MBOAT_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HKA4_LEIBR

TriTrypDb:

LbrM.32.1320 , LBRM2903_320018500

Length:

364

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4HKA4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKA4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	260	264	PF00656	0.714
CLV_C14_Caspase3-7	272	276	PF00656	0.555
CLV_MEL_PAP_1	299	305	PF00089	0.321
CLV_NRD_NRD_1	114	116	PF00675	0.539
CLV_NRD_NRD_1	191	193	PF00675	0.458
CLV_NRD_NRD_1	219	221	PF00675	0.399
CLV_NRD_NRD_1	55	57	PF00675	0.471
CLV_PCSK_KEX2_1	113	115	PF00082	0.539
CLV_PCSK_KEX2_1	191	193	PF00082	0.455
CLV_PCSK_KEX2_1	219	221	PF00082	0.398
CLV_PCSK_KEX2_1	55	57	PF00082	0.471
CLV_PCSK_SKI1_1	114	118	PF00082	0.526
CLV_PCSK_SKI1_1	219	223	PF00082	0.440
DEG_APCC_DBOX_1	112	120	PF00400	0.404
DEG_Nend_UBRbox_3	1	3	PF02207	0.432
DEG_SCF_FBW7_1	140	147	PF00400	0.274
DOC_CKS1_1	141	146	PF01111	0.270
DOC_CKS1_1	184	189	PF01111	0.382
DOC_CYCLIN_RxL_1	109	122	PF00134	0.388
DOC_CYCLIN_yCln2_LP_2	346	352	PF00134	0.330
DOC_MAPK_gen_1	113	119	PF00069	0.345
DOC_MAPK_gen_1	191	198	PF00069	0.307
DOC_MAPK_MEF2A_6	79	88	PF00069	0.577
DOC_PP4_FxxP_1	141	144	PF00568	0.271
DOC_SPAK_OSR1_1	137	141	PF12202	0.393
DOC_USP7_MATH_1	146	150	PF00917	0.512
DOC_WW_Pin1_4	1	6	PF00397	0.354
DOC_WW_Pin1_4	104	109	PF00397	0.254
DOC_WW_Pin1_4	140	145	PF00397	0.350
DOC_WW_Pin1_4	183	188	PF00397	0.374
DOC_WW_Pin1_4	229	234	PF00397	0.549
DOC_WW_Pin1_4	273	278	PF00397	0.589
LIG_14-3-3_CanoR_1	191	197	PF00244	0.340
LIG_14-3-3_CanoR_1	302	306	PF00244	0.694
LIG_14-3-3_CanoR_1	99	108	PF00244	0.379
LIG_BRCT_BRCA1_1	14	18	PF00533	0.482
LIG_deltaCOP1_diTrp_1	126	135	PF00928	0.390
LIG_FHA_1	128	134	PF00498	0.359
LIG_FHA_1	202	208	PF00498	0.353
LIG_FHA_1	257	263	PF00498	0.716
LIG_FHA_1	312	318	PF00498	0.615
LIG_FHA_1	357	363	PF00498	0.210
LIG_FHA_1	67	73	PF00498	0.638
LIG_FHA_1	88	94	PF00498	0.246
LIG_FHA_2	184	190	PF00498	0.380
LIG_FHA_2	258	264	PF00498	0.745
LIG_LIR_Apic_2	159	163	PF02991	0.354
LIG_LIR_Gen_1	143	151	PF02991	0.408
LIG_LIR_Gen_1	15	26	PF02991	0.454
LIG_LIR_Gen_1	175	184	PF02991	0.449
LIG_LIR_Gen_1	204	211	PF02991	0.421
LIG_LIR_Gen_1	312	323	PF02991	0.572
LIG_LIR_Gen_1	32	43	PF02991	0.297
LIG_LIR_Gen_1	332	342	PF02991	0.334
LIG_LIR_Nem_3	122	128	PF02991	0.446
LIG_LIR_Nem_3	15	21	PF02991	0.470
LIG_LIR_Nem_3	171	176	PF02991	0.483
LIG_LIR_Nem_3	204	208	PF02991	0.376
LIG_LIR_Nem_3	312	318	PF02991	0.517
LIG_LIR_Nem_3	32	38	PF02991	0.297
LIG_LIR_Nem_3	332	337	PF02991	0.361
LIG_NRBOX	342	348	PF00104	0.330
LIG_NRBOX	80	86	PF00104	0.615
LIG_PDZ_Class_2	359	364	PF00595	0.512
LIG_Pex14_1	135	139	PF04695	0.385
LIG_Pex14_2	141	145	PF04695	0.328
LIG_SH2_CRK	176	180	PF00017	0.442
LIG_SH2_CRK	193	197	PF00017	0.150
LIG_SH2_CRK	215	219	PF00017	0.565
LIG_SH2_CRK	330	334	PF00017	0.284
LIG_SH2_CRK	94	98	PF00017	0.395
LIG_SH2_NCK_1	94	98	PF00017	0.197
LIG_SH2_STAP1	330	334	PF00017	0.357
LIG_SH2_STAP1	94	98	PF00017	0.402
LIG_SH2_STAT5	139	142	PF00017	0.380
LIG_SH2_STAT5	215	218	PF00017	0.513
LIG_SH2_STAT5	235	238	PF00017	0.638
LIG_SH3_3	102	108	PF00018	0.218
LIG_SH3_3	181	187	PF00018	0.472
LIG_SH3_3	271	277	PF00018	0.636
LIG_SH3_3	69	75	PF00018	0.528
LIG_Sin3_3	351	358	PF02671	0.197
LIG_SUMO_SIM_anti_2	204	210	PF11976	0.410
LIG_SUMO_SIM_anti_2	41	46	PF11976	0.298
LIG_SUMO_SIM_par_1	351	356	PF11976	0.333
LIG_SUMO_SIM_par_1	84	90	PF11976	0.355
LIG_TYR_ITSM	330	337	PF00017	0.355
LIG_WRC_WIRS_1	37	42	PF05994	0.366
MOD_CK1_1	149	155	PF00069	0.440
MOD_CK1_1	356	362	PF00069	0.292
MOD_CK2_1	183	189	PF00069	0.389
MOD_CMANNOS	129	132	PF00535	0.598
MOD_CMANNOS	319	322	PF00535	0.407
MOD_DYRK1A_RPxSP_1	183	187	PF00069	0.279
MOD_GlcNHglycan	148	151	PF01048	0.616
MOD_GlcNHglycan	222	225	PF01048	0.440
MOD_GlcNHglycan	227	230	PF01048	0.498
MOD_GlcNHglycan	305	308	PF01048	0.322
MOD_GlcNHglycan	59	62	PF01048	0.460
MOD_GSK3_1	1	8	PF00069	0.484
MOD_GSK3_1	140	147	PF00069	0.377
MOD_GSK3_1	149	156	PF00069	0.407
MOD_GSK3_1	179	186	PF00069	0.493
MOD_GSK3_1	197	204	PF00069	0.266
MOD_GSK3_1	225	232	PF00069	0.692
MOD_GSK3_1	252	259	PF00069	0.740
MOD_GSK3_1	269	276	PF00069	0.663
MOD_GSK3_1	303	310	PF00069	0.684
MOD_N-GLC_1	1	6	PF02516	0.625
MOD_N-GLC_1	12	17	PF02516	0.602
MOD_N-GLC_1	179	184	PF02516	0.645
MOD_N-GLC_1	256	261	PF02516	0.367
MOD_N-GLC_2	155	157	PF02516	0.501
MOD_NEK2_1	119	124	PF00069	0.366
MOD_NEK2_1	179	184	PF00069	0.426
MOD_NEK2_1	201	206	PF00069	0.321
MOD_NEK2_1	227	232	PF00069	0.719
MOD_NEK2_1	29	34	PF00069	0.303
MOD_NEK2_1	353	358	PF00069	0.333
MOD_PIKK_1	149	155	PF00454	0.331
MOD_PK_1	192	198	PF00069	0.252
MOD_PKA_2	301	307	PF00069	0.690
MOD_PKA_2	57	63	PF00069	0.643
MOD_Plk_1	12	18	PF00069	0.497
MOD_Plk_1	269	275	PF00069	0.677
MOD_Plk_4	119	125	PF00069	0.386
MOD_Plk_4	213	219	PF00069	0.589
MOD_Plk_4	269	275	PF00069	0.646
MOD_Plk_4	30	36	PF00069	0.294
MOD_Plk_4	329	335	PF00069	0.417
MOD_Plk_4	353	359	PF00069	0.267
MOD_ProDKin_1	1	7	PF00069	0.353
MOD_ProDKin_1	104	110	PF00069	0.254
MOD_ProDKin_1	140	146	PF00069	0.358
MOD_ProDKin_1	183	189	PF00069	0.369
MOD_ProDKin_1	229	235	PF00069	0.552
MOD_ProDKin_1	273	279	PF00069	0.582
MOD_SUMO_rev_2	156	163	PF00179	0.476
TRG_DiLeu_BaEn_4	282	288	PF01217	0.525
TRG_DiLeu_BaLyEn_6	112	117	PF01217	0.393
TRG_DiLeu_BaLyEn_6	338	343	PF01217	0.311
TRG_DiLeu_BaLyEn_6	80	85	PF01217	0.559
TRG_ENDOCYTIC_2	176	179	PF00928	0.440
TRG_ENDOCYTIC_2	193	196	PF00928	0.195
TRG_ENDOCYTIC_2	215	218	PF00928	0.570
TRG_ENDOCYTIC_2	330	333	PF00928	0.302
TRG_ENDOCYTIC_2	334	337	PF00928	0.304
TRG_ENDOCYTIC_2	94	97	PF00928	0.328
TRG_ER_diArg_1	113	115	PF00400	0.309
TRG_ER_diArg_1	190	192	PF00400	0.264
TRG_ER_diArg_1	218	220	PF00400	0.664
TRG_ER_diArg_1	54	56	PF00400	0.611
TRG_Pf-PMV_PEXEL_1	285	289	PF00026	0.461

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEL3	Leptomonas seymouri	42%	94%
A0A1X0NUK5	Trypanosomatidae	26%	100%
A0A3Q8ID27	Leishmania donovani	70%	100%
A0A422P1F3	Trypanosoma rangeli	27%	100%
A4I7T4	Leishmania infantum	71%	100%
D0A9Z4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9B2P2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	89%
Q4Q5G5	Leishmania major	69%	100%
V5DHL3	Trypanosoma cruzi	28%	100%