Elongation of fatty acids protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

long chain polyunsaturated fatty acid elongation enzyme-like protein

Species:

Leishmania braziliensis

UniProt:

A4HKA3_LEIBR

TriTrypDb:

LbrM.32.1310 , LBRM2903_320018400

Length:

328

Annotations

LeishMANIAdb annotations

Related to ELOVL5 proteins found in multicellular animals. Probably also involved in very long chain fatty acid biosynthesis in ER.. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A4HKA3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKA3

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	10
GO:0006629	lipid metabolic process	3	10
GO:0006631	fatty acid metabolic process	4	10
GO:0006633	fatty acid biosynthetic process	5	10
GO:0008152	metabolic process	1	10
GO:0008610	lipid biosynthetic process	4	10
GO:0009058	biosynthetic process	2	10
GO:0009987	cellular process	1	10
GO:0016053	organic acid biosynthetic process	4	10
GO:0019752	carboxylic acid metabolic process	5	10
GO:0032787	monocarboxylic acid metabolic process	6	10
GO:0043436	oxoacid metabolic process	4	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044249	cellular biosynthetic process	3	10
GO:0044255	cellular lipid metabolic process	3	10
GO:0044281	small molecule metabolic process	2	10
GO:0044283	small molecule biosynthetic process	3	10
GO:0046394	carboxylic acid biosynthetic process	5	10
GO:0071704	organic substance metabolic process	2	10
GO:0072330	monocarboxylic acid biosynthetic process	6	10
GO:1901576	organic substance biosynthetic process	3	10
GO:0000038	very long-chain fatty acid metabolic process	5	1
GO:0006643	membrane lipid metabolic process	4	1
GO:0006665	sphingolipid metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0019367	fatty acid elongation, saturated fatty acid	7	1
GO:0019368	fatty acid elongation, unsaturated fatty acid	7	1
GO:0030148	sphingolipid biosynthetic process	5	1
GO:0030497	fatty acid elongation	6	1
GO:0034625	fatty acid elongation, monounsaturated fatty acid	8	1
GO:0034626	fatty acid elongation, polyunsaturated fatty acid	8	1
GO:0042761	very long-chain fatty acid biosynthetic process	6	1
GO:0046467	membrane lipid biosynthetic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004312	fatty acid synthase activity	5	10
GO:0009922	fatty acid elongase activity	6	10
GO:0016740	transferase activity	2	10
GO:0016746	acyltransferase activity	3	10
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	10
GO:0102756	very-long-chain 3-ketoacyl-CoA synthase activity	5	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	321	323	PF00082	0.425
CLV_PCSK_KEX2_1	67	69	PF00082	0.440
CLV_PCSK_PC1ET2_1	321	323	PF00082	0.470
CLV_PCSK_PC1ET2_1	67	69	PF00082	0.394
CLV_PCSK_SKI1_1	149	153	PF00082	0.387
CLV_PCSK_SKI1_1	237	241	PF00082	0.180
CLV_PCSK_SKI1_1	324	328	PF00082	0.339
CLV_PCSK_SKI1_1	41	45	PF00082	0.394
DEG_MDM2_SWIB_1	192	200	PF02201	0.297
DEG_Nend_Nbox_1	1	3	PF02207	0.249
DOC_MAPK_gen_1	6	16	PF00069	0.183
DOC_MAPK_RevD_3	289	304	PF00069	0.181
DOC_PP1_RVXF_1	150	156	PF00149	0.175
DOC_PP1_RVXF_1	159	166	PF00149	0.194
DOC_PP2B_LxvP_1	200	203	PF13499	0.249
DOC_USP7_MATH_1	204	208	PF00917	0.228
DOC_USP7_MATH_1	232	236	PF00917	0.147
DOC_USP7_MATH_1	315	319	PF00917	0.558
DOC_USP7_UBL2_3	301	305	PF12436	0.352
DOC_WW_Pin1_4	141	146	PF00397	0.186
DOC_WW_Pin1_4	274	279	PF00397	0.142
LIG_14-3-3_CanoR_1	22	28	PF00244	0.198
LIG_14-3-3_CterR_2	324	328	PF00244	0.499
LIG_Actin_WH2_2	262	277	PF00022	0.311
LIG_Actin_WH2_2	7	24	PF00022	0.184
LIG_AP2alpha_1	35	39	PF02296	0.186
LIG_APCC_ABBA_1	32	37	PF00400	0.194
LIG_BRCT_BRCA1_1	188	192	PF00533	0.163
LIG_CaMK_CASK_1	265	271	PF00069	0.210
LIG_CSL_BTD_1	267	270	PF09270	0.297
LIG_DCNL_PONY_1	1	4	PF03556	0.215
LIG_deltaCOP1_diTrp_1	147	155	PF00928	0.176
LIG_EH1_1	75	83	PF00400	0.232
LIG_eIF4E_1	120	126	PF01652	0.285
LIG_eIF4E_1	224	230	PF01652	0.214
LIG_FHA_1	188	194	PF00498	0.271
LIG_FHA_1	231	237	PF00498	0.191
LIG_GBD_Chelix_1	108	116	PF00786	0.210
LIG_IRF3_LxIS_1	123	128	PF10401	0.297
LIG_LIR_Gen_1	118	127	PF02991	0.239
LIG_LIR_Gen_1	181	186	PF02991	0.394
LIG_LIR_Gen_1	206	217	PF02991	0.187
LIG_LIR_Gen_1	26	36	PF02991	0.212
LIG_LIR_Gen_1	262	270	PF02991	0.328
LIG_LIR_Gen_1	48	58	PF02991	0.205
LIG_LIR_Nem_3	118	123	PF02991	0.239
LIG_LIR_Nem_3	181	185	PF02991	0.375
LIG_LIR_Nem_3	26	32	PF02991	0.222
LIG_LIR_Nem_3	262	267	PF02991	0.252
LIG_LIR_Nem_3	48	54	PF02991	0.220
LIG_MYND_1	70	74	PF01753	0.249
LIG_NRBOX	279	285	PF00104	0.163
LIG_PCNA_PIPBox_1	288	297	PF02747	0.258
LIG_Pex14_1	253	257	PF04695	0.210
LIG_Pex14_2	192	196	PF04695	0.211
LIG_Pex14_2	35	39	PF04695	0.190
LIG_Pex14_2	53	57	PF04695	0.219
LIG_SH2_CRK	120	124	PF00017	0.274
LIG_SH2_GRB2like	71	74	PF00017	0.243
LIG_SH2_SRC	71	74	PF00017	0.249
LIG_SH2_STAP1	209	213	PF00017	0.249
LIG_SH2_STAP1	264	268	PF00017	0.202
LIG_SH2_STAT5	158	161	PF00017	0.194
LIG_SH2_STAT5	225	228	PF00017	0.194
LIG_SH2_STAT5	46	49	PF00017	0.226
LIG_SH2_STAT5	71	74	PF00017	0.204
LIG_SH2_STAT5	84	87	PF00017	0.189
LIG_SH3_3	264	270	PF00018	0.306
LIG_SH3_3	90	96	PF00018	0.168
LIG_SUMO_SIM_anti_2	167	174	PF11976	0.297
LIG_TYR_ITIM	82	87	PF00017	0.210
LIG_UBA3_1	1	9	PF00899	0.201
LIG_UBA3_1	153	161	PF00899	0.211
LIG_UBA3_1	170	174	PF00899	0.211
MOD_CK1_1	207	213	PF00069	0.255
MOD_CK1_1	99	105	PF00069	0.380
MOD_CK2_1	141	147	PF00069	0.249
MOD_GlcNHglycan	127	130	PF01048	0.239
MOD_GlcNHglycan	209	212	PF01048	0.434
MOD_GlcNHglycan	214	217	PF01048	0.429
MOD_GlcNHglycan	23	26	PF01048	0.464
MOD_GlcNHglycan	261	264	PF01048	0.345
MOD_GlcNHglycan	317	320	PF01048	0.414
MOD_GlcNHglycan	47	50	PF01048	0.401
MOD_GSK3_1	23	30	PF00069	0.237
MOD_NEK2_1	125	130	PF00069	0.217
MOD_NEK2_1	157	162	PF00069	0.194
MOD_NEK2_1	21	26	PF00069	0.393
MOD_NEK2_1	212	217	PF00069	0.200
MOD_NEK2_1	245	250	PF00069	0.396
MOD_NEK2_1	27	32	PF00069	0.292
MOD_NEK2_1	299	304	PF00069	0.451
MOD_NEK2_1	39	44	PF00069	0.191
MOD_NEK2_1	45	50	PF00069	0.203
MOD_NEK2_1	53	58	PF00069	0.244
MOD_NEK2_2	232	237	PF00069	0.191
MOD_PKA_2	21	27	PF00069	0.194
MOD_Plk_1	39	45	PF00069	0.232
MOD_Plk_4	115	121	PF00069	0.194
MOD_Plk_4	132	138	PF00069	0.175
MOD_Plk_4	165	171	PF00069	0.194
MOD_Plk_4	178	184	PF00069	0.375
MOD_Plk_4	187	193	PF00069	0.178
MOD_Plk_4	204	210	PF00069	0.175
MOD_Plk_4	225	231	PF00069	0.213
MOD_Plk_4	23	29	PF00069	0.214
MOD_Plk_4	53	59	PF00069	0.217
MOD_Plk_4	77	83	PF00069	0.257
MOD_ProDKin_1	141	147	PF00069	0.186
MOD_ProDKin_1	274	280	PF00069	0.142
TRG_ENDOCYTIC_2	120	123	PF00928	0.274
TRG_ENDOCYTIC_2	209	212	PF00928	0.235
TRG_ENDOCYTIC_2	224	227	PF00928	0.183
TRG_ENDOCYTIC_2	264	267	PF00928	0.297
TRG_ENDOCYTIC_2	29	32	PF00928	0.249
TRG_ENDOCYTIC_2	51	54	PF00928	0.215
TRG_ENDOCYTIC_2	84	87	PF00928	0.216
TRG_NLS_MonoExtN_4	301	307	PF00514	0.470

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0C5PHQ7	Tachysurus fulvidraco	34%	100%
A0A0N0P994	Leptomonas seymouri	72%	91%
A0A0N1PBS4	Leptomonas seymouri	29%	100%
A0A0S4IVJ6	Bodo saltans	29%	100%
A0A0S4J4C4	Bodo saltans	33%	100%
A0A0S4JCZ3	Bodo saltans	52%	100%
A0A0S4JH58	Bodo saltans	30%	100%
A0A0S4KMP5	Bodo saltans	47%	100%
A0A1X0NUJ4	Trypanosomatidae	54%	91%
A0A1X0P2P0	Trypanosomatidae	30%	100%
A0A3Q8I9X8	Leishmania donovani	26%	98%
A0A3Q8IT78	Leishmania donovani	77%	86%
A0A422NNP1	Trypanosoma rangeli	26%	100%
A4H4G1	Leishmania braziliensis	34%	100%
A4H7M6	Leishmania braziliensis	25%	100%
A4HSN8	Leishmania infantum	33%	100%
A4HW12	Leishmania infantum	25%	98%
A4I7T3	Leishmania infantum	77%	86%
C9ZPY9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
D4A612	Rattus norvegicus	33%	100%
E9APR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	98%
E9B2P1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	86%
Q2KJD9	Bos taurus	36%	100%
Q32NI8	Xenopus laevis	36%	100%
Q4Q5G6	Leishmania major	78%	100%
Q4QFR5	Leishmania major	25%	100%
Q4QJ85	Leishmania major	33%	100%
Q4R516	Macaca fascicularis	34%	100%
Q5M8U1	Xenopus tropicalis	37%	100%
Q5RFL5	Pongo abelii	35%	100%
Q920L7	Rattus norvegicus	34%	100%
Q9BW60	Homo sapiens	31%	100%
Q9EQC4	Mus musculus	32%	100%
Q9JLJ5	Mus musculus	31%	100%
Q9NXB9	Homo sapiens	34%	100%
Q9NYP7	Homo sapiens	35%	100%
Q9VHX7	Drosophila melanogaster	27%	100%
V5AUX1	Trypanosoma cruzi	31%	100%