Maf-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Maf-like protein

Gene product:

Maf-like protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HK85_LEIBR

TriTrypDb:

LbrM.32.1130 , LBRM2903_320017100

Length:

209

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HK85

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK85

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0016462	pyrophosphatase activity	5	10
GO:0016787	hydrolase activity	2	10
GO:0016817	hydrolase activity, acting on acid anhydrides	3	10
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	10
GO:0047429	nucleoside triphosphate diphosphatase activity	6	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	15	17	PF00675	0.266
CLV_PCSK_KEX2_1	14	16	PF00082	0.336
CLV_PCSK_KEX2_1	177	179	PF00082	0.315
CLV_PCSK_PC1ET2_1	177	179	PF00082	0.277
CLV_PCSK_SKI1_1	200	204	PF00082	0.308
DEG_APCC_DBOX_1	199	207	PF00400	0.506
DEG_Nend_UBRbox_2	1	3	PF02207	0.335
DOC_MAPK_gen_1	177	183	PF00069	0.507
DOC_MAPK_MEF2A_6	78	86	PF00069	0.508
DOC_USP7_MATH_1	48	52	PF00917	0.491
DOC_WW_Pin1_4	30	35	PF00397	0.467
LIG_AP2alpha_2	45	47	PF02296	0.440
LIG_BRCT_BRCA1_1	43	47	PF00533	0.468
LIG_FHA_1	121	127	PF00498	0.440
LIG_FHA_1	48	54	PF00498	0.444
LIG_FHA_2	185	191	PF00498	0.506
LIG_LIR_Apic_2	28	34	PF02991	0.485
LIG_LIR_Gen_1	85	92	PF02991	0.423
LIG_LIR_Nem_3	143	148	PF02991	0.425
LIG_LIR_Nem_3	85	89	PF02991	0.423
LIG_PCNA_yPIPBox_3	111	122	PF02747	0.365
LIG_SH2_CRK	27	31	PF00017	0.506
LIG_SH2_GRB2like	113	116	PF00017	0.458
LIG_SH2_NCK_1	27	31	PF00017	0.506
LIG_SH2_STAP1	27	31	PF00017	0.506
LIG_SH2_STAT5	31	34	PF00017	0.506
LIG_SH3_4	99	106	PF00018	0.444
LIG_TRAF2_1	187	190	PF00917	0.510
LIG_TYR_ITSM	141	148	PF00017	0.506
MOD_CK1_1	149	155	PF00069	0.421
MOD_CK2_1	184	190	PF00069	0.508
MOD_GlcNHglycan	10	13	PF01048	0.242
MOD_GlcNHglycan	50	53	PF01048	0.182
MOD_GSK3_1	117	124	PF00069	0.474
MOD_GSK3_1	133	140	PF00069	0.504
MOD_GSK3_1	158	165	PF00069	0.403
MOD_GSK3_1	78	85	PF00069	0.488
MOD_N-GLC_1	138	143	PF02516	0.265
MOD_NEK2_1	109	114	PF00069	0.456
MOD_NEK2_1	47	52	PF00069	0.443
MOD_NEK2_2	195	200	PF00069	0.477
MOD_PIKK_1	99	105	PF00454	0.365
MOD_PK_1	78	84	PF00069	0.477
MOD_PKA_2	158	164	PF00069	0.561
MOD_PKA_2	41	47	PF00069	0.468
MOD_PKA_2	66	72	PF00069	0.430
MOD_Plk_1	138	144	PF00069	0.496
MOD_Plk_1	149	155	PF00069	0.517
MOD_Plk_1	195	201	PF00069	0.509
MOD_Plk_2-3	184	190	PF00069	0.477
MOD_Plk_4	117	123	PF00069	0.478
MOD_Plk_4	140	146	PF00069	0.433
MOD_ProDKin_1	30	36	PF00069	0.467
MOD_SUMO_for_1	56	59	PF00179	0.365
MOD_SUMO_rev_2	175	183	PF00179	0.484
MOD_SUMO_rev_2	33	41	PF00179	0.457
TRG_ENDOCYTIC_2	145	148	PF00928	0.506
TRG_ENDOCYTIC_2	27	30	PF00928	0.465
TRG_ER_diArg_1	13	16	PF00400	0.569
TRG_Pf-PMV_PEXEL_1	16	20	PF00026	0.312
TRG_Pf-PMV_PEXEL_1	200	205	PF00026	0.306

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PGQ1	Leptomonas seymouri	65%	100%
A0A0S4KKD9	Bodo saltans	28%	75%
A0A1X0NW04	Trypanosomatidae	39%	100%
A0A3Q8IGW3	Leishmania donovani	85%	95%
A0A3R7M9P1	Trypanosoma rangeli	46%	100%
A4I7S0	Leishmania infantum	85%	95%
B0B7R8	Chlamydia trachomatis serovar L2 (strain 434/Bu / ATCC VR-902B)	29%	100%
B0BBY3	Chlamydia trachomatis serovar L2b (strain UCH-1/proctitis)	29%	100%
B0C1T2	Acaryochloris marina (strain MBIC 11017)	25%	100%
B9KXM8	Thermomicrobium roseum (strain ATCC 27502 / DSM 5159 / P-2)	29%	96%
D0A9X9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9B2M8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	95%
O84353	Chlamydia trachomatis (strain D/UW-3/Cx)	29%	100%
Q12IW9	Shewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013)	28%	100%
Q253S7	Chlamydia felis (strain Fe/C-56)	25%	100%
Q3KM09	Chlamydia trachomatis serovar A (strain ATCC VR-571B / DSM 19440 / HAR-13)	29%	100%
Q46BZ6	Methanosarcina barkeri (strain Fusaro / DSM 804)	26%	100%
Q4Q5H9	Leishmania major	85%	100%
Q54TC5	Dictyostelium discoideum	30%	100%
Q823U1	Chlamydia caviae (strain ATCC VR-813 / DSM 19441 / 03DC25 / GPIC)	25%	100%
Q8A749	Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 / VPI-5482 / E50)	25%	100%
Q8U476	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	25%	100%
Q9K0J8	Neisseria meningitidis serogroup B (strain MC58)	28%	100%
Q9PK45	Chlamydia muridarum (strain MoPn / Nigg)	28%	100%
Q9RV24	Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)	26%	100%