Vacuolar protein sorting-associated protein 29

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

vacuolar sorting-like protein

Species:

Leishmania braziliensis

UniProt:

A4HK87_LEIBR

TriTrypDb:

LbrM.32.1150 , LBRM2903_320017300

Length:

204

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	11
GO:0030904	retromer complex	3	11
GO:0032991	protein-containing complex	1	11
GO:0098796	membrane protein complex	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005768	endosome	7	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1

Expansion

Sequence features

A4HK87

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK87

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0008104	protein localization	4	11
GO:0009987	cellular process	1	11
GO:0015031	protein transport	4	11
GO:0016192	vesicle-mediated transport	4	11
GO:0016197	endosomal transport	4	11
GO:0016482	cytosolic transport	4	11
GO:0033036	macromolecule localization	2	11
GO:0042147	retrograde transport, endosome to Golgi	5	11
GO:0045184	establishment of protein localization	3	11
GO:0046907	intracellular transport	3	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0051649	establishment of localization in cell	3	11
GO:0070727	cellular macromolecule localization	3	11
GO:0071702	organic substance transport	4	11
GO:0071705	nitrogen compound transport	4	11
GO:0006886	intracellular protein transport	4	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	173	177	PF00656	0.438
DEG_COP1_1	141	152	PF00400	0.359
DOC_MAPK_MEF2A_6	106	114	PF00069	0.263
DOC_PP4_FxxP_1	131	134	PF00568	0.263
DOC_USP7_MATH_1	13	17	PF00917	0.293
DOC_USP7_UBL2_3	199	203	PF12436	0.387
DOC_WW_Pin1_4	25	30	PF00397	0.383
LIG_14-3-3_CanoR_1	31	36	PF00244	0.194
LIG_Actin_WH2_2	69	86	PF00022	0.392
LIG_BRCT_BRCA1_1	127	131	PF00533	0.367
LIG_BRCT_BRCA1_1	23	27	PF00533	0.313
LIG_CSL_BTD_1	10	13	PF09270	0.453
LIG_FHA_1	158	164	PF00498	0.351
LIG_FHA_1	32	38	PF00498	0.300
LIG_FHA_2	140	146	PF00498	0.346
LIG_FHA_2	178	184	PF00498	0.667
LIG_LIR_Apic_2	128	134	PF02991	0.392
LIG_LIR_Gen_1	151	157	PF02991	0.276
LIG_LIR_Gen_1	21	29	PF02991	0.447
LIG_LIR_Nem_3	151	155	PF02991	0.304
LIG_Pex14_2	23	27	PF04695	0.372
LIG_SH2_CRK	47	51	PF00017	0.392
LIG_SH2_SRC	169	172	PF00017	0.421
LIG_SH2_STAT3	167	170	PF00017	0.368
LIG_SH2_STAT5	123	126	PF00017	0.392
LIG_SH2_STAT5	49	52	PF00017	0.263
LIG_SUMO_SIM_anti_2	109	115	PF11976	0.263
LIG_SUMO_SIM_par_1	153	161	PF11976	0.289
LIG_SUMO_SIM_par_1	3	10	PF11976	0.283
LIG_SUMO_SIM_par_1	33	38	PF11976	0.180
LIG_SUMO_SIM_par_1	73	82	PF11976	0.347
LIG_WRC_WIRS_1	149	154	PF05994	0.339
LIG_WRC_WIRS_1	162	167	PF05994	0.261
MOD_CDC14_SPxK_1	28	31	PF00782	0.498
MOD_CDK_SPxK_1	25	31	PF00069	0.384
MOD_CK1_1	115	121	PF00069	0.264
MOD_CK1_1	161	167	PF00069	0.439
MOD_CK1_1	172	178	PF00069	0.648
MOD_CK2_1	139	145	PF00069	0.205
MOD_CK2_1	177	183	PF00069	0.638
MOD_GlcNHglycan	114	117	PF01048	0.268
MOD_GlcNHglycan	137	140	PF01048	0.402
MOD_GlcNHglycan	16	19	PF01048	0.487
MOD_GSK3_1	135	142	PF00069	0.307
MOD_GSK3_1	157	164	PF00069	0.361
MOD_GSK3_1	21	28	PF00069	0.319
MOD_GSK3_1	31	38	PF00069	0.222
MOD_GSK3_1	72	79	PF00069	0.362
MOD_NEK2_1	72	77	PF00069	0.195
MOD_PKA_2	14	20	PF00069	0.488
MOD_Plk_1	158	164	PF00069	0.370
MOD_Plk_1	60	66	PF00069	0.177
MOD_Plk_4	148	154	PF00069	0.286
MOD_Plk_4	158	164	PF00069	0.355
MOD_Plk_4	31	37	PF00069	0.209
MOD_Plk_4	7	13	PF00069	0.437
MOD_Plk_4	72	78	PF00069	0.359
MOD_ProDKin_1	25	31	PF00069	0.384
TRG_ENDOCYTIC_2	123	126	PF00928	0.392
TRG_ENDOCYTIC_2	47	50	PF00928	0.282
TRG_NES_CRM1_1	99	111	PF08389	0.282
TRG_Pf-PMV_PEXEL_1	106	111	PF00026	0.315

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAX5	Leptomonas seymouri	72%	98%
A0A0S4KLN9	Bodo saltans	46%	100%
A0A1X0NUK2	Trypanosomatidae	47%	100%
A0A3S7X5E5	Leishmania donovani	83%	100%
A0A422P1G5	Trypanosoma rangeli	50%	100%
A4I7S2	Leishmania infantum	83%	100%
B2RZ78	Rattus norvegicus	45%	100%
D0A9Y0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	90%
E9B2N0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
P38759	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	72%
Q3T0M0	Bos taurus	45%	100%
Q4Q5H7	Leishmania major	84%	100%
Q54IF7	Dictyostelium discoideum	42%	100%
Q58040	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	30%	100%
Q5R9Z1	Pongo abelii	45%	100%
Q5ZIL2	Gallus gallus	45%	100%
Q6DEU3	Xenopus tropicalis	44%	100%
Q6GP62	Xenopus laevis	44%	100%
Q7ZV68	Danio rerio	45%	100%
Q9QZ88	Mus musculus	45%	100%
Q9STT2	Arabidopsis thaliana	41%	100%
Q9UBQ0	Homo sapiens	45%	100%
Q9UTI5	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	100%