DNA helicase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Download

Quick info

Protein:

DNA helicase

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HKA0_LEIBR

TriTrypDb:

LbrM.32.1280 , LBRM2903_320018100

Length:

564

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKA0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKA0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	322	326	PF00656	0.814
CLV_MEL_PAP_1	334	340	PF00089	0.801
CLV_NRD_NRD_1	207	209	PF00675	0.873
CLV_NRD_NRD_1	267	269	PF00675	0.815
CLV_NRD_NRD_1	3	5	PF00675	0.845
CLV_NRD_NRD_1	343	345	PF00675	0.763
CLV_NRD_NRD_1	367	369	PF00675	0.749
CLV_NRD_NRD_1	373	375	PF00675	0.639
CLV_NRD_NRD_1	460	462	PF00675	0.847
CLV_NRD_NRD_1	48	50	PF00675	0.862
CLV_NRD_NRD_1	493	495	PF00675	0.888
CLV_NRD_NRD_1	556	558	PF00675	0.859
CLV_PCSK_FUR_1	341	345	PF00082	0.777
CLV_PCSK_FUR_1	538	542	PF00082	0.851
CLV_PCSK_KEX2_1	135	137	PF00082	0.869
CLV_PCSK_KEX2_1	209	211	PF00082	0.871
CLV_PCSK_KEX2_1	3	5	PF00082	0.845
CLV_PCSK_KEX2_1	340	342	PF00082	0.800
CLV_PCSK_KEX2_1	343	345	PF00082	0.710
CLV_PCSK_KEX2_1	373	375	PF00082	0.744
CLV_PCSK_KEX2_1	460	462	PF00082	0.847
CLV_PCSK_KEX2_1	48	50	PF00082	0.862
CLV_PCSK_KEX2_1	487	489	PF00082	0.880
CLV_PCSK_KEX2_1	493	495	PF00082	0.783
CLV_PCSK_KEX2_1	540	542	PF00082	0.853
CLV_PCSK_KEX2_1	556	558	PF00082	0.579
CLV_PCSK_PC1ET2_1	135	137	PF00082	0.869
CLV_PCSK_PC1ET2_1	209	211	PF00082	0.871
CLV_PCSK_PC1ET2_1	340	342	PF00082	0.800
CLV_PCSK_PC1ET2_1	487	489	PF00082	0.880
CLV_PCSK_PC1ET2_1	540	542	PF00082	0.853
CLV_PCSK_SKI1_1	475	479	PF00082	0.792
CLV_PCSK_SKI1_1	505	509	PF00082	0.883
CLV_PCSK_SKI1_1	528	532	PF00082	0.876
CLV_PCSK_SKI1_1	541	545	PF00082	0.618
CLV_PCSK_SKI1_1	557	561	PF00082	0.583
CLV_PCSK_SKI1_1	56	60	PF00082	0.865
CLV_Separin_Metazoa	165	169	PF03568	0.832
DEG_APCC_DBOX_1	3	11	PF00400	0.843
DEG_SCF_FBW7_1	257	264	PF00400	0.858
DEG_SPOP_SBC_1	261	265	PF00917	0.855
DEG_SPOP_SBC_1	451	455	PF00917	0.868
DEG_SPOP_SBC_1	521	525	PF00917	0.870
DOC_ANK_TNKS_1	102	109	PF00023	0.860
DOC_CKS1_1	226	231	PF01111	0.827
DOC_CYCLIN_RxL_1	472	482	PF00134	0.803
DOC_CYCLIN_yCln2_LP_2	163	169	PF00134	0.827
DOC_CYCLIN_yCln2_LP_2	77	83	PF00134	0.841
DOC_MAPK_DCC_7	73	83	PF00069	0.847
DOC_MAPK_gen_1	3	10	PF00069	0.844
DOC_PP2B_LxvP_1	44	47	PF13499	0.855
DOC_PP4_FxxP_1	478	481	PF00568	0.827
DOC_USP7_MATH_1	112	116	PF00917	0.848
DOC_USP7_MATH_1	2	6	PF00917	0.839
DOC_USP7_MATH_1	261	265	PF00917	0.855
DOC_USP7_MATH_1	28	32	PF00917	0.846
DOC_USP7_MATH_1	298	302	PF00917	0.787
DOC_USP7_MATH_1	360	364	PF00917	0.720
DOC_USP7_MATH_1	404	408	PF00917	0.881
DOC_USP7_MATH_1	414	418	PF00917	0.706
DOC_USP7_MATH_1	424	428	PF00917	0.529
DOC_USP7_MATH_1	451	455	PF00917	0.868
DOC_USP7_MATH_1	497	501	PF00917	0.885
DOC_USP7_MATH_1	559	563	PF00917	0.873
DOC_USP7_UBL2_3	365	369	PF12436	0.741
DOC_USP7_UBL2_3	498	502	PF12436	0.888
DOC_USP7_UBL2_3	505	509	PF12436	0.761
DOC_USP7_UBL2_3	528	532	PF12436	0.876
DOC_USP7_UBL2_3	540	544	PF12436	0.640
DOC_WW_Pin1_4	101	106	PF00397	0.863
DOC_WW_Pin1_4	12	17	PF00397	0.852
DOC_WW_Pin1_4	172	177	PF00397	0.827
DOC_WW_Pin1_4	187	192	PF00397	0.604
DOC_WW_Pin1_4	200	205	PF00397	0.645
DOC_WW_Pin1_4	213	218	PF00397	0.618
DOC_WW_Pin1_4	225	230	PF00397	0.615
DOC_WW_Pin1_4	249	254	PF00397	0.845
DOC_WW_Pin1_4	257	262	PF00397	0.722
DOC_WW_Pin1_4	397	402	PF00397	0.850
DOC_WW_Pin1_4	408	413	PF00397	0.683
DOC_WW_Pin1_4	42	47	PF00397	0.857
DOC_WW_Pin1_4	420	425	PF00397	0.676
DOC_WW_Pin1_4	445	450	PF00397	0.856
DOC_WW_Pin1_4	452	457	PF00397	0.738
DOC_WW_Pin1_4	479	484	PF00397	0.852
DOC_WW_Pin1_4	493	498	PF00397	0.639
DOC_WW_Pin1_4	507	512	PF00397	0.627
DOC_WW_Pin1_4	72	77	PF00397	0.856
LIG_14-3-3_CanoR_1	210	218	PF00244	0.852
LIG_14-3-3_CanoR_1	266	276	PF00244	0.788
LIG_14-3-3_CanoR_1	3	8	PF00244	0.842
LIG_14-3-3_CanoR_1	341	347	PF00244	0.764
LIG_14-3-3_CanoR_1	368	373	PF00244	0.743
LIG_14-3-3_CanoR_1	493	497	PF00244	0.881
LIG_14-3-3_CanoR_1	538	544	PF00244	0.850
LIG_14-3-3_CanoR_1	56	64	PF00244	0.859
LIG_14-3-3_CanoR_1	79	84	PF00244	0.842
LIG_14-3-3_CanoR_1	94	100	PF00244	0.598
LIG_BIR_II_1	1	5	PF00653	0.840
LIG_CtBP_PxDLS_1	534	538	PF00389	0.858
LIG_CtBP_PxDLS_1	80	84	PF00389	0.841
LIG_FHA_1	169	175	PF00498	0.835
LIG_FHA_1	325	331	PF00498	0.815
LIG_FHA_1	33	39	PF00498	0.844
LIG_FHA_1	401	407	PF00498	0.871
LIG_LIR_Gen_1	159	167	PF02991	0.811
LIG_LIR_Nem_3	127	131	PF02991	0.857
LIG_LIR_Nem_3	159	163	PF02991	0.801
LIG_LIR_Nem_3	345	349	PF02991	0.750
LIG_LIR_Nem_3	350	355	PF02991	0.619
LIG_PCNA_yPIPBox_3	79	93	PF02747	0.845
LIG_PDZ_Class_1	559	564	PF00595	0.877
LIG_PTB_Apo_2	345	352	PF02174	0.736
LIG_PTB_Phospho_1	345	351	PF10480	0.737
LIG_SH2_GRB2like	346	349	PF00017	0.750
LIG_SH2_SRC	355	358	PF00017	0.692
LIG_SH2_STAP1	349	353	PF00017	0.722
LIG_SH2_STAT3	351	354	PF00017	0.714
LIG_SH2_STAT5	183	186	PF00017	0.855
LIG_SH2_STAT5	352	355	PF00017	0.708
LIG_SH3_3	128	134	PF00018	0.853
LIG_SH3_3	163	169	PF00018	0.827
LIG_SH3_3	192	198	PF00018	0.871
LIG_SH3_3	20	26	PF00018	0.865
LIG_SH3_3	223	229	PF00018	0.829
LIG_SH3_3	27	33	PF00018	0.726
LIG_SH3_3	35	41	PF00018	0.582
LIG_SH3_3	443	449	PF00018	0.854
LIG_SUMO_SIM_anti_2	5	11	PF11976	0.843
LIG_SUMO_SIM_par_1	170	175	PF11976	0.834
LIG_SUMO_SIM_par_1	79	85	PF11976	0.841
LIG_TRAF2_1	441	444	PF00917	0.859
LIG_WW_3	45	49	PF00397	0.856
MOD_CDC14_SPxK_1	482	485	PF00782	0.869
MOD_CDK_SPK_2	257	262	PF00069	0.862
MOD_CDK_SPK_2	420	425	PF00069	0.886
MOD_CDK_SPK_2	493	498	PF00069	0.884
MOD_CDK_SPK_2	511	516	PF00069	0.547
MOD_CDK_SPxK_1	42	48	PF00069	0.860
MOD_CDK_SPxK_1	479	485	PF00069	0.855
MOD_CDK_SPxxK_3	408	415	PF00069	0.876
MOD_CDK_SPxxK_3	42	49	PF00069	0.859
MOD_CDK_SPxxK_3	72	79	PF00069	0.854
MOD_CK1_1	213	219	PF00069	0.845
MOD_CK1_1	239	245	PF00069	0.838
MOD_CK1_1	255	261	PF00069	0.575
MOD_CK1_1	31	37	PF00069	0.841
MOD_CK1_1	310	316	PF00069	0.831
MOD_CK1_1	319	325	PF00069	0.662
MOD_CK1_1	332	338	PF00069	0.573
MOD_CK1_1	400	406	PF00069	0.867
MOD_CK1_1	496	502	PF00069	0.883
MOD_CK1_1	503	509	PF00069	0.761
MOD_CK1_1	510	516	PF00069	0.619
MOD_CK1_1	520	526	PF00069	0.576
MOD_CK1_1	82	88	PF00069	0.840
MOD_CK2_1	267	273	PF00069	0.794
MOD_CK2_1	404	410	PF00069	0.882
MOD_Cter_Amidation	266	269	PF01082	0.826
MOD_Cter_Amidation	458	461	PF01082	0.845
MOD_Cter_Amidation	538	541	PF01082	0.853
MOD_GlcNHglycan	114	117	PF01048	0.847
MOD_GlcNHglycan	212	215	PF01048	0.850
MOD_GlcNHglycan	237	241	PF01048	0.834
MOD_GlcNHglycan	30	33	PF01048	0.845
MOD_GlcNHglycan	300	303	PF01048	0.801
MOD_GlcNHglycan	313	316	PF01048	0.607
MOD_GlcNHglycan	318	321	PF01048	0.516
MOD_GlcNHglycan	362	365	PF01048	0.726
MOD_GlcNHglycan	416	419	PF01048	0.881
MOD_GlcNHglycan	420	423	PF01048	0.818
MOD_GlcNHglycan	426	429	PF01048	0.707
MOD_GlcNHglycan	469	472	PF01048	0.775
MOD_GlcNHglycan	499	502	PF01048	0.884
MOD_GlcNHglycan	518	522	PF01048	0.551
MOD_GlcNHglycan	69	72	PF01048	0.869
MOD_GSK3_1	168	175	PF00069	0.835
MOD_GSK3_1	177	184	PF00069	0.675
MOD_GSK3_1	200	207	PF00069	0.872
MOD_GSK3_1	228	235	PF00069	0.829
MOD_GSK3_1	239	246	PF00069	0.646
MOD_GSK3_1	257	264	PF00069	0.542
MOD_GSK3_1	28	35	PF00069	0.847
MOD_GSK3_1	307	314	PF00069	0.826
MOD_GSK3_1	319	326	PF00069	0.608
MOD_GSK3_1	332	339	PF00069	0.571
MOD_GSK3_1	400	407	PF00069	0.868
MOD_GSK3_1	414	421	PF00069	0.638
MOD_GSK3_1	431	438	PF00069	0.574
MOD_GSK3_1	463	470	PF00069	0.808
MOD_GSK3_1	492	499	PF00069	0.883
MOD_GSK3_1	503	510	PF00069	0.689
MOD_GSK3_1	517	524	PF00069	0.633
MOD_GSK3_1	63	70	PF00069	0.863
MOD_GSK3_1	95	102	PF00069	0.859
MOD_N-GLC_2	67	69	PF02516	0.871
MOD_NEK2_1	126	131	PF00069	0.859
MOD_NEK2_1	236	241	PF00069	0.834
MOD_NEK2_1	311	316	PF00069	0.831
MOD_NEK2_1	330	335	PF00069	0.475
MOD_NEK2_1	359	364	PF00069	0.718
MOD_NEK2_1	463	468	PF00069	0.824
MOD_NEK2_1	93	98	PF00069	0.862
MOD_NEK2_2	243	248	PF00069	0.842
MOD_NEK2_2	539	544	PF00069	0.848
MOD_PIKK_1	255	261	PF00454	0.856
MOD_PIKK_1	267	273	PF00454	0.584
MOD_PIKK_1	332	338	PF00454	0.800
MOD_PIKK_1	416	422	PF00454	0.885
MOD_PIKK_1	82	88	PF00454	0.840
MOD_PK_1	368	374	PF00069	0.746
MOD_PKA_1	135	141	PF00069	0.874
MOD_PKA_1	208	214	PF00069	0.864
MOD_PKA_1	3	9	PF00069	0.843
MOD_PKA_1	368	374	PF00069	0.746
MOD_PKA_2	135	141	PF00069	0.874
MOD_PKA_2	2	8	PF00069	0.841
MOD_PKA_2	261	267	PF00069	0.851
MOD_PKA_2	307	313	PF00069	0.827
MOD_PKA_2	316	322	PF00069	0.675
MOD_PKA_2	336	342	PF00069	0.448
MOD_PKA_2	414	420	PF00069	0.882
MOD_PKA_2	424	430	PF00069	0.705
MOD_PKA_2	492	498	PF00069	0.883
MOD_PKA_2	93	99	PF00069	0.862
MOD_PKB_1	208	216	PF00069	0.858
MOD_Plk_1	144	150	PF00069	0.854
MOD_Plk_1	324	330	PF00069	0.812
MOD_Plk_4	177	183	PF00069	0.831
MOD_Plk_4	3	9	PF00069	0.843
MOD_Plk_4	387	393	PF00069	0.799
MOD_ProDKin_1	101	107	PF00069	0.860
MOD_ProDKin_1	12	18	PF00069	0.853
MOD_ProDKin_1	172	178	PF00069	0.828
MOD_ProDKin_1	187	193	PF00069	0.604
MOD_ProDKin_1	200	206	PF00069	0.646
MOD_ProDKin_1	213	219	PF00069	0.618
MOD_ProDKin_1	225	231	PF00069	0.617
MOD_ProDKin_1	249	255	PF00069	0.844
MOD_ProDKin_1	257	263	PF00069	0.721
MOD_ProDKin_1	397	403	PF00069	0.854
MOD_ProDKin_1	408	414	PF00069	0.680
MOD_ProDKin_1	42	48	PF00069	0.860
MOD_ProDKin_1	420	426	PF00069	0.675
MOD_ProDKin_1	445	451	PF00069	0.858
MOD_ProDKin_1	452	458	PF00069	0.736
MOD_ProDKin_1	479	485	PF00069	0.855
MOD_ProDKin_1	493	499	PF00069	0.639
MOD_ProDKin_1	507	513	PF00069	0.629
MOD_ProDKin_1	72	78	PF00069	0.855
MOD_SUMO_for_1	515	518	PF00179	0.870
TRG_DiLeu_BaEn_3	273	279	PF01217	0.747
TRG_DiLeu_BaLyEn_6	15	20	PF01217	0.860
TRG_ER_diArg_1	341	344	PF00400	0.784
TRG_ER_diArg_1	372	374	PF00400	0.744
TRG_ER_diArg_1	47	49	PF00400	0.859
TRG_ER_diArg_1	492	494	PF00400	0.885
TRG_ER_diArg_1	555	557	PF00400	0.854
TRG_NLS_MonoCore_2	339	344	PF00514	0.788
TRG_NLS_MonoExtC_3	207	212	PF00514	0.869
TRG_NLS_MonoExtC_3	339	344	PF00514	0.788
TRG_NLS_MonoExtC_3	364	369	PF00514	0.739
TRG_NLS_MonoExtN_4	208	213	PF00514	0.865
TRG_NLS_MonoExtN_4	337	344	PF00514	0.790
TRG_NLS_MonoExtN_4	485	491	PF00514	0.877
TRG_Pf-PMV_PEXEL_1	56	61	PF00026	0.865