RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HK79_LEIBR

TriTrypDb:

LbrM.32.1070 , LBRM2903_320016100

Length:

555

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HK79

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK79

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	5
GO:0005488	binding	1	5
GO:0097159	organic cyclic compound binding	2	5
GO:1901363	heterocyclic compound binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	34	38	PF00656	0.588
CLV_NRD_NRD_1	551	553	PF00675	0.603
CLV_PCSK_KEX2_1	241	243	PF00082	0.404
CLV_PCSK_KEX2_1	551	553	PF00082	0.615
CLV_PCSK_PC1ET2_1	241	243	PF00082	0.404
CLV_PCSK_SKI1_1	160	164	PF00082	0.431
CLV_PCSK_SKI1_1	212	216	PF00082	0.487
CLV_PCSK_SKI1_1	241	245	PF00082	0.399
CLV_PCSK_SKI1_1	278	282	PF00082	0.446
DEG_APCC_DBOX_1	269	277	PF00400	0.502
DEG_ODPH_VHL_1	92	103	PF01847	0.508
DEG_SPOP_SBC_1	122	126	PF00917	0.708
DEG_SPOP_SBC_1	393	397	PF00917	0.564
DOC_CKS1_1	39	44	PF01111	0.666
DOC_CYCLIN_RxL_1	152	161	PF00134	0.476
DOC_MAPK_gen_1	219	228	PF00069	0.465
DOC_PP2B_LxvP_1	427	430	PF13499	0.486
DOC_PP2B_LxvP_1	46	49	PF13499	0.579
DOC_PP2B_LxvP_1	91	94	PF13499	0.516
DOC_PP4_MxPP_1	327	330	PF00568	0.476
DOC_USP7_MATH_1	122	126	PF00917	0.793
DOC_USP7_MATH_1	401	405	PF00917	0.496
DOC_USP7_MATH_1	519	523	PF00917	0.611
DOC_USP7_MATH_1	75	79	PF00917	0.684
DOC_USP7_MATH_1	81	85	PF00917	0.507
DOC_USP7_MATH_1	94	98	PF00917	0.768
DOC_WW_Pin1_4	127	132	PF00397	0.660
DOC_WW_Pin1_4	147	152	PF00397	0.425
DOC_WW_Pin1_4	284	289	PF00397	0.488
DOC_WW_Pin1_4	301	306	PF00397	0.661
DOC_WW_Pin1_4	315	320	PF00397	0.632
DOC_WW_Pin1_4	356	361	PF00397	0.625
DOC_WW_Pin1_4	38	43	PF00397	0.663
DOC_WW_Pin1_4	444	449	PF00397	0.721
DOC_WW_Pin1_4	496	501	PF00397	0.521
DOC_WW_Pin1_4	96	101	PF00397	0.597
LIG_14-3-3_CanoR_1	293	301	PF00244	0.553
LIG_14-3-3_CterR_2	551	555	PF00244	0.507
LIG_Actin_WH2_2	258	276	PF00022	0.476
LIG_APCC_ABBA_1	168	173	PF00400	0.519
LIG_BIR_II_1	1	5	PF00653	0.626
LIG_BIR_III_2	37	41	PF00653	0.507
LIG_BRCT_BRCA1_1	155	159	PF00533	0.493
LIG_EH1_1	85	93	PF00400	0.521
LIG_EVH1_2	329	333	PF00568	0.488
LIG_FHA_1	12	18	PF00498	0.746
LIG_FHA_1	232	238	PF00498	0.449
LIG_FHA_1	305	311	PF00498	0.573
LIG_FHA_1	329	335	PF00498	0.520
LIG_FHA_1	362	368	PF00498	0.506
LIG_FHA_1	388	394	PF00498	0.562
LIG_FHA_1	39	45	PF00498	0.669
LIG_FHA_2	32	38	PF00498	0.712
LIG_LIR_Apic_2	404	410	PF02991	0.548
LIG_LIR_Gen_1	21	30	PF02991	0.520
LIG_LIR_Gen_1	222	233	PF02991	0.402
LIG_LIR_Gen_1	43	49	PF02991	0.565
LIG_LIR_Gen_1	432	441	PF02991	0.500
LIG_LIR_Gen_1	483	492	PF02991	0.423
LIG_LIR_Nem_3	156	162	PF02991	0.484
LIG_LIR_Nem_3	21	26	PF02991	0.589
LIG_LIR_Nem_3	222	228	PF02991	0.410
LIG_LIR_Nem_3	43	48	PF02991	0.571
LIG_LIR_Nem_3	432	436	PF02991	0.621
LIG_LIR_Nem_3	502	508	PF02991	0.511
LIG_PCNA_PIPBox_1	1	10	PF02747	0.492
LIG_PCNA_PIPBox_1	479	488	PF02747	0.416
LIG_PCNA_yPIPBox_3	85	98	PF02747	0.514
LIG_Rb_pABgroove_1	2	10	PF01858	0.489
LIG_SH2_CRK	144	148	PF00017	0.555
LIG_SH2_CRK	407	411	PF00017	0.514
LIG_SH2_GRB2like	144	147	PF00017	0.593
LIG_SH2_NCK_1	144	148	PF00017	0.528
LIG_SH2_SRC	144	147	PF00017	0.582
LIG_SH2_SRC	349	352	PF00017	0.499
LIG_SH2_STAP1	144	148	PF00017	0.528
LIG_SH2_STAT5	309	312	PF00017	0.606
LIG_SH2_STAT5	349	352	PF00017	0.499
LIG_SH2_STAT5	485	488	PF00017	0.475
LIG_SH3_1	383	389	PF00018	0.664
LIG_SH3_3	383	389	PF00018	0.724
LIG_SH3_3	442	448	PF00018	0.675
LIG_SH3_3	454	460	PF00018	0.571
LIG_SH3_3	494	500	PF00018	0.600
LIG_SUMO_SIM_par_1	478	483	PF11976	0.551
LIG_TYR_ITIM	503	508	PF00017	0.507
MOD_CDK_SPK_2	127	132	PF00069	0.540
MOD_CDK_SPxxK_3	284	291	PF00069	0.569
MOD_CDK_SPxxK_3	444	451	PF00069	0.690
MOD_CK1_1	126	132	PF00069	0.657
MOD_CK1_1	137	143	PF00069	0.770
MOD_CK1_1	292	298	PF00069	0.769
MOD_CK1_1	299	305	PF00069	0.575
MOD_CK1_1	537	543	PF00069	0.762
MOD_CK1_1	55	61	PF00069	0.696
MOD_CK1_1	99	105	PF00069	0.713
MOD_CK2_1	185	191	PF00069	0.425
MOD_CK2_1	429	435	PF00069	0.648
MOD_GlcNHglycan	1	4	PF01048	0.633
MOD_GlcNHglycan	341	344	PF01048	0.610
MOD_GlcNHglycan	351	355	PF01048	0.624
MOD_GlcNHglycan	396	399	PF01048	0.559
MOD_GlcNHglycan	452	456	PF01048	0.712
MOD_GlcNHglycan	508	511	PF01048	0.575
MOD_GlcNHglycan	526	529	PF01048	0.527
MOD_GlcNHglycan	61	64	PF01048	0.778
MOD_GlcNHglycan	88	91	PF01048	0.530
MOD_GSK3_1	11	18	PF00069	0.503
MOD_GSK3_1	118	125	PF00069	0.678
MOD_GSK3_1	127	134	PF00069	0.654
MOD_GSK3_1	289	296	PF00069	0.744
MOD_GSK3_1	300	307	PF00069	0.604
MOD_GSK3_1	389	396	PF00069	0.577
MOD_GSK3_1	461	468	PF00069	0.593
MOD_GSK3_1	524	531	PF00069	0.595
MOD_GSK3_1	535	542	PF00069	0.659
MOD_GSK3_1	55	62	PF00069	0.583
MOD_GSK3_1	71	78	PF00069	0.652
MOD_LATS_1	217	223	PF00433	0.517
MOD_N-GLC_1	132	137	PF02516	0.673
MOD_N-GLC_1	299	304	PF02516	0.743
MOD_N-GLC_1	31	36	PF02516	0.508
MOD_NEK2_1	118	123	PF00069	0.696
MOD_NEK2_1	237	242	PF00069	0.409
MOD_NEK2_1	320	325	PF00069	0.661
MOD_NEK2_1	350	355	PF00069	0.605
MOD_NEK2_1	361	366	PF00069	0.480
MOD_NEK2_1	378	383	PF00069	0.741
MOD_NEK2_1	394	399	PF00069	0.577
MOD_NEK2_1	480	485	PF00069	0.522
MOD_NEK2_1	59	64	PF00069	0.700
MOD_NEK2_1	71	76	PF00069	0.616
MOD_NEK2_2	389	394	PF00069	0.670
MOD_OFUCOSY	216	223	PF10250	0.528
MOD_PIKK_1	123	129	PF00454	0.689
MOD_PIKK_1	132	138	PF00454	0.700
MOD_PIKK_1	253	259	PF00454	0.364
MOD_PIKK_1	480	486	PF00454	0.578
MOD_PIKK_1	81	87	PF00454	0.511
MOD_PKA_2	292	298	PF00069	0.698
MOD_Plk_1	31	37	PF00069	0.631
MOD_Plk_1	350	356	PF00069	0.630
MOD_Plk_1	379	385	PF00069	0.585
MOD_Plk_1	55	61	PF00069	0.541
MOD_Plk_1	71	77	PF00069	0.602
MOD_Plk_2-3	31	37	PF00069	0.545
MOD_Plk_4	18	24	PF00069	0.491
MOD_Plk_4	320	326	PF00069	0.717
MOD_Plk_4	328	334	PF00069	0.640
MOD_Plk_4	389	395	PF00069	0.683
MOD_Plk_4	40	46	PF00069	0.572
MOD_Plk_4	402	408	PF00069	0.480
MOD_Plk_4	458	464	PF00069	0.562
MOD_ProDKin_1	127	133	PF00069	0.660
MOD_ProDKin_1	147	153	PF00069	0.415
MOD_ProDKin_1	284	290	PF00069	0.501
MOD_ProDKin_1	301	307	PF00069	0.661
MOD_ProDKin_1	315	321	PF00069	0.630
MOD_ProDKin_1	356	362	PF00069	0.628
MOD_ProDKin_1	38	44	PF00069	0.667
MOD_ProDKin_1	444	450	PF00069	0.726
MOD_ProDKin_1	496	502	PF00069	0.513
MOD_ProDKin_1	96	102	PF00069	0.601
MOD_SUMO_rev_2	537	542	PF00179	0.618
TRG_ENDOCYTIC_2	144	147	PF00928	0.560
TRG_ENDOCYTIC_2	309	312	PF00928	0.606
TRG_ENDOCYTIC_2	349	352	PF00928	0.499
TRG_ENDOCYTIC_2	485	488	PF00928	0.448
TRG_ENDOCYTIC_2	505	508	PF00928	0.502
TRG_Pf-PMV_PEXEL_1	242	246	PF00026	0.374

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMP7	Leptomonas seymouri	52%	99%
A0A1X0NUL4	Trypanosomatidae	34%	87%
A0A3S7X5C4	Leishmania donovani	74%	99%
A4I7R4	Leishmania infantum	75%	99%
E9B2M2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	99%
Q4Q5I4	Leishmania major	74%	100%