LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HK86_LEIBR
TriTrypDb:
LbrM.32.1140 , LBRM2903_320017200 *
Length:
580

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
TermNameLevelCount
GO:0016020 membrane 2 7
GO:0110165 cellular anatomical entity 1 7
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Expansion

Sequence features

A4HK86
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK86

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 135 139 PF00656 0.613
CLV_C14_Caspase3-7 187 191 PF00656 0.698
CLV_C14_Caspase3-7 347 351 PF00656 0.580
CLV_C14_Caspase3-7 369 373 PF00656 0.661
CLV_NRD_NRD_1 197 199 PF00675 0.440
CLV_NRD_NRD_1 242 244 PF00675 0.481
CLV_NRD_NRD_1 259 261 PF00675 0.291
CLV_NRD_NRD_1 428 430 PF00675 0.443
CLV_NRD_NRD_1 545 547 PF00675 0.315
CLV_NRD_NRD_1 82 84 PF00675 0.450
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1I4B6 Leptomonas seymouri 37% 99%
A0A1X0NV17 Trypanosomatidae 27% 100%
A0A3S7X5F4 Leishmania donovani 63% 100%
A4I7S1 Leishmania infantum 63% 93%
E9B2M9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 62% 82%
Q4Q5H8 Leishmania major 59% 100%
V5BGM1 Trypanosoma cruzi 27% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS