Putative dynein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative dynein

Gene product:

Dynein intermediate chain, axonemal

Species:

Leishmania braziliensis

UniProt:

A4HK88_LEIBR

TriTrypDb:

LbrM.32.1160 , LBRM2903_320017400

Length:

601

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005858	axonemal dynein complex	4	1
GO:0005875	microtubule associated complex	2	1
GO:0005930	axoneme	2	1
GO:0030286	dynein complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0036157	outer dynein arm	5	1
GO:0110165	cellular anatomical entity	1	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

A4HK88

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK88

Function

Biological processes
Term	Name	Level	Count
GO:0003341	cilium movement	4	1
GO:0007017	microtubule-based process	2	1
GO:0007018	microtubule-based movement	3	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0036158	outer dynein arm assembly	7	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0070286	axonemal dynein complex assembly	6	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0003774	cytoskeletal motor activity	1	1
GO:0003777	microtubule motor activity	2	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0045503	dynein light chain binding	3	1
GO:0045504	dynein heavy chain binding	3	1
GO:0140657	ATP-dependent activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	438	442	PF00656	0.351
CLV_C14_Caspase3-7	580	584	PF00656	0.574
CLV_NRD_NRD_1	178	180	PF00675	0.390
CLV_NRD_NRD_1	357	359	PF00675	0.436
CLV_NRD_NRD_1	538	540	PF00675	0.487
CLV_PCSK_FUR_1	536	540	PF00082	0.488
CLV_PCSK_KEX2_1	165	167	PF00082	0.413
CLV_PCSK_KEX2_1	178	180	PF00082	0.388
CLV_PCSK_KEX2_1	529	531	PF00082	0.472
CLV_PCSK_KEX2_1	538	540	PF00082	0.505
CLV_PCSK_PC1ET2_1	165	167	PF00082	0.413
CLV_PCSK_PC1ET2_1	529	531	PF00082	0.426
CLV_PCSK_PC7_1	534	540	PF00082	0.558
CLV_PCSK_SKI1_1	121	125	PF00082	0.338
CLV_PCSK_SKI1_1	300	304	PF00082	0.581
CLV_PCSK_SKI1_1	324	328	PF00082	0.428
CLV_PCSK_SKI1_1	390	394	PF00082	0.347
CLV_PCSK_SKI1_1	524	528	PF00082	0.457
DEG_APCC_DBOX_1	323	331	PF00400	0.561
DEG_ODPH_VHL_1	32	44	PF01847	0.547
DOC_CKS1_1	215	220	PF01111	0.437
DOC_CKS1_1	453	458	PF01111	0.391
DOC_CYCLIN_yClb5_NLxxxL_5	517	526	PF00134	0.456
DOC_MAPK_gen_1	121	131	PF00069	0.339
DOC_MAPK_MEF2A_6	452	460	PF00069	0.396
DOC_PP1_RVXF_1	184	190	PF00149	0.432
DOC_PP1_RVXF_1	399	405	PF00149	0.442
DOC_USP7_MATH_1	194	198	PF00917	0.518
DOC_USP7_MATH_1	220	224	PF00917	0.376
DOC_USP7_MATH_1	23	27	PF00917	0.654
DOC_USP7_MATH_1	235	239	PF00917	0.315
DOC_USP7_MATH_1	255	259	PF00917	0.255
DOC_USP7_MATH_1	47	51	PF00917	0.687
DOC_USP7_UBL2_3	96	100	PF12436	0.450
DOC_WW_Pin1_4	190	195	PF00397	0.475
DOC_WW_Pin1_4	214	219	PF00397	0.424
DOC_WW_Pin1_4	452	457	PF00397	0.400
DOC_WW_Pin1_4	491	496	PF00397	0.396
LIG_14-3-3_CanoR_1	305	314	PF00244	0.330
LIG_14-3-3_CanoR_1	358	368	PF00244	0.440
LIG_14-3-3_CanoR_1	452	456	PF00244	0.405
LIG_14-3-3_CanoR_1	538	546	PF00244	0.527
LIG_Actin_WH2_2	437	454	PF00022	0.368
LIG_BIR_III_2	138	142	PF00653	0.423
LIG_BRCT_BRCA1_1	388	392	PF00533	0.360
LIG_BRCT_BRCA1_1	456	460	PF00533	0.524
LIG_deltaCOP1_diTrp_1	266	273	PF00928	0.458
LIG_deltaCOP1_diTrp_1	397	404	PF00928	0.336
LIG_FHA_1	397	403	PF00498	0.480
LIG_FHA_1	421	427	PF00498	0.441
LIG_FHA_1	453	459	PF00498	0.393
LIG_FHA_1	479	485	PF00498	0.518
LIG_FHA_1	63	69	PF00498	0.536
LIG_FHA_2	125	131	PF00498	0.566
LIG_FHA_2	360	366	PF00498	0.443
LIG_FHA_2	436	442	PF00498	0.344
LIG_FHA_2	508	514	PF00498	0.522
LIG_FHA_2	549	555	PF00498	0.645
LIG_FHA_2	576	582	PF00498	0.614
LIG_FHA_2	61	67	PF00498	0.653
LIG_FHA_2	87	93	PF00498	0.471
LIG_LIR_Apic_2	5	11	PF02991	0.577
LIG_LIR_Gen_1	200	211	PF02991	0.427
LIG_LIR_Gen_1	389	400	PF02991	0.342
LIG_LIR_Gen_1	441	451	PF02991	0.360
LIG_LIR_Nem_3	130	135	PF02991	0.486
LIG_LIR_Nem_3	238	242	PF02991	0.378
LIG_LIR_Nem_3	389	395	PF02991	0.347
LIG_LIR_Nem_3	441	446	PF02991	0.380
LIG_MLH1_MIPbox_1	388	392	PF16413	0.360
LIG_Pex14_1	403	407	PF04695	0.356
LIG_Pex14_2	388	392	PF04695	0.360
LIG_Pex14_2	409	413	PF04695	0.402
LIG_PTB_Apo_2	382	389	PF02174	0.402
LIG_REV1ctd_RIR_1	433	443	PF16727	0.344
LIG_SH2_CRK	184	188	PF00017	0.407
LIG_SH2_CRK	8	12	PF00017	0.555
LIG_SH2_NCK_1	8	12	PF00017	0.649
LIG_SH2_PTP2	443	446	PF00017	0.489
LIG_SH2_SRC	443	446	PF00017	0.456
LIG_SH2_STAT3	334	337	PF00017	0.396
LIG_SH2_STAT3	380	383	PF00017	0.367
LIG_SH2_STAT5	107	110	PF00017	0.449
LIG_SH2_STAT5	135	138	PF00017	0.579
LIG_SH2_STAT5	391	394	PF00017	0.338
LIG_SH2_STAT5	421	424	PF00017	0.344
LIG_SH2_STAT5	443	446	PF00017	0.417
LIG_SH2_STAT5	478	481	PF00017	0.455
LIG_SH2_STAT5	97	100	PF00017	0.446
LIG_SH3_3	134	140	PF00018	0.531
LIG_SH3_3	205	211	PF00018	0.342
LIG_SH3_3	248	254	PF00018	0.464
LIG_SH3_3	295	301	PF00018	0.486
LIG_SH3_3	310	316	PF00018	0.422
LIG_SH3_3	335	341	PF00018	0.423
LIG_SUMO_SIM_par_1	280	287	PF11976	0.448
LIG_TRAF2_1	141	144	PF00917	0.672
LIG_TRAF2_1	161	164	PF00917	0.257
LIG_TRAF2_1	551	554	PF00917	0.672
LIG_TYR_ITIM	182	187	PF00017	0.378
LIG_WRC_WIRS_1	413	418	PF05994	0.369
MOD_CK1_1	197	203	PF00069	0.465
MOD_CK1_1	283	289	PF00069	0.458
MOD_CK1_1	496	502	PF00069	0.424
MOD_CK1_1	579	585	PF00069	0.389
MOD_CK1_1	59	65	PF00069	0.595
MOD_CK2_1	255	261	PF00069	0.455
MOD_CK2_1	303	309	PF00069	0.562
MOD_CK2_1	359	365	PF00069	0.528
MOD_CK2_1	486	492	PF00069	0.371
MOD_CK2_1	507	513	PF00069	0.519
MOD_CK2_1	548	554	PF00069	0.595
MOD_CK2_1	575	581	PF00069	0.611
MOD_CK2_1	60	66	PF00069	0.598
MOD_CK2_1	86	92	PF00069	0.529
MOD_Cter_Amidation	176	179	PF01082	0.414
MOD_GlcNHglycan	277	280	PF01048	0.258
MOD_GSK3_1	188	195	PF00069	0.456
MOD_GSK3_1	2	9	PF00069	0.572
MOD_GSK3_1	216	223	PF00069	0.424
MOD_GSK3_1	345	352	PF00069	0.382
MOD_GSK3_1	452	459	PF00069	0.397
MOD_GSK3_1	466	473	PF00069	0.368
MOD_GSK3_1	544	551	PF00069	0.615
MOD_GSK3_1	56	63	PF00069	0.573
MOD_GSK3_1	575	582	PF00069	0.640
MOD_N-GLC_1	23	28	PF02516	0.620
MOD_N-GLC_1	486	491	PF02516	0.364
MOD_N-GLC_1	513	518	PF02516	0.430
MOD_NEK2_1	245	250	PF00069	0.508
MOD_NEK2_1	412	417	PF00069	0.369
MOD_NEK2_1	435	440	PF00069	0.328
MOD_NEK2_1	451	456	PF00069	0.410
MOD_NEK2_2	466	471	PF00069	0.481
MOD_PIKK_1	188	194	PF00454	0.578
MOD_PIKK_1	359	365	PF00454	0.455
MOD_PIKK_1	47	53	PF00454	0.643
MOD_PIKK_1	470	476	PF00454	0.535
MOD_PKA_1	538	544	PF00069	0.518
MOD_PKA_2	451	457	PF00069	0.405
MOD_PKA_2	537	543	PF00069	0.514
MOD_PKB_1	536	544	PF00069	0.505
MOD_Plk_1	143	149	PF00069	0.561
MOD_Plk_1	2	8	PF00069	0.573
MOD_Plk_1	486	492	PF00069	0.356
MOD_Plk_1	513	519	PF00069	0.435
MOD_Plk_1	566	572	PF00069	0.368
MOD_Plk_2-3	513	519	PF00069	0.426
MOD_Plk_4	211	217	PF00069	0.480
MOD_Plk_4	349	355	PF00069	0.390
MOD_Plk_4	412	418	PF00069	0.364
MOD_Plk_4	486	492	PF00069	0.371
MOD_Plk_4	507	513	PF00069	0.469
MOD_ProDKin_1	190	196	PF00069	0.466
MOD_ProDKin_1	214	220	PF00069	0.419
MOD_ProDKin_1	452	458	PF00069	0.396
MOD_ProDKin_1	491	497	PF00069	0.394
MOD_SUMO_rev_2	160	167	PF00179	0.498
MOD_SUMO_rev_2	405	410	PF00179	0.415
MOD_SUMO_rev_2	87	95	PF00179	0.466
TRG_DiLeu_BaEn_2	404	410	PF01217	0.279
TRG_ENDOCYTIC_2	184	187	PF00928	0.391
TRG_ENDOCYTIC_2	443	446	PF00928	0.417
TRG_ER_diArg_1	178	180	PF00400	0.416
TRG_Pf-PMV_PEXEL_1	257	261	PF00026	0.469
TRG_Pf-PMV_PEXEL_1	305	309	PF00026	0.479
TRG_Pf-PMV_PEXEL_1	524	528	PF00026	0.471

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P997	Leptomonas seymouri	86%	100%
A0A0N1I862	Leptomonas seymouri	26%	88%
A0A0S4IN87	Bodo saltans	28%	78%
A0A0S4INJ7	Bodo saltans	25%	93%
A0A0S4JPP6	Bodo saltans	23%	78%
A0A1X0NJ43	Trypanosomatidae	24%	89%
A0A1X0NR76	Trypanosomatidae	24%	67%
A0A1X0NUK4	Trypanosomatidae	69%	100%
A0A1X0P0W1	Trypanosomatidae	22%	100%
A0A3Q8ICR4	Leishmania donovani	26%	88%
A0A3S7X5B2	Leishmania donovani	92%	100%
A0A422P1D5	Trypanosoma rangeli	68%	100%
A0A422P471	Trypanosoma rangeli	25%	90%
A2AC93	Mus musculus	42%	96%
A4HD84	Leishmania braziliensis	26%	88%
A4I2V5	Leishmania infantum	24%	71%
A4I447	Leishmania infantum	24%	100%
A4I7S3	Leishmania infantum	92%	100%
D0A634	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	22%	74%
D0A6Z5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	92%
D0A9Y1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	100%
E9ADE2	Leishmania major	23%	71%
E9ADL2	Leishmania major	24%	100%
E9AH39	Leishmania infantum	26%	88%
E9AM69	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9AWL7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	88%
E9AZ66	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	72%
E9B2N1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
P27766	Chlamydomonas reinhardtii	43%	100%
P54703	Dictyostelium discoideum	26%	92%
Q16959	Heliocidaris crassispina	29%	86%
Q16960	Heliocidaris crassispina	44%	100%
Q24246	Drosophila melanogaster	24%	91%
Q32KS2	Bos taurus	25%	86%
Q39578	Chlamydomonas reinhardtii	28%	88%
Q4Q5H6	Leishmania major	91%	100%
Q4QAV3	Leishmania major	26%	88%
Q4QR00	Xenopus laevis	41%	100%
Q5XIL8	Rattus norvegicus	25%	85%
Q66HC9	Rattus norvegicus	42%	97%
Q8C0M8	Mus musculus	25%	86%
Q9GZS0	Homo sapiens	43%	99%
Q9UI46	Homo sapiens	25%	86%
V5B145	Trypanosoma cruzi	69%	100%
V5BGF1	Trypanosoma cruzi	25%	74%
V5DSN6	Trypanosoma cruzi	24%	90%