LeishMANIAdb
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Mitochondrial carrier protein-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Mitochondrial carrier protein-like protein
Gene product:
mitochondrial carrier protein-like protein
Species:
Leishmania braziliensis
UniProt:
A4HK94_LEIBR
TriTrypDb:
LbrM.32.1220 , LBRM2903_320018000 *
Length:
337

Annotations

LeishMANIAdb annotations

Homologous to eukaryotic mitochondrial carriers responsible for FAD and/or folate uptake. In some organisms, homologs also transport thiamine.. Localization: Mitochondrial (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 26
NetGPI no yes: 0, no: 26
Cellular components
Term Name Level Count
GO:0016020 membrane 2 27
GO:0110165 cellular anatomical entity 1 27
GO:0005739 mitochondrion 5 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2

Expansion

Sequence features

A4HK94
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK94

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 27
GO:0006862 nucleotide transport 6 25
GO:0009987 cellular process 1 27
GO:0015748 organophosphate ester transport 5 25
GO:0015931 nucleobase-containing compound transport 5 25
GO:0051179 localization 1 27
GO:0051234 establishment of localization 2 27
GO:0055085 transmembrane transport 2 27
GO:0071702 organic substance transport 4 27
GO:0071705 nitrogen compound transport 4 27
GO:0006811 monoatomic ion transport 4 2
GO:0006820 monoatomic anion transport 5 2
GO:0006835 dicarboxylic acid transport 7 2
GO:0015711 organic anion transport 5 2
GO:0015849 organic acid transport 5 2
GO:0015884 folic acid transport 5 2
GO:0034220 monoatomic ion transmembrane transport 3 2
GO:0035461 vitamin transmembrane transport 3 2
GO:0042886 amide transport 5 2
GO:0046942 carboxylic acid transport 6 2
GO:0051180 vitamin transport 4 2
GO:0072337 modified amino acid transport 5 2
GO:0098656 monoatomic anion transmembrane transport 4 2
GO:0098838 folate transmembrane transport 4 2
GO:1903825 organic acid transmembrane transport 3 2
GO:1904947 folate import into mitochondrion 4 2
GO:1905039 carboxylic acid transmembrane transport 4 2
GO:1990542 mitochondrial transmembrane transport 3 2
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 2
GO:0005342 organic acid transmembrane transporter activity 3 2
GO:0008509 monoatomic anion transmembrane transporter activity 4 2
GO:0008514 organic anion transmembrane transporter activity 5 2
GO:0008517 folic acid transmembrane transporter activity 4 2
GO:0015075 monoatomic ion transmembrane transporter activity 3 2
GO:0015215 nucleotide transmembrane transporter activity 4 2
GO:0015230 FAD transmembrane transporter activity 5 2
GO:0015605 organophosphate ester transmembrane transporter activity 3 2
GO:0015932 nucleobase-containing compound transmembrane transporter activity 3 2
GO:0022857 transmembrane transporter activity 2 2
GO:0042887 amide transmembrane transporter activity 3 2
GO:0046943 carboxylic acid transmembrane transporter activity 4 2
GO:0072349 modified amino acid transmembrane transporter activity 3 2
GO:0090482 vitamin transmembrane transporter activity 3 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 189 193 PF00656 0.138
CLV_MEL_PAP_1 143 149 PF00089 0.277
CLV_NRD_NRD_1 120 122 PF00675 0.486
CLV_PCSK_FUR_1 118 122 PF00082 0.457
CLV_PCSK_KEX2_1 112 114 PF00082 0.409
CLV_PCSK_KEX2_1 120 122 PF00082 0.443
CLV_PCSK_PC1ET2_1 112 114 PF00082 0.439
CLV_PCSK_SKI1_1 185 189 PF00082 0.389
CLV_PCSK_SKI1_1 256 260 PF00082 0.321
CLV_PCSK_SKI1_1 318 322 PF00082 0.352
CLV_PCSK_SKI1_1 331 335 PF00082 0.498
CLV_PCSK_SKI1_1 5 9 PF00082 0.340
CLV_PCSK_SKI1_1 58 62 PF00082 0.433
DEG_APCC_DBOX_1 119 127 PF00400 0.487
DEG_APCC_DBOX_1 317 325 PF00400 0.268
DEG_Nend_UBRbox_1 1 4 PF02207 0.722
DOC_CYCLIN_yCln2_LP_2 262 268 PF00134 0.315
DOC_CYCLIN_yCln2_LP_2 30 36 PF00134 0.343
DOC_MAPK_gen_1 118 126 PF00069 0.488
DOC_MAPK_gen_1 236 245 PF00069 0.454
DOC_MAPK_MEF2A_6 231 239 PF00069 0.138
DOC_PP2B_LxvP_1 216 219 PF13499 0.253
DOC_PP4_FxxP_1 222 225 PF00568 0.313
LIG_14-3-3_CanoR_1 100 106 PF00244 0.350
LIG_14-3-3_CanoR_1 185 191 PF00244 0.322
LIG_14-3-3_CanoR_1 208 216 PF00244 0.239
LIG_14-3-3_CanoR_1 306 316 PF00244 0.474
LIG_Actin_WH2_2 317 333 PF00022 0.383
LIG_AP_GAE_1 129 135 PF02883 0.469
LIG_APCC_ABBA_1 322 327 PF00400 0.422
LIG_FHA_1 154 160 PF00498 0.344
LIG_FHA_1 178 184 PF00498 0.334
LIG_FHA_1 198 204 PF00498 0.254
LIG_FHA_1 24 30 PF00498 0.298
LIG_FHA_1 253 259 PF00498 0.302
LIG_FHA_1 290 296 PF00498 0.539
LIG_FHA_1 37 43 PF00498 0.247
LIG_FHA_2 187 193 PF00498 0.138
LIG_LIR_Gen_1 129 138 PF02991 0.659
LIG_LIR_Gen_1 139 147 PF02991 0.531
LIG_LIR_Gen_1 282 289 PF02991 0.352
LIG_LIR_Gen_1 327 336 PF02991 0.256
LIG_LIR_Gen_1 61 68 PF02991 0.159
LIG_LIR_Nem_3 129 135 PF02991 0.651
LIG_LIR_Nem_3 139 143 PF02991 0.507
LIG_LIR_Nem_3 205 210 PF02991 0.265
LIG_LIR_Nem_3 282 288 PF02991 0.432
LIG_LIR_Nem_3 327 332 PF02991 0.197
LIG_LIR_Nem_3 55 60 PF02991 0.214
LIG_LIR_Nem_3 61 67 PF02991 0.208
LIG_NRBOX 257 263 PF00104 0.268
LIG_Pex14_2 325 329 PF04695 0.388
LIG_REV1ctd_RIR_1 75 83 PF16727 0.333
LIG_SH2_CRK 227 231 PF00017 0.305
LIG_SH2_CRK 57 61 PF00017 0.254
LIG_SH2_CRK 95 99 PF00017 0.328
LIG_SH2_STAP1 326 330 PF00017 0.238
LIG_SH2_STAT3 99 102 PF00017 0.407
LIG_SH2_STAT5 97 100 PF00017 0.302
LIG_SUMO_SIM_anti_2 242 247 PF11976 0.294
LIG_SUMO_SIM_par_1 122 127 PF11976 0.486
LIG_SUMO_SIM_par_1 265 271 PF11976 0.362
LIG_UBA3_1 234 240 PF00899 0.234
LIG_WRC_WIRS_1 187 192 PF05994 0.274
LIG_WRC_WIRS_1 285 290 PF05994 0.465
MOD_CK1_1 136 142 PF00069 0.575
MOD_CK1_1 154 160 PF00069 0.313
MOD_CK1_1 177 183 PF00069 0.298
MOD_CK1_1 252 258 PF00069 0.309
MOD_CK1_1 291 297 PF00069 0.501
MOD_GlcNHglycan 126 129 PF01048 0.412
MOD_GlcNHglycan 135 138 PF01048 0.362
MOD_GlcNHglycan 156 159 PF01048 0.357
MOD_GlcNHglycan 174 179 PF01048 0.449
MOD_GlcNHglycan 210 213 PF01048 0.441
MOD_GlcNHglycan 5 8 PF01048 0.464
MOD_GSK3_1 10 17 PF00069 0.459
MOD_GSK3_1 124 131 PF00069 0.646
MOD_GSK3_1 147 154 PF00069 0.329
MOD_GSK3_1 194 201 PF00069 0.258
MOD_GSK3_1 248 255 PF00069 0.214
MOD_GSK3_1 284 291 PF00069 0.463
MOD_GSK3_1 308 315 PF00069 0.312
MOD_GSK3_1 36 43 PF00069 0.283
MOD_GSK3_1 81 88 PF00069 0.420
MOD_NEK2_1 101 106 PF00069 0.275
MOD_NEK2_1 14 19 PF00069 0.277
MOD_NEK2_1 147 152 PF00069 0.316
MOD_NEK2_1 166 171 PF00069 0.250
MOD_NEK2_1 194 199 PF00069 0.242
MOD_NEK2_1 226 231 PF00069 0.261
MOD_NEK2_1 288 293 PF00069 0.479
MOD_NEK2_1 312 317 PF00069 0.333
MOD_PIKK_1 17 23 PF00454 0.324
MOD_PIKK_1 40 46 PF00454 0.239
MOD_PKA_2 305 311 PF00069 0.520
MOD_PKB_1 38 46 PF00069 0.223
MOD_Plk_1 128 134 PF00069 0.581
MOD_Plk_1 241 247 PF00069 0.284
MOD_Plk_1 9 15 PF00069 0.495
MOD_Plk_4 101 107 PF00069 0.420
MOD_Plk_4 241 247 PF00069 0.261
MOD_Plk_4 25 31 PF00069 0.267
MOD_Plk_4 284 290 PF00069 0.359
MOD_Plk_4 291 297 PF00069 0.360
MOD_SUMO_for_1 239 242 PF00179 0.248
TRG_ENDOCYTIC_2 227 230 PF00928 0.238
TRG_ENDOCYTIC_2 285 288 PF00928 0.438
TRG_ENDOCYTIC_2 326 329 PF00928 0.226
TRG_ENDOCYTIC_2 57 60 PF00928 0.262
TRG_ENDOCYTIC_2 95 98 PF00928 0.320
TRG_ER_diArg_1 118 121 PF00400 0.613
TRG_ER_diArg_1 235 238 PF00400 0.365
TRG_ER_diArg_1 37 40 PF00400 0.259
TRG_Pf-PMV_PEXEL_1 40 44 PF00026 0.462

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P4V4 Leptomonas seymouri 29% 95%
A0A0N0P7T5 Leptomonas seymouri 23% 100%
A0A0N0P7X0 Leptomonas seymouri 24% 100%
A0A0N0P8W6 Leptomonas seymouri 22% 99%
A0A0N1IMP5 Leptomonas seymouri 66% 100%
A0A0N1PFJ3 Leptomonas seymouri 40% 93%
A0A0S4J045 Bodo saltans 24% 95%
A0A0S4J9F4 Bodo saltans 42% 100%
A0A0S4JHC1 Bodo saltans 29% 97%
A0A0S4JN82 Bodo saltans 23% 100%
A0A1D6N272 Zea mays 26% 100%
A0A1X0NUM8 Trypanosomatidae 42% 100%
A0A1X0NUU7 Trypanosomatidae 51% 100%
A0A1X0P6S2 Trypanosomatidae 32% 100%
A0A1X0PA63 Trypanosomatidae 23% 87%
A0A3Q8IFU6 Leishmania donovani 78% 100%
A0A3Q8IIC0 Leishmania donovani 25% 100%
A0A3Q8IKX9 Leishmania donovani 42% 100%
A0A3R7LCB2 Trypanosoma rangeli 46% 100%
A0A3R7P246 Trypanosoma rangeli 41% 100%
A0A3S5H7M7 Leishmania donovani 25% 100%
A0A3S5H800 Leishmania donovani 27% 93%
A0A3S7WVJ8 Leishmania donovani 26% 98%
A0A3S7WYS1 Leishmania donovani 23% 100%
A0A422N763 Trypanosoma rangeli 30% 99%
A0A422NF39 Trypanosoma rangeli 21% 100%
A3KPP4 Danio rerio 23% 100%
A4HA67 Leishmania braziliensis 24% 100%
A4HDW8 Leishmania braziliensis 22% 94%
A4HI60 Leishmania braziliensis 26% 100%
A4HK93 Leishmania braziliensis 41% 100%
A4HN00 Leishmania braziliensis 27% 93%
A4HN69 Leishmania braziliensis 27% 100%
A4HYC8 Leishmania infantum 26% 98%
A4I163 Leishmania infantum 23% 100%
A4I5D6 Leishmania infantum 25% 100%
A4I7S8 Leishmania infantum 41% 100%
A4I7S9 Leishmania infantum 79% 100%
A4IBM3 Leishmania infantum 26% 93%
A4IBT7 Leishmania infantum 24% 100%
A4RF23 Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) 27% 100%
B0DK57 Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686) 24% 100%
B0G159 Dictyostelium discoideum 22% 71%
B4F8I5 Zea mays 24% 100%
B4FIJ0 Zea mays 26% 100%
C9ZM27 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 22% 88%
C9ZZ11 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 25% 100%
D0A9Y8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 97%
D0A9Z0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 99%
E8NHL5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 93%
E9AFF7 Leishmania major 27% 100%
E9AFM4 Leishmania major 24% 94%
E9ALE6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 23% 100%
E9AS62 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 98%
E9AX97 Leishmania mexicana (strain MHOM/GT/2001/U1103) 23% 100%
E9B0N4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
E9B2N6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 41% 100%
E9B2N7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 78% 100%
E9B6S7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 98%
O04200 Arabidopsis thaliana 25% 100%
O13660 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 22% 100%
O22261 Arabidopsis thaliana 24% 100%
O43808 Homo sapiens 25% 100%
O70579 Mus musculus 24% 100%
O95258 Homo sapiens 24% 100%
O95847 Homo sapiens 23% 100%
P32332 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 21% 100%
P38127 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 23% 89%
P39953 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 25% 100%
P40464 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 24% 100%
P40556 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 23% 90%
Q1LZB3 Bos taurus 23% 100%
Q287T7 Danio rerio 23% 100%
Q29RM1 Bos taurus 24% 100%
Q3TZX3 Mus musculus 23% 100%
Q4Q5H0 Leishmania major 76% 100%
Q4Q5H1 Leishmania major 42% 100%
Q4Q7J8 Leishmania major 24% 100%
Q4QA75 Leishmania major 23% 95%
Q4QDA4 Leishmania major 25% 100%
Q54FU9 Dictyostelium discoideum 21% 100%
Q54MZ4 Dictyostelium discoideum 22% 78%
Q54QN2 Dictyostelium discoideum 25% 100%
Q55E45 Dictyostelium discoideum 24% 100%
Q5AVW1 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 24% 100%
Q5PQM9 Rattus norvegicus 26% 100%
Q5SVS4 Homo sapiens 25% 100%
Q5XGI1 Xenopus tropicalis 23% 100%
Q5ZKP7 Gallus gallus 22% 100%
Q6BPW0 Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) 22% 100%
Q6DG32 Danio rerio 23% 100%
Q6GQ22 Xenopus laevis 24% 100%
Q6IZB5 Cricetulus griseus 24% 100%
Q6P036 Danio rerio 26% 100%
Q75A82 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 21% 99%
Q76P23 Dictyostelium discoideum 21% 100%
Q7K566 Drosophila melanogaster 27% 100%
Q7XA87 Arabidopsis thaliana 27% 100%
Q8BMG8 Mus musculus 24% 100%
Q8HXE3 Macaca fascicularis 26% 100%
Q8R0Z5 Mus musculus 24% 93%
Q8RWA5 Arabidopsis thaliana 24% 93%
Q8RXZ9 Arabidopsis thaliana 24% 100%
Q922G0 Mus musculus 24% 100%
Q95J75 Macaca fascicularis 23% 100%
Q96A46 Homo sapiens 24% 93%
Q96CQ1 Homo sapiens 23% 100%
Q9BSK2 Homo sapiens 23% 100%
Q9CR58 Mus musculus 25% 100%
Q9FI43 Arabidopsis thaliana 23% 69%
Q9FI73 Arabidopsis thaliana 24% 99%
Q9GMZ1 Canis lupus familiaris 22% 100%
Q9H2D1 Homo sapiens 23% 100%
Q9LJX5 Arabidopsis thaliana 22% 97%
Q9NYZ2 Homo sapiens 22% 100%
Q9P6L7 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 26% 93%
Q9SUV1 Arabidopsis thaliana 23% 86%
Q9Z2B2 Mus musculus 25% 100%
Q9ZWG1 Arabidopsis thaliana 25% 100%
V5B150 Trypanosoma cruzi 46% 100%
V5BGM6 Trypanosoma cruzi 45% 100%
V5BKU8 Trypanosoma cruzi 22% 88%
V5BTA6 Trypanosoma cruzi 25% 100%
V5BTE8 Trypanosoma cruzi 29% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS