PPR_long domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pentatricopeptide repeat domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HKA8_LEIBR

TriTrypDb:

LbrM.32.1360 , LBRM2903_320018900

Length:

801

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HKA8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKA8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	736	740	PF00656	0.346
CLV_NRD_NRD_1	14	16	PF00675	0.605
CLV_NRD_NRD_1	454	456	PF00675	0.611
CLV_NRD_NRD_1	700	702	PF00675	0.539
CLV_PCSK_KEX2_1	101	103	PF00082	0.556
CLV_PCSK_KEX2_1	14	16	PF00082	0.509
CLV_PCSK_KEX2_1	300	302	PF00082	0.527
CLV_PCSK_KEX2_1	454	456	PF00082	0.371
CLV_PCSK_KEX2_1	5	7	PF00082	0.632
CLV_PCSK_KEX2_1	700	702	PF00082	0.495
CLV_PCSK_KEX2_1	709	711	PF00082	0.533
CLV_PCSK_PC1ET2_1	101	103	PF00082	0.556
CLV_PCSK_PC1ET2_1	300	302	PF00082	0.489
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.656
CLV_PCSK_PC1ET2_1	709	711	PF00082	0.493
CLV_PCSK_SKI1_1	145	149	PF00082	0.461
CLV_PCSK_SKI1_1	491	495	PF00082	0.478
CLV_PCSK_SKI1_1	673	677	PF00082	0.396
CLV_PCSK_SKI1_1	709	713	PF00082	0.459
CLV_PCSK_SKI1_1	771	775	PF00082	0.519
CLV_PCSK_SKI1_1	780	784	PF00082	0.492
DEG_APCC_DBOX_1	770	778	PF00400	0.555
DEG_APCC_KENBOX_2	123	127	PF00400	0.572
DEG_Nend_Nbox_1	1	3	PF02207	0.635
DEG_SPOP_SBC_1	566	570	PF00917	0.477
DOC_CKS1_1	495	500	PF01111	0.548
DOC_CKS1_1	783	788	PF01111	0.633
DOC_CYCLIN_RxL_1	777	785	PF00134	0.554
DOC_MAPK_gen_1	454	460	PF00069	0.617
DOC_MAPK_gen_1	5	13	PF00069	0.693
DOC_MAPK_MEF2A_6	716	724	PF00069	0.380
DOC_PP1_RVXF_1	100	107	PF00149	0.390
DOC_PP1_RVXF_1	474	481	PF00149	0.570
DOC_PP2B_LxvP_1	198	201	PF13499	0.397
DOC_PP4_FxxP_1	23	26	PF00568	0.679
DOC_PP4_FxxP_1	783	786	PF00568	0.548
DOC_USP7_MATH_1	299	303	PF00917	0.562
DOC_USP7_MATH_1	387	391	PF00917	0.764
DOC_USP7_MATH_1	591	595	PF00917	0.613
DOC_USP7_MATH_1	646	650	PF00917	0.630
DOC_USP7_MATH_1	65	69	PF00917	0.664
DOC_USP7_MATH_1	715	719	PF00917	0.337
DOC_USP7_MATH_1	756	760	PF00917	0.572
DOC_WW_Pin1_4	494	499	PF00397	0.566
DOC_WW_Pin1_4	752	757	PF00397	0.496
DOC_WW_Pin1_4	782	787	PF00397	0.623
LIG_14-3-3_CanoR_1	105	112	PF00244	0.519
LIG_14-3-3_CanoR_1	251	259	PF00244	0.259
LIG_14-3-3_CanoR_1	292	297	PF00244	0.502
LIG_14-3-3_CanoR_1	419	425	PF00244	0.460
LIG_14-3-3_CanoR_1	455	461	PF00244	0.352
LIG_14-3-3_CanoR_1	716	724	PF00244	0.411
LIG_14-3-3_CanoR_1	83	91	PF00244	0.531
LIG_Actin_WH2_2	223	238	PF00022	0.455
LIG_APCC_ABBA_1	112	117	PF00400	0.401
LIG_APCC_ABBA_1	224	229	PF00400	0.393
LIG_APCC_ABBA_1	353	358	PF00400	0.523
LIG_APCC_ABBAyCdc20_2	66	72	PF00400	0.659
LIG_BIR_III_4	767	771	PF00653	0.593
LIG_Clathr_ClatBox_1	466	470	PF01394	0.549
LIG_EH1_1	311	319	PF00400	0.393
LIG_FHA_1	133	139	PF00498	0.284
LIG_FHA_1	187	193	PF00498	0.400
LIG_FHA_1	221	227	PF00498	0.399
LIG_FHA_1	25	31	PF00498	0.512
LIG_FHA_1	44	50	PF00498	0.550
LIG_FHA_1	536	542	PF00498	0.429
LIG_FHA_1	574	580	PF00498	0.447
LIG_FHA_1	758	764	PF00498	0.468
LIG_FHA_1	93	99	PF00498	0.420
LIG_FHA_2	111	117	PF00498	0.517
LIG_FHA_2	37	43	PF00498	0.659
LIG_FHA_2	516	522	PF00498	0.453
LIG_FHA_2	552	558	PF00498	0.468
LIG_FHA_2	731	737	PF00498	0.560
LIG_GBD_Chelix_1	317	325	PF00786	0.474
LIG_LIR_Apic_2	20	26	PF02991	0.659
LIG_LIR_Gen_1	113	123	PF02991	0.238
LIG_LIR_Gen_1	135	142	PF02991	0.363
LIG_LIR_Gen_1	169	180	PF02991	0.277
LIG_LIR_Gen_1	206	215	PF02991	0.309
LIG_LIR_Gen_1	241	249	PF02991	0.267
LIG_LIR_Gen_1	256	265	PF02991	0.308
LIG_LIR_Gen_1	275	283	PF02991	0.198
LIG_LIR_Gen_1	438	446	PF02991	0.448
LIG_LIR_Gen_1	44	55	PF02991	0.532
LIG_LIR_Gen_1	518	527	PF02991	0.563
LIG_LIR_Gen_1	57	65	PF02991	0.346
LIG_LIR_Gen_1	611	622	PF02991	0.378
LIG_LIR_Gen_1	690	699	PF02991	0.509
LIG_LIR_Gen_1	93	104	PF02991	0.395
LIG_LIR_Nem_3	113	118	PF02991	0.218
LIG_LIR_Nem_3	135	139	PF02991	0.356
LIG_LIR_Nem_3	152	156	PF02991	0.352
LIG_LIR_Nem_3	161	166	PF02991	0.455
LIG_LIR_Nem_3	169	175	PF02991	0.283
LIG_LIR_Nem_3	206	210	PF02991	0.324
LIG_LIR_Nem_3	241	245	PF02991	0.255
LIG_LIR_Nem_3	256	262	PF02991	0.308
LIG_LIR_Nem_3	275	280	PF02991	0.198
LIG_LIR_Nem_3	350	356	PF02991	0.483
LIG_LIR_Nem_3	438	443	PF02991	0.383
LIG_LIR_Nem_3	44	50	PF02991	0.550
LIG_LIR_Nem_3	514	520	PF02991	0.490
LIG_LIR_Nem_3	57	63	PF02991	0.357
LIG_LIR_Nem_3	611	617	PF02991	0.376
LIG_LIR_Nem_3	690	695	PF02991	0.439
LIG_LIR_Nem_3	93	99	PF02991	0.398
LIG_NRBOX	340	346	PF00104	0.268
LIG_NRBOX	463	469	PF00104	0.519
LIG_PALB2_WD40_1	628	636	PF16756	0.554
LIG_PCNA_yPIPBox_3	587	596	PF02747	0.355
LIG_PCNA_yPIPBox_3	97	105	PF02747	0.435
LIG_Pex14_2	439	443	PF04695	0.310
LIG_PTB_Apo_2	147	154	PF02174	0.550
LIG_Rb_pABgroove_1	109	117	PF01858	0.490
LIG_REV1ctd_RIR_1	618	628	PF16727	0.566
LIG_SH2_CRK	136	140	PF00017	0.391
LIG_SH2_CRK	156	160	PF00017	0.432
LIG_SH2_CRK	172	176	PF00017	0.219
LIG_SH2_CRK	207	211	PF00017	0.324
LIG_SH2_CRK	242	246	PF00017	0.343
LIG_SH2_CRK	277	281	PF00017	0.308
LIG_SH2_CRK	47	51	PF00017	0.557
LIG_SH2_CRK	547	551	PF00017	0.450
LIG_SH2_CRK	614	618	PF00017	0.471
LIG_SH2_CRK	656	660	PF00017	0.439
LIG_SH2_CRK	669	673	PF00017	0.433
LIG_SH2_CRK	692	696	PF00017	0.521
LIG_SH2_CRK	727	731	PF00017	0.383
LIG_SH2_CRK	743	747	PF00017	0.570
LIG_SH2_CRK	784	788	PF00017	0.643
LIG_SH2_CRK	96	100	PF00017	0.386
LIG_SH2_NCK_1	255	259	PF00017	0.254
LIG_SH2_NCK_1	784	788	PF00017	0.643
LIG_SH2_SRC	115	118	PF00017	0.369
LIG_SH2_SRC	279	282	PF00017	0.203
LIG_SH2_STAP1	220	224	PF00017	0.401
LIG_SH2_STAP1	255	259	PF00017	0.308
LIG_SH2_STAP1	56	60	PF00017	0.424
LIG_SH2_STAP1	567	571	PF00017	0.571
LIG_SH2_STAP1	656	660	PF00017	0.499
LIG_SH2_STAT5	178	181	PF00017	0.400
LIG_SH2_STAT5	2	5	PF00017	0.624
LIG_SH2_STAT5	279	282	PF00017	0.368
LIG_SH2_STAT5	290	293	PF00017	0.387
LIG_SH2_STAT5	335	338	PF00017	0.495
LIG_SH2_STAT5	547	550	PF00017	0.437
LIG_SH2_STAT5	56	59	PF00017	0.434
LIG_SH2_STAT5	598	601	PF00017	0.445
LIG_SH2_STAT5	656	659	PF00017	0.410
LIG_SH2_STAT5	663	666	PF00017	0.376
LIG_SH2_STAT5	784	787	PF00017	0.616
LIG_SH3_3	388	394	PF00018	0.504
LIG_SH3_3	783	789	PF00018	0.616
LIG_SUMO_SIM_par_1	279	285	PF11976	0.416
LIG_SUMO_SIM_par_1	465	470	PF11976	0.547
LIG_SUMO_SIM_par_1	788	793	PF11976	0.396
LIG_TRAF2_1	572	575	PF00917	0.606
LIG_TRFH_1	163	167	PF08558	0.542
LIG_TYR_ITIM	154	159	PF00017	0.412
LIG_TYR_ITSM	111	118	PF00017	0.288
LIG_UBA3_1	111	119	PF00899	0.455
LIG_UBA3_1	484	489	PF00899	0.438
MOD_CK1_1	238	244	PF00069	0.391
MOD_CK1_1	250	256	PF00069	0.398
MOD_CK1_1	295	301	PF00069	0.677
MOD_CK1_1	378	384	PF00069	0.759
MOD_CK1_1	456	462	PF00069	0.596
MOD_CK1_1	644	650	PF00069	0.446
MOD_CK2_1	279	285	PF00069	0.429
MOD_CK2_1	299	305	PF00069	0.335
MOD_CK2_1	387	393	PF00069	0.612
MOD_CK2_1	515	521	PF00069	0.534
MOD_CK2_1	551	557	PF00069	0.474
MOD_CK2_1	65	71	PF00069	0.677
MOD_CK2_1	680	686	PF00069	0.589
MOD_CK2_1	730	736	PF00069	0.447
MOD_CK2_1	752	758	PF00069	0.579
MOD_GlcNHglycan	144	148	PF01048	0.539
MOD_GlcNHglycan	216	219	PF01048	0.447
MOD_GlcNHglycan	297	300	PF01048	0.664
MOD_GlcNHglycan	377	380	PF01048	0.583
MOD_GlcNHglycan	448	452	PF01048	0.575
MOD_GlcNHglycan	455	458	PF01048	0.504
MOD_GlcNHglycan	460	463	PF01048	0.374
MOD_GlcNHglycan	530	533	PF01048	0.463
MOD_GlcNHglycan	644	647	PF01048	0.600
MOD_GlcNHglycan	648	651	PF01048	0.461
MOD_GlcNHglycan	682	685	PF01048	0.360
MOD_GSK3_1	291	298	PF00069	0.571
MOD_GSK3_1	374	381	PF00069	0.727
MOD_GSK3_1	456	463	PF00069	0.596
MOD_GSK3_1	642	649	PF00069	0.635
MOD_GSK3_1	726	733	PF00069	0.456
MOD_GSK3_1	752	759	PF00069	0.364
MOD_LATS_1	81	87	PF00433	0.565
MOD_N-GLC_1	125	130	PF02516	0.536
MOD_N-GLC_1	149	154	PF02516	0.514
MOD_N-GLC_1	16	21	PF02516	0.422
MOD_N-GLC_1	238	243	PF02516	0.454
MOD_N-GLC_1	394	399	PF02516	0.468
MOD_N-GLC_1	641	646	PF02516	0.687
MOD_N-GLC_2	558	560	PF02516	0.309
MOD_NEK2_1	1	6	PF00069	0.741
MOD_NEK2_1	214	219	PF00069	0.430
MOD_NEK2_1	308	313	PF00069	0.459
MOD_NEK2_1	317	322	PF00069	0.371
MOD_NEK2_1	453	458	PF00069	0.550
MOD_NEK2_1	460	465	PF00069	0.430
MOD_NEK2_1	613	618	PF00069	0.501
MOD_NEK2_2	110	115	PF00069	0.538
MOD_NEK2_2	220	225	PF00069	0.407
MOD_NEK2_2	65	70	PF00069	0.658
MOD_PIKK_1	90	96	PF00454	0.575
MOD_PK_1	292	298	PF00069	0.381
MOD_PK_1	339	345	PF00069	0.520
MOD_PKA_1	300	306	PF00069	0.405
MOD_PKA_2	104	110	PF00069	0.558
MOD_PKA_2	235	241	PF00069	0.203
MOD_PKA_2	250	256	PF00069	0.144
MOD_PKA_2	291	297	PF00069	0.566
MOD_PKA_2	300	306	PF00069	0.505
MOD_PKA_2	374	380	PF00069	0.653
MOD_PKA_2	387	393	PF00069	0.509
MOD_PKA_2	418	424	PF00069	0.443
MOD_PKA_2	426	432	PF00069	0.371
MOD_PKA_2	453	459	PF00069	0.611
MOD_PKA_2	634	640	PF00069	0.605
MOD_PKA_2	715	721	PF00069	0.522
MOD_Plk_1	124	130	PF00069	0.514
MOD_Plk_1	143	149	PF00069	0.292
MOD_Plk_1	238	244	PF00069	0.418
MOD_Plk_1	43	49	PF00069	0.623
MOD_Plk_1	573	579	PF00069	0.515
MOD_Plk_1	757	763	PF00069	0.557
MOD_Plk_4	132	138	PF00069	0.516
MOD_Plk_4	171	177	PF00069	0.311
MOD_Plk_4	186	192	PF00069	0.321
MOD_Plk_4	209	215	PF00069	0.365
MOD_Plk_4	241	247	PF00069	0.393
MOD_Plk_4	292	298	PF00069	0.534
MOD_Plk_4	317	323	PF00069	0.388
MOD_Plk_4	339	345	PF00069	0.405
MOD_Plk_4	435	441	PF00069	0.313
MOD_Plk_4	502	508	PF00069	0.374
MOD_Plk_4	558	564	PF00069	0.487
MOD_Plk_4	591	597	PF00069	0.589
MOD_Plk_4	613	619	PF00069	0.536
MOD_Plk_4	655	661	PF00069	0.533
MOD_Plk_4	726	732	PF00069	0.502
MOD_ProDKin_1	494	500	PF00069	0.559
MOD_ProDKin_1	752	758	PF00069	0.499
MOD_ProDKin_1	782	788	PF00069	0.626
MOD_SUMO_for_1	118	121	PF00179	0.455
MOD_SUMO_rev_2	193	198	PF00179	0.429
MOD_SUMO_rev_2	482	490	PF00179	0.472
TRG_DiLeu_BaEn_1	161	166	PF01217	0.541
TRG_DiLeu_BaEn_4	193	199	PF01217	0.429
TRG_ENDOCYTIC_2	115	118	PF00928	0.399
TRG_ENDOCYTIC_2	136	139	PF00928	0.404
TRG_ENDOCYTIC_2	156	159	PF00928	0.190
TRG_ENDOCYTIC_2	172	175	PF00928	0.295
TRG_ENDOCYTIC_2	207	210	PF00928	0.308
TRG_ENDOCYTIC_2	242	245	PF00928	0.296
TRG_ENDOCYTIC_2	277	280	PF00928	0.308
TRG_ENDOCYTIC_2	356	359	PF00928	0.421
TRG_ENDOCYTIC_2	440	443	PF00928	0.399
TRG_ENDOCYTIC_2	47	50	PF00928	0.587
TRG_ENDOCYTIC_2	520	523	PF00928	0.552
TRG_ENDOCYTIC_2	614	617	PF00928	0.389
TRG_ENDOCYTIC_2	656	659	PF00928	0.416
TRG_ENDOCYTIC_2	669	672	PF00928	0.386
TRG_ENDOCYTIC_2	692	695	PF00928	0.416
TRG_ENDOCYTIC_2	727	730	PF00928	0.384
TRG_ENDOCYTIC_2	743	746	PF00928	0.454
TRG_ENDOCYTIC_2	96	99	PF00928	0.377
TRG_ER_diArg_1	13	15	PF00400	0.625
TRG_ER_diArg_1	453	455	PF00400	0.349
TRG_Pf-PMV_PEXEL_1	796	800	PF00026	0.652

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAW5	Leptomonas seymouri	56%	100%
A0A0S4JD08	Bodo saltans	32%	95%
A0A1X0NW71	Trypanosomatidae	41%	100%
A0A3S7X5H9	Leishmania donovani	80%	100%
A0A422P1H7	Trypanosoma rangeli	38%	100%
A4I7T8	Leishmania infantum	80%	100%
B8Y6I0	Zea mays	20%	100%
D0A9Z8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	97%
E9B2P6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q0WMY5	Arabidopsis thaliana	20%	84%
Q4Q5G1	Leishmania major	79%	100%
Q9FJE6	Arabidopsis thaliana	21%	88%
Q9SXD1	Arabidopsis thaliana	22%	100%
Q9SZ52	Arabidopsis thaliana	20%	72%
V5BL80	Trypanosoma cruzi	41%	100%