Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HK90_LEIBR

TriTrypDb:

LbrM.32.1180 , LBRM2903_320017600

Length:

188

Annotations

LeishMANIAdb annotations

Short membrane protein unique to Kinetoplastids. Very unclear topology and function.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 7
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A4HK90

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK90

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	134	136	PF00675	0.547
CLV_NRD_NRD_1	169	171	PF00675	0.442
CLV_NRD_NRD_1	173	175	PF00675	0.435
CLV_NRD_NRD_1	96	98	PF00675	0.412
CLV_PCSK_KEX2_1	173	175	PF00082	0.435
CLV_PCSK_KEX2_1	63	65	PF00082	0.410
CLV_PCSK_KEX2_1	96	98	PF00082	0.412
CLV_PCSK_PC1ET2_1	63	65	PF00082	0.410
CLV_PCSK_SKI1_1	63	67	PF00082	0.426
DOC_CYCLIN_yCln2_LP_2	19	22	PF00134	0.444
DOC_PP2B_LxvP_1	19	22	PF13499	0.444
DOC_PP4_FxxP_1	119	122	PF00568	0.666
DOC_USP7_UBL2_3	158	162	PF12436	0.656
DOC_USP7_UBL2_3	184	188	PF12436	0.557
LIG_14-3-3_CanoR_1	68	77	PF00244	0.610
LIG_Actin_WH2_2	165	181	PF00022	0.659
LIG_BIR_II_1	1	5	PF00653	0.448
LIG_BRCT_BRCA1_1	73	77	PF00533	0.533
LIG_CSL_BTD_1	7	10	PF09270	0.369
LIG_deltaCOP1_diTrp_1	5	11	PF00928	0.369
LIG_eIF4E_1	31	37	PF01652	0.624
LIG_FHA_1	89	95	PF00498	0.684
LIG_FHA_2	148	154	PF00498	0.561
LIG_FHA_2	21	27	PF00498	0.344
LIG_Integrin_RGD_1	128	130	PF01839	0.403
LIG_LIR_Nem_3	107	113	PF02991	0.717
LIG_LIR_Nem_3	12	18	PF02991	0.363
LIG_LIR_Nem_3	26	31	PF02991	0.546
LIG_LIR_Nem_3	5	11	PF02991	0.373
LIG_LIR_Nem_3	59	65	PF02991	0.622
LIG_Pex14_1	110	114	PF04695	0.754
LIG_Pex14_2	117	121	PF04695	0.649
LIG_SH2_SRC	112	115	PF00017	0.651
LIG_SH2_SRC	152	155	PF00017	0.705
LIG_SH2_SRC	18	21	PF00017	0.344
LIG_SH2_SRC	39	42	PF00017	0.683
LIG_SH2_SRC	44	47	PF00017	0.719
LIG_SH2_STAP1	44	48	PF00017	0.684
LIG_SH2_STAP1	88	92	PF00017	0.606
LIG_SH2_STAT3	164	167	PF00017	0.710
LIG_SH2_STAT5	112	115	PF00017	0.558
LIG_SH2_STAT5	15	18	PF00017	0.344
LIG_SH2_STAT5	93	96	PF00017	0.625
LIG_TRAF2_1	180	183	PF00917	0.603
LIG_TYR_ITIM	37	42	PF00017	0.688
MOD_CK1_1	29	35	PF00069	0.634
MOD_CK1_1	71	77	PF00069	0.673
MOD_CK1_1	84	90	PF00069	0.646
MOD_CK2_1	147	153	PF00069	0.561
MOD_CK2_1	20	26	PF00069	0.344
MOD_CMANNOS	80	83	PF00535	0.434
MOD_GSK3_1	67	74	PF00069	0.685
MOD_GSK3_1	84	91	PF00069	0.637
MOD_NEK2_2	88	93	PF00069	0.626
MOD_PKA_2	55	61	PF00069	0.659
MOD_PKA_2	67	73	PF00069	0.558
MOD_Plk_1	104	110	PF00069	0.630
MOD_Plk_1	44	50	PF00069	0.636
MOD_Plk_1	88	94	PF00069	0.611
MOD_Plk_4	104	110	PF00069	0.573
MOD_Plk_4	122	128	PF00069	0.735
MOD_Plk_4	20	26	PF00069	0.365
MOD_SUMO_rev_2	151	157	PF00179	0.739
TRG_ENDOCYTIC_2	114	117	PF00928	0.668
TRG_ENDOCYTIC_2	166	169	PF00928	0.628
TRG_ENDOCYTIC_2	39	42	PF00928	0.674
TRG_ENDOCYTIC_2	62	65	PF00928	0.656
TRG_ER_diArg_1	172	174	PF00400	0.627
TRG_ER_diArg_1	95	97	PF00400	0.612
TRG_NLS_MonoExtC_3	169	174	PF00514	0.639
TRG_Pf-PMV_PEXEL_1	97	102	PF00026	0.518

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P9L5	Leptomonas seymouri	81%	100%
A0A0S4J4N9	Bodo saltans	59%	98%
A0A1X0NUL5	Trypanosomatidae	73%	100%
A0A3S5H7R7	Leishmania donovani	94%	100%
A4I7S5	Leishmania infantum	94%	100%
D0A9Y4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	100%
E9B2N3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q5H4	Leishmania major	93%	100%