Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HKA2_LEIBR

TriTrypDb:

LbrM.32.1300 , LBRM2903_320018300

Length:

305

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKA2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKA2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	211	215	PF00656	0.665
CLV_C14_Caspase3-7	89	93	PF00656	0.363
CLV_NRD_NRD_1	139	141	PF00675	0.520
CLV_NRD_NRD_1	193	195	PF00675	0.686
CLV_PCSK_KEX2_1	138	140	PF00082	0.536
CLV_PCSK_KEX2_1	193	195	PF00082	0.692
CLV_PCSK_KEX2_1	293	295	PF00082	0.442
CLV_PCSK_PC1ET2_1	293	295	PF00082	0.442
CLV_PCSK_SKI1_1	186	190	PF00082	0.457
DEG_Nend_UBRbox_2	1	3	PF02207	0.509
DEG_SCF_FBW7_1	283	288	PF00400	0.296
DEG_SCF_TRCP1_1	214	219	PF00400	0.522
DOC_MAPK_gen_1	74	81	PF00069	0.469
DOC_MAPK_RevD_3	235	250	PF00069	0.512
DOC_PP1_RVXF_1	160	166	PF00149	0.451
DOC_PP1_RVXF_1	241	248	PF00149	0.442
DOC_PP4_FxxP_1	30	33	PF00568	0.509
DOC_USP7_MATH_1	239	243	PF00917	0.481
DOC_USP7_MATH_1	299	303	PF00917	0.635
DOC_USP7_MATH_2	124	130	PF00917	0.465
DOC_WW_Pin1_4	253	258	PF00397	0.585
DOC_WW_Pin1_4	281	286	PF00397	0.434
LIG_APCC_ABBA_1	65	70	PF00400	0.408
LIG_BRCT_BRCA1_1	129	133	PF00533	0.432
LIG_Clathr_ClatBox_1	286	290	PF01394	0.551
LIG_deltaCOP1_diTrp_1	225	235	PF00928	0.526
LIG_FHA_1	155	161	PF00498	0.351
LIG_FHA_1	232	238	PF00498	0.523
LIG_FHA_2	187	193	PF00498	0.672
LIG_FHA_2	205	211	PF00498	0.686
LIG_FHA_2	221	227	PF00498	0.612
LIG_FHA_2	259	265	PF00498	0.611
LIG_FHA_2	266	272	PF00498	0.533
LIG_FHA_2	89	95	PF00498	0.553
LIG_GBD_Chelix_1	104	112	PF00786	0.521
LIG_LIR_Apic_2	27	33	PF02991	0.488
LIG_LIR_Gen_1	102	109	PF02991	0.483
LIG_LIR_Nem_3	102	106	PF02991	0.491
LIG_LIR_Nem_3	226	232	PF02991	0.449
LIG_LIR_Nem_3	254	258	PF02991	0.547
LIG_LIR_Nem_3	73	79	PF02991	0.368
LIG_MYND_1	142	146	PF01753	0.535
LIG_Pex14_2	133	137	PF04695	0.424
LIG_REV1ctd_RIR_1	79	88	PF16727	0.487
LIG_SH2_CRK	21	25	PF00017	0.421
LIG_SH2_STAT5	78	81	PF00017	0.440
LIG_SH2_STAT5	95	98	PF00017	0.276
LIG_SH3_3	12	18	PF00018	0.517
LIG_SH3_3	146	152	PF00018	0.328
LIG_SUMO_SIM_par_1	256	261	PF11976	0.396
LIG_WRC_WIRS_1	134	139	PF05994	0.305
LIG_WRC_WIRS_1	155	160	PF05994	0.357
LIG_WRC_WIRS_1	232	237	PF05994	0.457
LIG_WRC_WIRS_1	252	257	PF05994	0.254
LIG_WRC_WIRS_1	78	83	PF05994	0.411
MOD_CK1_1	129	135	PF00069	0.432
MOD_CK2_1	170	176	PF00069	0.494
MOD_CK2_1	204	210	PF00069	0.747
MOD_CK2_1	220	226	PF00069	0.553
MOD_CK2_1	238	244	PF00069	0.304
MOD_GlcNHglycan	183	186	PF01048	0.630
MOD_GlcNHglycan	2	6	PF01048	0.483
MOD_GlcNHglycan	214	217	PF01048	0.754
MOD_GlcNHglycan	218	221	PF01048	0.730
MOD_GSK3_1	107	114	PF00069	0.416
MOD_GSK3_1	129	136	PF00069	0.393
MOD_GSK3_1	154	161	PF00069	0.341
MOD_GSK3_1	193	200	PF00069	0.753
MOD_GSK3_1	204	211	PF00069	0.764
MOD_GSK3_1	212	219	PF00069	0.571
MOD_GSK3_1	281	288	PF00069	0.421
MOD_N-GLC_1	170	175	PF02516	0.574
MOD_N-GLC_1	265	270	PF02516	0.508
MOD_NEK2_1	1	6	PF00069	0.743
MOD_NEK2_1	112	117	PF00069	0.364
MOD_NEK2_1	133	138	PF00069	0.407
MOD_NEK2_1	158	163	PF00069	0.358
MOD_NEK2_1	258	263	PF00069	0.617
MOD_NEK2_1	279	284	PF00069	0.465
MOD_NEK2_2	77	82	PF00069	0.408
MOD_PIKK_1	107	113	PF00454	0.488
MOD_PIKK_1	119	125	PF00454	0.460
MOD_PKA_1	193	199	PF00069	0.718
MOD_PKA_2	193	199	PF00069	0.733
MOD_Plk_1	170	176	PF00069	0.549
MOD_Plk_1	279	285	PF00069	0.437
MOD_Plk_4	129	135	PF00069	0.396
MOD_Plk_4	154	160	PF00069	0.444
MOD_Plk_4	77	83	PF00069	0.386
MOD_ProDKin_1	253	259	PF00069	0.593
MOD_ProDKin_1	281	287	PF00069	0.429
MOD_SUMO_for_1	153	156	PF00179	0.263
MOD_SUMO_for_1	292	295	PF00179	0.444
MOD_SUMO_rev_2	271	276	PF00179	0.531
MOD_SUMO_rev_2	70	76	PF00179	0.443
TRG_DiLeu_BaLyEn_6	139	144	PF01217	0.532
TRG_DiLeu_BaLyEn_6	254	259	PF01217	0.486
TRG_ENDOCYTIC_2	21	24	PF00928	0.421
TRG_ENDOCYTIC_2	78	81	PF00928	0.470
TRG_ER_diArg_1	137	140	PF00400	0.518
TRG_ER_diArg_1	162	165	PF00400	0.546

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9E0	Leptomonas seymouri	51%	100%
A0A0S4J915	Bodo saltans	29%	100%
A0A1X0NV05	Trypanosomatidae	34%	100%
A0A3R7N1Z4	Trypanosoma rangeli	36%	100%
A0A3S7X5F5	Leishmania donovani	68%	100%
A4I7T2	Leishmania infantum	68%	100%
D0A9Z3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9B2P0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
Q4Q5G7	Leishmania major	69%	100%
V5BGN1	Trypanosoma cruzi	38%	100%