Putative proteasome regulatory non-ATP-ase subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

proteasome regulatory non-ATP-ase subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4HKA7_LEIBR

TriTrypDb:

LbrM.32.1350 , LBRM2903_320018800

Length:

274

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005838	proteasome regulatory particle	2	11
GO:0032991	protein-containing complex	1	12
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0008541	proteasome regulatory particle, lid subcomplex	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HKA7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKA7

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0019538	protein metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0030163	protein catabolic process	4	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	27	31	PF00656	0.524
CLV_NRD_NRD_1	171	173	PF00675	0.359
CLV_NRD_NRD_1	42	44	PF00675	0.523
CLV_PCSK_KEX2_1	251	253	PF00082	0.498
CLV_PCSK_KEX2_1	41	43	PF00082	0.526
CLV_PCSK_PC1ET2_1	251	253	PF00082	0.531
CLV_PCSK_PC1ET2_1	41	43	PF00082	0.533
CLV_PCSK_SKI1_1	167	171	PF00082	0.341
CLV_PCSK_SKI1_1	19	23	PF00082	0.523
DEG_SPOP_SBC_1	55	59	PF00917	0.409
DOC_CYCLIN_yClb5_NLxxxL_5	115	124	PF00134	0.499
DOC_MAPK_gen_1	39	47	PF00069	0.471
DOC_MAPK_MEF2A_6	68	75	PF00069	0.518
DOC_MAPK_NFAT4_5	68	76	PF00069	0.518
DOC_PP1_RVXF_1	41	48	PF00149	0.553
DOC_PP2B_LxvP_1	206	209	PF13499	0.585
DOC_PP4_FxxP_1	50	53	PF00568	0.512
DOC_SPAK_OSR1_1	151	155	PF12202	0.510
DOC_USP7_MATH_1	53	57	PF00917	0.615
DOC_WW_Pin1_4	106	111	PF00397	0.495
LIG_Actin_WH2_2	7	24	PF00022	0.541
LIG_BIR_II_1	1	5	PF00653	0.595
LIG_FHA_1	237	243	PF00498	0.586
LIG_FHA_2	1	7	PF00498	0.575
LIG_FHA_2	188	194	PF00498	0.585
LIG_FHA_2	231	237	PF00498	0.468
LIG_FHA_2	242	248	PF00498	0.523
LIG_FHA_2	25	31	PF00498	0.481
LIG_FHA_2	57	63	PF00498	0.530
LIG_FHA_2	67	73	PF00498	0.297
LIG_LIR_Apic_2	49	53	PF02991	0.503
LIG_LIR_Gen_1	109	120	PF02991	0.429
LIG_LIR_Gen_1	146	156	PF02991	0.537
LIG_LIR_Gen_1	162	169	PF02991	0.391
LIG_LIR_Gen_1	69	77	PF02991	0.479
LIG_LIR_Gen_1	88	98	PF02991	0.257
LIG_LIR_Nem_3	109	115	PF02991	0.463
LIG_LIR_Nem_3	146	152	PF02991	0.537
LIG_LIR_Nem_3	162	168	PF02991	0.391
LIG_LIR_Nem_3	177	183	PF02991	0.500
LIG_LIR_Nem_3	201	206	PF02991	0.524
LIG_LIR_Nem_3	69	73	PF02991	0.470
LIG_LIR_Nem_3	86	90	PF02991	0.296
LIG_LRP6_Inhibitor_1	116	122	PF00058	0.385
LIG_NRBOX	119	125	PF00104	0.499
LIG_Pex14_2	87	91	PF04695	0.418
LIG_SH2_CRK	165	169	PF00017	0.499
LIG_SH2_CRK	203	207	PF00017	0.491
LIG_SH2_GRB2like	90	93	PF00017	0.421
LIG_SH2_NCK_1	98	102	PF00017	0.476
LIG_SH2_SRC	180	183	PF00017	0.510
LIG_SH2_STAT3	90	93	PF00017	0.421
LIG_SH2_STAT5	112	115	PF00017	0.523
LIG_SH2_STAT5	149	152	PF00017	0.499
LIG_SH2_STAT5	159	162	PF00017	0.499
LIG_SH2_STAT5	180	183	PF00017	0.499
LIG_SH2_STAT5	70	73	PF00017	0.514
LIG_SH2_STAT5	90	93	PF00017	0.222
LIG_SH3_3	104	110	PF00018	0.530
LIG_SUMO_SIM_par_1	213	221	PF11976	0.515
LIG_TYR_ITIM	96	101	PF00017	0.469
LIG_UBA3_1	36	41	PF00899	0.471
LIG_WRC_WIRS_1	47	52	PF05994	0.479
LIG_WRC_WIRS_1	84	89	PF05994	0.458
MOD_CK1_1	56	62	PF00069	0.523
MOD_CK2_1	131	137	PF00069	0.497
MOD_CK2_1	230	236	PF00069	0.572
MOD_CK2_1	56	62	PF00069	0.549
MOD_CK2_1	66	72	PF00069	0.301
MOD_GlcNHglycan	77	80	PF01048	0.412
MOD_GSK3_1	232	239	PF00069	0.569
MOD_GSK3_1	24	31	PF00069	0.382
MOD_GSK3_1	54	61	PF00069	0.580
MOD_GSK3_1	62	69	PF00069	0.513
MOD_GSK3_1	96	103	PF00069	0.507
MOD_N-GLC_1	28	33	PF02516	0.473
MOD_NEK2_1	124	129	PF00069	0.559
MOD_NEK2_1	161	166	PF00069	0.499
MOD_NEK2_1	168	173	PF00069	0.494
MOD_NEK2_1	187	192	PF00069	0.498
MOD_NEK2_1	66	71	PF00069	0.484
MOD_NEK2_1	7	12	PF00069	0.583
MOD_PIKK_1	28	34	PF00454	0.371
MOD_PK_1	204	210	PF00069	0.576
MOD_Plk_1	187	193	PF00069	0.505
MOD_Plk_1	230	236	PF00069	0.423
MOD_Plk_1	246	252	PF00069	0.670
MOD_Plk_1	5	11	PF00069	0.590
MOD_Plk_1	62	68	PF00069	0.498
MOD_Plk_2-3	100	106	PF00069	0.538
MOD_Plk_2-3	131	137	PF00069	0.559
MOD_Plk_2-3	83	89	PF00069	0.459
MOD_Plk_4	46	52	PF00069	0.513
MOD_ProDKin_1	106	112	PF00069	0.485
MOD_SUMO_for_1	250	253	PF00179	0.491
MOD_SUMO_rev_2	16	21	PF00179	0.600
MOD_SUMO_rev_2	218	223	PF00179	0.559
TRG_DiLeu_BaLyEn_6	119	124	PF01217	0.499
TRG_ENDOCYTIC_2	112	115	PF00928	0.410
TRG_ENDOCYTIC_2	149	152	PF00928	0.499
TRG_ENDOCYTIC_2	165	168	PF00928	0.499
TRG_ENDOCYTIC_2	180	183	PF00928	0.499
TRG_ENDOCYTIC_2	203	206	PF00928	0.498
TRG_ENDOCYTIC_2	70	73	PF00928	0.483
TRG_ENDOCYTIC_2	98	101	PF00928	0.471
TRG_ER_diArg_1	42	44	PF00400	0.570
TRG_NLS_MonoExtC_3	171	176	PF00514	0.585
TRG_NLS_MonoExtN_4	39	45	PF00514	0.479
TRG_Pf-PMV_PEXEL_1	12	16	PF00026	0.593
TRG_Pf-PMV_PEXEL_1	158	162	PF00026	0.299
TRG_Pf-PMV_PEXEL_1	213	218	PF00026	0.350

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4A9	Leptomonas seymouri	82%	100%
A0A0S4J927	Bodo saltans	52%	79%
A0A1X0NUT6	Trypanosomatidae	59%	100%
A0A3R7M9M8	Trypanosoma rangeli	63%	100%
A0A3S7X5G0	Leishmania donovani	91%	100%
A4I7T7	Leishmania infantum	91%	100%
D0A9Z7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
E9B2P5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
P02889	Dictyostelium discoideum	36%	100%
P32496	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	100%
P48556	Homo sapiens	35%	78%
P50524	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
Q23449	Caenorhabditis elegans	32%	100%
Q3SYT7	Bos taurus	34%	95%
Q4Q5G2	Leishmania major	90%	100%
Q5RE15	Pongo abelii	35%	95%
Q9CX56	Mus musculus	35%	78%
Q9SGW3	Arabidopsis thaliana	34%	100%
V5DHL8	Trypanosoma cruzi	60%	100%