V-type proton ATPase subunit a

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

vacuolar proton-ATPase-like protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HK73_LEIBR

TriTrypDb:

LbrM.32.1010 , LBRM2903_320015400

Length:

897

Annotations

LeishMANIAdb annotations

Homologous to animal V-type proton pumps, vacuolar or lysosomal. For some reason, this family expanded in kinetoplastids. Localization: Endosomal (by homology) / Lysosomal (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

Show entries

Cellular components
Term	Name	Level	Count
GO:0000220	vacuolar proton-transporting V-type ATPase, V0 domain	5	22
GO:0000323	lytic vacuole	6	1
GO:0005764	lysosome	7	1
GO:0005773	vacuole	5	1
GO:0005794	Golgi apparatus	5	1
GO:0016020	membrane	2	22
GO:0016469	proton-transporting two-sector ATPase complex	3	2
GO:0016471	vacuolar proton-transporting V-type ATPase complex	5	2
GO:0020022	acidocalcisome	5	1
GO:0032991	protein-containing complex	1	22

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Expansion

Sequence features

A4HK73

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK73

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006873	intracellular monoatomic ion homeostasis	4	2
GO:0006885	regulation of pH	8	2
GO:0007035	vacuolar acidification	10	2
GO:0009987	cellular process	1	2
GO:0019725	cellular homeostasis	2	2
GO:0030003	intracellular monoatomic cation homeostasis	5	2
GO:0030004	obsolete cellular monovalent inorganic cation homeostasis	6	2
GO:0030641	regulation of cellular pH	7	2
GO:0042592	homeostatic process	3	2
GO:0048878	chemical homeostasis	4	2

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Show entries

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0005215	transporter activity	1	22
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0008324	monoatomic cation transmembrane transporter activity	4	22
GO:0009678	pyrophosphate hydrolysis-driven proton transmembrane transporter activity	5	22
GO:0015075	monoatomic ion transmembrane transporter activity	3	22
GO:0015078	proton transmembrane transporter activity	5	22
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	22
GO:0015399	primary active transmembrane transporter activity	4	22

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Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	389	393	PF00656	0.279
CLV_NRD_NRD_1	250	252	PF00675	0.397
CLV_NRD_NRD_1	292	294	PF00675	0.482
CLV_NRD_NRD_1	347	349	PF00675	0.486
CLV_NRD_NRD_1	63	65	PF00675	0.453
CLV_NRD_NRD_1	671	673	PF00675	0.242
CLV_NRD_NRD_1	69	71	PF00675	0.449
CLV_NRD_NRD_1	79	81	PF00675	0.320
CLV_PCSK_KEX2_1	229	231	PF00082	0.348
CLV_PCSK_KEX2_1	291	293	PF00082	0.540

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Homologs

Show entries


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P622	Leptomonas seymouri	42%	100%
A0A0N1PFQ1	Leptomonas seymouri	69%	98%
A0A0S4JG87	Bodo saltans	39%	99%
A0A0S4JMR5	Bodo saltans	44%	100%
A0A1X0NV83	Trypanosomatidae	48%	100%
A0A1X0NWN0	Trypanosomatidae	43%	100%
A0A3Q8IB62	Leishmania donovani	43%	100%
A0A3Q8IGN1	Leishmania donovani	86%	100%
A0A3R7KUW1	Trypanosoma rangeli	49%	100%
A0A422NJD7	Trypanosoma rangeli	42%	100%

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