DAO domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

FAD dependent oxidoreductase, putative

Species:

Leishmania braziliensis

UniProt:

A4HK74_LEIBR

TriTrypDb:

LbrM.32.1020 , LBRM2903_320015600

Length:

704

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HK74

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK74

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0003824	catalytic activity	1	1
GO:0005488	binding	1	2
GO:0016491	oxidoreductase activity	2	1
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	1
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0050660	flavin adenine dinucleotide binding	4	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	685	689	PF00656	0.535
CLV_NRD_NRD_1	282	284	PF00675	0.320
CLV_NRD_NRD_1	301	303	PF00675	0.305
CLV_NRD_NRD_1	351	353	PF00675	0.227
CLV_NRD_NRD_1	529	531	PF00675	0.376
CLV_NRD_NRD_1	544	546	PF00675	0.329
CLV_NRD_NRD_1	617	619	PF00675	0.309
CLV_NRD_NRD_1	64	66	PF00675	0.343
CLV_NRD_NRD_1	95	97	PF00675	0.400
CLV_PCSK_KEX2_1	266	268	PF00082	0.387
CLV_PCSK_KEX2_1	282	284	PF00082	0.217
CLV_PCSK_KEX2_1	301	303	PF00082	0.305
CLV_PCSK_KEX2_1	544	546	PF00082	0.335
CLV_PCSK_KEX2_1	590	592	PF00082	0.378
CLV_PCSK_KEX2_1	617	619	PF00082	0.298
CLV_PCSK_KEX2_1	64	66	PF00082	0.343
CLV_PCSK_KEX2_1	674	676	PF00082	0.377
CLV_PCSK_KEX2_1	95	97	PF00082	0.400
CLV_PCSK_PC1ET2_1	266	268	PF00082	0.430
CLV_PCSK_PC1ET2_1	590	592	PF00082	0.408
CLV_PCSK_PC1ET2_1	674	676	PF00082	0.377
CLV_PCSK_SKI1_1	249	253	PF00082	0.394
CLV_PCSK_SKI1_1	283	287	PF00082	0.370
CLV_PCSK_SKI1_1	378	382	PF00082	0.398
CLV_PCSK_SKI1_1	390	394	PF00082	0.197
CLV_PCSK_SKI1_1	413	417	PF00082	0.291
CLV_PCSK_SKI1_1	452	456	PF00082	0.356
CLV_PCSK_SKI1_1	544	548	PF00082	0.256
CLV_PCSK_SKI1_1	600	604	PF00082	0.378
CLV_PCSK_SKI1_1	692	696	PF00082	0.392
CLV_Separin_Metazoa	61	65	PF03568	0.532
DEG_COP1_1	200	208	PF00400	0.543
DEG_Nend_Nbox_1	1	3	PF02207	0.242
DEG_SPOP_SBC_1	382	386	PF00917	0.482
DEG_SPOP_SBC_1	639	643	PF00917	0.627
DOC_CDC14_PxL_1	100	108	PF14671	0.592
DOC_CKS1_1	199	204	PF01111	0.536
DOC_CKS1_1	429	434	PF01111	0.532
DOC_CKS1_1	475	480	PF01111	0.592
DOC_CYCLIN_yCln2_LP_2	253	259	PF00134	0.591
DOC_CYCLIN_yCln2_LP_2	393	399	PF00134	0.510
DOC_CYCLIN_yCln2_LP_2	438	444	PF00134	0.521
DOC_CYCLIN_yCln2_LP_2	475	481	PF00134	0.564
DOC_MAPK_gen_1	327	336	PF00069	0.600
DOC_MAPK_gen_1	95	102	PF00069	0.586
DOC_MAPK_MEF2A_6	327	336	PF00069	0.443
DOC_MAPK_MEF2A_6	390	399	PF00069	0.394
DOC_MAPK_NFAT4_5	390	398	PF00069	0.488
DOC_MIT_MIM_1	297	306	PF04212	0.568
DOC_PP1_RVXF_1	450	457	PF00149	0.560
DOC_PP1_RVXF_1	96	103	PF00149	0.584
DOC_PP2B_LxvP_1	253	256	PF13499	0.566
DOC_PP2B_LxvP_1	284	287	PF13499	0.568
DOC_PP2B_LxvP_1	380	383	PF13499	0.673
DOC_PP2B_LxvP_1	393	396	PF13499	0.480
DOC_PP2B_LxvP_1	438	441	PF13499	0.570
DOC_PP2B_LxvP_1	568	571	PF13499	0.517
DOC_USP7_MATH_1	259	263	PF00917	0.552
DOC_USP7_MATH_1	285	289	PF00917	0.571
DOC_USP7_MATH_1	415	419	PF00917	0.503
DOC_USP7_MATH_1	514	518	PF00917	0.680
DOC_USP7_MATH_1	520	524	PF00917	0.674
DOC_USP7_MATH_1	551	555	PF00917	0.469
DOC_USP7_MATH_1	611	615	PF00917	0.500
DOC_USP7_MATH_1	630	634	PF00917	0.537
DOC_USP7_MATH_1	639	643	PF00917	0.626
DOC_USP7_MATH_1	645	649	PF00917	0.551
DOC_USP7_MATH_1	679	683	PF00917	0.584
DOC_USP7_UBL2_3	596	600	PF12436	0.653
DOC_WW_Pin1_4	123	128	PF00397	0.670
DOC_WW_Pin1_4	198	203	PF00397	0.607
DOC_WW_Pin1_4	361	366	PF00397	0.526
DOC_WW_Pin1_4	428	433	PF00397	0.536
DOC_WW_Pin1_4	474	479	PF00397	0.595
DOC_WW_Pin1_4	641	646	PF00397	0.648
LIG_14-3-3_CanoR_1	21	30	PF00244	0.551
LIG_14-3-3_CanoR_1	214	224	PF00244	0.657
LIG_14-3-3_CanoR_1	237	243	PF00244	0.496
LIG_14-3-3_CanoR_1	301	306	PF00244	0.517
LIG_14-3-3_CanoR_1	513	521	PF00244	0.675
LIG_14-3-3_CanoR_1	544	552	PF00244	0.566
LIG_14-3-3_CanoR_1	608	616	PF00244	0.603
LIG_14-3-3_CanoR_1	64	72	PF00244	0.480
LIG_14-3-3_CanoR_1	683	691	PF00244	0.576
LIG_14-3-3_CanoR_1	692	700	PF00244	0.596
LIG_14-3-3_CanoR_1	98	103	PF00244	0.579
LIG_14-3-3_CterR_2	701	704	PF00244	0.546
LIG_Actin_WH2_2	102	118	PF00022	0.483
LIG_Actin_WH2_2	49	66	PF00022	0.405
LIG_BRCT_BRCA1_1	240	244	PF00533	0.477
LIG_BRCT_BRCA1_1	562	566	PF00533	0.574
LIG_BRCT_BRCA1_1	633	637	PF00533	0.580
LIG_FHA_1	183	189	PF00498	0.504
LIG_FHA_1	23	29	PF00498	0.616
LIG_FHA_1	248	254	PF00498	0.562
LIG_FHA_1	36	42	PF00498	0.613
LIG_FHA_1	384	390	PF00498	0.556
LIG_FHA_1	481	487	PF00498	0.509
LIG_FHA_1	510	516	PF00498	0.536
LIG_FHA_1	565	571	PF00498	0.499
LIG_FHA_1	67	73	PF00498	0.646
LIG_FHA_1	693	699	PF00498	0.611
LIG_FHA_2	124	130	PF00498	0.650
LIG_FHA_2	216	222	PF00498	0.555
LIG_FHA_2	308	314	PF00498	0.536
LIG_FHA_2	497	503	PF00498	0.562
LIG_FHA_2	545	551	PF00498	0.477
LIG_FHA_2	608	614	PF00498	0.518
LIG_FHA_2	683	689	PF00498	0.493
LIG_LIR_Gen_1	307	317	PF02991	0.546
LIG_LIR_Gen_1	45	54	PF02991	0.455
LIG_LIR_Gen_1	563	574	PF02991	0.595
LIG_LIR_Nem_3	307	312	PF02991	0.538
LIG_LIR_Nem_3	45	49	PF02991	0.467
LIG_LIR_Nem_3	563	569	PF02991	0.584
LIG_LIR_Nem_3	666	672	PF02991	0.638
LIG_MYND_1	428	432	PF01753	0.537
LIG_NRBOX	598	604	PF00104	0.456
LIG_Pex14_1	16	20	PF04695	0.513
LIG_SH2_CRK	168	172	PF00017	0.572
LIG_SH2_NCK_1	309	313	PF00017	0.493
LIG_SH2_PTP2	46	49	PF00017	0.482
LIG_SH2_SRC	257	260	PF00017	0.441
LIG_SH2_STAT3	131	134	PF00017	0.609
LIG_SH2_STAT5	131	134	PF00017	0.517
LIG_SH2_STAT5	139	142	PF00017	0.576
LIG_SH2_STAT5	257	260	PF00017	0.617
LIG_SH2_STAT5	274	277	PF00017	0.395
LIG_SH2_STAT5	309	312	PF00017	0.492
LIG_SH2_STAT5	429	432	PF00017	0.601
LIG_SH2_STAT5	46	49	PF00017	0.482
LIG_SH2_STAT5	619	622	PF00017	0.454
LIG_SH3_3	104	110	PF00018	0.605
LIG_SH3_3	196	202	PF00018	0.508
LIG_SH3_3	233	239	PF00018	0.616
LIG_SH3_3	253	259	PF00018	0.541
LIG_SH3_3	451	457	PF00018	0.544
LIG_SUMO_SIM_anti_2	4	9	PF11976	0.410
LIG_SUMO_SIM_par_1	562	573	PF11976	0.599
LIG_SUMO_SIM_par_1	71	77	PF11976	0.511
LIG_TYR_ITSM	305	312	PF00017	0.338
LIG_WRC_WIRS_1	17	22	PF05994	0.311
LIG_WRC_WIRS_1	99	104	PF05994	0.447
MOD_CDK_SPK_2	361	366	PF00069	0.393
MOD_CK1_1	151	157	PF00069	0.481
MOD_CK1_1	304	310	PF00069	0.388
MOD_CK1_1	31	37	PF00069	0.538
MOD_CK1_1	406	412	PF00069	0.597
MOD_CK1_1	572	578	PF00069	0.520
MOD_CK1_1	589	595	PF00069	0.490
MOD_CK1_1	631	637	PF00069	0.413
MOD_CK1_1	640	646	PF00069	0.547
MOD_CK1_1	662	668	PF00069	0.346
MOD_CK1_1	682	688	PF00069	0.208
MOD_CK2_1	123	129	PF00069	0.593
MOD_CK2_1	197	203	PF00069	0.386
MOD_CK2_1	215	221	PF00069	0.560
MOD_CK2_1	444	450	PF00069	0.271
MOD_CK2_1	496	502	PF00069	0.469
MOD_CK2_1	520	526	PF00069	0.344
MOD_CK2_1	544	550	PF00069	0.304
MOD_CK2_1	607	613	PF00069	0.416
MOD_Cter_Amidation	280	283	PF01082	0.363
MOD_Cter_Amidation	672	675	PF01082	0.485
MOD_Cter_Amidation	93	96	PF01082	0.510
MOD_GlcNHglycan	151	154	PF01048	0.468
MOD_GlcNHglycan	158	161	PF01048	0.350
MOD_GlcNHglycan	261	264	PF01048	0.398
MOD_GlcNHglycan	287	290	PF01048	0.459
MOD_GlcNHglycan	399	402	PF01048	0.462
MOD_GlcNHglycan	405	408	PF01048	0.475
MOD_GlcNHglycan	417	420	PF01048	0.447
MOD_GlcNHglycan	591	594	PF01048	0.577
MOD_GlcNHglycan	630	633	PF01048	0.307
MOD_GlcNHglycan	660	664	PF01048	0.274
MOD_GlcNHglycan	669	672	PF01048	0.480
MOD_GlcNHglycan	76	79	PF01048	0.432
MOD_GlcNHglycan	82	85	PF01048	0.511
MOD_GSK3_1	147	154	PF00069	0.461
MOD_GSK3_1	193	200	PF00069	0.287
MOD_GSK3_1	31	38	PF00069	0.428
MOD_GSK3_1	560	567	PF00069	0.426
MOD_GSK3_1	603	610	PF00069	0.519
MOD_GSK3_1	637	644	PF00069	0.484
MOD_GSK3_1	658	665	PF00069	0.371
MOD_NEK2_1	146	151	PF00069	0.416
MOD_NEK2_1	182	187	PF00069	0.441
MOD_NEK2_1	397	402	PF00069	0.518
MOD_NEK2_1	433	438	PF00069	0.351
MOD_NEK2_1	603	608	PF00069	0.350
MOD_NEK2_1	637	642	PF00069	0.551
MOD_NEK2_1	74	79	PF00069	0.529
MOD_NEK2_2	16	21	PF00069	0.415
MOD_NEK2_2	247	252	PF00069	0.331
MOD_PIKK_1	421	427	PF00454	0.498
MOD_PIKK_1	444	450	PF00454	0.253
MOD_PK_1	301	307	PF00069	0.444
MOD_PKA_1	301	307	PF00069	0.412
MOD_PKA_1	544	550	PF00069	0.419
MOD_PKA_1	674	680	PF00069	0.438
MOD_PKA_2	118	124	PF00069	0.435
MOD_PKA_2	22	28	PF00069	0.429
MOD_PKA_2	301	307	PF00069	0.355
MOD_PKA_2	336	342	PF00069	0.417
MOD_PKA_2	35	41	PF00069	0.375
MOD_PKA_2	369	375	PF00069	0.311
MOD_PKA_2	544	550	PF00069	0.509
MOD_PKA_2	607	613	PF00069	0.520
MOD_PKA_2	63	69	PF00069	0.432
MOD_PKA_2	674	680	PF00069	0.494
MOD_PKA_2	682	688	PF00069	0.469
MOD_PKB_1	96	104	PF00069	0.478
MOD_Plk_1	564	570	PF00069	0.325
MOD_Plk_1	659	665	PF00069	0.393
MOD_Plk_4	118	124	PF00069	0.639
MOD_Plk_4	193	199	PF00069	0.413
MOD_Plk_4	301	307	PF00069	0.356
MOD_Plk_4	433	439	PF00069	0.394
MOD_Plk_4	611	617	PF00069	0.470
MOD_ProDKin_1	123	129	PF00069	0.593
MOD_ProDKin_1	198	204	PF00069	0.510
MOD_ProDKin_1	361	367	PF00069	0.396
MOD_ProDKin_1	428	434	PF00069	0.409
MOD_ProDKin_1	474	480	PF00069	0.489
MOD_ProDKin_1	641	647	PF00069	0.549
MOD_SUMO_rev_2	408	418	PF00179	0.359
MOD_SUMO_rev_2	592	602	PF00179	0.595
TRG_DiLeu_BaEn_1	598	603	PF01217	0.391
TRG_DiLeu_BaLyEn_6	363	368	PF01217	0.450
TRG_DiLeu_BaLyEn_6	393	398	PF01217	0.295
TRG_DiLeu_BaLyEn_6	95	100	PF01217	0.482
TRG_ENDOCYTIC_2	168	171	PF00928	0.552
TRG_ENDOCYTIC_2	17	20	PF00928	0.522
TRG_ENDOCYTIC_2	274	277	PF00928	0.438
TRG_ENDOCYTIC_2	309	312	PF00928	0.349
TRG_ENDOCYTIC_2	374	377	PF00928	0.355
TRG_ENDOCYTIC_2	46	49	PF00928	0.342
TRG_ER_diArg_1	20	23	PF00400	0.437
TRG_ER_diArg_1	282	284	PF00400	0.360
TRG_ER_diArg_1	301	303	PF00400	0.367
TRG_ER_diArg_1	544	546	PF00400	0.410
TRG_ER_diArg_1	616	618	PF00400	0.361
TRG_ER_diArg_1	63	65	PF00400	0.417
TRG_Pf-PMV_PEXEL_1	544	548	PF00026	0.462
TRG_Pf-PMV_PEXEL_1	600	604	PF00026	0.492

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAY3	Leptomonas seymouri	58%	99%
A0A1X0NUW5	Trypanosomatidae	32%	100%
A0A3S5H7R6	Leishmania donovani	78%	100%
A0A422N8N4	Trypanosoma rangeli	31%	100%
A4I7Q9	Leishmania infantum	77%	100%
D0A9W4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9B2L7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4Q5I9	Leishmania major	78%	100%
V5BGK4	Trypanosoma cruzi	32%	100%