ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ankyrin repeats (3 copies), putative

Species:

Leishmania braziliensis

UniProt:

A4HKA5_LEIBR

TriTrypDb:

LbrM.32.1330 , LBRM2903_320018600

Length:

666

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKA5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKA5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	580	584	PF00656	0.686
CLV_MEL_PAP_1	588	594	PF00089	0.525
CLV_NRD_NRD_1	207	209	PF00675	0.620
CLV_NRD_NRD_1	25	27	PF00675	0.433
CLV_NRD_NRD_1	445	447	PF00675	0.654
CLV_PCSK_KEX2_1	206	208	PF00082	0.637
CLV_PCSK_KEX2_1	25	27	PF00082	0.433
CLV_PCSK_KEX2_1	445	447	PF00082	0.654
CLV_PCSK_PC1ET2_1	206	208	PF00082	0.585
CLV_PCSK_PC7_1	202	208	PF00082	0.699
CLV_PCSK_PC7_1	441	447	PF00082	0.608
CLV_PCSK_SKI1_1	109	113	PF00082	0.499
CLV_PCSK_SKI1_1	121	125	PF00082	0.513
CLV_PCSK_SKI1_1	25	29	PF00082	0.352
CLV_PCSK_SKI1_1	309	313	PF00082	0.490
CLV_PCSK_SKI1_1	354	358	PF00082	0.516
DEG_Nend_Nbox_1	1	3	PF02207	0.502
DEG_SPOP_SBC_1	490	494	PF00917	0.520
DOC_CYCLIN_yCln2_LP_2	288	294	PF00134	0.467
DOC_CYCLIN_yCln2_LP_2	317	323	PF00134	0.506
DOC_MAPK_gen_1	253	261	PF00069	0.507
DOC_MAPK_gen_1	578	588	PF00069	0.529
DOC_PP1_SILK_1	415	420	PF00149	0.531
DOC_PP2B_LxvP_1	169	172	PF13499	0.642
DOC_PP2B_LxvP_1	288	291	PF13499	0.557
DOC_PP2B_LxvP_1	293	296	PF13499	0.536
DOC_USP7_MATH_1	191	195	PF00917	0.524
DOC_USP7_MATH_1	235	239	PF00917	0.646
DOC_USP7_MATH_1	380	384	PF00917	0.571
DOC_USP7_MATH_1	413	417	PF00917	0.694
DOC_USP7_MATH_1	461	465	PF00917	0.596
DOC_USP7_MATH_1	490	494	PF00917	0.522
DOC_USP7_MATH_1	566	570	PF00917	0.546
DOC_USP7_UBL2_3	221	225	PF12436	0.507
DOC_USP7_UBL2_3	347	351	PF12436	0.608
DOC_WW_Pin1_4	15	20	PF00397	0.498
DOC_WW_Pin1_4	312	317	PF00397	0.491
DOC_WW_Pin1_4	411	416	PF00397	0.711
DOC_WW_Pin1_4	457	462	PF00397	0.695
DOC_WW_Pin1_4	529	534	PF00397	0.708
DOC_WW_Pin1_4	73	78	PF00397	0.312
LIG_14-3-3_CanoR_1	183	187	PF00244	0.630
LIG_14-3-3_CanoR_1	41	45	PF00244	0.388
LIG_14-3-3_CanoR_1	445	454	PF00244	0.529
LIG_14-3-3_CanoR_1	472	481	PF00244	0.521
LIG_14-3-3_CanoR_1	537	543	PF00244	0.563
LIG_14-3-3_CanoR_1	589	595	PF00244	0.572
LIG_14-3-3_CanoR_1	629	639	PF00244	0.714
LIG_14-3-3_CanoR_1	97	103	PF00244	0.421
LIG_AP2alpha_2	22	24	PF02296	0.344
LIG_BRCT_BRCA1_1	152	156	PF00533	0.509
LIG_FHA_1	101	107	PF00498	0.544
LIG_FHA_1	133	139	PF00498	0.450
LIG_FHA_1	190	196	PF00498	0.550
LIG_FHA_1	266	272	PF00498	0.601
LIG_FHA_1	398	404	PF00498	0.717
LIG_FHA_1	412	418	PF00498	0.683
LIG_FHA_2	110	116	PF00498	0.484
LIG_Integrin_isoDGR_2	484	486	PF01839	0.525
LIG_LIR_Gen_1	124	133	PF02991	0.379
LIG_LIR_Gen_1	283	293	PF02991	0.522
LIG_LIR_LC3C_4	302	307	PF02991	0.495
LIG_LIR_Nem_3	21	27	PF02991	0.391
LIG_LIR_Nem_3	283	288	PF02991	0.538
LIG_LIR_Nem_3	376	381	PF02991	0.730
LIG_LIR_Nem_3	583	588	PF02991	0.529
LIG_MYND_1	290	294	PF01753	0.471
LIG_MYND_1	549	553	PF01753	0.639
LIG_NRBOX	12	18	PF00104	0.441
LIG_NRBOX	132	138	PF00104	0.537
LIG_PDZ_Class_1	661	666	PF00595	0.503
LIG_PTAP_UEV_1	542	547	PF05743	0.550
LIG_REV1ctd_RIR_1	259	269	PF16727	0.507
LIG_SH2_CRK	285	289	PF00017	0.462
LIG_SH2_SRC	393	396	PF00017	0.485
LIG_SH2_STAP1	397	401	PF00017	0.647
LIG_SH2_STAP1	518	522	PF00017	0.527
LIG_SH2_STAT5	230	233	PF00017	0.515
LIG_SH2_STAT5	393	396	PF00017	0.597
LIG_SH2_STAT5	401	404	PF00017	0.635
LIG_SH2_STAT5	480	483	PF00017	0.517
LIG_SH2_STAT5	631	634	PF00017	0.453
LIG_SH3_2	201	206	PF14604	0.618
LIG_SH3_3	198	204	PF00018	0.658
LIG_SH3_3	288	294	PF00018	0.467
LIG_SH3_3	530	536	PF00018	0.593
LIG_SH3_3	540	546	PF00018	0.578
LIG_SH3_3	87	93	PF00018	0.507
LIG_SUMO_SIM_anti_2	300	308	PF11976	0.495
LIG_SUMO_SIM_par_1	300	308	PF11976	0.546
LIG_TRAF2_1	171	174	PF00917	0.640
LIG_TRAF2_1	264	267	PF00917	0.601
MOD_CDK_SPK_2	457	462	PF00069	0.536
MOD_CDK_SPxxK_3	312	319	PF00069	0.495
MOD_CK1_1	101	107	PF00069	0.445
MOD_CK1_1	143	149	PF00069	0.551
MOD_CK1_1	150	156	PF00069	0.604
MOD_CK1_1	158	164	PF00069	0.593
MOD_CK1_1	194	200	PF00069	0.536
MOD_CK1_1	238	244	PF00069	0.662
MOD_CK1_1	247	253	PF00069	0.590
MOD_CK1_1	369	375	PF00069	0.478
MOD_CK1_1	450	456	PF00069	0.719
MOD_CK1_1	460	466	PF00069	0.598
MOD_CK1_1	493	499	PF00069	0.672
MOD_CK1_1	593	599	PF00069	0.558
MOD_CK1_1	601	607	PF00069	0.660
MOD_CK1_1	612	618	PF00069	0.763
MOD_CK1_1	7	13	PF00069	0.480
MOD_CK2_1	109	115	PF00069	0.555
MOD_CK2_1	15	21	PF00069	0.448
MOD_CK2_1	261	267	PF00069	0.603
MOD_CK2_1	446	452	PF00069	0.684
MOD_GlcNHglycan	109	112	PF01048	0.450
MOD_GlcNHglycan	149	152	PF01048	0.539
MOD_GlcNHglycan	157	160	PF01048	0.606
MOD_GlcNHglycan	222	225	PF01048	0.620
MOD_GlcNHglycan	238	241	PF01048	0.565
MOD_GlcNHglycan	249	252	PF01048	0.669
MOD_GlcNHglycan	333	336	PF01048	0.485
MOD_GlcNHglycan	4	9	PF01048	0.557
MOD_GlcNHglycan	543	546	PF01048	0.580
MOD_GlcNHglycan	600	603	PF01048	0.815
MOD_GlcNHglycan	611	614	PF01048	0.586
MOD_GlcNHglycan	646	649	PF01048	0.611
MOD_GlcNHglycan	663	666	PF01048	0.493
MOD_GSK3_1	100	107	PF00069	0.486
MOD_GSK3_1	109	116	PF00069	0.561
MOD_GSK3_1	117	124	PF00069	0.362
MOD_GSK3_1	143	150	PF00069	0.595
MOD_GSK3_1	151	158	PF00069	0.647
MOD_GSK3_1	226	233	PF00069	0.548
MOD_GSK3_1	243	250	PF00069	0.633
MOD_GSK3_1	261	268	PF00069	0.495
MOD_GSK3_1	397	404	PF00069	0.609
MOD_GSK3_1	446	453	PF00069	0.753
MOD_GSK3_1	457	464	PF00069	0.609
MOD_GSK3_1	468	475	PF00069	0.626
MOD_GSK3_1	489	496	PF00069	0.777
MOD_GSK3_1	537	544	PF00069	0.638
MOD_GSK3_1	598	605	PF00069	0.691
MOD_GSK3_1	654	661	PF00069	0.462
MOD_N-GLC_1	140	145	PF02516	0.477
MOD_N-GLC_1	446	451	PF02516	0.597
MOD_N-GLC_1	464	469	PF02516	0.590
MOD_N-GLC_2	477	479	PF02516	0.516
MOD_NEK2_1	147	152	PF00069	0.601
MOD_NEK2_1	403	408	PF00069	0.662
MOD_NEK2_1	503	508	PF00069	0.538
MOD_NEK2_1	632	637	PF00069	0.594
MOD_NEK2_1	644	649	PF00069	0.514
MOD_PIKK_1	176	182	PF00454	0.513
MOD_PIKK_1	632	638	PF00454	0.531
MOD_PKA_2	182	188	PF00069	0.643
MOD_PKA_2	254	260	PF00069	0.506
MOD_PKA_2	40	46	PF00069	0.388
MOD_PKA_2	450	456	PF00069	0.609
MOD_PKA_2	536	542	PF00069	0.561
MOD_PKA_2	590	596	PF00069	0.520
MOD_PKA_2	618	624	PF00069	0.601
MOD_PKA_2	644	650	PF00069	0.573
MOD_PKA_2	654	660	PF00069	0.515
MOD_Plk_1	143	149	PF00069	0.552
MOD_Plk_1	369	375	PF00069	0.472
MOD_Plk_1	464	470	PF00069	0.530
MOD_Plk_4	113	119	PF00069	0.462
MOD_Plk_4	132	138	PF00069	0.485
MOD_Plk_4	143	149	PF00069	0.472
MOD_Plk_4	254	260	PF00069	0.516
MOD_Plk_4	40	46	PF00069	0.312
MOD_Plk_4	413	419	PF00069	0.684
MOD_Plk_4	453	459	PF00069	0.553
MOD_Plk_4	517	523	PF00069	0.648
MOD_ProDKin_1	15	21	PF00069	0.500
MOD_ProDKin_1	312	318	PF00069	0.492
MOD_ProDKin_1	411	417	PF00069	0.714
MOD_ProDKin_1	457	463	PF00069	0.693
MOD_ProDKin_1	529	535	PF00069	0.712
MOD_ProDKin_1	73	79	PF00069	0.312
MOD_SUMO_for_1	407	410	PF00179	0.510
MOD_SUMO_for_1	418	421	PF00179	0.517
MOD_SUMO_for_1	510	513	PF00179	0.534
MOD_SUMO_rev_2	302	312	PF00179	0.581
TRG_DiLeu_BaEn_1	132	137	PF01217	0.535
TRG_DiLeu_BaEn_1	283	288	PF01217	0.459
TRG_DiLeu_BaEn_1	301	306	PF01217	0.453
TRG_DiLeu_BaEn_3	437	443	PF01217	0.664
TRG_DiLeu_BaEn_4	173	179	PF01217	0.642
TRG_DiLeu_BaLyEn_6	164	169	PF01217	0.653
TRG_DiLeu_BaLyEn_6	288	293	PF01217	0.466
TRG_DiLeu_BaLyEn_6	90	95	PF01217	0.544
TRG_ENDOCYTIC_2	285	288	PF00928	0.533
TRG_ENDOCYTIC_2	58	61	PF00928	0.388
TRG_ENDOCYTIC_2	640	643	PF00928	0.524
TRG_ER_diArg_1	207	209	PF00400	0.685
TRG_ER_diArg_1	24	26	PF00400	0.425
TRG_ER_diArg_1	444	446	PF00400	0.656
TRG_ER_diArg_1	588	591	PF00400	0.531
TRG_Pf-PMV_PEXEL_1	354	359	PF00026	0.594
TRG_Pf-PMV_PEXEL_1	642	646	PF00026	0.535

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P9L2	Leptomonas seymouri	37%	100%
A0A3S7X5E8	Leishmania donovani	57%	100%
A4I7T5	Leishmania infantum	58%	100%
E9B2P3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	56%	100%
Q4Q5G4	Leishmania major	58%	99%