Homologous to eukaryotic mitochondrial carriers responsible for FAD and/or folate uptake. In some organisms, homologs also transport thiamine.. Localization: Mitochondrial (by homology)
Source | Evidence on protein | Close homologs |
---|---|---|
Cuervo et al. | no | yes: 0 |
Hassani et al. | no | yes: 0 |
Forrest at al. (metacyclic) | no | yes: 0 |
Forrest at al. (procyclic) | no | yes: 0 |
Silverman et al. | no | yes: 0 |
Pissara et al. | no | yes: 0 |
Source | Evidence on protein | Close homologs |
---|---|---|
Pires et al. | no | yes: 0 |
Source | Evidence on protein | Close homologs |
---|---|---|
Silverman et al. | no | yes: 0 |
Source | Evidence on protein | Close homologs |
---|---|---|
Jamdhade et al. | no | yes: 0 |
Source | Evidence on protein | Close homologs |
---|---|---|
DeepLoc | ||
SignalP6 | no | yes: 0, no: 26 |
NetGPI | no | yes: 0, no: 26 |
Term | Name | Level | Count |
---|---|---|---|
GO:0016020 | membrane | 2 | 27 |
GO:0110165 | cellular anatomical entity | 1 | 27 |
GO:0005739 | mitochondrion | 5 | 2 |
GO:0043226 | organelle | 2 | 2 |
GO:0043227 | membrane-bounded organelle | 3 | 2 |
GO:0043229 | intracellular organelle | 3 | 2 |
GO:0043231 | intracellular membrane-bounded organelle | 4 | 2 |
Related structures:
AlphaFold database: A4HK94
Term | Name | Level | Count |
---|---|---|---|
GO:0006810 | transport | 3 | 27 |
GO:0006862 | nucleotide transport | 6 | 25 |
GO:0009987 | cellular process | 1 | 27 |
GO:0015748 | organophosphate ester transport | 5 | 25 |
GO:0015931 | nucleobase-containing compound transport | 5 | 25 |
GO:0051179 | localization | 1 | 27 |
GO:0051234 | establishment of localization | 2 | 27 |
GO:0055085 | transmembrane transport | 2 | 27 |
GO:0071702 | organic substance transport | 4 | 27 |
GO:0071705 | nitrogen compound transport | 4 | 27 |
GO:0006811 | monoatomic ion transport | 4 | 2 |
GO:0006820 | monoatomic anion transport | 5 | 2 |
GO:0006835 | dicarboxylic acid transport | 7 | 2 |
GO:0015711 | organic anion transport | 5 | 2 |
GO:0015849 | organic acid transport | 5 | 2 |
GO:0015884 | folic acid transport | 5 | 2 |
GO:0034220 | monoatomic ion transmembrane transport | 3 | 2 |
GO:0035461 | vitamin transmembrane transport | 3 | 2 |
GO:0042886 | amide transport | 5 | 2 |
GO:0046942 | carboxylic acid transport | 6 | 2 |
GO:0051180 | vitamin transport | 4 | 2 |
GO:0072337 | modified amino acid transport | 5 | 2 |
GO:0098656 | monoatomic anion transmembrane transport | 4 | 2 |
GO:0098838 | folate transmembrane transport | 4 | 2 |
GO:1903825 | organic acid transmembrane transport | 3 | 2 |
GO:1904947 | folate import into mitochondrion | 4 | 2 |
GO:1905039 | carboxylic acid transmembrane transport | 4 | 2 |
GO:1990542 | mitochondrial transmembrane transport | 3 | 2 |
Term | Name | Level | Count |
---|---|---|---|
GO:0005215 | transporter activity | 1 | 2 |
GO:0005342 | organic acid transmembrane transporter activity | 3 | 2 |
GO:0008509 | monoatomic anion transmembrane transporter activity | 4 | 2 |
GO:0008514 | organic anion transmembrane transporter activity | 5 | 2 |
GO:0008517 | folic acid transmembrane transporter activity | 4 | 2 |
GO:0015075 | monoatomic ion transmembrane transporter activity | 3 | 2 |
GO:0015215 | nucleotide transmembrane transporter activity | 4 | 2 |
GO:0015230 | FAD transmembrane transporter activity | 5 | 2 |
GO:0015605 | organophosphate ester transmembrane transporter activity | 3 | 2 |
GO:0015932 | nucleobase-containing compound transmembrane transporter activity | 3 | 2 |
GO:0022857 | transmembrane transporter activity | 2 | 2 |
GO:0042887 | amide transmembrane transporter activity | 3 | 2 |
GO:0046943 | carboxylic acid transmembrane transporter activity | 4 | 2 |
GO:0072349 | modified amino acid transmembrane transporter activity | 3 | 2 |
GO:0090482 | vitamin transmembrane transporter activity | 3 | 2 |
Leishmania | From | To | Domain/Motif | Score |
---|---|---|---|---|
CLV_C14_Caspase3-7 | 189 | 193 | PF00656 | 0.138 |
CLV_MEL_PAP_1 | 143 | 149 | PF00089 | 0.277 |
CLV_NRD_NRD_1 | 120 | 122 | PF00675 | 0.486 |
CLV_PCSK_FUR_1 | 118 | 122 | PF00082 | 0.457 |
CLV_PCSK_KEX2_1 | 112 | 114 | PF00082 | 0.409 |
CLV_PCSK_KEX2_1 | 120 | 122 | PF00082 | 0.443 |
CLV_PCSK_PC1ET2_1 | 112 | 114 | PF00082 | 0.439 |
CLV_PCSK_SKI1_1 | 185 | 189 | PF00082 | 0.389 |
CLV_PCSK_SKI1_1 | 256 | 260 | PF00082 | 0.321 |
CLV_PCSK_SKI1_1 | 318 | 322 | PF00082 | 0.352 |
CLV_PCSK_SKI1_1 | 331 | 335 | PF00082 | 0.498 |
CLV_PCSK_SKI1_1 | 5 | 9 | PF00082 | 0.340 |
CLV_PCSK_SKI1_1 | 58 | 62 | PF00082 | 0.433 |
DEG_APCC_DBOX_1 | 119 | 127 | PF00400 | 0.487 |
DEG_APCC_DBOX_1 | 317 | 325 | PF00400 | 0.268 |
DEG_Nend_UBRbox_1 | 1 | 4 | PF02207 | 0.722 |
DOC_CYCLIN_yCln2_LP_2 | 262 | 268 | PF00134 | 0.315 |
DOC_CYCLIN_yCln2_LP_2 | 30 | 36 | PF00134 | 0.343 |
DOC_MAPK_gen_1 | 118 | 126 | PF00069 | 0.488 |
DOC_MAPK_gen_1 | 236 | 245 | PF00069 | 0.454 |
DOC_MAPK_MEF2A_6 | 231 | 239 | PF00069 | 0.138 |
DOC_PP2B_LxvP_1 | 216 | 219 | PF13499 | 0.253 |
DOC_PP4_FxxP_1 | 222 | 225 | PF00568 | 0.313 |
LIG_14-3-3_CanoR_1 | 100 | 106 | PF00244 | 0.350 |
LIG_14-3-3_CanoR_1 | 185 | 191 | PF00244 | 0.322 |
LIG_14-3-3_CanoR_1 | 208 | 216 | PF00244 | 0.239 |
LIG_14-3-3_CanoR_1 | 306 | 316 | PF00244 | 0.474 |
LIG_Actin_WH2_2 | 317 | 333 | PF00022 | 0.383 |
LIG_AP_GAE_1 | 129 | 135 | PF02883 | 0.469 |
LIG_APCC_ABBA_1 | 322 | 327 | PF00400 | 0.422 |
LIG_FHA_1 | 154 | 160 | PF00498 | 0.344 |
LIG_FHA_1 | 178 | 184 | PF00498 | 0.334 |
LIG_FHA_1 | 198 | 204 | PF00498 | 0.254 |
LIG_FHA_1 | 24 | 30 | PF00498 | 0.298 |
LIG_FHA_1 | 253 | 259 | PF00498 | 0.302 |
LIG_FHA_1 | 290 | 296 | PF00498 | 0.539 |
LIG_FHA_1 | 37 | 43 | PF00498 | 0.247 |
LIG_FHA_2 | 187 | 193 | PF00498 | 0.138 |
LIG_LIR_Gen_1 | 129 | 138 | PF02991 | 0.659 |
LIG_LIR_Gen_1 | 139 | 147 | PF02991 | 0.531 |
LIG_LIR_Gen_1 | 282 | 289 | PF02991 | 0.352 |
LIG_LIR_Gen_1 | 327 | 336 | PF02991 | 0.256 |
LIG_LIR_Gen_1 | 61 | 68 | PF02991 | 0.159 |
LIG_LIR_Nem_3 | 129 | 135 | PF02991 | 0.651 |
LIG_LIR_Nem_3 | 139 | 143 | PF02991 | 0.507 |
LIG_LIR_Nem_3 | 205 | 210 | PF02991 | 0.265 |
LIG_LIR_Nem_3 | 282 | 288 | PF02991 | 0.432 |
LIG_LIR_Nem_3 | 327 | 332 | PF02991 | 0.197 |
LIG_LIR_Nem_3 | 55 | 60 | PF02991 | 0.214 |
LIG_LIR_Nem_3 | 61 | 67 | PF02991 | 0.208 |
LIG_NRBOX | 257 | 263 | PF00104 | 0.268 |
LIG_Pex14_2 | 325 | 329 | PF04695 | 0.388 |
LIG_REV1ctd_RIR_1 | 75 | 83 | PF16727 | 0.333 |
LIG_SH2_CRK | 227 | 231 | PF00017 | 0.305 |
LIG_SH2_CRK | 57 | 61 | PF00017 | 0.254 |
LIG_SH2_CRK | 95 | 99 | PF00017 | 0.328 |
LIG_SH2_STAP1 | 326 | 330 | PF00017 | 0.238 |
LIG_SH2_STAT3 | 99 | 102 | PF00017 | 0.407 |
LIG_SH2_STAT5 | 97 | 100 | PF00017 | 0.302 |
LIG_SUMO_SIM_anti_2 | 242 | 247 | PF11976 | 0.294 |
LIG_SUMO_SIM_par_1 | 122 | 127 | PF11976 | 0.486 |
LIG_SUMO_SIM_par_1 | 265 | 271 | PF11976 | 0.362 |
LIG_UBA3_1 | 234 | 240 | PF00899 | 0.234 |
LIG_WRC_WIRS_1 | 187 | 192 | PF05994 | 0.274 |
LIG_WRC_WIRS_1 | 285 | 290 | PF05994 | 0.465 |
MOD_CK1_1 | 136 | 142 | PF00069 | 0.575 |
MOD_CK1_1 | 154 | 160 | PF00069 | 0.313 |
MOD_CK1_1 | 177 | 183 | PF00069 | 0.298 |
MOD_CK1_1 | 252 | 258 | PF00069 | 0.309 |
MOD_CK1_1 | 291 | 297 | PF00069 | 0.501 |
MOD_GlcNHglycan | 126 | 129 | PF01048 | 0.412 |
MOD_GlcNHglycan | 135 | 138 | PF01048 | 0.362 |
MOD_GlcNHglycan | 156 | 159 | PF01048 | 0.357 |
MOD_GlcNHglycan | 174 | 179 | PF01048 | 0.449 |
MOD_GlcNHglycan | 210 | 213 | PF01048 | 0.441 |
MOD_GlcNHglycan | 5 | 8 | PF01048 | 0.464 |
MOD_GSK3_1 | 10 | 17 | PF00069 | 0.459 |
MOD_GSK3_1 | 124 | 131 | PF00069 | 0.646 |
MOD_GSK3_1 | 147 | 154 | PF00069 | 0.329 |
MOD_GSK3_1 | 194 | 201 | PF00069 | 0.258 |
MOD_GSK3_1 | 248 | 255 | PF00069 | 0.214 |
MOD_GSK3_1 | 284 | 291 | PF00069 | 0.463 |
MOD_GSK3_1 | 308 | 315 | PF00069 | 0.312 |
MOD_GSK3_1 | 36 | 43 | PF00069 | 0.283 |
MOD_GSK3_1 | 81 | 88 | PF00069 | 0.420 |
MOD_NEK2_1 | 101 | 106 | PF00069 | 0.275 |
MOD_NEK2_1 | 14 | 19 | PF00069 | 0.277 |
MOD_NEK2_1 | 147 | 152 | PF00069 | 0.316 |
MOD_NEK2_1 | 166 | 171 | PF00069 | 0.250 |
MOD_NEK2_1 | 194 | 199 | PF00069 | 0.242 |
MOD_NEK2_1 | 226 | 231 | PF00069 | 0.261 |
MOD_NEK2_1 | 288 | 293 | PF00069 | 0.479 |
MOD_NEK2_1 | 312 | 317 | PF00069 | 0.333 |
MOD_PIKK_1 | 17 | 23 | PF00454 | 0.324 |
MOD_PIKK_1 | 40 | 46 | PF00454 | 0.239 |
MOD_PKA_2 | 305 | 311 | PF00069 | 0.520 |
MOD_PKB_1 | 38 | 46 | PF00069 | 0.223 |
MOD_Plk_1 | 128 | 134 | PF00069 | 0.581 |
MOD_Plk_1 | 241 | 247 | PF00069 | 0.284 |
MOD_Plk_1 | 9 | 15 | PF00069 | 0.495 |
MOD_Plk_4 | 101 | 107 | PF00069 | 0.420 |
MOD_Plk_4 | 241 | 247 | PF00069 | 0.261 |
MOD_Plk_4 | 25 | 31 | PF00069 | 0.267 |
MOD_Plk_4 | 284 | 290 | PF00069 | 0.359 |
MOD_Plk_4 | 291 | 297 | PF00069 | 0.360 |
MOD_SUMO_for_1 | 239 | 242 | PF00179 | 0.248 |
TRG_ENDOCYTIC_2 | 227 | 230 | PF00928 | 0.238 |
TRG_ENDOCYTIC_2 | 285 | 288 | PF00928 | 0.438 |
TRG_ENDOCYTIC_2 | 326 | 329 | PF00928 | 0.226 |
TRG_ENDOCYTIC_2 | 57 | 60 | PF00928 | 0.262 |
TRG_ENDOCYTIC_2 | 95 | 98 | PF00928 | 0.320 |
TRG_ER_diArg_1 | 118 | 121 | PF00400 | 0.613 |
TRG_ER_diArg_1 | 235 | 238 | PF00400 | 0.365 |
TRG_ER_diArg_1 | 37 | 40 | PF00400 | 0.259 |
TRG_Pf-PMV_PEXEL_1 | 40 | 44 | PF00026 | 0.462 |
Protein | Taxonomy | Sequence identity | Coverage |
---|---|---|---|
A0A0N0P4V4 | Leptomonas seymouri | 29% | 95% |
A0A0N0P7T5 | Leptomonas seymouri | 23% | 100% |
A0A0N0P7X0 | Leptomonas seymouri | 24% | 100% |
A0A0N0P8W6 | Leptomonas seymouri | 22% | 99% |
A0A0N1IMP5 | Leptomonas seymouri | 66% | 100% |
A0A0N1PFJ3 | Leptomonas seymouri | 40% | 93% |
A0A0S4J045 | Bodo saltans | 24% | 95% |
A0A0S4J9F4 | Bodo saltans | 42% | 100% |
A0A0S4JHC1 | Bodo saltans | 29% | 97% |
A0A0S4JN82 | Bodo saltans | 23% | 100% |
A0A1D6N272 | Zea mays | 26% | 100% |
A0A1X0NUM8 | Trypanosomatidae | 42% | 100% |
A0A1X0NUU7 | Trypanosomatidae | 51% | 100% |
A0A1X0P6S2 | Trypanosomatidae | 32% | 100% |
A0A1X0PA63 | Trypanosomatidae | 23% | 87% |
A0A3Q8IFU6 | Leishmania donovani | 78% | 100% |
A0A3Q8IIC0 | Leishmania donovani | 25% | 100% |
A0A3Q8IKX9 | Leishmania donovani | 42% | 100% |
A0A3R7LCB2 | Trypanosoma rangeli | 46% | 100% |
A0A3R7P246 | Trypanosoma rangeli | 41% | 100% |
A0A3S5H7M7 | Leishmania donovani | 25% | 100% |
A0A3S5H800 | Leishmania donovani | 27% | 93% |
A0A3S7WVJ8 | Leishmania donovani | 26% | 98% |
A0A3S7WYS1 | Leishmania donovani | 23% | 100% |
A0A422N763 | Trypanosoma rangeli | 30% | 99% |
A0A422NF39 | Trypanosoma rangeli | 21% | 100% |
A3KPP4 | Danio rerio | 23% | 100% |
A4HA67 | Leishmania braziliensis | 24% | 100% |
A4HDW8 | Leishmania braziliensis | 22% | 94% |
A4HI60 | Leishmania braziliensis | 26% | 100% |
A4HK93 | Leishmania braziliensis | 41% | 100% |
A4HN00 | Leishmania braziliensis | 27% | 93% |
A4HN69 | Leishmania braziliensis | 27% | 100% |
A4HYC8 | Leishmania infantum | 26% | 98% |
A4I163 | Leishmania infantum | 23% | 100% |
A4I5D6 | Leishmania infantum | 25% | 100% |
A4I7S8 | Leishmania infantum | 41% | 100% |
A4I7S9 | Leishmania infantum | 79% | 100% |
A4IBM3 | Leishmania infantum | 26% | 93% |
A4IBT7 | Leishmania infantum | 24% | 100% |
A4RF23 | Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) | 27% | 100% |
B0DK57 | Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686) | 24% | 100% |
B0G159 | Dictyostelium discoideum | 22% | 71% |
B4F8I5 | Zea mays | 24% | 100% |
B4FIJ0 | Zea mays | 26% | 100% |
C9ZM27 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 22% | 88% |
C9ZZ11 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 25% | 100% |
D0A9Y8 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 43% | 97% |
D0A9Z0 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 44% | 99% |
E8NHL5 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 27% | 93% |
E9AFF7 | Leishmania major | 27% | 100% |
E9AFM4 | Leishmania major | 24% | 94% |
E9ALE6 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 23% | 100% |
E9AS62 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 25% | 98% |
E9AX97 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 23% | 100% |
E9B0N4 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 26% | 100% |
E9B2N6 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 41% | 100% |
E9B2N7 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 78% | 100% |
E9B6S7 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 25% | 98% |
O04200 | Arabidopsis thaliana | 25% | 100% |
O13660 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 22% | 100% |
O22261 | Arabidopsis thaliana | 24% | 100% |
O43808 | Homo sapiens | 25% | 100% |
O70579 | Mus musculus | 24% | 100% |
O95258 | Homo sapiens | 24% | 100% |
O95847 | Homo sapiens | 23% | 100% |
P32332 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 21% | 100% |
P38127 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 23% | 89% |
P39953 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 25% | 100% |
P40464 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 24% | 100% |
P40556 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 23% | 90% |
Q1LZB3 | Bos taurus | 23% | 100% |
Q287T7 | Danio rerio | 23% | 100% |
Q29RM1 | Bos taurus | 24% | 100% |
Q3TZX3 | Mus musculus | 23% | 100% |
Q4Q5H0 | Leishmania major | 76% | 100% |
Q4Q5H1 | Leishmania major | 42% | 100% |
Q4Q7J8 | Leishmania major | 24% | 100% |
Q4QA75 | Leishmania major | 23% | 95% |
Q4QDA4 | Leishmania major | 25% | 100% |
Q54FU9 | Dictyostelium discoideum | 21% | 100% |
Q54MZ4 | Dictyostelium discoideum | 22% | 78% |
Q54QN2 | Dictyostelium discoideum | 25% | 100% |
Q55E45 | Dictyostelium discoideum | 24% | 100% |
Q5AVW1 | Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) | 24% | 100% |
Q5PQM9 | Rattus norvegicus | 26% | 100% |
Q5SVS4 | Homo sapiens | 25% | 100% |
Q5XGI1 | Xenopus tropicalis | 23% | 100% |
Q5ZKP7 | Gallus gallus | 22% | 100% |
Q6BPW0 | Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) | 22% | 100% |
Q6DG32 | Danio rerio | 23% | 100% |
Q6GQ22 | Xenopus laevis | 24% | 100% |
Q6IZB5 | Cricetulus griseus | 24% | 100% |
Q6P036 | Danio rerio | 26% | 100% |
Q75A82 | Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) | 21% | 99% |
Q76P23 | Dictyostelium discoideum | 21% | 100% |
Q7K566 | Drosophila melanogaster | 27% | 100% |
Q7XA87 | Arabidopsis thaliana | 27% | 100% |
Q8BMG8 | Mus musculus | 24% | 100% |
Q8HXE3 | Macaca fascicularis | 26% | 100% |
Q8R0Z5 | Mus musculus | 24% | 93% |
Q8RWA5 | Arabidopsis thaliana | 24% | 93% |
Q8RXZ9 | Arabidopsis thaliana | 24% | 100% |
Q922G0 | Mus musculus | 24% | 100% |
Q95J75 | Macaca fascicularis | 23% | 100% |
Q96A46 | Homo sapiens | 24% | 93% |
Q96CQ1 | Homo sapiens | 23% | 100% |
Q9BSK2 | Homo sapiens | 23% | 100% |
Q9CR58 | Mus musculus | 25% | 100% |
Q9FI43 | Arabidopsis thaliana | 23% | 69% |
Q9FI73 | Arabidopsis thaliana | 24% | 99% |
Q9GMZ1 | Canis lupus familiaris | 22% | 100% |
Q9H2D1 | Homo sapiens | 23% | 100% |
Q9LJX5 | Arabidopsis thaliana | 22% | 97% |
Q9NYZ2 | Homo sapiens | 22% | 100% |
Q9P6L7 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 26% | 93% |
Q9SUV1 | Arabidopsis thaliana | 23% | 86% |
Q9Z2B2 | Mus musculus | 25% | 100% |
Q9ZWG1 | Arabidopsis thaliana | 25% | 100% |
V5B150 | Trypanosoma cruzi | 46% | 100% |
V5BGM6 | Trypanosoma cruzi | 45% | 100% |
V5BKU8 | Trypanosoma cruzi | 22% | 88% |
V5BTA6 | Trypanosoma cruzi | 25% | 100% |
V5BTE8 | Trypanosoma cruzi | 29% | 99% |