Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HK96_LEIBR

TriTrypDb:

LbrM.32.1240 , LBRM2903_320019400

Length:

433

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HK96

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK96

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	375	379	PF00656	0.452
CLV_C14_Caspase3-7	389	393	PF00656	0.579
CLV_C14_Caspase3-7	81	85	PF00656	0.589
CLV_NRD_NRD_1	122	124	PF00675	0.601
CLV_NRD_NRD_1	187	189	PF00675	0.668
CLV_NRD_NRD_1	239	241	PF00675	0.518
CLV_NRD_NRD_1	264	266	PF00675	0.747
CLV_NRD_NRD_1	333	335	PF00675	0.546
CLV_NRD_NRD_1	357	359	PF00675	0.502
CLV_PCSK_KEX2_1	122	124	PF00082	0.601
CLV_PCSK_KEX2_1	187	189	PF00082	0.676
CLV_PCSK_KEX2_1	239	241	PF00082	0.518
CLV_PCSK_KEX2_1	263	265	PF00082	0.766
CLV_PCSK_SKI1_1	295	299	PF00082	0.527
DEG_SPOP_SBC_1	299	303	PF00917	0.494
DEG_SPOP_SBC_1	307	311	PF00917	0.627
DOC_CKS1_1	39	44	PF01111	0.512
DOC_MAPK_DCC_7	263	273	PF00069	0.427
DOC_MAPK_gen_1	263	271	PF00069	0.566
DOC_MAPK_MEF2A_6	264	273	PF00069	0.550
DOC_MAPK_MEF2A_6	6	13	PF00069	0.347
DOC_MAPK_MEF2A_6	99	107	PF00069	0.469
DOC_PP2B_LxvP_1	25	28	PF13499	0.557
DOC_PP4_FxxP_1	50	53	PF00568	0.423
DOC_USP7_MATH_1	126	130	PF00917	0.381
DOC_USP7_MATH_1	155	159	PF00917	0.612
DOC_USP7_MATH_1	253	257	PF00917	0.533
DOC_USP7_MATH_1	306	310	PF00917	0.681
DOC_USP7_MATH_1	78	82	PF00917	0.581
DOC_USP7_MATH_1	92	96	PF00917	0.668
DOC_WW_Pin1_4	38	43	PF00397	0.524
LIG_14-3-3_CanoR_1	263	271	PF00244	0.675
LIG_14-3-3_CanoR_1	6	10	PF00244	0.428
LIG_14-3-3_CanoR_1	99	103	PF00244	0.637
LIG_Actin_WH2_2	61	79	PF00022	0.552
LIG_BIR_II_1	1	5	PF00653	0.451
LIG_BIR_III_1	1	5	PF00653	0.451
LIG_BIR_III_3	1	5	PF00653	0.451
LIG_CtBP_PxDLS_1	270	274	PF00389	0.345
LIG_EVH1_1	50	54	PF00568	0.422
LIG_FHA_1	181	187	PF00498	0.637
LIG_FHA_1	205	211	PF00498	0.555
LIG_FHA_1	284	290	PF00498	0.430
LIG_FHA_1	318	324	PF00498	0.522
LIG_FHA_1	344	350	PF00498	0.454
LIG_FHA_1	6	12	PF00498	0.432
LIG_FHA_1	69	75	PF00498	0.464
LIG_FHA_1	92	98	PF00498	0.616
LIG_FHA_1	99	105	PF00498	0.438
LIG_FHA_2	163	169	PF00498	0.685
LIG_FHA_2	219	225	PF00498	0.466
LIG_FHA_2	352	358	PF00498	0.398
LIG_FHA_2	406	412	PF00498	0.482
LIG_FHA_2	427	433	PF00498	0.606
LIG_LIR_Apic_2	47	53	PF02991	0.419
LIG_LIR_Gen_1	101	109	PF02991	0.408
LIG_LIR_Gen_1	339	349	PF02991	0.441
LIG_LIR_Nem_3	101	105	PF02991	0.411
LIG_LIR_Nem_3	20	24	PF02991	0.353
LIG_LIR_Nem_3	339	344	PF02991	0.489
LIG_LIR_Nem_3	415	419	PF02991	0.540
LIG_SH2_PTP2	102	105	PF00017	0.450
LIG_SH2_PTP2	39	42	PF00017	0.487
LIG_SH2_SRC	137	140	PF00017	0.404
LIG_SH2_SRC	376	379	PF00017	0.493
LIG_SH2_SRC	410	413	PF00017	0.486
LIG_SH2_STAP1	345	349	PF00017	0.412
LIG_SH2_STAP1	406	410	PF00017	0.639
LIG_SH2_STAT5	102	105	PF00017	0.450
LIG_SH2_STAT5	137	140	PF00017	0.404
LIG_SH2_STAT5	345	348	PF00017	0.416
LIG_SH2_STAT5	376	379	PF00017	0.488
LIG_SH2_STAT5	39	42	PF00017	0.487
LIG_SH3_2	51	56	PF14604	0.448
LIG_SH3_3	245	251	PF00018	0.711
LIG_SH3_3	48	54	PF00018	0.416
LIG_SUMO_SIM_anti_2	101	108	PF11976	0.571
LIG_SUMO_SIM_par_1	101	108	PF11976	0.406
LIG_SUMO_SIM_par_1	206	211	PF11976	0.527
LIG_UBA3_1	288	295	PF00899	0.496
LIG_WRC_WIRS_1	352	357	PF05994	0.553
LIG_WW_3	3	7	PF00397	0.415
MOD_CK1_1	162	168	PF00069	0.706
MOD_CK1_1	230	236	PF00069	0.473
MOD_CK1_1	347	353	PF00069	0.457
MOD_CK1_1	95	101	PF00069	0.530
MOD_CK2_1	218	224	PF00069	0.479
MOD_CK2_1	312	318	PF00069	0.577
MOD_CK2_1	351	357	PF00069	0.475
MOD_CK2_1	426	432	PF00069	0.596
MOD_GlcNHglycan	116	119	PF01048	0.633
MOD_GlcNHglycan	128	131	PF01048	0.363
MOD_GlcNHglycan	210	213	PF01048	0.639
MOD_GlcNHglycan	229	232	PF01048	0.350
MOD_GlcNHglycan	302	305	PF01048	0.706
MOD_GlcNHglycan	382	385	PF01048	0.716
MOD_GlcNHglycan	42	45	PF01048	0.448
MOD_GlcNHglycan	86	89	PF01048	0.622
MOD_GlcNHglycan	94	97	PF01048	0.684
MOD_GSK3_1	155	162	PF00069	0.792
MOD_GSK3_1	166	173	PF00069	0.584
MOD_GSK3_1	204	211	PF00069	0.577
MOD_GSK3_1	308	315	PF00069	0.592
MOD_GSK3_1	343	350	PF00069	0.437
MOD_GSK3_1	40	47	PF00069	0.572
MOD_GSK3_1	78	85	PF00069	0.585
MOD_GSK3_1	91	98	PF00069	0.587
MOD_N-GLC_1	204	209	PF02516	0.482
MOD_N-GLC_1	213	218	PF02516	0.540
MOD_NEK2_1	213	218	PF00069	0.542
MOD_NEK2_1	275	280	PF00069	0.453
MOD_NEK2_1	344	349	PF00069	0.428
MOD_NEK2_2	45	50	PF00069	0.552
MOD_NEK2_2	5	10	PF00069	0.451
MOD_PIKK_1	283	289	PF00454	0.469
MOD_PIKK_1	329	335	PF00454	0.567
MOD_PIKK_1	66	72	PF00454	0.531
MOD_PK_1	187	193	PF00069	0.494
MOD_PKA_1	187	193	PF00069	0.552
MOD_PKA_1	263	269	PF00069	0.562
MOD_PKA_2	187	193	PF00069	0.555
MOD_PKA_2	263	269	PF00069	0.598
MOD_PKA_2	5	11	PF00069	0.428
MOD_PKA_2	76	82	PF00069	0.459
MOD_PKA_2	98	104	PF00069	0.642
MOD_PKB_1	75	83	PF00069	0.452
MOD_Plk_1	204	210	PF00069	0.672
MOD_Plk_2-3	351	357	PF00069	0.475
MOD_Plk_4	141	147	PF00069	0.353
MOD_Plk_4	318	324	PF00069	0.584
MOD_Plk_4	344	350	PF00069	0.422
MOD_Plk_4	45	51	PF00069	0.559
MOD_Plk_4	68	74	PF00069	0.454
MOD_Plk_4	98	104	PF00069	0.612
MOD_ProDKin_1	38	44	PF00069	0.518
MOD_SUMO_rev_2	162	172	PF00179	0.529
MOD_SUMO_rev_2	351	361	PF00179	0.466
TRG_ENDOCYTIC_2	102	105	PF00928	0.398
TRG_ENDOCYTIC_2	345	348	PF00928	0.416
TRG_ER_diArg_1	186	188	PF00400	0.673
TRG_ER_diArg_1	239	241	PF00400	0.445
TRG_ER_diArg_1	263	265	PF00400	0.512
TRG_ER_diArg_1	74	77	PF00400	0.418
TRG_NES_CRM1_1	16	31	PF08389	0.382

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILY1	Leptomonas seymouri	45%	100%
A0A3S7WWI8	Leishmania donovani	69%	97%
E9AGV8	Leishmania infantum	69%	97%
E9AV74	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
Q4QCA7	Leishmania major	70%	100%