Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania braziliensis

UniProt:

A4HK84_LEIBR

TriTrypDb:

LbrM.32.1120 , LBRM2903_320017000

Length:

828

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HK84

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK84

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016310	phosphorylation	5	11
GO:0019538	protein metabolic process	3	11
GO:0036211	protein modification process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0004672	protein kinase activity	3	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016301	kinase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0140096	catalytic activity, acting on a protein	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11
GO:0004674	protein serine/threonine kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	162	164	PF00675	0.636
CLV_NRD_NRD_1	373	375	PF00675	0.715
CLV_NRD_NRD_1	440	442	PF00675	0.379
CLV_NRD_NRD_1	630	632	PF00675	0.332
CLV_NRD_NRD_1	789	791	PF00675	0.610
CLV_PCSK_FUR_1	160	164	PF00082	0.738
CLV_PCSK_FUR_1	2	6	PF00082	0.669
CLV_PCSK_KEX2_1	162	164	PF00082	0.626
CLV_PCSK_KEX2_1	373	375	PF00082	0.757
CLV_PCSK_KEX2_1	4	6	PF00082	0.663
CLV_PCSK_KEX2_1	562	564	PF00082	0.480
CLV_PCSK_KEX2_1	630	632	PF00082	0.346
CLV_PCSK_KEX2_1	772	774	PF00082	0.502
CLV_PCSK_KEX2_1	789	791	PF00082	0.537
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.732
CLV_PCSK_PC1ET2_1	562	564	PF00082	0.480
CLV_PCSK_PC1ET2_1	772	774	PF00082	0.595
CLV_PCSK_SKI1_1	447	451	PF00082	0.559
CLV_PCSK_SKI1_1	543	547	PF00082	0.639
CLV_PCSK_SKI1_1	559	563	PF00082	0.215
CLV_PCSK_SKI1_1	577	581	PF00082	0.294
CLV_Separin_Metazoa	506	510	PF03568	0.546
DEG_APCC_DBOX_1	576	584	PF00400	0.480
DEG_Nend_UBRbox_1	1	4	PF02207	0.662
DEG_SPOP_SBC_1	214	218	PF00917	0.767
DEG_SPOP_SBC_1	314	318	PF00917	0.670
DOC_ANK_TNKS_1	410	417	PF00023	0.439
DOC_CYCLIN_yCln2_LP_2	740	746	PF00134	0.355
DOC_MAPK_gen_1	373	380	PF00069	0.525
DOC_MAPK_MEF2A_6	478	485	PF00069	0.443
DOC_MAPK_MEF2A_6	563	572	PF00069	0.335
DOC_PP1_RVXF_1	708	715	PF00149	0.335
DOC_PP2B_LxvP_1	222	225	PF13499	0.528
DOC_PP2B_LxvP_1	236	239	PF13499	0.673
DOC_USP7_MATH_1	104	108	PF00917	0.668
DOC_USP7_MATH_1	113	117	PF00917	0.688
DOC_USP7_MATH_1	232	236	PF00917	0.690
DOC_USP7_MATH_1	242	246	PF00917	0.580
DOC_USP7_MATH_1	251	255	PF00917	0.713
DOC_USP7_MATH_1	314	318	PF00917	0.590
DOC_USP7_MATH_1	366	370	PF00917	0.630
DOC_USP7_MATH_1	470	474	PF00917	0.547
DOC_USP7_MATH_1	62	66	PF00917	0.690
DOC_USP7_MATH_1	73	77	PF00917	0.709
DOC_USP7_UBL2_3	443	447	PF12436	0.581
DOC_USP7_UBL2_3	526	530	PF12436	0.563
DOC_USP7_UBL2_3	608	612	PF12436	0.257
DOC_USP7_UBL2_3	768	772	PF12436	0.578
DOC_WW_Pin1_4	108	113	PF00397	0.662
DOC_WW_Pin1_4	199	204	PF00397	0.717
DOC_WW_Pin1_4	216	221	PF00397	0.672
DOC_WW_Pin1_4	223	228	PF00397	0.664
DOC_WW_Pin1_4	262	267	PF00397	0.699
DOC_WW_Pin1_4	282	287	PF00397	0.705
DOC_WW_Pin1_4	301	306	PF00397	0.690
DOC_WW_Pin1_4	307	312	PF00397	0.592
DOC_WW_Pin1_4	319	324	PF00397	0.631
DOC_WW_Pin1_4	47	52	PF00397	0.614
DOC_WW_Pin1_4	538	543	PF00397	0.587
DOC_WW_Pin1_4	562	567	PF00397	0.359
LIG_14-3-3_CanoR_1	197	203	PF00244	0.774
LIG_14-3-3_CanoR_1	269	276	PF00244	0.524
LIG_14-3-3_CanoR_1	332	338	PF00244	0.752
LIG_14-3-3_CanoR_1	5	14	PF00244	0.548
LIG_14-3-3_CanoR_1	509	519	PF00244	0.565
LIG_14-3-3_CanoR_1	548	552	PF00244	0.588
LIG_14-3-3_CanoR_1	733	737	PF00244	0.336
LIG_14-3-3_CterR_2	826	828	PF00244	0.658
LIG_APCC_ABBA_1	138	143	PF00400	0.554
LIG_APCC_ABBA_1	591	596	PF00400	0.227
LIG_BRCT_BRCA1_1	264	268	PF00533	0.735
LIG_BRCT_BRCA1_1	335	339	PF00533	0.767
LIG_BRCT_BRCA1_1	714	718	PF00533	0.355
LIG_BRCT_BRCA1_1	766	770	PF00533	0.436
LIG_BRCT_BRCA1_2	766	772	PF00533	0.561
LIG_FHA_1	316	322	PF00498	0.686
LIG_FHA_1	373	379	PF00498	0.646
LIG_FHA_1	431	437	PF00498	0.568
LIG_FHA_1	792	798	PF00498	0.560
LIG_FHA_1	805	811	PF00498	0.397
LIG_FHA_2	147	153	PF00498	0.629
LIG_FHA_2	170	176	PF00498	0.662
LIG_FHA_2	489	495	PF00498	0.295
LIG_FHA_2	526	532	PF00498	0.398
LIG_FHA_2	548	554	PF00498	0.613
LIG_FHA_2	75	81	PF00498	0.740
LIG_LIR_Apic_2	550	554	PF02991	0.571
LIG_LIR_Apic_2	637	643	PF02991	0.335
LIG_LIR_Gen_1	120	131	PF02991	0.558
LIG_LIR_Gen_1	569	579	PF02991	0.347
LIG_LIR_Gen_1	716	726	PF02991	0.358
LIG_LIR_Nem_3	120	126	PF02991	0.592
LIG_LIR_Nem_3	129	135	PF02991	0.528
LIG_LIR_Nem_3	336	342	PF02991	0.770
LIG_LIR_Nem_3	513	518	PF02991	0.572
LIG_LIR_Nem_3	588	593	PF02991	0.335
LIG_LIR_Nem_3	694	699	PF02991	0.335
LIG_LIR_Nem_3	715	721	PF02991	0.357
LIG_LIR_Nem_3	804	809	PF02991	0.486
LIG_LIR_Nem_3	820	825	PF02991	0.651
LIG_Pex14_1	252	256	PF04695	0.723
LIG_Pex14_1	714	718	PF04695	0.355
LIG_Pex14_2	692	696	PF04695	0.447
LIG_Pex14_2	744	748	PF04695	0.494
LIG_SH2_CRK	539	543	PF00017	0.617
LIG_SH2_CRK	719	723	PF00017	0.408
LIG_SH2_STAP1	335	339	PF00017	0.515
LIG_SH2_STAP1	719	723	PF00017	0.376
LIG_SH2_STAP1	806	810	PF00017	0.614
LIG_SH2_STAT3	606	609	PF00017	0.429
LIG_SH2_STAT5	590	593	PF00017	0.227
LIG_SH2_STAT5	806	809	PF00017	0.590
LIG_SH3_2	239	244	PF14604	0.707
LIG_SH3_3	190	196	PF00018	0.685
LIG_SH3_3	203	209	PF00018	0.703
LIG_SH3_3	235	241	PF00018	0.676
LIG_SH3_3	334	340	PF00018	0.746
LIG_TRAF2_1	172	175	PF00917	0.693
LIG_TRAF2_1	379	382	PF00917	0.703
LIG_TRAF2_1	503	506	PF00917	0.581
LIG_TYR_ITIM	717	722	PF00017	0.227
LIG_TYR_ITSM	586	593	PF00017	0.447
LIG_WRC_WIRS_1	487	492	PF05994	0.398
MOD_CDC14_SPxK_1	226	229	PF00782	0.486
MOD_CDK_SPK_2	538	543	PF00069	0.621
MOD_CDK_SPxK_1	223	229	PF00069	0.495
MOD_CDK_SPxxK_3	262	269	PF00069	0.737
MOD_CK1_1	111	117	PF00069	0.692
MOD_CK1_1	146	152	PF00069	0.650
MOD_CK1_1	169	175	PF00069	0.671
MOD_CK1_1	215	221	PF00069	0.601
MOD_CK1_1	280	286	PF00069	0.665
MOD_CK1_1	295	301	PF00069	0.652
MOD_CK1_1	304	310	PF00069	0.532
MOD_CK1_1	319	325	PF00069	0.595
MOD_CK1_1	338	344	PF00069	0.490
MOD_CK1_1	347	353	PF00069	0.588
MOD_CK1_1	386	392	PF00069	0.566
MOD_CK1_1	525	531	PF00069	0.425
MOD_CK1_1	63	69	PF00069	0.694
MOD_CK1_1	804	810	PF00069	0.591
MOD_CK2_1	146	152	PF00069	0.630
MOD_CK2_1	169	175	PF00069	0.698
MOD_CK2_1	251	257	PF00069	0.720
MOD_CK2_1	376	382	PF00069	0.664
MOD_CK2_1	525	531	PF00069	0.513
MOD_CK2_1	547	553	PF00069	0.679
MOD_CK2_1	74	80	PF00069	0.704
MOD_Cter_Amidation	439	442	PF01082	0.402
MOD_DYRK1A_RPxSP_1	282	286	PF00069	0.698
MOD_GlcNHglycan	106	109	PF01048	0.638
MOD_GlcNHglycan	115	118	PF01048	0.628
MOD_GlcNHglycan	181	185	PF01048	0.656
MOD_GlcNHglycan	262	265	PF01048	0.683
MOD_GlcNHglycan	318	321	PF01048	0.687
MOD_GlcNHglycan	355	358	PF01048	0.699
MOD_GlcNHglycan	362	365	PF01048	0.712
MOD_GlcNHglycan	368	371	PF01048	0.546
MOD_GlcNHglycan	519	522	PF01048	0.521
MOD_GlcNHglycan	71	74	PF01048	0.569
MOD_GlcNHglycan	9	12	PF01048	0.759
MOD_GlcNHglycan	99	102	PF01048	0.637
MOD_GSK3_1	104	111	PF00069	0.706
MOD_GSK3_1	144	151	PF00069	0.637
MOD_GSK3_1	195	202	PF00069	0.707
MOD_GSK3_1	208	215	PF00069	0.631
MOD_GSK3_1	216	223	PF00069	0.713
MOD_GSK3_1	268	275	PF00069	0.732
MOD_GSK3_1	278	285	PF00069	0.735
MOD_GSK3_1	293	300	PF00069	0.603
MOD_GSK3_1	301	308	PF00069	0.630
MOD_GSK3_1	310	317	PF00069	0.600
MOD_GSK3_1	346	353	PF00069	0.595
MOD_GSK3_1	360	367	PF00069	0.518
MOD_GSK3_1	372	379	PF00069	0.590
MOD_GSK3_1	450	457	PF00069	0.570
MOD_GSK3_1	47	54	PF00069	0.616
MOD_GSK3_1	497	504	PF00069	0.549
MOD_GSK3_1	517	524	PF00069	0.322
MOD_GSK3_1	63	70	PF00069	0.620
MOD_GSK3_1	728	735	PF00069	0.405
MOD_GSK3_1	813	820	PF00069	0.618
MOD_LATS_1	771	777	PF00433	0.590
MOD_N-GLC_1	126	131	PF02516	0.531
MOD_N-GLC_1	269	274	PF02516	0.526
MOD_N-GLC_1	277	282	PF02516	0.476
MOD_N-GLC_1	386	391	PF02516	0.537
MOD_N-GLC_1	430	435	PF02516	0.626
MOD_N-GLC_1	712	717	PF02516	0.392
MOD_N-GLC_1	74	79	PF02516	0.703
MOD_NEK2_1	14	19	PF00069	0.668
MOD_NEK2_1	268	273	PF00069	0.769
MOD_NEK2_1	292	297	PF00069	0.699
MOD_NEK2_1	454	459	PF00069	0.542
MOD_NEK2_1	508	513	PF00069	0.445
MOD_NEK2_1	67	72	PF00069	0.739
MOD_NEK2_1	7	12	PF00069	0.680
MOD_NEK2_1	703	708	PF00069	0.335
MOD_NEK2_1	732	737	PF00069	0.480
MOD_NEK2_1	784	789	PF00069	0.504
MOD_NEK2_2	232	237	PF00069	0.529
MOD_NEK2_2	251	256	PF00069	0.680
MOD_NEK2_2	557	562	PF00069	0.227
MOD_PIKK_1	402	408	PF00454	0.481
MOD_PIKK_1	508	514	PF00454	0.458
MOD_PK_1	376	382	PF00069	0.501
MOD_PK_1	479	485	PF00069	0.519
MOD_PKA_2	268	274	PF00069	0.649
MOD_PKA_2	360	366	PF00069	0.667
MOD_PKA_2	372	378	PF00069	0.672
MOD_PKA_2	508	514	PF00069	0.551
MOD_PKA_2	547	553	PF00069	0.580
MOD_PKA_2	7	13	PF00069	0.631
MOD_PKA_2	732	738	PF00069	0.335
MOD_Plk_1	386	392	PF00069	0.512
MOD_Plk_1	447	453	PF00069	0.555
MOD_Plk_1	45	51	PF00069	0.646
MOD_Plk_1	557	563	PF00069	0.349
MOD_Plk_1	63	69	PF00069	0.767
MOD_Plk_1	728	734	PF00069	0.493
MOD_Plk_1	74	80	PF00069	0.723
MOD_Plk_1	817	823	PF00069	0.698
MOD_Plk_4	208	214	PF00069	0.599
MOD_Plk_4	232	238	PF00069	0.776
MOD_Plk_4	251	257	PF00069	0.688
MOD_Plk_4	347	353	PF00069	0.714
MOD_Plk_4	405	411	PF00069	0.541
MOD_Plk_4	447	453	PF00069	0.553
MOD_Plk_4	479	485	PF00069	0.519
MOD_Plk_4	570	576	PF00069	0.330
MOD_Plk_4	634	640	PF00069	0.373
MOD_Plk_4	817	823	PF00069	0.670
MOD_ProDKin_1	108	114	PF00069	0.662
MOD_ProDKin_1	199	205	PF00069	0.718
MOD_ProDKin_1	216	222	PF00069	0.672
MOD_ProDKin_1	223	229	PF00069	0.665
MOD_ProDKin_1	262	268	PF00069	0.701
MOD_ProDKin_1	282	288	PF00069	0.706
MOD_ProDKin_1	301	307	PF00069	0.690
MOD_ProDKin_1	319	325	PF00069	0.665
MOD_ProDKin_1	47	53	PF00069	0.615
MOD_ProDKin_1	538	544	PF00069	0.594
MOD_ProDKin_1	562	568	PF00069	0.359
MOD_SUMO_for_1	561	564	PF00179	0.480
MOD_SUMO_rev_2	116	124	PF00179	0.728
MOD_SUMO_rev_2	139	147	PF00179	0.560
MOD_SUMO_rev_2	254	262	PF00179	0.752
MOD_SUMO_rev_2	473	481	PF00179	0.585
MOD_SUMO_rev_2	764	770	PF00179	0.547
MOD_SUMO_rev_2	793	802	PF00179	0.381
TRG_DiLeu_BaEn_1	152	157	PF01217	0.640
TRG_DiLeu_BaLyEn_6	217	222	PF01217	0.525
TRG_DiLeu_LyEn_5	152	157	PF01217	0.709
TRG_ENDOCYTIC_2	590	593	PF00928	0.355
TRG_ENDOCYTIC_2	719	722	PF00928	0.324
TRG_ER_diArg_1	160	163	PF00400	0.488
TRG_ER_diArg_1	372	374	PF00400	0.742
TRG_ER_diArg_1	410	413	PF00400	0.528
TRG_ER_diArg_1	456	459	PF00400	0.628
TRG_NES_CRM1_1	754	766	PF08389	0.345
TRG_NLS_MonoExtN_4	160	167	PF00514	0.494
TRG_NLS_MonoExtN_4	438	445	PF00514	0.412
TRG_Pf-PMV_PEXEL_1	155	159	PF00026	0.698

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9E7	Leptomonas seymouri	64%	100%
A0A1X0NW98	Trypanosomatidae	42%	100%
A0A3Q8ID17	Leishmania donovani	78%	100%
A0A3R7KXA1	Trypanosoma rangeli	44%	100%
A4I7R9	Leishmania infantum	78%	100%
D0A9X8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9B2M7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4Q5I0	Leishmania major	78%	98%
V5BQQ4	Trypanosoma cruzi	45%	100%