBL2_3	185	189	PF12436	0.534
DOC_WW_Pin1_4	478	483	PF00397	0.688
DOC_WW_Pin1_4	505	510	PF00397	0.569
DOC_WW_Pin1_4	569	574	PF00397	0.530
DOC_WW_Pin1_4	720	725	PF00397	0.596
LIG_14-3-3_CanoR_1	104	112	PF00244	0.432
LIG_14-3-3_CanoR_1	234	238	PF00244	0.425
LIG_14-3-3_CanoR_1	252	262	PF00244	0.358
LIG_14-3-3_CanoR_1	299	307	PF00244	0.388
LIG_14-3-3_CanoR_1	362	368	PF00244	0.460
LIG_14-3-3_CanoR_1	416	424	PF00244	0.622
LIG_14-3-3_CanoR_1	472	480	PF00244	0.687
LIG_14-3-3_CanoR_1	484	488	PF00244	0.710
LIG_14-3-3_CanoR_1	646	651	PF00244	0.583
LIG_14-3-3_CanoR_1	669	673	PF00244	0.503
LIG_14-3-3_CanoR_1	8	14	PF00244	0.628
LIG_Actin_WH2_2	330	345	PF00022	0.582
LIG_BRCT_BRCA1_1	113	117	PF00533	0.440
LIG_BRCT_BRCA1_1	280	284	PF00533	0.337
LIG_BRCT_BRCA1_1	636	640	PF00533	0.642
LIG_BRCT_BRCA1_1	99	103	PF00533	0.452
LIG_BRCT_BRCA1_2	636	642	PF00533	0.642
LIG_CaM_IQ_9	135	150	PF13499	0.599
LIG_FHA_1	104	110	PF00498	0.418
LIG_FHA_1	354	360	PF00498	0.613
LIG_FHA_1	501	507	PF00498	0.527
LIG_FHA_1	614	620	PF00498	0.643
LIG_FHA_1	687	693	PF00498	0.546
LIG_FHA_1	720	726	PF00498	0.513
LIG_FHA_1	91	97	PF00498	0.493
LIG_FHA_2	205	211	PF00498	0.480
LIG_FHA_2	304	310	PF00498	0.461
LIG_FHA_2	371	377	PF00498	0.504
LIG_FHA_2	621	627	PF00498	0.675
LIG_FHA_2	782	788	PF00498	0.527
LIG_FHA_2	789	795	PF00498	0.588
LIG_LIR_Gen_1	273	282	PF02991	0.548
LIG_LIR_Gen_1	290	300	PF02991	0.295
LIG_LIR_Gen_1	328	337	PF02991	0.502
LIG_LIR_Gen_1	45	54	PF02991	0.464
LIG_LIR_Gen_1	532	541	PF02991	0.458
LIG_LIR_Gen_1	68	78	PF02991	0.510
LIG_LIR_Nem_3	114	120	PF02991	0.538
LIG_LIR_Nem_3	273	278	PF02991	0.577
LIG_LIR_Nem_3	290	296	PF02991	0.295
LIG_LIR_Nem_3	328	332	PF02991	0.529
LIG_LIR_Nem_3	37	43	PF02991	0.509
LIG_LIR_Nem_3	376	381	PF02991	0.630
LIG_LIR_Nem_3	45	51	PF02991	0.451
LIG_LIR_Nem_3	532	537	PF02991	0.462
LIG_LIR_Nem_3	637	643	PF02991	0.628
LIG_LIR_Nem_3	68	73	PF02991	0.468
LIG_LIR_Nem_3	74	78	PF02991	0.421
LIG_MLH1_MIPbox_1	113	117	PF16413	0.557
LIG_NRBOX	108	114	PF00104	0.455
LIG_PDZ_Class_3	792	797	PF00595	0.610
LIG_Pex14_1	386	390	PF04695	0.586
LIG_Pex14_2	117	121	PF04695	0.457
LIG_SH2_CRK	40	44	PF00017	0.580
LIG_SH2_CRK	70	74	PF00017	0.516
LIG_SH2_GRB2like	48	51	PF00017	0.504
LIG_SH2_NCK_1	275	279	PF00017	0.532
LIG_SH2_NCK_1	70	74	PF00017	0.433
LIG_SH2_SRC	171	174	PF00017	0.523
LIG_SH2_STAP1	48	52	PF00017	0.574
LIG_SH2_STAP1	699	703	PF00017	0.455
LIG_SH2_STAT3	335	338	PF00017	0.383
LIG_SH2_STAT5	326	329	PF00017	0.385
LIG_SH2_STAT5	390	393	PF00017	0.567
LIG_SH3_3	362	368	PF00018	0.497
LIG_SH3_3	503	509	PF00018	0.695
LIG_SUMO_SIM_anti_2	60	66	PF11976	0.459
LIG_SUMO_SIM_par_1	563	568	PF11976	0.505
LIG_SUMO_SIM_par_1	93	100	PF11976	0.483
LIG_TRAF2_1	310	313	PF00917	0.421
LIG_TRAF2_1	317	320	PF00917	0.394
LIG_TRAF2_1	629	632	PF00917	0.574
LIG_TRAF2_1	791	794	PF00917	0.447
LIG_UBA3_1	220	225	PF00899	0.328
LIG_UBA3_1	314	323	PF00899	0.402
LIG_WRC_WIRS_1	326	331	PF05994	0.386
LIG_WRC_WIRS_1	531	536	PF05994	0.525
LIG_WRC_WIRS_1	72	77	PF05994	0.426
LIG_WW_1	488	491	PF00397	0.512
MOD_CDK_SPK_2	569	574	PF00069	0.521
MOD_CDK_SPxK_1	478	484	PF00069	0.514
MOD_CDK_SPxxK_3	720	727	PF00069	0.604
MOD_CK1_1	32	38	PF00069	0.436
MOD_CK1_1	502	508	PF00069	0.674
MOD_CK1_1	517	523	PF00069	0.535
MOD_CK1_1	530	536	PF00069	0.480
MOD_CK1_1	568	574	PF00069	0.518
MOD_CK1_1	60	66	PF00069	0.459
MOD_CK1_1	613	619	PF00069	0.649
MOD_CK1_1	620	626	PF00069	0.628
MOD_CK1_1	635	641	PF00069	0.607
MOD_CK1_1	645	651	PF00069	0.669
MOD_CK1_1	668	674	PF00069	0.475
MOD_CK2_1	147	153	PF00069	0.596
MOD_CK2_1	204	210	PF00069	0.508
MOD_CK2_1	240	246	PF00069	0.514
MOD_CK2_1	303	309	PF00069	0.458
MOD_CK2_1	31	37	PF00069	0.525
MOD_CK2_1	495	501	PF00069	0.610
MOD_CK2_1	620	626	PF00069	0.724
MOD_CK2_1	645	651	PF00069	0.735
MOD_CK2_1	653	659	PF00069	0.769
MOD_CK2_1	781	787	PF00069	0.529
MOD_CK2_1	788	794	PF00069	0.585
MOD_Cter_Amidation	14	17	PF01082	0.659
MOD_Cter_Amidation	267	270	PF01082	0.558
MOD_GlcNHglycan	149	152	PF01048	0.534
MOD_GlcNHglycan	315	318	PF01048	0.370
MOD_GlcNHglycan	368	371	PF01048	0.566
MOD_GlcNHglycan	418	421	PF01048	0.517
MOD_GlcNHglycan	424	427	PF01048	0.531
MOD_GlcNHglycan	458	461	PF01048	0.575
MOD_GlcNHglycan	475	478	PF01048	0.554
MOD_GlcNHglycan	485	488	PF01048	0.703
MOD_GlcNHglycan	567	570	PF01048	0.582
MOD_GlcNHglycan	612	615	PF01048	0.725
MOD_GlcNHglycan	87	90	PF01048	0.415
MOD_GSK3_1	233	240	PF00069	0.449
MOD_GSK3_1	25	32	PF00069	0.478
MOD_GSK3_1	274	281	PF00069	0.482
MOD_GSK3_1	303	310	PF00069	0.472
MOD_GSK3_1	366	373	PF00069	0.550
MOD_GSK3_1	416	423	PF00069	0.666
MOD_GSK3_1	478	485	PF00069	0.671
MOD_GSK3_1	487	494	PF00069	0.527
MOD_GSK3_1	495	502	PF00069	0.576
MOD_GSK3_1	513	520	PF00069	0.558
MOD_GSK3_1	563	570	PF00069	0.516
MOD_GSK3_1	613	620	PF00069	0.715
MOD_GSK3_1	632	639	PF00069	0.546
MOD_GSK3_1	642	649	PF00069	0.613
MOD_GSK3_1	726	733	PF00069	0.745
MOD_GSK3_1	81	88	PF00069	0.530
MOD_N-GLC_1	354	359	PF02516	0.473
MOD_N-GLC_1	370	375	PF02516	0.501
MOD_N-GLC_1	626	631	PF02516	0.628
MOD_N-GLC_1	632	637	PF02516	0.558
MOD_N-GLC_1	659	664	PF02516	0.604
MOD_NEK2_1	162	167	PF00069	0.442
MOD_NEK2_1	179	184	PF00069	0.539
MOD_NEK2_1	226	231	PF00069	0.376
MOD_NEK2_1	248	253	PF00069	0.457
MOD_NEK2_1	263	268	PF00069	0.449
MOD_NEK2_1	288	293	PF00069	0.424
MOD_NEK2_1	325	330	PF00069	0.415
MOD_NEK2_1	435	440	PF00069	0.534
MOD_NEK2_1	565	570	PF00069	0.561
MOD_NEK2_1	57	62	PF00069	0.515
MOD_NEK2_1	636	641	PF00069	0.632
MOD_NEK2_1	725	730	PF00069	0.534
MOD_NEK2_1	96	101	PF00069	0.456
MOD_NEK2_2	233	238	PF00069	0.477
MOD_NEK2_2	9	14	PF00069	0.474
MOD_PIKK_1	263	269	PF00454	0.575
MOD_PIKK_1	347	353	PF00454	0.407
MOD_PIKK_1	380	386	PF00454	0.492
MOD_PIKK_1	435	441	PF00454	0.687
MOD_PIKK_1	454	460	PF00454	0.460
MOD_PIKK_1	788	794	PF00454	0.444
MOD_PK_1	188	194	PF00069	0.343
MOD_PKA_1	188	194	PF00069	0.538
MOD_PKA_1	471	477	PF00069	0.659
MOD_PKA_2	103	109	PF00069	0.441
MOD_PKA_2	233	239	PF00069	0.449
MOD_PKA_2	248	254	PF00069	0.397
MOD_PKA_2	298	304	PF00069	0.387
MOD_PKA_2	415	421	PF00069	0.622
MOD_PKA_2	471	477	PF00069	0.767
MOD_PKA_2	483	489	PF00069	0.607
MOD_PKA_2	645	651	PF00069	0.596
MOD_PKA_2	668	674	PF00069	0.660
MOD_PKA_2	708	714	PF00069	0.638
MOD_PKA_2	726	732	PF00069	0.802
MOD_PKA_2	9	15	PF00069	0.586
MOD_Plk_1	25	31	PF00069	0.485
MOD_Plk_1	289	295	PF00069	0.309
MOD_Plk_1	370	376	PF00069	0.567
MOD_Plk_1	632	638	PF00069	0.590
MOD_Plk_1	709	715	PF00069	0.569
MOD_Plk_2-3	71	77	PF00069	0.429
MOD_Plk_4	25	31	PF00069	0.594
MOD_Plk_4	303	309	PF00069	0.541
MOD_Plk_4	530	536	PF00069	0.457
MOD_Plk_4	60	66	PF00069	0.411
MOD_Plk_4	735	741	PF00069	0.651
MOD_ProDKin_1	478	484	PF00069	0.688
MOD_ProDKin_1	505	511	PF00069	0.570
MOD_ProDKin_1	569	575	PF00069	0.531
MOD_ProDKin_1	720	726	PF00069	0.601
MOD_SUMO_rev_2	150	159	PF00179	0.561
MOD_SUMO_rev_2	210	216	PF00179	0.531
MOD_SUMO_rev_2	316	324	PF00179	0.353
MOD_SUMO_rev_2	793	797	PF00179	0.471
TRG_DiLeu_BaEn_1	108	113	PF01217	0.497
TRG_DiLeu_BaEn_2	556	562	PF01217	0.446
TRG_DiLeu_BaLyEn_6	133	138	PF01217	0.551
TRG_DiLeu_BaLyEn_6	250	255	PF01217	0.324
TRG_DiLeu_LyEn_5	108	113	PF01217	0.483
TRG_ENDOCYTIC_2	217	220	PF00928	0.436
TRG_ENDOCYTIC_2	275	278	PF00928	0.600
TRG_ENDOCYTIC_2	326	329	PF00928	0.371
TRG_ENDOCYTIC_2	40	43	PF00928	0.543
TRG_ENDOCYTIC_2	48	51	PF00928	0.474
TRG_ENDOCYTIC_2	70	73	PF00928	0.511
TRG_ER_diArg_1	103	105	PF00400	0.447
TRG_ER_diArg_1	16	18	PF00400	0.621
TRG_ER_diArg_1	252	254	PF00400	0.338
TRG_ER_diArg_1	360	362	PF00400	0.643
TRG_ER_diArg_1	715	717	PF00400	0.484
TRG_ER_diArg_1	8	11	PF00400	0.634
TRG_NES_CRM1_1	108	123	PF08389	0.501
TRG_NES_CRM1_1	53	68	PF08389	0.469
TRG_NES_CRM1_1	544	557	PF08389	0.550
TRG_NLS_MonoExtN_4	768	775	PF00514	0.519
TRG_Pf-PMV_PEXEL_1	136	141	PF00026	0.480
TRG_Pf-PMV_PEXEL_1	143	147	PF00026	0.486
TRG_Pf-PMV_PEXEL_1	157	161	PF00026	0.406
TRG_Pf-PMV_PEXEL_1	17	21	PF00026	0.467
TRG_Pf-PMV_PEXEL_1	252	257	PF00026	0.398
TRG_Pf-PMV_PEXEL_1	550	555	PF00026	0.435
TRG_Pf-PMV_PEXEL_1	715	719	PF00026	0.460
TRG_Pf-PMV_PEXEL_1	778	782	PF00026	0.655

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ICL4	Leptomonas seymouri	60%	100%
A0A1X0NVY2	Trypanosomatidae	39%	100%
A0A3S5ISI8	Trypanosoma rangeli	39%	100%
A0A3S7X5E6	Leishmania donovani	77%	100%
A4I7T9	Leishmania infantum	77%	100%
D0A9Z9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9B2P7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4Q5G0	Leishmania major	76%	100%