Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HK86_LEIBR

TriTrypDb:

LbrM.32.1140 , LBRM2903_320017200

Length:

580

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A4HK86

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK86

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	135	139	PF00656	0.613
CLV_C14_Caspase3-7	187	191	PF00656	0.698
CLV_C14_Caspase3-7	347	351	PF00656	0.580
CLV_C14_Caspase3-7	369	373	PF00656	0.661
CLV_NRD_NRD_1	197	199	PF00675	0.440
CLV_NRD_NRD_1	242	244	PF00675	0.481
CLV_NRD_NRD_1	259	261	PF00675	0.291
CLV_NRD_NRD_1	428	430	PF00675	0.443
CLV_NRD_NRD_1	545	547	PF00675	0.315
CLV_NRD_NRD_1	82	84	PF00675	0.450
CLV_PCSK_KEX2_1	242	244	PF00082	0.465
CLV_PCSK_KEX2_1	259	261	PF00082	0.345
CLV_PCSK_KEX2_1	428	430	PF00082	0.466
CLV_PCSK_KEX2_1	545	547	PF00082	0.317
CLV_PCSK_KEX2_1	574	576	PF00082	0.767
CLV_PCSK_PC1ET2_1	574	576	PF00082	0.601
CLV_PCSK_SKI1_1	194	198	PF00082	0.390
CLV_PCSK_SKI1_1	228	232	PF00082	0.500
CLV_PCSK_SKI1_1	445	449	PF00082	0.394
CLV_PCSK_SKI1_1	545	549	PF00082	0.291
CLV_PCSK_SKI1_1	70	74	PF00082	0.463
DEG_APCC_DBOX_1	193	201	PF00400	0.588
DEG_APCC_KENBOX_2	513	517	PF00400	0.592
DEG_Nend_UBRbox_3	1	3	PF02207	0.643
DOC_MAPK_gen_1	436	444	PF00069	0.705
DOC_MAPK_gen_1	511	520	PF00069	0.664
DOC_MAPK_gen_1	542	550	PF00069	0.528
DOC_MAPK_MEF2A_6	404	413	PF00069	0.520
DOC_MAPK_MEF2A_6	70	79	PF00069	0.696
DOC_MAPK_RevD_3	184	199	PF00069	0.544
DOC_PP1_RVXF_1	544	551	PF00149	0.429
DOC_PP1_RVXF_1	74	80	PF00149	0.634
DOC_USP7_MATH_1	119	123	PF00917	0.764
DOC_USP7_MATH_1	132	136	PF00917	0.710
DOC_USP7_MATH_1	248	252	PF00917	0.691
DOC_USP7_MATH_1	275	279	PF00917	0.652
DOC_USP7_MATH_1	286	290	PF00917	0.680
DOC_USP7_MATH_1	430	434	PF00917	0.521
DOC_USP7_MATH_1	451	455	PF00917	0.617
DOC_USP7_MATH_1	541	545	PF00917	0.701
DOC_USP7_MATH_2	275	281	PF00917	0.617
DOC_WW_Pin1_4	519	524	PF00397	0.631
LIG_14-3-3_CanoR_1	165	172	PF00244	0.641
LIG_14-3-3_CanoR_1	208	212	PF00244	0.553
LIG_14-3-3_CanoR_1	285	291	PF00244	0.773
LIG_14-3-3_CanoR_1	41	51	PF00244	0.678
LIG_14-3-3_CanoR_1	429	437	PF00244	0.629
LIG_14-3-3_CanoR_1	490	494	PF00244	0.610
LIG_14-3-3_CanoR_1	545	551	PF00244	0.429
LIG_14-3-3_CanoR_1	6	12	PF00244	0.634
LIG_Actin_WH2_2	65	80	PF00022	0.699
LIG_Clathr_ClatBox_1	322	326	PF01394	0.793
LIG_deltaCOP1_diTrp_1	500	509	PF00928	0.563
LIG_eIF4E_1	172	178	PF01652	0.543
LIG_FHA_1	307	313	PF00498	0.740
LIG_FHA_1	418	424	PF00498	0.639
LIG_FHA_1	46	52	PF00498	0.608
LIG_FHA_1	565	571	PF00498	0.550
LIG_FHA_2	64	70	PF00498	0.689
LIG_LIR_Gen_1	210	218	PF02991	0.697
LIG_LIR_Gen_1	7	14	PF02991	0.552
LIG_LIR_Nem_3	210	214	PF02991	0.695
LIG_LIR_Nem_3	308	314	PF02991	0.634
LIG_LIR_Nem_3	549	553	PF02991	0.428
LIG_LIR_Nem_3	55	61	PF02991	0.580
LIG_LIR_Nem_3	7	11	PF02991	0.655
LIG_PDZ_Class_3	575	580	PF00595	0.520
LIG_SH2_NCK_1	172	176	PF00017	0.641
LIG_SH2_PTP2	561	564	PF00017	0.255
LIG_SH2_SRC	172	175	PF00017	0.642
LIG_SH2_STAP1	211	215	PF00017	0.622
LIG_SH2_STAT5	141	144	PF00017	0.601
LIG_SH2_STAT5	311	314	PF00017	0.686
LIG_SH2_STAT5	561	564	PF00017	0.349
LIG_SH3_3	110	116	PF00018	0.785
LIG_SH3_3	465	471	PF00018	0.718
LIG_SH3_3	475	481	PF00018	0.736
LIG_SUMO_SIM_anti_2	552	558	PF11976	0.255
LIG_SUMO_SIM_par_1	10	19	PF11976	0.703
LIG_SUMO_SIM_par_1	321	328	PF11976	0.728
LIG_TYR_ITIM	559	564	PF00017	0.255
LIG_WRC_WIRS_1	211	216	PF05994	0.526
LIG_WRC_WIRS_1	5	10	PF05994	0.673
LIG_WRC_WIRS_1	547	552	PF05994	0.255
MOD_CK1_1	114	120	PF00069	0.666
MOD_CK1_1	122	128	PF00069	0.649
MOD_CK1_1	210	216	PF00069	0.601
MOD_CK1_1	26	32	PF00069	0.680
MOD_CK1_1	45	51	PF00069	0.705
MOD_CK1_1	454	460	PF00069	0.738
MOD_CK1_1	569	575	PF00069	0.373
MOD_CK2_1	141	147	PF00069	0.599
MOD_CK2_1	210	216	PF00069	0.621
MOD_CK2_1	248	254	PF00069	0.679
MOD_CK2_1	54	60	PF00069	0.647
MOD_CK2_1	63	69	PF00069	0.637
MOD_CMANNOS	499	502	PF00535	0.436
MOD_CMANNOS	510	513	PF00535	0.437
MOD_GlcNHglycan	250	253	PF01048	0.523
MOD_GlcNHglycan	254	257	PF01048	0.493
MOD_GlcNHglycan	293	296	PF01048	0.600
MOD_GlcNHglycan	363	367	PF01048	0.501
MOD_GlcNHglycan	451	454	PF01048	0.487
MOD_GlcNHglycan	458	461	PF01048	0.467
MOD_GlcNHglycan	463	467	PF01048	0.445
MOD_GSK3_1	107	114	PF00069	0.707
MOD_GSK3_1	115	122	PF00069	0.750
MOD_GSK3_1	137	144	PF00069	0.671
MOD_GSK3_1	161	168	PF00069	0.709
MOD_GSK3_1	210	217	PF00069	0.678
MOD_GSK3_1	244	251	PF00069	0.676
MOD_GSK3_1	291	298	PF00069	0.807
MOD_GSK3_1	321	328	PF00069	0.717
MOD_GSK3_1	331	338	PF00069	0.649
MOD_GSK3_1	358	365	PF00069	0.717
MOD_GSK3_1	447	454	PF00069	0.663
MOD_GSK3_1	566	573	PF00069	0.426
MOD_N-GLC_1	306	311	PF02516	0.477
MOD_N-GLC_1	495	500	PF02516	0.434
MOD_N-GLC_1	526	531	PF02516	0.506
MOD_NEK2_1	120	125	PF00069	0.742
MOD_NEK2_1	137	142	PF00069	0.514
MOD_NEK2_1	325	330	PF00069	0.631
MOD_NEK2_1	4	9	PF00069	0.668
MOD_NEK2_1	566	571	PF00069	0.578
MOD_NEK2_2	141	146	PF00069	0.625
MOD_PIKK_1	23	29	PF00454	0.744
MOD_PIKK_1	295	301	PF00454	0.812
MOD_PIKK_1	335	341	PF00454	0.641
MOD_PIKK_1	45	51	PF00454	0.634
MOD_PIKK_1	451	457	PF00454	0.585
MOD_PKA_2	207	213	PF00069	0.561
MOD_PKA_2	248	254	PF00069	0.544
MOD_PKA_2	284	290	PF00069	0.772
MOD_PKA_2	358	364	PF00069	0.638
MOD_PKA_2	489	495	PF00069	0.609
MOD_PKA_2	541	547	PF00069	0.705
MOD_PKA_2	570	576	PF00069	0.380
MOD_PKB_1	163	171	PF00069	0.551
MOD_Plk_1	132	138	PF00069	0.681
MOD_Plk_1	161	167	PF00069	0.664
MOD_Plk_1	306	312	PF00069	0.641
MOD_Plk_1	495	501	PF00069	0.722
MOD_Plk_1	54	60	PF00069	0.690
MOD_Plk_1	63	69	PF00069	0.674
MOD_Plk_1	70	76	PF00069	0.645
MOD_Plk_2-3	207	213	PF00069	0.540
MOD_Plk_2-3	277	283	PF00069	0.622
MOD_Plk_2-3	64	70	PF00069	0.707
MOD_Plk_4	132	138	PF00069	0.734
MOD_Plk_4	210	216	PF00069	0.643
MOD_Plk_4	307	313	PF00069	0.636
MOD_Plk_4	549	555	PF00069	0.418
MOD_Plk_4	7	13	PF00069	0.665
MOD_ProDKin_1	519	525	PF00069	0.630
MOD_SUMO_for_1	236	239	PF00179	0.656
MOD_SUMO_rev_2	433	437	PF00179	0.634
TRG_DiLeu_BaEn_1	173	178	PF01217	0.542
TRG_DiLeu_BaEn_1	227	232	PF01217	0.664
TRG_DiLeu_BaEn_4	161	167	PF01217	0.689
TRG_DiLeu_BaLyEn_6	543	548	PF01217	0.576
TRG_ENDOCYTIC_2	211	214	PF00928	0.656
TRG_ENDOCYTIC_2	561	564	PF00928	0.464
TRG_ENDOCYTIC_2	58	61	PF00928	0.664
TRG_ER_diArg_1	163	166	PF00400	0.559
TRG_ER_diArg_1	258	260	PF00400	0.669
TRG_ER_diArg_1	391	394	PF00400	0.530
TRG_ER_diArg_1	476	479	PF00400	0.604
TRG_ER_diArg_1	545	547	PF00400	0.531
TRG_ER_diArg_1	75	78	PF00400	0.621
TRG_NES_CRM1_1	42	55	PF08389	0.537
TRG_Pf-PMV_PEXEL_1	198	203	PF00026	0.431
TRG_Pf-PMV_PEXEL_1	259	263	PF00026	0.470
TRG_Pf-PMV_PEXEL_1	379	383	PF00026	0.498
TRG_Pf-PMV_PEXEL_1	59	63	PF00026	0.463

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4B6	Leptomonas seymouri	37%	99%
A0A1X0NV17	Trypanosomatidae	27%	100%
A0A3S7X5F4	Leishmania donovani	63%	100%
A4I7S1	Leishmania infantum	63%	93%
E9B2M9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	82%
Q4Q5H8	Leishmania major	59%	100%
V5BGM1	Trypanosoma cruzi	27%	100%