Staphylococcal nuclease domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Staphylococcal nuclease homologue/Tudor domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HK76_LEIBR

TriTrypDb:

LbrM.32.1040 , LBRM2903_320015800

Length:

934

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 4
Pissara et al.	yes	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0016442	RISC complex	4	11
GO:0031332	RNAi effector complex	3	11
GO:0032991	protein-containing complex	1	11
GO:0110165	cellular anatomical entity	1	11
GO:1990904	ribonucleoprotein complex	2	11
GO:0005634	nucleus	5	1
GO:0005829	cytosol	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A4HK76

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK76

Function

Biological processes
Term	Name	Level	Count
GO:0009892	negative regulation of metabolic process	4	11
GO:0010468	regulation of gene expression	5	11
GO:0010605	negative regulation of macromolecule metabolic process	5	11
GO:0010629	negative regulation of gene expression	6	11
GO:0019222	regulation of metabolic process	3	11
GO:0031047	RNA-mediated gene silencing	7	11
GO:0048519	negative regulation of biological process	3	11
GO:0050789	regulation of biological process	2	11
GO:0060255	regulation of macromolecule metabolic process	4	11
GO:0065007	biological regulation	1	11
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006401	RNA catabolic process	5	1
GO:0006402	mRNA catabolic process	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0019439	aromatic compound catabolic process	4	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046700	heterocycle catabolic process	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004518	nuclease activity	4	11
GO:0016787	hydrolase activity	2	11
GO:0016788	hydrolase activity, acting on ester bonds	3	11
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	205	209	PF00656	0.669
CLV_C14_Caspase3-7	236	240	PF00656	0.388
CLV_C14_Caspase3-7	327	331	PF00656	0.578
CLV_C14_Caspase3-7	345	349	PF00656	0.680
CLV_C14_Caspase3-7	627	631	PF00656	0.383
CLV_C14_Caspase3-7	928	932	PF00656	0.492
CLV_NRD_NRD_1	136	138	PF00675	0.461
CLV_NRD_NRD_1	385	387	PF00675	0.341
CLV_NRD_NRD_1	42	44	PF00675	0.388
CLV_NRD_NRD_1	894	896	PF00675	0.581
CLV_NRD_NRD_1	914	916	PF00675	0.268
CLV_PCSK_KEX2_1	385	387	PF00082	0.341
CLV_PCSK_KEX2_1	42	44	PF00082	0.354
CLV_PCSK_KEX2_1	894	896	PF00082	0.548
CLV_PCSK_SKI1_1	13	17	PF00082	0.533
CLV_PCSK_SKI1_1	138	142	PF00082	0.433
CLV_PCSK_SKI1_1	150	154	PF00082	0.527
CLV_PCSK_SKI1_1	224	228	PF00082	0.318
CLV_PCSK_SKI1_1	229	233	PF00082	0.357
CLV_PCSK_SKI1_1	28	32	PF00082	0.331
CLV_PCSK_SKI1_1	421	425	PF00082	0.354
CLV_PCSK_SKI1_1	43	47	PF00082	0.294
CLV_PCSK_SKI1_1	607	611	PF00082	0.474
CLV_PCSK_SKI1_1	666	670	PF00082	0.445
CLV_PCSK_SKI1_1	682	686	PF00082	0.413
DEG_APCC_DBOX_1	385	393	PF00400	0.450
DEG_APCC_DBOX_1	526	534	PF00400	0.528
DEG_APCC_KENBOX_2	563	567	PF00400	0.501
DEG_COP1_1	870	880	PF00400	0.574
DOC_CDC14_PxL_1	34	42	PF14671	0.388
DOC_CKS1_1	576	581	PF01111	0.369
DOC_CYCLIN_RxL_1	134	144	PF00134	0.462
DOC_CYCLIN_RxL_1	884	893	PF00134	0.536
DOC_MAPK_gen_1	447	457	PF00069	0.378
DOC_MAPK_gen_1	525	532	PF00069	0.447
DOC_MAPK_gen_1	780	788	PF00069	0.517
DOC_MAPK_MEF2A_6	178	186	PF00069	0.485
DOC_MAPK_MEF2A_6	458	466	PF00069	0.474
DOC_MAPK_MEF2A_6	546	553	PF00069	0.468
DOC_MAPK_MEF2A_6	564	573	PF00069	0.433
DOC_PP1_RVXF_1	430	437	PF00149	0.493
DOC_PP1_RVXF_1	68	75	PF00149	0.354
DOC_PP2B_LxvP_1	776	779	PF13499	0.587
DOC_PP4_FxxP_1	567	570	PF00568	0.396
DOC_USP7_MATH_1	251	255	PF00917	0.415
DOC_USP7_MATH_1	284	288	PF00917	0.506
DOC_USP7_MATH_1	748	752	PF00917	0.361
DOC_USP7_UBL2_3	262	266	PF12436	0.501
DOC_USP7_UBL2_3	498	502	PF12436	0.478
DOC_WW_Pin1_4	153	158	PF00397	0.457
DOC_WW_Pin1_4	178	183	PF00397	0.455
DOC_WW_Pin1_4	247	252	PF00397	0.431
DOC_WW_Pin1_4	347	352	PF00397	0.723
DOC_WW_Pin1_4	403	408	PF00397	0.354
DOC_WW_Pin1_4	47	52	PF00397	0.462
DOC_WW_Pin1_4	505	510	PF00397	0.654
DOC_WW_Pin1_4	575	580	PF00397	0.369
DOC_WW_Pin1_4	750	755	PF00397	0.562
DOC_WW_Pin1_4	814	819	PF00397	0.560
LIG_14-3-3_CanoR_1	150	156	PF00244	0.563
LIG_14-3-3_CanoR_1	385	390	PF00244	0.443
LIG_14-3-3_CanoR_1	410	414	PF00244	0.349
LIG_14-3-3_CanoR_1	450	456	PF00244	0.430
LIG_14-3-3_CanoR_1	527	533	PF00244	0.569
LIG_14-3-3_CanoR_1	64	68	PF00244	0.369
LIG_14-3-3_CanoR_1	772	776	PF00244	0.598
LIG_14-3-3_CanoR_1	894	901	PF00244	0.555
LIG_Actin_WH2_2	530	548	PF00022	0.473
LIG_Actin_WH2_2	816	832	PF00022	0.585
LIG_AP2alpha_2	590	592	PF02296	0.411
LIG_APCC_ABBA_1	433	438	PF00400	0.287
LIG_APCC_ABBAyCdc20_2	432	438	PF00400	0.287
LIG_BIR_II_1	1	5	PF00653	0.433
LIG_BRCT_BRCA1_1	579	583	PF00533	0.439
LIG_CAP-Gly_1	928	934	PF01302	0.717
LIG_CtBP_PxDLS_1	157	161	PF00389	0.624
LIG_deltaCOP1_diTrp_1	415	423	PF00928	0.369
LIG_EH1_1	219	227	PF00400	0.501
LIG_eIF4E_1	123	129	PF01652	0.248
LIG_eIF4E_1	57	63	PF01652	0.474
LIG_FHA_1	181	187	PF00498	0.452
LIG_FHA_1	269	275	PF00498	0.430
LIG_FHA_1	354	360	PF00498	0.595
LIG_FHA_1	371	377	PF00498	0.422
LIG_FHA_1	444	450	PF00498	0.354
LIG_FHA_1	452	458	PF00498	0.354
LIG_FHA_1	473	479	PF00498	0.356
LIG_FHA_1	608	614	PF00498	0.439
LIG_FHA_1	697	703	PF00498	0.451
LIG_FHA_1	792	798	PF00498	0.560
LIG_FHA_1	97	103	PF00498	0.501
LIG_FHA_2	107	113	PF00498	0.386
LIG_FHA_2	154	160	PF00498	0.431
LIG_FHA_2	18	24	PF00498	0.621
LIG_FHA_2	203	209	PF00498	0.519
LIG_FHA_2	274	280	PF00498	0.489
LIG_FHA_2	343	349	PF00498	0.690
LIG_FHA_2	410	416	PF00498	0.355
LIG_FHA_2	48	54	PF00498	0.447
LIG_FHA_2	625	631	PF00498	0.457
LIG_HCF-1_HBM_1	865	868	PF13415	0.320
LIG_IRF3_LxIS_1	182	188	PF10401	0.505
LIG_KLC1_Yacidic_2	76	81	PF13176	0.474
LIG_LIR_Apic_2	565	570	PF02991	0.399
LIG_LIR_Gen_1	124	133	PF02991	0.412
LIG_LIR_Gen_1	239	249	PF02991	0.439
LIG_LIR_Gen_1	261	272	PF02991	0.411
LIG_LIR_Gen_1	438	444	PF02991	0.434
LIG_LIR_Gen_1	470	478	PF02991	0.340
LIG_LIR_Gen_1	641	649	PF02991	0.411
LIG_LIR_Gen_1	785	796	PF02991	0.561
LIG_LIR_Gen_1	810	819	PF02991	0.554
LIG_LIR_Gen_1	862	872	PF02991	0.308
LIG_LIR_Nem_3	121	126	PF02991	0.373
LIG_LIR_Nem_3	2	6	PF02991	0.404
LIG_LIR_Nem_3	239	244	PF02991	0.359
LIG_LIR_Nem_3	26	30	PF02991	0.557
LIG_LIR_Nem_3	261	267	PF02991	0.411
LIG_LIR_Nem_3	412	416	PF02991	0.354
LIG_LIR_Nem_3	438	442	PF02991	0.434
LIG_LIR_Nem_3	470	476	PF02991	0.340
LIG_LIR_Nem_3	641	646	PF02991	0.411
LIG_LIR_Nem_3	705	711	PF02991	0.458
LIG_LIR_Nem_3	785	791	PF02991	0.512
LIG_LIR_Nem_3	810	814	PF02991	0.554
LIG_LIR_Nem_3	817	823	PF02991	0.557
LIG_LIR_Nem_3	835	841	PF02991	0.361
LIG_LIR_Nem_3	862	867	PF02991	0.424
LIG_REV1ctd_RIR_1	218	228	PF16727	0.501
LIG_REV1ctd_RIR_1	474	484	PF16727	0.411
LIG_SH2_CRK	355	359	PF00017	0.507
LIG_SH2_CRK	439	443	PF00017	0.411
LIG_SH2_CRK	811	815	PF00017	0.585
LIG_SH2_NCK_1	57	61	PF00017	0.474
LIG_SH2_NCK_1	728	732	PF00017	0.556
LIG_SH2_NCK_1	869	873	PF00017	0.473
LIG_SH2_PTP2	264	267	PF00017	0.469
LIG_SH2_PTP2	299	302	PF00017	0.662
LIG_SH2_SRC	299	302	PF00017	0.626
LIG_SH2_SRC	728	731	PF00017	0.412
LIG_SH2_SRC	79	82	PF00017	0.447
LIG_SH2_STAP1	416	420	PF00017	0.354
LIG_SH2_STAP1	439	443	PF00017	0.411
LIG_SH2_STAP1	473	477	PF00017	0.411
LIG_SH2_STAP1	55	59	PF00017	0.466
LIG_SH2_STAT5	155	158	PF00017	0.525
LIG_SH2_STAT5	264	267	PF00017	0.469
LIG_SH2_STAT5	299	302	PF00017	0.662
LIG_SH2_STAT5	3	6	PF00017	0.405
LIG_SH2_STAT5	34	37	PF00017	0.439
LIG_SH2_STAT5	355	358	PF00017	0.575
LIG_SH2_STAT5	428	431	PF00017	0.380
LIG_SH2_STAT5	529	532	PF00017	0.433
LIG_SH2_STAT5	561	564	PF00017	0.442
LIG_SH2_STAT5	711	714	PF00017	0.460
LIG_SH2_STAT5	752	755	PF00017	0.455
LIG_SH2_STAT5	79	82	PF00017	0.360
LIG_SH2_STAT5	828	831	PF00017	0.504
LIG_SH2_STAT5	869	872	PF00017	0.436
LIG_SH3_1	506	512	PF00018	0.657
LIG_SH3_1	803	809	PF00018	0.522
LIG_SH3_2	509	514	PF14604	0.627
LIG_SH3_3	176	182	PF00018	0.420
LIG_SH3_3	314	320	PF00018	0.639
LIG_SH3_3	331	337	PF00018	0.753
LIG_SH3_3	48	54	PF00018	0.400
LIG_SH3_3	506	512	PF00018	0.585
LIG_SH3_3	549	555	PF00018	0.495
LIG_SH3_3	557	563	PF00018	0.294
LIG_SH3_3	803	809	PF00018	0.523
LIG_SUMO_SIM_anti_2	183	188	PF11976	0.481
LIG_SUMO_SIM_anti_2	635	641	PF11976	0.474
LIG_SUMO_SIM_par_1	181	188	PF11976	0.426
LIG_SUMO_SIM_par_1	244	250	PF11976	0.474
LIG_SUMO_SIM_par_1	372	379	PF11976	0.480
LIG_TRAF2_1	156	159	PF00917	0.586
LIG_TRAF2_1	254	257	PF00917	0.501
LIG_TRAF2_1	497	500	PF00917	0.473
LIG_TRAF2_1	50	53	PF00917	0.474
LIG_TRAF2_1	845	848	PF00917	0.545
LIG_TRAF2_1	909	912	PF00917	0.565
LIG_TYR_ITIM	233	238	PF00017	0.474
LIG_UBA3_1	184	190	PF00899	0.554
LIG_UBA3_1	245	252	PF00899	0.501
LIG_WRC_WIRS_1	473	478	PF05994	0.369
LIG_WRC_WIRS_1	529	534	PF05994	0.441
LIG_WW_3	114	118	PF00397	0.439
MOD_CDK_SPK_2	247	252	PF00069	0.431
MOD_CDK_SPK_2	750	755	PF00069	0.562
MOD_CDK_SPxK_1	750	756	PF00069	0.562
MOD_CDK_SPxxK_3	403	410	PF00069	0.354
MOD_CK1_1	127	133	PF00069	0.436
MOD_CK1_1	213	219	PF00069	0.387
MOD_CK1_1	247	253	PF00069	0.354
MOD_CK1_1	283	289	PF00069	0.509
MOD_CK1_1	406	412	PF00069	0.369
MOD_CK1_1	624	630	PF00069	0.445
MOD_CK2_1	153	159	PF00069	0.435
MOD_CK2_1	171	177	PF00069	0.538
MOD_CK2_1	185	191	PF00069	0.535
MOD_CK2_1	251	257	PF00069	0.501
MOD_CK2_1	47	53	PF00069	0.405
MOD_CK2_1	847	853	PF00069	0.605
MOD_CK2_1	876	882	PF00069	0.477
MOD_GlcNHglycan	129	132	PF01048	0.392
MOD_GlcNHglycan	141	144	PF01048	0.479
MOD_GlcNHglycan	282	285	PF01048	0.512
MOD_GlcNHglycan	286	289	PF01048	0.487
MOD_GlcNHglycan	579	582	PF01048	0.440
MOD_GlcNHglycan	662	665	PF01048	0.362
MOD_GlcNHglycan	673	676	PF01048	0.596
MOD_GlcNHglycan	764	767	PF01048	0.374
MOD_GlcNHglycan	830	833	PF01048	0.644
MOD_GlcNHglycan	85	88	PF01048	0.397
MOD_GlcNHglycan	896	899	PF01048	0.576
MOD_GSK3_1	199	206	PF00069	0.515
MOD_GSK3_1	247	254	PF00069	0.361
MOD_GSK3_1	268	275	PF00069	0.382
MOD_GSK3_1	280	287	PF00069	0.359
MOD_GSK3_1	43	50	PF00069	0.511
MOD_GSK3_1	762	769	PF00069	0.557
MOD_GSK3_1	867	874	PF00069	0.403
MOD_GSK3_1	876	883	PF00069	0.445
MOD_N-GLC_1	210	215	PF02516	0.400
MOD_N-GLC_1	268	273	PF02516	0.413
MOD_N-GLC_1	632	637	PF02516	0.411
MOD_N-GLC_1	743	748	PF02516	0.603
MOD_NEK2_1	185	190	PF00069	0.443
MOD_NEK2_1	192	197	PF00069	0.421
MOD_NEK2_1	361	366	PF00069	0.447
MOD_NEK2_1	423	428	PF00069	0.404
MOD_NEK2_1	451	456	PF00069	0.490
MOD_NEK2_1	521	526	PF00069	0.533
MOD_NEK2_1	62	67	PF00069	0.388
MOD_NEK2_1	622	627	PF00069	0.369
MOD_NEK2_1	702	707	PF00069	0.521
MOD_NEK2_1	743	748	PF00069	0.551
MOD_NEK2_1	83	88	PF00069	0.420
MOD_NEK2_1	880	885	PF00069	0.494
MOD_NEK2_2	472	477	PF00069	0.411
MOD_PIKK_1	192	198	PF00454	0.491
MOD_PKA_1	385	391	PF00069	0.326
MOD_PKA_1	894	900	PF00069	0.599
MOD_PKA_2	385	391	PF00069	0.437
MOD_PKA_2	392	398	PF00069	0.468
MOD_PKA_2	409	415	PF00069	0.299
MOD_PKA_2	63	69	PF00069	0.369
MOD_PKA_2	748	754	PF00069	0.489
MOD_PKA_2	771	777	PF00069	0.598
MOD_PKA_2	894	900	PF00069	0.591
MOD_Plk_1	210	216	PF00069	0.651
MOD_Plk_1	268	274	PF00069	0.440
MOD_Plk_1	414	420	PF00069	0.458
MOD_Plk_1	632	638	PF00069	0.411
MOD_Plk_1	703	709	PF00069	0.507
MOD_Plk_1	766	772	PF00069	0.509
MOD_Plk_2-3	847	853	PF00069	0.605
MOD_Plk_4	124	130	PF00069	0.411
MOD_Plk_4	180	186	PF00069	0.438
MOD_Plk_4	30	36	PF00069	0.449
MOD_Plk_4	361	367	PF00069	0.501
MOD_Plk_4	370	376	PF00069	0.454
MOD_Plk_4	472	478	PF00069	0.389
MOD_Plk_4	528	534	PF00069	0.445
MOD_Plk_4	63	69	PF00069	0.369
MOD_Plk_4	771	777	PF00069	0.532
MOD_Plk_4	880	886	PF00069	0.463
MOD_ProDKin_1	153	159	PF00069	0.455
MOD_ProDKin_1	178	184	PF00069	0.455
MOD_ProDKin_1	247	253	PF00069	0.431
MOD_ProDKin_1	347	353	PF00069	0.720
MOD_ProDKin_1	403	409	PF00069	0.354
MOD_ProDKin_1	47	53	PF00069	0.462
MOD_ProDKin_1	505	511	PF00069	0.654
MOD_ProDKin_1	575	581	PF00069	0.369
MOD_ProDKin_1	750	756	PF00069	0.562
MOD_ProDKin_1	814	820	PF00069	0.560
MOD_SUMO_for_1	497	500	PF00179	0.474
MOD_SUMO_for_1	684	687	PF00179	0.619
MOD_SUMO_rev_2	212	221	PF00179	0.475
MOD_SUMO_rev_2	325	334	PF00179	0.804
MOD_SUMO_rev_2	415	423	PF00179	0.431
MOD_SUMO_rev_2	494	504	PF00179	0.459
MOD_SUMO_rev_2	590	599	PF00179	0.353
TRG_DiLeu_BaEn_1	124	129	PF01217	0.387
TRG_DiLeu_BaEn_1	58	63	PF01217	0.369
TRG_DiLeu_BaEn_2	216	222	PF01217	0.501
TRG_DiLeu_BaEn_2	418	424	PF01217	0.369
TRG_DiLeu_BaEn_2	703	709	PF01217	0.368
TRG_DiLeu_BaLyEn_6	221	226	PF01217	0.474
TRG_ENDOCYTIC_2	126	129	PF00928	0.368
TRG_ENDOCYTIC_2	235	238	PF00928	0.461
TRG_ENDOCYTIC_2	264	267	PF00928	0.442
TRG_ENDOCYTIC_2	439	442	PF00928	0.411
TRG_ENDOCYTIC_2	473	476	PF00928	0.340
TRG_ENDOCYTIC_2	529	532	PF00928	0.433
TRG_ENDOCYTIC_2	728	731	PF00928	0.412
TRG_ENDOCYTIC_2	811	814	PF00928	0.585
TRG_ENDOCYTIC_2	868	871	PF00928	0.416
TRG_ENDOCYTIC_2	924	927	PF00928	0.543
TRG_ER_diArg_1	384	386	PF00400	0.362
TRG_ER_diArg_1	42	44	PF00400	0.383
TRG_ER_diArg_1	424	427	PF00400	0.474
TRG_ER_diArg_1	525	528	PF00400	0.569
TRG_Pf-PMV_PEXEL_1	120	124	PF00026	0.501
TRG_Pf-PMV_PEXEL_1	682	687	PF00026	0.650
TRG_Pf-PMV_PEXEL_1	700	704	PF00026	0.393
TRG_Pf-PMV_PEXEL_1	759	763	PF00026	0.322

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMX5	Leptomonas seymouri	75%	99%
A0A0S4KLR8	Bodo saltans	41%	100%
A0A1X0NW15	Trypanosomatidae	51%	100%
A0A3Q8IFE0	Leishmania donovani	86%	100%
A0A3R7K553	Trypanosoma rangeli	51%	100%
A4I7R1	Leishmania infantum	86%	100%
D0A9W6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9B2L9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q5I7	Leishmania major	87%	100%
Q5REU4	Pongo abelii	29%	100%
Q66X93	Rattus norvegicus	29%	100%
Q78PY7	Mus musculus	29%	100%
Q7KZF4	Homo sapiens	29%	100%
Q7ZT42	Danio rerio	28%	100%
Q863B3	Bos taurus	29%	100%
Q8VZG7	Arabidopsis thaliana	27%	94%
Q9FLT0	Arabidopsis thaliana	27%	95%
Q9W0S7	Drosophila melanogaster	26%	100%
Q9Y7U7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
V5BL57	Trypanosoma cruzi	49%	100%