LeishMANIAdb
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Putative small nuclear ribonucleoprotein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative small nuclear ribonucleoprotein
Gene product:
small nuclear ribonucleoprotein, putative
Species:
Leishmania braziliensis
UniProt:
A4HK89_LEIBR
TriTrypDb:
LbrM.32.1170 , LBRM2903_320017500
Length:
82

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0032991 protein-containing complex 1 8
GO:1990904 ribonucleoprotein complex 2 8
GO:0005681 spliceosomal complex 3 1
GO:0005682 U5 snRNP 5 1
GO:0005684 U2-type spliceosomal complex 4 1
GO:0005685 U1 snRNP 5 1
GO:0005686 U2 snRNP 5 1
GO:0005687 U4 snRNP 5 1
GO:0005689 U12-type spliceosomal complex 4 1
GO:0030532 small nuclear ribonucleoprotein complex 3 1
GO:0034719 SMN-Sm protein complex 3 1
GO:0035770 ribonucleoprotein granule 3 1
GO:0036464 cytoplasmic ribonucleoprotein granule 4 1
GO:0043186 P granule 5 1
GO:0043226 organelle 2 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0071004 U2-type prespliceosome 5 1
GO:0071010 prespliceosome 4 1
GO:0071011 precatalytic spliceosome 4 1
GO:0071013 catalytic step 2 spliceosome 3 1
GO:0097525 spliceosomal snRNP complex 4 1
GO:0097526 spliceosomal tri-snRNP complex 5 1
GO:0099080 supramolecular complex 2 1
GO:0110165 cellular anatomical entity 1 1
GO:0120114 Sm-like protein family complex 2 1
GO:0140513 nuclear protein-containing complex 2 1
GO:1902494 catalytic complex 2 1

Expansion

Sequence features

A4HK89
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK89

Function

Biological processes
Term Name Level Count
GO:0000375 RNA splicing, via transesterification reactions 8 1
GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 9 1
GO:0000398 mRNA splicing, via spliceosome 8 1
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006396 RNA processing 6 1
GO:0006397 mRNA processing 7 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0008380 RNA splicing 7 1
GO:0009987 cellular process 1 1
GO:0016070 RNA metabolic process 5 1
GO:0016071 mRNA metabolic process 6 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0043170 macromolecule metabolic process 3 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0046483 heterocycle metabolic process 3 1
GO:0071704 organic substance metabolic process 2 1
GO:0090304 nucleic acid metabolic process 4 1
GO:1901360 organic cyclic compound metabolic process 3 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_KEX2_1 16 18 PF00082 0.310
CLV_PCSK_PC1ET2_1 16 18 PF00082 0.310
DOC_MAPK_gen_1 16 22 PF00069 0.488
DOC_USP7_MATH_1 53 57 PF00917 0.528
LIG_FHA_1 64 70 PF00498 0.473
LIG_FHA_2 76 82 PF00498 0.615
LIG_SUMO_SIM_par_1 72 79 PF11976 0.577
MOD_GlcNHglycan 28 31 PF01048 0.296
MOD_GlcNHglycan 71 74 PF01048 0.318
MOD_GlcNHglycan 78 81 PF01048 0.544
MOD_GSK3_1 53 60 PF00069 0.407
MOD_N-GLC_1 3 8 PF02516 0.463
MOD_N-GLC_1 53 58 PF02516 0.374
MOD_NEK2_1 47 52 PF00069 0.519
MOD_NEK2_1 64 69 PF00069 0.408
MOD_PKA_2 69 75 PF00069 0.506
MOD_Plk_1 3 9 PF00069 0.570
MOD_Plk_4 37 43 PF00069 0.462
MOD_Plk_4 64 70 PF00069 0.496

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1ICM1 Leptomonas seymouri 78% 100%
A0A3Q8IGP1 Leishmania donovani 85% 100%
A4I7S4 Leishmania infantum 85% 100%
D0A9Y3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 55% 100%
E9B2N2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 100%
O74499 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 33% 73%
O74966 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 31% 100%
O82221 Arabidopsis thaliana 32% 100%
P40204 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 37% 100%
P53905 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 31% 71%
P62308 Homo sapiens 30% 100%
P62309 Mus musculus 30% 100%
Q3ZBL0 Bos taurus 30% 100%
Q4Q5H5 Leishmania major 85% 99%
Q9N4G9 Caenorhabditis elegans 38% 100%
Q9VXE0 Drosophila melanogaster 34% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS