Kinetoplast polyadenylation/uridylation factor 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinetoplast polyadenylation/uridylation factor 2, putative

Species:

Leishmania braziliensis

UniProt:

A4HKA1_LEIBR

TriTrypDb:

LbrM.32.1290 , LBRM2903_320018200

Length:

756

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HKA1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKA1

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006378	mRNA polyadenylation	7	1
GO:0006396	RNA processing	6	1
GO:0006397	mRNA processing	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009894	regulation of catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031123	RNA 3'-end processing	7	1
GO:0031124	mRNA 3'-end processing	8	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031329	regulation of cellular catabolic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043487	regulation of RNA stability	3	1
GO:0043488	regulation of mRNA stability	4	1
GO:0043631	RNA polyadenylation	6	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0061013	regulation of mRNA catabolic process	6	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1903311	regulation of mRNA metabolic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0043021	ribonucleoprotein complex binding	3	1
GO:0043022	ribosome binding	4	1
GO:0044877	protein-containing complex binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	151	155	PF00656	0.749
CLV_C14_Caspase3-7	232	236	PF00656	0.495
CLV_NRD_NRD_1	152	154	PF00675	0.538
CLV_NRD_NRD_1	253	255	PF00675	0.453
CLV_NRD_NRD_1	338	340	PF00675	0.440
CLV_NRD_NRD_1	369	371	PF00675	0.403
CLV_NRD_NRD_1	382	384	PF00675	0.504
CLV_NRD_NRD_1	392	394	PF00675	0.464
CLV_NRD_NRD_1	405	407	PF00675	0.605
CLV_NRD_NRD_1	453	455	PF00675	0.403
CLV_NRD_NRD_1	725	727	PF00675	0.522
CLV_PCSK_KEX2_1	152	154	PF00082	0.643
CLV_PCSK_KEX2_1	338	340	PF00082	0.526
CLV_PCSK_KEX2_1	369	371	PF00082	0.369
CLV_PCSK_KEX2_1	392	394	PF00082	0.513
CLV_PCSK_KEX2_1	405	407	PF00082	0.605
CLV_PCSK_KEX2_1	453	455	PF00082	0.403
CLV_PCSK_KEX2_1	725	727	PF00082	0.433
CLV_PCSK_SKI1_1	216	220	PF00082	0.594
CLV_PCSK_SKI1_1	254	258	PF00082	0.500
CLV_PCSK_SKI1_1	297	301	PF00082	0.411
CLV_PCSK_SKI1_1	383	387	PF00082	0.388
CLV_PCSK_SKI1_1	715	719	PF00082	0.318
CLV_Separin_Metazoa	307	311	PF03568	0.270
CLV_Separin_Metazoa	611	615	PF03568	0.449
DEG_APCC_DBOX_1	183	191	PF00400	0.513
DEG_APCC_DBOX_1	253	261	PF00400	0.474
DEG_SCF_TRCP1_1	235	241	PF00400	0.486
DEG_SPOP_SBC_1	239	243	PF00917	0.457
DOC_ANK_TNKS_1	391	398	PF00023	0.580
DOC_CYCLIN_RxL_1	291	301	PF00134	0.323
DOC_MAPK_gen_1	392	400	PF00069	0.517
DOC_MAPK_gen_1	583	591	PF00069	0.421
DOC_MAPK_MEF2A_6	121	130	PF00069	0.521
DOC_PP2B_PxIxI_1	353	359	PF00149	0.401
DOC_USP7_MATH_1	129	133	PF00917	0.654
DOC_USP7_MATH_1	142	146	PF00917	0.727
DOC_USP7_MATH_1	233	237	PF00917	0.722
DOC_USP7_MATH_1	534	538	PF00917	0.593
DOC_USP7_MATH_1	60	64	PF00917	0.468
DOC_USP7_MATH_1	704	708	PF00917	0.550
DOC_USP7_MATH_1	81	85	PF00917	0.520
DOC_USP7_UBL2_3	746	750	PF12436	0.460
DOC_WW_Pin1_4	145	150	PF00397	0.667
DOC_WW_Pin1_4	154	159	PF00397	0.643
DOC_WW_Pin1_4	241	246	PF00397	0.568
DOC_WW_Pin1_4	27	32	PF00397	0.551
DOC_WW_Pin1_4	350	355	PF00397	0.474
DOC_WW_Pin1_4	509	514	PF00397	0.616
DOC_WW_Pin1_4	617	622	PF00397	0.764
DOC_WW_Pin1_4	679	684	PF00397	0.284
LIG_14-3-3_CanoR_1	184	188	PF00244	0.554
LIG_14-3-3_CanoR_1	26	31	PF00244	0.534
LIG_14-3-3_CanoR_1	310	315	PF00244	0.458
LIG_14-3-3_CanoR_1	338	346	PF00244	0.522
LIG_14-3-3_CanoR_1	414	420	PF00244	0.522
LIG_14-3-3_CanoR_1	453	459	PF00244	0.538
LIG_14-3-3_CanoR_1	542	548	PF00244	0.382
LIG_14-3-3_CanoR_1	583	591	PF00244	0.501
LIG_14-3-3_CanoR_1	622	630	PF00244	0.776
LIG_14-3-3_CanoR_1	641	646	PF00244	0.507
LIG_14-3-3_CanoR_1	80	86	PF00244	0.656
LIG_Actin_WH2_2	391	407	PF00022	0.600
LIG_APCC_ABBA_1	718	723	PF00400	0.386
LIG_BRCT_BRCA1_1	171	175	PF00533	0.545
LIG_BRCT_BRCA1_1	712	716	PF00533	0.388
LIG_FHA_1	206	212	PF00498	0.459
LIG_FHA_1	242	248	PF00498	0.485
LIG_FHA_1	459	465	PF00498	0.391
LIG_FHA_1	569	575	PF00498	0.391
LIG_FHA_1	648	654	PF00498	0.349
LIG_FHA_1	680	686	PF00498	0.380
LIG_FHA_1	735	741	PF00498	0.417
LIG_FHA_2	230	236	PF00498	0.717
LIG_FHA_2	241	247	PF00498	0.397
LIG_FHA_2	414	420	PF00498	0.745
LIG_FHA_2	434	440	PF00498	0.431
LIG_FHA_2	496	502	PF00498	0.517
LIG_FHA_2	514	520	PF00498	0.741
LIG_FHA_2	522	528	PF00498	0.775
LIG_FHA_2	534	540	PF00498	0.530
LIG_FHA_2	543	549	PF00498	0.452
LIG_LIR_Gen_1	18	25	PF02991	0.605
LIG_LIR_Gen_1	183	191	PF02991	0.519
LIG_LIR_Gen_1	479	487	PF02991	0.471
LIG_LIR_Gen_1	573	582	PF02991	0.345
LIG_LIR_Gen_1	586	595	PF02991	0.340
LIG_LIR_Gen_1	650	658	PF02991	0.335
LIG_LIR_Gen_1	72	81	PF02991	0.512
LIG_LIR_Nem_3	18	24	PF02991	0.601
LIG_LIR_Nem_3	183	188	PF02991	0.542
LIG_LIR_Nem_3	447	451	PF02991	0.386
LIG_LIR_Nem_3	479	483	PF02991	0.418
LIG_LIR_Nem_3	545	550	PF02991	0.561
LIG_LIR_Nem_3	573	578	PF02991	0.420
LIG_LIR_Nem_3	586	591	PF02991	0.311
LIG_LIR_Nem_3	606	612	PF02991	0.587
LIG_LIR_Nem_3	650	654	PF02991	0.342
LIG_LIR_Nem_3	665	671	PF02991	0.300
LIG_LIR_Nem_3	72	78	PF02991	0.583
LIG_MYND_1	636	640	PF01753	0.329
LIG_NRBOX	332	338	PF00104	0.382
LIG_NRBOX	577	583	PF00104	0.467
LIG_PTB_Apo_2	486	493	PF02174	0.399
LIG_PTB_Phospho_1	486	492	PF10480	0.399
LIG_REV1ctd_RIR_1	173	182	PF16727	0.508
LIG_SH2_CRK	21	25	PF00017	0.627
LIG_SH2_CRK	480	484	PF00017	0.411
LIG_SH2_GRB2like	21	24	PF00017	0.425
LIG_SH2_NCK_1	21	25	PF00017	0.431
LIG_SH2_PTP2	492	495	PF00017	0.466
LIG_SH2_STAP1	21	25	PF00017	0.627
LIG_SH2_STAP1	480	484	PF00017	0.411
LIG_SH2_STAP1	651	655	PF00017	0.340
LIG_SH2_STAP1	671	675	PF00017	0.205
LIG_SH2_STAP1	686	690	PF00017	0.395
LIG_SH2_STAT3	660	663	PF00017	0.496
LIG_SH2_STAT5	21	24	PF00017	0.552
LIG_SH2_STAT5	293	296	PF00017	0.373
LIG_SH2_STAT5	492	495	PF00017	0.464
LIG_SH2_STAT5	580	583	PF00017	0.477
LIG_SH2_STAT5	660	663	PF00017	0.448
LIG_SH3_1	121	127	PF00018	0.517
LIG_SH3_2	636	641	PF14604	0.334
LIG_SH3_3	121	127	PF00018	0.666
LIG_SH3_3	133	139	PF00018	0.607
LIG_SH3_3	161	167	PF00018	0.644
LIG_SH3_3	215	221	PF00018	0.532
LIG_SH3_3	259	265	PF00018	0.564
LIG_SH3_3	34	40	PF00018	0.615
LIG_SH3_3	348	354	PF00018	0.564
LIG_SH3_3	54	60	PF00018	0.640
LIG_SH3_3	633	639	PF00018	0.464
LIG_SUMO_SIM_anti_2	687	692	PF11976	0.441
LIG_SUMO_SIM_par_1	126	133	PF11976	0.518
LIG_SUMO_SIM_par_1	687	692	PF11976	0.441
LIG_TRAF2_1	498	501	PF00917	0.584
LIG_TRAF2_2	262	267	PF00917	0.561
LIG_TYR_ITIM	478	483	PF00017	0.425
LIG_UBA3_1	187	192	PF00899	0.312
LIG_UBA3_1	467	475	PF00899	0.491
LIG_UBA3_1	578	585	PF00899	0.423
LIG_WRC_WIRS_1	4	9	PF05994	0.476
LIG_WW_3	260	264	PF00397	0.544
LIG_WW_3	638	642	PF00397	0.427
MOD_CDK_SPK_2	617	622	PF00069	0.477
MOD_CDK_SPK_2	679	684	PF00069	0.284
MOD_CDK_SPxxK_3	145	152	PF00069	0.541
MOD_CK1_1	145	151	PF00069	0.796
MOD_CK1_1	15	21	PF00069	0.686
MOD_CK1_1	238	244	PF00069	0.572
MOD_CK1_1	29	35	PF00069	0.444
MOD_CK1_1	521	527	PF00069	0.697
MOD_CK1_1	615	621	PF00069	0.561
MOD_CK1_1	625	631	PF00069	0.678
MOD_CK1_1	707	713	PF00069	0.530
MOD_CK1_1	93	99	PF00069	0.620
MOD_CK2_1	240	246	PF00069	0.610
MOD_CK2_1	354	360	PF00069	0.574
MOD_CK2_1	495	501	PF00069	0.598
MOD_CK2_1	513	519	PF00069	0.741
MOD_CK2_1	542	548	PF00069	0.491
MOD_CMANNOS	642	645	PF00535	0.476
MOD_GlcNHglycan	113	116	PF01048	0.673
MOD_GlcNHglycan	144	147	PF01048	0.749
MOD_GlcNHglycan	179	183	PF01048	0.599
MOD_GlcNHglycan	18	21	PF01048	0.654
MOD_GlcNHglycan	226	229	PF01048	0.582
MOD_GlcNHglycan	235	238	PF01048	0.630
MOD_GlcNHglycan	416	419	PF01048	0.789
MOD_GlcNHglycan	52	55	PF01048	0.567
MOD_GlcNHglycan	527	531	PF01048	0.635
MOD_GlcNHglycan	614	617	PF01048	0.599
MOD_GlcNHglycan	624	627	PF01048	0.626
MOD_GlcNHglycan	631	634	PF01048	0.594
MOD_GlcNHglycan	705	709	PF01048	0.470
MOD_GlcNHglycan	83	86	PF01048	0.617
MOD_GlcNHglycan	89	93	PF01048	0.565
MOD_GSK3_1	12	19	PF00069	0.484
MOD_GSK3_1	140	147	PF00069	0.736
MOD_GSK3_1	229	236	PF00069	0.571
MOD_GSK3_1	27	34	PF00069	0.470
MOD_GSK3_1	337	344	PF00069	0.531
MOD_GSK3_1	350	357	PF00069	0.597
MOD_GSK3_1	454	461	PF00069	0.399
MOD_GSK3_1	504	511	PF00069	0.590
MOD_GSK3_1	528	535	PF00069	0.775
MOD_GSK3_1	538	545	PF00069	0.581
MOD_GSK3_1	625	632	PF00069	0.532
MOD_GSK3_1	707	714	PF00069	0.514
MOD_GSK3_1	730	737	PF00069	0.442
MOD_GSK3_1	742	749	PF00069	0.437
MOD_N-GLC_1	111	116	PF02516	0.645
MOD_N-GLC_1	154	159	PF02516	0.542
MOD_N-GLC_1	430	435	PF02516	0.501
MOD_N-GLC_2	8	10	PF02516	0.615
MOD_NEK2_1	256	261	PF00069	0.378
MOD_NEK2_1	285	290	PF00069	0.427
MOD_NEK2_1	3	8	PF00069	0.588
MOD_NEK2_1	337	342	PF00069	0.532
MOD_NEK2_1	347	352	PF00069	0.510
MOD_NEK2_1	458	463	PF00069	0.443
MOD_NEK2_1	55	60	PF00069	0.566
MOD_NEK2_1	734	739	PF00069	0.518
MOD_PIKK_1	166	172	PF00454	0.788
MOD_PIKK_1	29	35	PF00454	0.491
MOD_PIKK_1	40	46	PF00454	0.527
MOD_PIKK_1	565	571	PF00454	0.298
MOD_PIKK_1	593	599	PF00454	0.276
MOD_PIKK_1	79	85	PF00454	0.531
MOD_PIKK_1	93	99	PF00454	0.683
MOD_PK_1	310	316	PF00069	0.422
MOD_PKA_2	183	189	PF00069	0.572
MOD_PKA_2	285	291	PF00069	0.317
MOD_PKA_2	337	343	PF00069	0.465
MOD_PKA_2	404	410	PF00069	0.649
MOD_PKA_2	413	419	PF00069	0.658
MOD_PKA_2	521	527	PF00069	0.507
MOD_PKA_2	640	646	PF00069	0.515
MOD_PKA_2	79	85	PF00069	0.653
MOD_PKB_1	88	96	PF00069	0.494
MOD_Plk_1	354	360	PF00069	0.553
MOD_Plk_1	430	436	PF00069	0.617
MOD_Plk_4	183	189	PF00069	0.588
MOD_Plk_4	347	353	PF00069	0.645
MOD_Plk_4	430	436	PF00069	0.636
MOD_Plk_4	479	485	PF00069	0.465
MOD_Plk_4	697	703	PF00069	0.440
MOD_ProDKin_1	145	151	PF00069	0.668
MOD_ProDKin_1	154	160	PF00069	0.640
MOD_ProDKin_1	241	247	PF00069	0.561
MOD_ProDKin_1	27	33	PF00069	0.555
MOD_ProDKin_1	350	356	PF00069	0.470
MOD_ProDKin_1	509	515	PF00069	0.614
MOD_ProDKin_1	617	623	PF00069	0.765
MOD_ProDKin_1	679	685	PF00069	0.279
TRG_DiLeu_BaEn_1	577	582	PF01217	0.459
TRG_ENDOCYTIC_2	185	188	PF00928	0.354
TRG_ENDOCYTIC_2	21	24	PF00928	0.622
TRG_ENDOCYTIC_2	292	295	PF00928	0.340
TRG_ENDOCYTIC_2	480	483	PF00928	0.412
TRG_ENDOCYTIC_2	651	654	PF00928	0.342
TRG_ENDOCYTIC_2	671	674	PF00928	0.197
TRG_ENDOCYTIC_2	686	689	PF00928	0.326
TRG_ENDOCYTIC_2	721	724	PF00928	0.379
TRG_ER_diArg_1	337	339	PF00400	0.520
TRG_ER_diArg_1	368	370	PF00400	0.344
TRG_ER_diArg_1	392	394	PF00400	0.335
TRG_ER_diArg_1	404	406	PF00400	0.349
TRG_ER_diArg_1	452	454	PF00400	0.395
TRG_ER_diArg_1	657	660	PF00400	0.479
TRG_ER_diArg_1	724	726	PF00400	0.505
TRG_NLS_Bipartite_1	369	387	PF00514	0.300
TRG_Pf-PMV_PEXEL_1	297	301	PF00026	0.463

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PGR3	Leptomonas seymouri	49%	100%
A0A1X0NVZ4	Trypanosomatidae	30%	100%
A0A3Q8IG45	Leishmania donovani	68%	100%
A0A3R7NTQ6	Trypanosoma rangeli	29%	100%
A4I7T1	Leishmania infantum	68%	100%
D0A9Z2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9B2N9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%
Q4Q5G8	Leishmania major	68%	99%
V5BQR4	Trypanosoma cruzi	28%	100%