tRNA_edit domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Aminoacyl-tRNA editing domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HK97_LEIBR

TriTrypDb:

LbrM.32.1250 , LBRM2903_320019500

Length:

335

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HK97

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK97

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0002161	aminoacyl-tRNA editing activity	5	12
GO:0003824	catalytic activity	1	12
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0052689	carboxylic ester hydrolase activity	4	12
GO:0140098	catalytic activity, acting on RNA	3	12
GO:0140101	catalytic activity, acting on a tRNA	4	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:0004812	aminoacyl-tRNA ligase activity	4	2
GO:0016874	ligase activity	2	2
GO:0016875	ligase activity, forming carbon-oxygen bonds	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	14	16	PF00675	0.453
CLV_NRD_NRD_1	150	152	PF00675	0.413
CLV_NRD_NRD_1	178	180	PF00675	0.350
CLV_NRD_NRD_1	18	20	PF00675	0.415
CLV_NRD_NRD_1	59	61	PF00675	0.431
CLV_NRD_NRD_1	85	87	PF00675	0.489
CLV_PCSK_KEX2_1	14	16	PF00082	0.453
CLV_PCSK_KEX2_1	150	152	PF00082	0.465
CLV_PCSK_KEX2_1	178	180	PF00082	0.350
CLV_PCSK_KEX2_1	18	20	PF00082	0.415
CLV_PCSK_KEX2_1	59	61	PF00082	0.431
CLV_PCSK_KEX2_1	85	87	PF00082	0.435
CLV_PCSK_KEX2_1	95	97	PF00082	0.382
CLV_PCSK_PC1ET2_1	95	97	PF00082	0.425
CLV_PCSK_PC7_1	14	20	PF00082	0.416
CLV_PCSK_SKI1_1	179	183	PF00082	0.370
CLV_PCSK_SKI1_1	192	196	PF00082	0.228
CLV_PCSK_SKI1_1	59	63	PF00082	0.430
DEG_APCC_DBOX_1	42	50	PF00400	0.438
DEG_Nend_UBRbox_4	1	3	PF02207	0.410
DOC_CKS1_1	37	42	PF01111	0.408
DOC_CYCLIN_RxL_1	56	64	PF00134	0.424
DOC_CYCLIN_yCln2_LP_2	127	133	PF00134	0.415
DOC_CYCLIN_yCln2_LP_2	250	256	PF00134	0.483
DOC_CYCLIN_yCln2_LP_2	287	293	PF00134	0.483
DOC_MAPK_gen_1	18	26	PF00069	0.456
DOC_MAPK_gen_1	210	218	PF00069	0.379
DOC_MAPK_RevD_3	164	179	PF00069	0.255
DOC_PP2B_LxvP_1	127	130	PF13499	0.559
DOC_PP2B_LxvP_1	182	185	PF13499	0.296
DOC_PP2B_LxvP_1	287	290	PF13499	0.462
DOC_USP7_MATH_1	113	117	PF00917	0.677
DOC_USP7_MATH_1	66	70	PF00917	0.661
DOC_USP7_MATH_1	71	75	PF00917	0.584
DOC_WW_Pin1_4	285	290	PF00397	0.379
DOC_WW_Pin1_4	32	37	PF00397	0.459
LIG_14-3-3_CanoR_1	14	18	PF00244	0.416
LIG_14-3-3_CanoR_1	224	233	PF00244	0.523
LIG_14-3-3_CanoR_1	30	38	PF00244	0.446
LIG_14-3-3_CanoR_1	59	68	PF00244	0.435
LIG_Actin_WH2_2	87	104	PF00022	0.484
LIG_BRCT_BRCA1_1	159	163	PF00533	0.306
LIG_CSL_BTD_1	164	167	PF09270	0.402
LIG_CtBP_PxDLS_1	130	134	PF00389	0.384
LIG_EVH1_1	37	41	PF00568	0.406
LIG_FHA_1	286	292	PF00498	0.503
LIG_FHA_1	312	318	PF00498	0.295
LIG_FHA_1	320	326	PF00498	0.260
LIG_FHA_2	324	330	PF00498	0.498
LIG_LIR_Gen_1	160	171	PF02991	0.468
LIG_LIR_Gen_1	212	222	PF02991	0.462
LIG_LIR_Gen_1	307	318	PF02991	0.507
LIG_LIR_Nem_3	160	166	PF02991	0.314
LIG_LIR_Nem_3	212	218	PF02991	0.462
LIG_LIR_Nem_3	307	313	PF02991	0.460
LIG_NRBOX	45	51	PF00104	0.439
LIG_PTB_Apo_2	153	160	PF02174	0.240
LIG_PTB_Phospho_1	153	159	PF10480	0.242
LIG_SH2_SRC	219	222	PF00017	0.472
LIG_SH2_STAP1	159	163	PF00017	0.348
LIG_SH2_STAT5	152	155	PF00017	0.246
LIG_SH2_STAT5	215	218	PF00017	0.465
LIG_SH2_STAT5	221	224	PF00017	0.465
LIG_SH2_STAT5	293	296	PF00017	0.507
LIG_SH3_2	38	43	PF14604	0.411
LIG_SH3_3	137	143	PF00018	0.569
LIG_SH3_3	271	277	PF00018	0.458
LIG_SH3_3	35	41	PF00018	0.439
LIG_SH3_CIN85_PxpxPR_1	38	43	PF14604	0.411
LIG_SUMO_SIM_par_1	129	134	PF11976	0.507
LIG_SUMO_SIM_par_1	276	281	PF11976	0.443
LIG_SUMO_SIM_par_1	45	51	PF11976	0.439
LIG_TRAF2_1	326	329	PF00917	0.396
LIG_TYR_ITIM	217	222	PF00017	0.539
LIG_WW_3	40	44	PF00397	0.419
LIG_WW_3	56	60	PF00397	0.385
MOD_CDK_SPxxK_3	36	43	PF00069	0.412
MOD_CK1_1	116	122	PF00069	0.684
MOD_CK1_1	32	38	PF00069	0.427
MOD_CK1_1	64	70	PF00069	0.577
MOD_CK2_1	323	329	PF00069	0.423
MOD_Cter_Amidation	241	244	PF01082	0.237
MOD_GlcNHglycan	115	118	PF01048	0.631
MOD_GlcNHglycan	120	123	PF01048	0.639
MOD_GlcNHglycan	124	127	PF01048	0.678
MOD_GlcNHglycan	132	136	PF01048	0.491
MOD_GlcNHglycan	159	162	PF01048	0.342
MOD_GlcNHglycan	263	266	PF01048	0.329
MOD_GlcNHglycan	280	283	PF01048	0.235
MOD_GlcNHglycan	31	34	PF01048	0.434
MOD_GlcNHglycan	68	71	PF01048	0.428
MOD_GSK3_1	112	119	PF00069	0.670
MOD_GSK3_1	257	264	PF00069	0.500
MOD_GSK3_1	278	285	PF00069	0.505
MOD_GSK3_1	304	311	PF00069	0.495
MOD_GSK3_1	319	326	PF00069	0.371
MOD_GSK3_1	32	39	PF00069	0.435
MOD_GSK3_1	60	67	PF00069	0.434
MOD_N-GLC_2	204	206	PF02516	0.179
MOD_NEK2_1	131	136	PF00069	0.347
MOD_NEK2_1	190	195	PF00069	0.274
MOD_NEK2_1	196	201	PF00069	0.438
MOD_NEK2_1	270	275	PF00069	0.409
MOD_NEK2_1	29	34	PF00069	0.437
MOD_NEK2_1	61	66	PF00069	0.438
MOD_OFUCOSY	2	7	PF10250	0.403
MOD_PKA_2	13	19	PF00069	0.414
MOD_PKA_2	209	215	PF00069	0.461
MOD_PKA_2	257	263	PF00069	0.396
MOD_PKA_2	29	35	PF00069	0.437
MOD_PKA_2	311	317	PF00069	0.541
MOD_Plk_1	131	137	PF00069	0.635
MOD_Plk_1	308	314	PF00069	0.379
MOD_Plk_4	190	196	PF00069	0.284
MOD_ProDKin_1	285	291	PF00069	0.379
MOD_ProDKin_1	32	38	PF00069	0.458
MOD_SUMO_rev_2	134	143	PF00179	0.383
MOD_SUMO_rev_2	88	97	PF00179	0.297
TRG_ENDOCYTIC_2	214	217	PF00928	0.465
TRG_ENDOCYTIC_2	219	222	PF00928	0.465
TRG_ER_diArg_1	13	15	PF00400	0.453
TRG_ER_diArg_1	149	151	PF00400	0.425
TRG_ER_diArg_1	17	19	PF00400	0.429
TRG_ER_diArg_1	177	179	PF00400	0.341
TRG_ER_diArg_1	58	60	PF00400	0.419
TRG_ER_diArg_1	84	86	PF00400	0.489
TRG_Pf-PMV_PEXEL_1	232	236	PF00026	0.309

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I030	Leptomonas seymouri	73%	100%
A0A0S4IHR6	Bodo saltans	50%	100%
A0A1X0NXR2	Trypanosomatidae	48%	100%
A0A3Q8IDY4	Leishmania donovani	79%	100%
A0A422NWD3	Trypanosoma rangeli	50%	100%
D0A1C2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9AGV9	Leishmania infantum	79%	88%
E9AV75	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4QCA6	Leishmania major	76%	100%
V5B6I0	Trypanosoma cruzi	47%	100%