TOG domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CLASP N terminal, putative

Species:

Leishmania braziliensis

UniProt:

A4HK75_LEIBR

TriTrypDb:

LbrM.32.1030 , LBRM2903_320015700

Length:

1049

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	1
GO:0005881	cytoplasmic microtubule	7	1
GO:0099080	supramolecular complex	2	1
GO:0099081	supramolecular polymer	3	1
GO:0099512	supramolecular fiber	4	1
GO:0099513	polymeric cytoskeletal fiber	5	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HK75

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK75

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007017	microtubule-based process	2	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0008017	microtubule binding	5	1
GO:0008092	cytoskeletal protein binding	3	1
GO:0015631	tubulin binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	256	260	PF00656	0.643
CLV_C14_Caspase3-7	673	677	PF00656	0.552
CLV_NRD_NRD_1	1014	1016	PF00675	0.602
CLV_NRD_NRD_1	16	18	PF00675	0.600
CLV_NRD_NRD_1	174	176	PF00675	0.403
CLV_NRD_NRD_1	224	226	PF00675	0.336
CLV_NRD_NRD_1	327	329	PF00675	0.675
CLV_NRD_NRD_1	38	40	PF00675	0.487
CLV_NRD_NRD_1	399	401	PF00675	0.496
CLV_NRD_NRD_1	615	617	PF00675	0.501
CLV_NRD_NRD_1	778	780	PF00675	0.465
CLV_NRD_NRD_1	791	793	PF00675	0.472
CLV_NRD_NRD_1	88	90	PF00675	0.419
CLV_PCSK_KEX2_1	1014	1016	PF00082	0.592
CLV_PCSK_KEX2_1	16	18	PF00082	0.600
CLV_PCSK_KEX2_1	174	176	PF00082	0.404
CLV_PCSK_KEX2_1	224	226	PF00082	0.336
CLV_PCSK_KEX2_1	399	401	PF00082	0.501
CLV_PCSK_KEX2_1	638	640	PF00082	0.572
CLV_PCSK_KEX2_1	780	782	PF00082	0.505
CLV_PCSK_KEX2_1	790	792	PF00082	0.522
CLV_PCSK_KEX2_1	88	90	PF00082	0.419
CLV_PCSK_KEX2_1	992	994	PF00082	0.325
CLV_PCSK_PC1ET2_1	638	640	PF00082	0.454
CLV_PCSK_PC1ET2_1	780	782	PF00082	0.429
CLV_PCSK_PC1ET2_1	992	994	PF00082	0.325
CLV_PCSK_PC7_1	220	226	PF00082	0.419
CLV_PCSK_SKI1_1	1014	1018	PF00082	0.551
CLV_PCSK_SKI1_1	151	155	PF00082	0.425
CLV_PCSK_SKI1_1	301	305	PF00082	0.761
CLV_PCSK_SKI1_1	336	340	PF00082	0.548
CLV_PCSK_SKI1_1	363	367	PF00082	0.594
CLV_PCSK_SKI1_1	462	466	PF00082	0.338
CLV_PCSK_SKI1_1	488	492	PF00082	0.429
CLV_PCSK_SKI1_1	506	510	PF00082	0.312
CLV_PCSK_SKI1_1	552	556	PF00082	0.585
CLV_PCSK_SKI1_1	612	616	PF00082	0.614
CLV_PCSK_SKI1_1	66	70	PF00082	0.595
CLV_PCSK_SKI1_1	698	702	PF00082	0.634
CLV_PCSK_SKI1_1	791	795	PF00082	0.509
CLV_PCSK_SKI1_1	869	873	PF00082	0.441
CLV_PCSK_SKI1_1	993	997	PF00082	0.318
CLV_Separin_Metazoa	13	17	PF03568	0.566
CLV_Separin_Metazoa	179	183	PF03568	0.620
CLV_Separin_Metazoa	823	827	PF03568	0.326
DEG_APCC_DBOX_1	181	189	PF00400	0.492
DEG_APCC_DBOX_1	461	469	PF00400	0.336
DEG_APCC_DBOX_1	487	495	PF00400	0.469
DEG_APCC_DBOX_1	551	559	PF00400	0.585
DEG_APCC_DBOX_1	790	798	PF00400	0.520
DEG_ODPH_VHL_1	1026	1039	PF01847	0.609
DEG_SCF_FBW7_1	352	358	PF00400	0.567
DEG_SPOP_SBC_1	2	6	PF00917	0.591
DEG_SPOP_SBC_1	273	277	PF00917	0.673
DEG_SPOP_SBC_1	862	866	PF00917	0.353
DOC_CKS1_1	352	357	PF01111	0.688
DOC_CYCLIN_RxL_1	789	799	PF00134	0.363
DOC_CYCLIN_yCln2_LP_2	729	735	PF00134	0.800
DOC_CYCLIN_yCln2_LP_2	979	985	PF00134	0.493
DOC_MAPK_gen_1	174	180	PF00069	0.604
DOC_MAPK_gen_1	224	232	PF00069	0.619
DOC_MAPK_gen_1	30	38	PF00069	0.601
DOC_MAPK_gen_1	39	49	PF00069	0.453
DOC_MAPK_gen_1	790	797	PF00069	0.516
DOC_MAPK_gen_1	88	94	PF00069	0.619
DOC_MAPK_MEF2A_6	1003	1011	PF00069	0.559
DOC_MAPK_MEF2A_6	189	197	PF00069	0.536
DOC_MAPK_MEF2A_6	30	38	PF00069	0.562
DOC_MAPK_MEF2A_6	43	51	PF00069	0.340
DOC_MAPK_RevD_3	1000	1015	PF00069	0.568
DOC_PP1_RVXF_1	430	437	PF00149	0.345
DOC_PP1_RVXF_1	64	70	PF00149	0.339
DOC_PP2B_LxvP_1	278	281	PF13499	0.542
DOC_PP2B_LxvP_1	357	360	PF13499	0.644
DOC_PP2B_LxvP_1	561	564	PF13499	0.455
DOC_PP2B_LxvP_1	979	982	PF13499	0.515
DOC_PP4_FxxP_1	1025	1028	PF00568	0.611
DOC_USP7_MATH_1	129	133	PF00917	0.610
DOC_USP7_MATH_1	2	6	PF00917	0.727
DOC_USP7_MATH_1	266	270	PF00917	0.599
DOC_USP7_MATH_1	274	278	PF00917	0.648
DOC_USP7_MATH_1	312	316	PF00917	0.554
DOC_USP7_MATH_1	390	394	PF00917	0.473
DOC_USP7_MATH_1	542	546	PF00917	0.605
DOC_USP7_MATH_1	577	581	PF00917	0.430
DOC_USP7_MATH_1	742	746	PF00917	0.691
DOC_USP7_MATH_1	767	771	PF00917	0.557
DOC_USP7_MATH_1	861	865	PF00917	0.503
DOC_USP7_MATH_1	914	918	PF00917	0.552
DOC_USP7_MATH_1	930	934	PF00917	0.367
DOC_WW_Pin1_4	267	272	PF00397	0.667
DOC_WW_Pin1_4	294	299	PF00397	0.598
DOC_WW_Pin1_4	323	328	PF00397	0.714
DOC_WW_Pin1_4	351	356	PF00397	0.688
DOC_WW_Pin1_4	368	373	PF00397	0.643
LIG_14-3-3_CanoR_1	174	179	PF00244	0.546
LIG_14-3-3_CanoR_1	301	306	PF00244	0.672
LIG_14-3-3_CanoR_1	323	327	PF00244	0.753
LIG_14-3-3_CanoR_1	361	366	PF00244	0.610
LIG_14-3-3_CanoR_1	474	483	PF00244	0.608
LIG_14-3-3_CanoR_1	575	585	PF00244	0.342
LIG_14-3-3_CanoR_1	686	691	PF00244	0.515
LIG_14-3-3_CanoR_1	792	798	PF00244	0.458
LIG_14-3-3_CanoR_1	986	992	PF00244	0.346
LIG_14-3-3_CanoR_1	993	1002	PF00244	0.363
LIG_Actin_WH2_2	416	434	PF00022	0.347
LIG_AP2alpha_2	884	886	PF02296	0.608
LIG_APCC_ABBA_1	827	832	PF00400	0.579
LIG_APCC_ABBAyCdc20_2	537	543	PF00400	0.342
LIG_APCC_ABBAyCdc20_2	826	832	PF00400	0.584
LIG_BIR_II_1	1	5	PF00653	0.759
LIG_BIR_III_2	295	299	PF00653	0.576
LIG_BIR_III_2	720	724	PF00653	0.549
LIG_BRCT_BRCA1_1	630	634	PF00533	0.400
LIG_EH1_1	466	474	PF00400	0.566
LIG_eIF4E_1	76	82	PF01652	0.416
LIG_FAT_LD_1	424	432	PF03623	0.330
LIG_FHA_1	1018	1024	PF00498	0.519
LIG_FHA_1	199	205	PF00498	0.624
LIG_FHA_1	2	8	PF00498	0.682
LIG_FHA_1	236	242	PF00498	0.619
LIG_FHA_1	273	279	PF00498	0.600
LIG_FHA_1	300	306	PF00498	0.797
LIG_FHA_1	352	358	PF00498	0.723
LIG_FHA_1	383	389	PF00498	0.671
LIG_FHA_1	544	550	PF00498	0.320
LIG_FHA_1	660	666	PF00498	0.648
LIG_FHA_1	870	876	PF00498	0.315
LIG_FHA_1	892	898	PF00498	0.452
LIG_FHA_1	957	963	PF00498	0.764
LIG_FHA_1	978	984	PF00498	0.542
LIG_FHA_2	302	308	PF00498	0.730
LIG_FHA_2	387	393	PF00498	0.650
LIG_FHA_2	414	420	PF00498	0.410
LIG_FHA_2	455	461	PF00498	0.602
LIG_FHA_2	653	659	PF00498	0.636
LIG_FHA_2	671	677	PF00498	0.480
LIG_FHA_2	8	14	PF00498	0.496
LIG_GBD_Chelix_1	420	428	PF00786	0.588
LIG_GBD_Chelix_1	59	67	PF00786	0.333
LIG_GBD_Chelix_1	867	875	PF00786	0.322
LIG_GBD_Chelix_1	987	995	PF00786	0.561
LIG_LIR_Apic_2	1022	1028	PF02991	0.612
LIG_LIR_Apic_2	118	122	PF02991	0.462
LIG_LIR_Apic_2	354	359	PF02991	0.561
LIG_LIR_Gen_1	539	549	PF02991	0.374
LIG_LIR_Gen_1	845	856	PF02991	0.330
LIG_LIR_Gen_1	883	893	PF02991	0.342
LIG_LIR_Gen_1	932	943	PF02991	0.463
LIG_LIR_Nem_3	157	162	PF02991	0.587
LIG_LIR_Nem_3	433	439	PF02991	0.595
LIG_LIR_Nem_3	460	464	PF02991	0.611
LIG_LIR_Nem_3	539	544	PF02991	0.443
LIG_LIR_Nem_3	595	599	PF02991	0.409
LIG_LIR_Nem_3	749	755	PF02991	0.578
LIG_LIR_Nem_3	845	851	PF02991	0.338
LIG_LIR_Nem_3	883	889	PF02991	0.379
LIG_LIR_Nem_3	932	938	PF02991	0.574
LIG_MYND_1	1024	1028	PF01753	0.616
LIG_MYND_1	355	359	PF01753	0.558
LIG_NRBOX	423	429	PF00104	0.584
LIG_NRBOX	853	859	PF00104	0.551
LIG_NRBOX	896	902	PF00104	0.539
LIG_PCNA_yPIPBox_3	437	450	PF02747	0.360
LIG_PCNA_yPIPBox_3	496	509	PF02747	0.483
LIG_Pex14_1	72	76	PF04695	0.491
LIG_RPA_C_Fungi	170	182	PF08784	0.397
LIG_SH2_STAP1	200	204	PF00017	0.513
LIG_SH2_STAP1	526	530	PF00017	0.339
LIG_SH2_STAT5	1040	1043	PF00017	0.616
LIG_SH2_STAT5	184	187	PF00017	0.448
LIG_SH2_STAT5	200	203	PF00017	0.279
LIG_SH2_STAT5	356	359	PF00017	0.712
LIG_SH2_STAT5	489	492	PF00017	0.312
LIG_SH2_STAT5	532	535	PF00017	0.449
LIG_SH3_3	1018	1024	PF00018	0.626
LIG_SH3_3	265	271	PF00018	0.740
LIG_SH3_3	720	726	PF00018	0.725
LIG_SH3_3	752	758	PF00018	0.549
LIG_SH3_3	962	968	PF00018	0.739
LIG_SUMO_SIM_anti_2	132	138	PF11976	0.261
LIG_SUMO_SIM_anti_2	177	183	PF11976	0.513
LIG_SUMO_SIM_anti_2	809	815	PF11976	0.492
LIG_SUMO_SIM_par_1	144	150	PF11976	0.412
LIG_SUMO_SIM_par_1	152	158	PF11976	0.482
LIG_SUMO_SIM_par_1	300	308	PF11976	0.788
LIG_SUMO_SIM_par_1	793	799	PF11976	0.605
LIG_TRAF2_1	10	13	PF00917	0.499
LIG_TRAF2_1	260	263	PF00917	0.652
LIG_TRAF2_1	500	503	PF00917	0.397
LIG_TRAF2_1	606	609	PF00917	0.645
LIG_WRC_WIRS_1	156	161	PF05994	0.261
LIG_WW_3	358	362	PF00397	0.565
MOD_CDC14_SPxK_1	358	361	PF00782	0.562
MOD_CDK_SPK_2	323	328	PF00069	0.685
MOD_CDK_SPK_2	368	373	PF00069	0.521
MOD_CDK_SPxK_1	323	329	PF00069	0.739
MOD_CDK_SPxK_1	355	361	PF00069	0.562
MOD_CDK_SPxxK_3	294	301	PF00069	0.574
MOD_CK1_1	132	138	PF00069	0.501
MOD_CK1_1	276	282	PF00069	0.760
MOD_CK1_1	378	384	PF00069	0.703
MOD_CK1_1	386	392	PF00069	0.477
MOD_CK1_1	580	586	PF00069	0.462
MOD_CK1_1	680	686	PF00069	0.576
MOD_CK1_1	84	90	PF00069	0.299
MOD_CK2_1	144	150	PF00069	0.407
MOD_CK2_1	386	392	PF00069	0.575
MOD_CK2_1	454	460	PF00069	0.612
MOD_CK2_1	603	609	PF00069	0.544
MOD_CK2_1	7	13	PF00069	0.569
MOD_CK2_1	793	799	PF00069	0.605
MOD_CK2_1	833	839	PF00069	0.675
MOD_Cter_Amidation	636	639	PF01082	0.447
MOD_DYRK1A_RPxSP_1	323	327	PF00069	0.712
MOD_GlcNHglycan	131	134	PF01048	0.424
MOD_GlcNHglycan	137	140	PF01048	0.396
MOD_GlcNHglycan	159	162	PF01048	0.387
MOD_GlcNHglycan	169	172	PF01048	0.495
MOD_GlcNHglycan	278	281	PF01048	0.659
MOD_GlcNHglycan	310	313	PF01048	0.744
MOD_GlcNHglycan	336	339	PF01048	0.751
MOD_GlcNHglycan	380	383	PF01048	0.629
MOD_GlcNHglycan	411	414	PF01048	0.529
MOD_GlcNHglycan	582	585	PF01048	0.400
MOD_GlcNHglycan	666	669	PF01048	0.682
MOD_GlcNHglycan	678	682	PF01048	0.530
MOD_GlcNHglycan	709	712	PF01048	0.734
MOD_GlcNHglycan	714	717	PF01048	0.691
MOD_GlcNHglycan	744	747	PF01048	0.551
MOD_GlcNHglycan	804	807	PF01048	0.499
MOD_GlcNHglycan	932	935	PF01048	0.406
MOD_GlcNHglycan	975	978	PF01048	0.668
MOD_GSK3_1	189	196	PF00069	0.454
MOD_GSK3_1	272	279	PF00069	0.684
MOD_GSK3_1	297	304	PF00069	0.799
MOD_GSK3_1	3	10	PF00069	0.570
MOD_GSK3_1	308	315	PF00069	0.600
MOD_GSK3_1	351	358	PF00069	0.719
MOD_GSK3_1	378	385	PF00069	0.679
MOD_GSK3_1	386	393	PF00069	0.532
MOD_GSK3_1	409	416	PF00069	0.388
MOD_GSK3_1	532	539	PF00069	0.338
MOD_GSK3_1	576	583	PF00069	0.369
MOD_GSK3_1	677	684	PF00069	0.664
MOD_GSK3_1	738	745	PF00069	0.730
MOD_GSK3_1	892	899	PF00069	0.345
MOD_GSK3_1	956	963	PF00069	0.522
MOD_GSK3_1	973	980	PF00069	0.439
MOD_N-GLC_1	474	479	PF02516	0.498
MOD_N-GLC_1	691	696	PF02516	0.620
MOD_NEK2_1	1	6	PF00069	0.699
MOD_NEK2_1	1017	1022	PF00069	0.497
MOD_NEK2_1	334	339	PF00069	0.777
MOD_NEK2_1	409	414	PF00069	0.548
MOD_NEK2_1	685	690	PF00069	0.455
MOD_NEK2_1	700	705	PF00069	0.428
MOD_NEK2_1	81	86	PF00069	0.374
MOD_NEK2_1	842	847	PF00069	0.463
MOD_NEK2_1	891	896	PF00069	0.339
MOD_NEK2_1	901	906	PF00069	0.469
MOD_NEK2_2	1028	1033	PF00069	0.360
MOD_NEK2_2	283	288	PF00069	0.561
MOD_NEK2_2	532	537	PF00069	0.306
MOD_NEK2_2	681	686	PF00069	0.495
MOD_NEK2_2	71	76	PF00069	0.581
MOD_NEK2_2	998	1003	PF00069	0.601
MOD_OFUCOSY	911	918	PF10250	0.550
MOD_PIKK_1	454	460	PF00454	0.612
MOD_PIKK_1	692	698	PF00454	0.390
MOD_PIKK_1	724	730	PF00454	0.546
MOD_PK_1	174	180	PF00069	0.397
MOD_PK_1	189	195	PF00069	0.236
MOD_PKA_1	174	180	PF00069	0.513
MOD_PKA_2	174	180	PF00069	0.513
MOD_PKA_2	29	35	PF00069	0.671
MOD_PKA_2	291	297	PF00069	0.645
MOD_PKA_2	322	328	PF00069	0.689
MOD_PKA_2	473	479	PF00069	0.592
MOD_PKA_2	536	542	PF00069	0.335
MOD_PKA_2	652	658	PF00069	0.476
MOD_PKA_2	685	691	PF00069	0.564
MOD_PKA_2	742	748	PF00069	0.588
MOD_PKA_2	87	93	PF00069	0.290
MOD_PKB_1	361	369	PF00069	0.565
MOD_Plk_1	542	548	PF00069	0.588
MOD_Plk_1	670	676	PF00069	0.571
MOD_Plk_2-3	670	676	PF00069	0.554
MOD_Plk_4	115	121	PF00069	0.327
MOD_Plk_4	132	138	PF00069	0.301
MOD_Plk_4	383	389	PF00069	0.685
MOD_Plk_4	445	451	PF00069	0.451
MOD_Plk_4	536	542	PF00069	0.588
MOD_Plk_4	71	77	PF00069	0.449
MOD_Plk_4	896	902	PF00069	0.578
MOD_Plk_4	99	105	PF00069	0.436
MOD_ProDKin_1	267	273	PF00069	0.667
MOD_ProDKin_1	294	300	PF00069	0.597
MOD_ProDKin_1	323	329	PF00069	0.714
MOD_ProDKin_1	351	357	PF00069	0.689
MOD_ProDKin_1	368	374	PF00069	0.632
TRG_DiLeu_BaEn_1	460	465	PF01217	0.601
TRG_DiLeu_BaEn_1	54	59	PF01217	0.558
TRG_DiLeu_BaEn_1	823	828	PF01217	0.441
TRG_DiLeu_BaLyEn_6	1012	1017	PF01217	0.323
TRG_DiLeu_BaLyEn_6	1032	1037	PF01217	0.314
TRG_DiLeu_BaLyEn_6	240	245	PF01217	0.261
TRG_DiLeu_BaLyEn_6	47	52	PF01217	0.567
TRG_DiLeu_LyEn_5	54	59	PF01217	0.306
TRG_DiLeu_LyEn_5	823	828	PF01217	0.458
TRG_ENDOCYTIC_2	526	529	PF00928	0.537
TRG_ENDOCYTIC_2	752	755	PF00928	0.556
TRG_ER_diArg_1	1013	1015	PF00400	0.573
TRG_ER_diArg_1	15	17	PF00400	0.612
TRG_ER_diArg_1	173	175	PF00400	0.513
TRG_ER_diArg_1	316	319	PF00400	0.646
TRG_ER_diArg_1	360	363	PF00400	0.813
TRG_ER_diArg_1	398	400	PF00400	0.497
TRG_ER_diArg_1	778	781	PF00400	0.640
TRG_ER_diArg_1	790	792	PF00400	0.447
TRG_ER_diArg_1	88	91	PF00400	0.336
TRG_NLS_MonoExtN_4	327	332	PF00514	0.521
TRG_Pf-PMV_PEXEL_1	1014	1019	PF00026	0.583
TRG_Pf-PMV_PEXEL_1	206	210	PF00026	0.513
TRG_Pf-PMV_PEXEL_1	251	256	PF00026	0.524
TRG_Pf-PMV_PEXEL_1	488	492	PF00026	0.467
TRG_Pf-PMV_PEXEL_1	50	54	PF00026	0.574
TRG_Pf-PMV_PEXEL_1	57	61	PF00026	0.458
TRG_Pf-PMV_PEXEL_1	597	601	PF00026	0.616
TRG_Pf-PMV_PEXEL_1	672	676	PF00026	0.556
TRG_Pf-PMV_PEXEL_1	833	837	PF00026	0.397

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X5E0	Leishmania donovani	68%	99%
A4I7R0	Leishmania infantum	69%	99%
D0A9W5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
E9B2L8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	99%
Q4Q5I8	Leishmania major	69%	100%