Tyrosine-protein phosphatase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tyrosine phosphatase family, putative

Species:

Leishmania braziliensis

UniProt:

A4HK83_LEIBR

TriTrypDb:

LbrM.32.1110 , LBRM2903_320016900

Length:

422

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HK83

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK83

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016787	hydrolase activity	2	3
GO:0016788	hydrolase activity, acting on ester bonds	3	3
GO:0016791	phosphatase activity	5	3
GO:0042578	phosphoric ester hydrolase activity	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	226	230	PF00656	0.585
CLV_NRD_NRD_1	118	120	PF00675	0.346
CLV_NRD_NRD_1	142	144	PF00675	0.282
CLV_NRD_NRD_1	208	210	PF00675	0.438
CLV_NRD_NRD_1	305	307	PF00675	0.516
CLV_PCSK_KEX2_1	118	120	PF00082	0.346
CLV_PCSK_KEX2_1	142	144	PF00082	0.282
CLV_PCSK_KEX2_1	208	210	PF00082	0.502
CLV_PCSK_KEX2_1	305	307	PF00082	0.516
CLV_PCSK_KEX2_1	60	62	PF00082	0.282
CLV_PCSK_PC1ET2_1	60	62	PF00082	0.282
CLV_PCSK_SKI1_1	60	64	PF00082	0.346
DEG_Kelch_actinfilin_1	300	304	PF01344	0.439
DOC_CYCLIN_RxL_1	106	117	PF00134	0.485
DOC_CYCLIN_RxL_1	57	66	PF00134	0.546
DOC_CYCLIN_yCln2_LP_2	12	15	PF00134	0.482
DOC_MAPK_gen_1	118	125	PF00069	0.546
DOC_MAPK_gen_1	164	174	PF00069	0.579
DOC_MAPK_MEF2A_6	167	174	PF00069	0.546
DOC_MAPK_NFAT4_5	167	175	PF00069	0.546
DOC_PP1_RVXF_1	108	115	PF00149	0.482
DOC_PP2B_LxvP_1	12	15	PF13499	0.479
DOC_PP2B_LxvP_1	283	286	PF13499	0.554
DOC_PP2B_LxvP_1	389	392	PF13499	0.531
DOC_PP4_FxxP_1	125	128	PF00568	0.482
DOC_USP7_MATH_1	183	187	PF00917	0.350
DOC_USP7_MATH_1	2	6	PF00917	0.500
DOC_USP7_MATH_1	240	244	PF00917	0.542
DOC_USP7_MATH_1	71	75	PF00917	0.421
DOC_WW_Pin1_4	275	280	PF00397	0.601
LIG_14-3-3_CanoR_1	222	231	PF00244	0.556
LIG_14-3-3_CanoR_1	367	372	PF00244	0.496
LIG_14-3-3_CanoR_1	408	412	PF00244	0.677
LIG_APCC_ABBA_1	170	175	PF00400	0.546
LIG_BIR_II_1	1	5	PF00653	0.488
LIG_BIR_III_1	1	5	PF00653	0.495
LIG_BIR_III_3	1	5	PF00653	0.495
LIG_BRCT_BRCA1_1	149	153	PF00533	0.600
LIG_BRCT_BRCA1_1	214	218	PF00533	0.497
LIG_Clathr_ClatBox_1	171	175	PF01394	0.546
LIG_Clathr_ClatBox_1	49	53	PF01394	0.482
LIG_deltaCOP1_diTrp_1	117	125	PF00928	0.482
LIG_EVH1_2	14	18	PF00568	0.482
LIG_FHA_1	132	138	PF00498	0.482
LIG_FHA_1	346	352	PF00498	0.430
LIG_FHA_1	43	49	PF00498	0.546
LIG_FHA_1	89	95	PF00498	0.471
LIG_LIR_Gen_1	157	166	PF02991	0.482
LIG_LIR_Gen_1	16	26	PF02991	0.546
LIG_LIR_Gen_1	338	347	PF02991	0.490
LIG_LIR_Nem_3	117	123	PF02991	0.482
LIG_LIR_Nem_3	157	162	PF02991	0.492
LIG_LIR_Nem_3	16	21	PF02991	0.572
LIG_LIR_Nem_3	338	342	PF02991	0.500
LIG_MYND_1	10	14	PF01753	0.321
LIG_Pex14_1	352	356	PF04695	0.378
LIG_Pex14_2	173	177	PF04695	0.546
LIG_SH2_CRK	159	163	PF00017	0.546
LIG_SH2_SRC	356	359	PF00017	0.476
LIG_SH2_STAT5	159	162	PF00017	0.571
LIG_SH2_STAT5	356	359	PF00017	0.570
LIG_SH2_STAT5	38	41	PF00017	0.482
LIG_SH3_3	273	279	PF00018	0.653
LIG_SUMO_SIM_anti_2	45	51	PF11976	0.546
LIG_SUMO_SIM_par_1	45	51	PF11976	0.485
LIG_TRAF2_1	204	207	PF00917	0.446
LIG_UBA3_1	248	257	PF00899	0.529
MOD_CDC14_SPxK_1	3	6	PF00782	0.484
MOD_CK1_1	223	229	PF00069	0.508
MOD_CK1_1	292	298	PF00069	0.524
MOD_CK1_1	372	378	PF00069	0.506
MOD_CK1_1	409	415	PF00069	0.603
MOD_CK1_1	65	71	PF00069	0.423
MOD_CK1_1	74	80	PF00069	0.308
MOD_CK2_1	151	157	PF00069	0.321
MOD_CK2_1	326	332	PF00069	0.651
MOD_CK2_1	335	341	PF00069	0.560
MOD_CK2_1	412	418	PF00069	0.583
MOD_CMANNOS	352	355	PF00535	0.384
MOD_GlcNHglycan	214	217	PF01048	0.590
MOD_GlcNHglycan	242	245	PF01048	0.737
MOD_GlcNHglycan	27	30	PF01048	0.320
MOD_GlcNHglycan	295	298	PF01048	0.597
MOD_GlcNHglycan	98	101	PF01048	0.321
MOD_GSK3_1	147	154	PF00069	0.411
MOD_GSK3_1	158	165	PF00069	0.501
MOD_GSK3_1	223	230	PF00069	0.658
MOD_GSK3_1	25	32	PF00069	0.325
MOD_GSK3_1	270	277	PF00069	0.714
MOD_GSK3_1	289	296	PF00069	0.620
MOD_GSK3_1	367	374	PF00069	0.508
MOD_GSK3_1	377	384	PF00069	0.631
MOD_GSK3_1	70	77	PF00069	0.472
MOD_N-GLC_1	220	225	PF02516	0.556
MOD_NEK2_1	158	163	PF00069	0.411
MOD_NEK2_1	166	171	PF00069	0.335
MOD_NEK2_2	148	153	PF00069	0.236
MOD_PKA_2	166	172	PF00069	0.321
MOD_PKA_2	223	229	PF00069	0.664
MOD_PKA_2	407	413	PF00069	0.681
MOD_Plk_1	270	276	PF00069	0.623
MOD_Plk_1	381	387	PF00069	0.504
MOD_Plk_2-3	227	233	PF00069	0.577
MOD_Plk_2-3	250	256	PF00069	0.529
MOD_Plk_4	148	154	PF00069	0.252
MOD_Plk_4	166	172	PF00069	0.321
MOD_Plk_4	258	264	PF00069	0.544
MOD_Plk_4	335	341	PF00069	0.574
MOD_Plk_4	412	418	PF00069	0.583
MOD_ProDKin_1	275	281	PF00069	0.602
MOD_SUMO_rev_2	250	259	PF00179	0.528
MOD_SUMO_rev_2	278	286	PF00179	0.546
MOD_SUMO_rev_2	338	348	PF00179	0.569
TRG_DiLeu_BaLyEn_6	58	63	PF01217	0.411
TRG_ENDOCYTIC_2	159	162	PF00928	0.459
TRG_ENDOCYTIC_2	269	272	PF00928	0.540
TRG_ER_diArg_1	118	120	PF00400	0.411
TRG_ER_diArg_1	141	143	PF00400	0.321
TRG_ER_diArg_1	191	194	PF00400	0.428
TRG_ER_diArg_1	304	306	PF00400	0.516
TRG_NLS_MonoExtN_4	208	213	PF00514	0.594
TRG_Pf-PMV_PEXEL_1	164	168	PF00026	0.411
TRG_Pf-PMV_PEXEL_1	61	66	PF00026	0.321

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE45	Leptomonas seymouri	58%	99%
A0A3Q8IT66	Leishmania donovani	76%	100%
A4I7R8	Leishmania infantum	77%	100%
E9B2M6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4Q5I1	Leishmania major	76%	100%