SB domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Vps23 core domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HK80_LEIBR

TriTrypDb:

LbrM.32.1080 , LBRM2903_320016200

Length:

409

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005768	endosome	7	12
GO:0031410	cytoplasmic vesicle	6	12
GO:0031982	vesicle	4	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0097708	intracellular vesicle	5	12
GO:0110165	cellular anatomical entity	1	12
GO:0000813	ESCRT I complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0036452	ESCRT complex	2	1
GO:0098796	membrane protein complex	2	1

Expansion

Sequence features

A4HK80

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK80

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	14
GO:0008104	protein localization	4	14
GO:0009987	cellular process	1	14
GO:0015031	protein transport	4	14
GO:0033036	macromolecule localization	2	14
GO:0045184	establishment of protein localization	3	14
GO:0051179	localization	1	14
GO:0051234	establishment of localization	2	14
GO:0051641	cellular localization	2	14
GO:0070727	cellular macromolecule localization	3	14
GO:0071702	organic substance transport	4	14
GO:0071705	nitrogen compound transport	4	14
GO:0007034	vacuolar transport	4	1
GO:0007041	lysosomal transport	5	1
GO:0008333	endosome to lysosome transport	5	1
GO:0016192	vesicle-mediated transport	4	1
GO:0046907	intracellular transport	3	1
GO:0051649	establishment of localization in cell	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0032182	ubiquitin-like protein binding	3	1
GO:0043130	ubiquitin binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	328	334	PF00089	0.348
CLV_NRD_NRD_1	65	67	PF00675	0.504
CLV_PCSK_KEX2_1	302	304	PF00082	0.308
CLV_PCSK_PC1ET2_1	302	304	PF00082	0.341
CLV_PCSK_SKI1_1	229	233	PF00082	0.451
CLV_PCSK_SKI1_1	303	307	PF00082	0.276
CLV_PCSK_SKI1_1	387	391	PF00082	0.400
CLV_PCSK_SKI1_1	405	409	PF00082	0.473
CLV_TASPASE1	255	261	PF01112	0.525
DEG_APCC_DBOX_1	116	124	PF00400	0.272
DEG_APCC_DBOX_1	386	394	PF00400	0.536
DEG_APCC_DBOX_1	400	408	PF00400	0.403
DEG_Nend_UBRbox_2	1	3	PF02207	0.527
DEG_SCF_FBW7_1	346	351	PF00400	0.522
DOC_CKS1_1	349	354	PF01111	0.676
DOC_CKS1_1	358	363	PF01111	0.668
DOC_CKS1_1	89	94	PF01111	0.566
DOC_CYCLIN_RxL_1	276	286	PF00134	0.442
DOC_CYCLIN_RxL_1	300	310	PF00134	0.376
DOC_CYCLIN_RxL_1	320	334	PF00134	0.541
DOC_CYCLIN_yCln2_LP_2	96	99	PF00134	0.463
DOC_MAPK_DCC_7	51	59	PF00069	0.306
DOC_MAPK_MEF2A_6	131	140	PF00069	0.331
DOC_MAPK_MEF2A_6	401	408	PF00069	0.318
DOC_PP1_RVXF_1	373	379	PF00149	0.324
DOC_PP1_RVXF_1	403	409	PF00149	0.327
DOC_PP2B_LxvP_1	96	99	PF13499	0.514
DOC_USP7_MATH_1	12	16	PF00917	0.315
DOC_USP7_MATH_1	162	166	PF00917	0.670
DOC_USP7_MATH_1	181	185	PF00917	0.618
DOC_USP7_MATH_1	35	39	PF00917	0.291
DOC_WW_Pin1_4	155	160	PF00397	0.560
DOC_WW_Pin1_4	344	349	PF00397	0.646
DOC_WW_Pin1_4	354	359	PF00397	0.745
DOC_WW_Pin1_4	45	50	PF00397	0.528
DOC_WW_Pin1_4	72	77	PF00397	0.475
DOC_WW_Pin1_4	88	93	PF00397	0.461
LIG_14-3-3_CanoR_1	182	186	PF00244	0.590
LIG_FHA_1	170	176	PF00498	0.568
LIG_FHA_1	258	264	PF00498	0.506
LIG_FHA_1	291	297	PF00498	0.562
LIG_FHA_1	369	375	PF00498	0.536
LIG_FHA_1	73	79	PF00498	0.458
LIG_FHA_2	260	266	PF00498	0.565
LIG_FHA_2	305	311	PF00498	0.508
LIG_FHA_2	358	364	PF00498	0.605
LIG_LIR_Apic_2	15	20	PF02991	0.506
LIG_LIR_Gen_1	130	141	PF02991	0.311
LIG_LIR_Gen_1	60	69	PF02991	0.498
LIG_LIR_LC3C_4	75	80	PF02991	0.495
LIG_LIR_Nem_3	130	136	PF02991	0.302
LIG_LIR_Nem_3	147	153	PF02991	0.410
LIG_LIR_Nem_3	15	21	PF02991	0.472
LIG_LIR_Nem_3	31	36	PF02991	0.256
LIG_LIR_Nem_3	60	65	PF02991	0.462
LIG_LYPXL_yS_3	150	153	PF13949	0.470
LIG_LYPXL_yS_3	18	21	PF13949	0.413
LIG_NRBOX	135	141	PF00104	0.360
LIG_OCRL_FandH_1	322	334	PF00620	0.472
LIG_PTAP_UEV_1	158	163	PF05743	0.442
LIG_Rb_LxCxE_1	304	321	PF01857	0.376
LIG_SH2_SRC	242	245	PF00017	0.598
LIG_SH2_STAP1	36	40	PF00017	0.501
LIG_SH2_STAT3	87	90	PF00017	0.511
LIG_SH2_STAT5	204	207	PF00017	0.385
LIG_SH2_STAT5	214	217	PF00017	0.403
LIG_SH2_STAT5	242	245	PF00017	0.598
LIG_SH2_STAT5	311	314	PF00017	0.458
LIG_SH2_STAT5	329	332	PF00017	0.393
LIG_SH3_1	66	72	PF00018	0.330
LIG_SH3_2	362	367	PF14604	0.718
LIG_SH3_3	126	132	PF00018	0.549
LIG_SH3_3	156	162	PF00018	0.496
LIG_SH3_3	269	275	PF00018	0.537
LIG_SH3_3	346	352	PF00018	0.606
LIG_SH3_3	355	361	PF00018	0.755
LIG_SH3_3	66	72	PF00018	0.388
LIG_SH3_3	92	98	PF00018	0.489
LIG_SUMO_SIM_anti_2	10	15	PF11976	0.452
LIG_SUMO_SIM_anti_2	290	299	PF11976	0.433
LIG_SUMO_SIM_anti_2	382	388	PF11976	0.485
LIG_SUMO_SIM_anti_2	75	82	PF11976	0.448
LIG_SUMO_SIM_par_1	137	144	PF11976	0.333
LIG_SUMO_SIM_par_1	193	199	PF11976	0.504
LIG_SUMO_SIM_par_1	290	299	PF11976	0.467
LIG_SUMO_SIM_par_1	75	82	PF11976	0.448
LIG_TRAF2_1	262	265	PF00917	0.594
LIG_TYR_ITIM	148	153	PF00017	0.497
LIG_WRC_WIRS_1	80	85	PF05994	0.493
MOD_CDK_SPxK_1	45	51	PF00069	0.410
MOD_CK1_1	110	116	PF00069	0.500
MOD_CK1_1	169	175	PF00069	0.708
MOD_CK1_1	24	30	PF00069	0.453
MOD_CK1_1	290	296	PF00069	0.433
MOD_CK1_1	357	363	PF00069	0.716
MOD_CK2_1	218	224	PF00069	0.486
MOD_CK2_1	259	265	PF00069	0.541
MOD_CK2_1	304	310	PF00069	0.409
MOD_CK2_1	357	363	PF00069	0.783
MOD_GlcNHglycan	159	162	PF01048	0.593
MOD_GlcNHglycan	21	24	PF01048	0.370
MOD_GlcNHglycan	379	382	PF01048	0.461
MOD_GlcNHglycan	92	95	PF01048	0.495
MOD_GSK3_1	162	169	PF00069	0.620
MOD_GSK3_1	24	31	PF00069	0.375
MOD_GSK3_1	332	339	PF00069	0.423
MOD_GSK3_1	344	351	PF00069	0.651
MOD_N-GLC_1	155	160	PF02516	0.532
MOD_N-GLC_1	218	223	PF02516	0.540
MOD_N-GLC_1	247	252	PF02516	0.553
MOD_NEK2_1	1	6	PF00069	0.466
MOD_NEK2_1	170	175	PF00069	0.487
MOD_NEK2_1	218	223	PF00069	0.540
MOD_NEK2_1	336	341	PF00069	0.532
MOD_PIKK_1	12	18	PF00454	0.453
MOD_PIKK_1	3	9	PF00454	0.485
MOD_PKA_1	313	319	PF00069	0.380
MOD_PKA_2	181	187	PF00069	0.551
MOD_PKA_2	330	336	PF00069	0.436
MOD_Plk_1	1	7	PF00069	0.466
MOD_Plk_1	247	253	PF00069	0.546
MOD_Plk_1	290	296	PF00069	0.508
MOD_Plk_1	395	401	PF00069	0.444
MOD_Plk_4	107	113	PF00069	0.455
MOD_Plk_4	121	127	PF00069	0.300
MOD_Plk_4	181	187	PF00069	0.497
MOD_Plk_4	248	254	PF00069	0.495
MOD_ProDKin_1	155	161	PF00069	0.567
MOD_ProDKin_1	344	350	PF00069	0.650
MOD_ProDKin_1	354	360	PF00069	0.780
MOD_ProDKin_1	45	51	PF00069	0.542
MOD_ProDKin_1	72	78	PF00069	0.472
MOD_ProDKin_1	88	94	PF00069	0.458
MOD_SUMO_for_1	301	304	PF00179	0.541
MOD_SUMO_rev_2	103	108	PF00179	0.338
TRG_DiLeu_BaEn_2	120	126	PF01217	0.495
TRG_DiLeu_BaLyEn_6	73	78	PF01217	0.512
TRG_ENDOCYTIC_2	109	112	PF00928	0.509
TRG_ENDOCYTIC_2	133	136	PF00928	0.317
TRG_ENDOCYTIC_2	150	153	PF00928	0.292
TRG_ENDOCYTIC_2	18	21	PF00928	0.446
TRG_ENDOCYTIC_2	329	332	PF00928	0.567
TRG_NES_CRM1_1	137	149	PF08389	0.378
TRG_NES_CRM1_1	388	403	PF08389	0.585

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P9L8	Leptomonas seymouri	69%	100%
A0A0S4KPG1	Bodo saltans	28%	84%
A0A1X0NUL1	Trypanosomatidae	31%	90%
A0A1X0NUM5	Trypanosomatidae	36%	96%
A0A3Q8IJ55	Leishmania donovani	80%	100%
A0A422P1F9	Trypanosoma rangeli	28%	100%
A0A422P1H3	Trypanosoma rangeli	33%	96%
A4I7R5	Leishmania infantum	80%	100%
D0A9X4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	90%
E9AEF7	Leishmania major	78%	100%
E9B2M3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
V5BQQ0	Trypanosoma cruzi	33%	96%