V-type proton ATPase subunit a

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

vacuolar proton-ATPase-like protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HK73_LEIBR

TriTrypDb:

LbrM.32.1010 , LBRM2903_320015400

Length:

897

Annotations

LeishMANIAdb annotations

Homologous to animal V-type proton pumps, vacuolar or lysosomal. For some reason, this family expanded in kinetoplastids. Localization: Endosomal (by homology) / Lysosomal (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0000220	vacuolar proton-transporting V-type ATPase, V0 domain	5	22
GO:0016020	membrane	2	22
GO:0032991	protein-containing complex	1	22
GO:0033177	proton-transporting two-sector ATPase complex, proton-transporting domain	3	22
GO:0033179	proton-transporting V-type ATPase, V0 domain	4	22
GO:0098796	membrane protein complex	2	22
GO:0110165	cellular anatomical entity	1	22
GO:0016469	proton-transporting two-sector ATPase complex	3	2
GO:0016471	vacuolar proton-transporting V-type ATPase complex	5	2
GO:0033176	proton-transporting V-type ATPase complex	4	2
GO:0000323	lytic vacuole	6	1
GO:0005764	lysosome	7	1
GO:0005773	vacuole	5	1
GO:0005794	Golgi apparatus	5	1
GO:0020022	acidocalcisome	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HK73

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK73

Function

Biological processes
Term	Name	Level	Count
GO:0006873	intracellular monoatomic ion homeostasis	4	2
GO:0006885	regulation of pH	8	2
GO:0007035	vacuolar acidification	10	2
GO:0009987	cellular process	1	2
GO:0019725	cellular homeostasis	2	2
GO:0030003	intracellular monoatomic cation homeostasis	5	2
GO:0030004	obsolete cellular monovalent inorganic cation homeostasis	6	2
GO:0030641	regulation of cellular pH	7	2
GO:0042592	homeostatic process	3	2
GO:0048878	chemical homeostasis	4	2
GO:0050801	monoatomic ion homeostasis	5	2
GO:0051452	intracellular pH reduction	9	2
GO:0051453	regulation of intracellular pH	8	2
GO:0055067	obsolete monovalent inorganic cation homeostasis	7	2
GO:0055080	monoatomic cation homeostasis	6	2
GO:0055082	intracellular chemical homeostasis	3	2
GO:0065007	biological regulation	1	2
GO:0065008	regulation of biological quality	2	2
GO:0098771	inorganic ion homeostasis	6	2

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	22
GO:0008324	monoatomic cation transmembrane transporter activity	4	22
GO:0009678	pyrophosphate hydrolysis-driven proton transmembrane transporter activity	5	22
GO:0015075	monoatomic ion transmembrane transporter activity	3	22
GO:0015078	proton transmembrane transporter activity	5	22
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	22
GO:0015399	primary active transmembrane transporter activity	4	22
GO:0019829	ATPase-coupled monoatomic cation transmembrane transporter activity	3	22
GO:0022804	active transmembrane transporter activity	3	22
GO:0022853	active monoatomic ion transmembrane transporter activity	4	22
GO:0022857	transmembrane transporter activity	2	22
GO:0022890	inorganic cation transmembrane transporter activity	4	22
GO:0042625	ATPase-coupled ion transmembrane transporter activity	3	22
GO:0042626	ATPase-coupled transmembrane transporter activity	2	22
GO:0044769	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism	4	22
GO:0046961	proton-transporting ATPase activity, rotational mechanism	4	22
GO:0140657	ATP-dependent activity	1	22
GO:0003824	catalytic activity	1	2
GO:0016787	hydrolase activity	2	2
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0019899	enzyme binding	3	2
GO:0051117	ATPase binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	389	393	PF00656	0.279
CLV_NRD_NRD_1	250	252	PF00675	0.397
CLV_NRD_NRD_1	292	294	PF00675	0.482
CLV_NRD_NRD_1	347	349	PF00675	0.486
CLV_NRD_NRD_1	63	65	PF00675	0.453
CLV_NRD_NRD_1	671	673	PF00675	0.242
CLV_NRD_NRD_1	69	71	PF00675	0.449
CLV_NRD_NRD_1	79	81	PF00675	0.320
CLV_PCSK_KEX2_1	229	231	PF00082	0.348
CLV_PCSK_KEX2_1	291	293	PF00082	0.540
CLV_PCSK_KEX2_1	347	349	PF00082	0.510
CLV_PCSK_KEX2_1	63	65	PF00082	0.453
CLV_PCSK_KEX2_1	666	668	PF00082	0.268
CLV_PCSK_KEX2_1	671	673	PF00082	0.249
CLV_PCSK_PC1ET2_1	229	231	PF00082	0.348
CLV_PCSK_PC1ET2_1	291	293	PF00082	0.536
CLV_PCSK_PC1ET2_1	666	668	PF00082	0.274
CLV_PCSK_PC7_1	667	673	PF00082	0.310
CLV_PCSK_SKI1_1	26	30	PF00082	0.522
CLV_PCSK_SKI1_1	316	320	PF00082	0.463
CLV_PCSK_SKI1_1	347	351	PF00082	0.441
CLV_PCSK_SKI1_1	459	463	PF00082	0.298
CLV_PCSK_SKI1_1	56	60	PF00082	0.438
DEG_APCC_DBOX_1	458	466	PF00400	0.303
DEG_SCF_FBW7_1	155	162	PF00400	0.148
DOC_CKS1_1	156	161	PF01111	0.238
DOC_CKS1_1	505	510	PF01111	0.231
DOC_CYCLIN_RxL_1	64	78	PF00134	0.325
DOC_CYCLIN_yClb1_LxF_4	532	537	PF00134	0.267
DOC_MAPK_gen_1	205	215	PF00069	0.279
DOC_MAPK_gen_1	306	314	PF00069	0.272
DOC_MAPK_gen_1	542	551	PF00069	0.247
DOC_MAPK_MEF2A_6	13	22	PF00069	0.332
DOC_MAPK_MEF2A_6	542	551	PF00069	0.253
DOC_MAPK_MEF2A_6	633	642	PF00069	0.161
DOC_PP1_RVXF_1	39	45	PF00149	0.320
DOC_PP1_RVXF_1	532	538	PF00149	0.280
DOC_PP1_RVXF_1	571	577	PF00149	0.510
DOC_PP1_RVXF_1	68	75	PF00149	0.318
DOC_PP1_RVXF_1	865	871	PF00149	0.447
DOC_PP2B_LxvP_1	577	580	PF13499	0.349
DOC_PP2B_LxvP_1	655	658	PF13499	0.319
DOC_PP4_FxxP_1	54	57	PF00568	0.267
DOC_PP4_FxxP_1	621	624	PF00568	0.247
DOC_PP4_FxxP_1	701	704	PF00568	0.463
DOC_USP7_MATH_1	164	168	PF00917	0.320
DOC_USP7_MATH_1	175	179	PF00917	0.306
DOC_USP7_MATH_1	353	357	PF00917	0.306
DOC_USP7_MATH_1	721	725	PF00917	0.348
DOC_USP7_MATH_1	753	757	PF00917	0.381
DOC_USP7_UBL2_3	309	313	PF12436	0.333
DOC_USP7_UBL2_3	569	573	PF12436	0.533
DOC_WW_Pin1_4	155	160	PF00397	0.333
DOC_WW_Pin1_4	504	509	PF00397	0.264
LIG_14-3-3_CanoR_1	183	188	PF00244	0.310
LIG_14-3-3_CanoR_1	306	312	PF00244	0.294
LIG_14-3-3_CanoR_1	382	390	PF00244	0.333
LIG_14-3-3_CanoR_1	685	689	PF00244	0.441
LIG_14-3-3_CanoR_1	708	714	PF00244	0.348
LIG_14-3-3_CanoR_1	720	726	PF00244	0.348
LIG_AP2alpha_1	696	700	PF02296	0.348
LIG_APCC_ABBA_1	365	370	PF00400	0.238
LIG_BIR_II_1	1	5	PF00653	0.443
LIG_BRCT_BRCA1_1	177	181	PF00533	0.276
LIG_BRCT_BRCA1_1	184	188	PF00533	0.255
LIG_BRCT_BRCA1_1	696	700	PF00533	0.473
LIG_BRCT_BRCA1_1	815	819	PF00533	0.306
LIG_Clathr_ClatBox_1	853	857	PF01394	0.298
LIG_CSL_BTD_1	336	339	PF09270	0.253
LIG_deltaCOP1_diTrp_1	568	578	PF00928	0.488
LIG_EH1_1	774	782	PF00400	0.533
LIG_eIF4E_1	149	155	PF01652	0.334
LIG_eIF4E_1	572	578	PF01652	0.438
LIG_EVH1_2	374	378	PF00568	0.267
LIG_FHA_1	124	130	PF00498	0.310
LIG_FHA_1	156	162	PF00498	0.331
LIG_FHA_1	233	239	PF00498	0.275
LIG_FHA_1	443	449	PF00498	0.438
LIG_FHA_1	519	525	PF00498	0.256
LIG_FHA_1	57	63	PF00498	0.267
LIG_FHA_1	759	765	PF00498	0.438
LIG_FHA_1	825	831	PF00498	0.258
LIG_FHA_1	847	853	PF00498	0.329
LIG_FHA_2	119	125	PF00498	0.330
LIG_FHA_2	128	134	PF00498	0.273
LIG_FHA_2	192	198	PF00498	0.215
LIG_FHA_2	30	36	PF00498	0.294
LIG_FHA_2	374	380	PF00498	0.250
LIG_FHA_2	96	102	PF00498	0.310
LIG_GBD_Chelix_1	551	559	PF00786	0.267
LIG_GBD_Chelix_1	836	844	PF00786	0.242
LIG_LIR_Apic_2	52	57	PF02991	0.269
LIG_LIR_Apic_2	618	624	PF02991	0.251
LIG_LIR_Apic_2	698	704	PF02991	0.466
LIG_LIR_Gen_1	178	188	PF02991	0.331
LIG_LIR_Gen_1	235	244	PF02991	0.284
LIG_LIR_Gen_1	310	319	PF02991	0.259
LIG_LIR_Gen_1	384	394	PF02991	0.257
LIG_LIR_Gen_1	536	546	PF02991	0.247
LIG_LIR_Gen_1	581	589	PF02991	0.296
LIG_LIR_Gen_1	695	704	PF02991	0.386
LIG_LIR_Gen_1	770	780	PF02991	0.473
LIG_LIR_Gen_1	799	810	PF02991	0.447
LIG_LIR_Nem_3	146	152	PF02991	0.312
LIG_LIR_Nem_3	178	184	PF02991	0.331
LIG_LIR_Nem_3	185	191	PF02991	0.298
LIG_LIR_Nem_3	235	240	PF02991	0.281
LIG_LIR_Nem_3	310	314	PF02991	0.262
LIG_LIR_Nem_3	335	340	PF02991	0.324
LIG_LIR_Nem_3	384	390	PF02991	0.248
LIG_LIR_Nem_3	411	415	PF02991	0.256
LIG_LIR_Nem_3	466	471	PF02991	0.364
LIG_LIR_Nem_3	478	482	PF02991	0.188
LIG_LIR_Nem_3	492	496	PF02991	0.215
LIG_LIR_Nem_3	536	541	PF02991	0.247
LIG_LIR_Nem_3	568	574	PF02991	0.482
LIG_LIR_Nem_3	581	585	PF02991	0.232
LIG_LIR_Nem_3	588	594	PF02991	0.289
LIG_LIR_Nem_3	695	699	PF02991	0.386
LIG_LIR_Nem_3	770	775	PF02991	0.465
LIG_LIR_Nem_3	799	805	PF02991	0.447
LIG_LIR_Nem_3	816	822	PF02991	0.298
LIG_NRBOX	554	560	PF00104	0.159
LIG_PCNA_PIPBox_1	856	865	PF02747	0.447
LIG_PCNA_yPIPBox_3	771	781	PF02747	0.348
LIG_Pex14_2	383	387	PF04695	0.256
LIG_Pex14_2	412	416	PF04695	0.247
LIG_Pex14_2	427	431	PF04695	0.298
LIG_Pex14_2	54	58	PF04695	0.284
LIG_Pex14_2	578	582	PF04695	0.379
LIG_Pex14_2	696	700	PF04695	0.348
LIG_Pex14_2	873	877	PF04695	0.447
LIG_PTB_Apo_2	474	481	PF02174	0.298
LIG_PTB_Apo_2	561	568	PF02174	0.306
LIG_PTB_Apo_2	626	633	PF02174	0.238
LIG_PTB_Apo_2	690	697	PF02174	0.383
LIG_PTB_Phospho_1	561	567	PF10480	0.306
LIG_REV1ctd_RIR_1	433	443	PF16727	0.286
LIG_SH2_CRK	152	156	PF00017	0.238
LIG_SH2_CRK	471	475	PF00017	0.442
LIG_SH2_CRK	538	542	PF00017	0.247
LIG_SH2_CRK	591	595	PF00017	0.306
LIG_SH2_SRC	302	305	PF00017	0.330
LIG_SH2_SRC	34	37	PF00017	0.148
LIG_SH2_SRC	784	787	PF00017	0.467
LIG_SH2_STAP1	567	571	PF00017	0.533
LIG_SH2_STAT3	150	153	PF00017	0.263
LIG_SH2_STAT5	311	314	PF00017	0.286
LIG_SH2_STAT5	414	417	PF00017	0.298
LIG_SH2_STAT5	460	463	PF00017	0.298
LIG_SH2_STAT5	491	494	PF00017	0.284
LIG_SH2_STAT5	520	523	PF00017	0.148
LIG_SH2_STAT5	659	662	PF00017	0.545
LIG_SH2_STAT5	713	716	PF00017	0.348
LIG_SH2_STAT5	791	794	PF00017	0.447
LIG_SH2_STAT5	802	805	PF00017	0.446
LIG_SH3_3	153	159	PF00018	0.238
LIG_SH3_3	502	508	PF00018	0.279
LIG_SH3_3	511	517	PF00018	0.273
LIG_SH3_3	624	630	PF00018	0.237
LIG_SH3_3	645	651	PF00018	0.356
LIG_SUMO_SIM_anti_2	593	598	PF11976	0.349
LIG_SUMO_SIM_anti_2	612	618	PF11976	0.120
LIG_SUMO_SIM_anti_2	82	87	PF11976	0.148
LIG_SUMO_SIM_par_1	157	165	PF11976	0.331
LIG_SUMO_SIM_par_1	460	466	PF11976	0.286
LIG_SUMO_SIM_par_1	558	563	PF11976	0.305
LIG_SUMO_SIM_par_1	612	618	PF11976	0.333
LIG_SUMO_SIM_par_1	687	692	PF11976	0.528
LIG_TRAF2_1	98	101	PF00917	0.333
LIG_TRFH_1	620	624	PF08558	0.298
LIG_TYR_ITIM	418	423	PF00017	0.315
LIG_UBA3_1	246	252	PF00899	0.418
LIG_UBA3_1	430	439	PF00899	0.313
LIG_UBA3_1	594	599	PF00899	0.265
LIG_Vh1_VBS_1	239	257	PF01044	0.320
LIG_WRC_WIRS_1	586	591	PF05994	0.279
MOD_CK1_1	162	168	PF00069	0.330
MOD_CK1_1	182	188	PF00069	0.304
MOD_CK1_1	328	334	PF00069	0.312
MOD_CK1_1	360	366	PF00069	0.357
MOD_CK1_1	386	392	PF00069	0.374
MOD_CK1_1	489	495	PF00069	0.332
MOD_CK1_1	687	693	PF00069	0.356
MOD_CK1_1	724	730	PF00069	0.334
MOD_CK1_1	794	800	PF00069	0.456
MOD_CK2_1	127	133	PF00069	0.254
MOD_CK2_1	191	197	PF00069	0.227
MOD_CK2_1	260	266	PF00069	0.360
MOD_CK2_1	29	35	PF00069	0.422
MOD_CK2_1	373	379	PF00069	0.345
MOD_CK2_1	562	568	PF00069	0.286
MOD_CK2_1	609	615	PF00069	0.314
MOD_CK2_1	713	719	PF00069	0.266
MOD_CK2_1	751	757	PF00069	0.444
MOD_CK2_1	95	101	PF00069	0.383
MOD_Cter_Amidation	227	230	PF01082	0.159
MOD_GlcNHglycan	242	245	PF01048	0.358
MOD_GlcNHglycan	254	257	PF01048	0.352
MOD_GlcNHglycan	327	330	PF01048	0.309
MOD_GlcNHglycan	334	337	PF01048	0.302
MOD_GlcNHglycan	355	358	PF01048	0.328
MOD_GlcNHglycan	488	491	PF01048	0.305
MOD_GlcNHglycan	508	511	PF01048	0.320
MOD_GlcNHglycan	715	718	PF01048	0.401
MOD_GlcNHglycan	8	11	PF01048	0.460
MOD_GlcNHglycan	833	836	PF01048	0.316
MOD_GlcNHglycan	859	862	PF01048	0.303
MOD_GlcNHglycan	95	98	PF01048	0.356
MOD_GSK3_1	102	109	PF00069	0.297
MOD_GSK3_1	123	130	PF00069	0.432
MOD_GSK3_1	155	162	PF00069	0.272
MOD_GSK3_1	175	182	PF00069	0.401
MOD_GSK3_1	272	279	PF00069	0.332
MOD_GSK3_1	328	335	PF00069	0.304
MOD_GSK3_1	353	360	PF00069	0.337
MOD_GSK3_1	373	380	PF00069	0.271
MOD_GSK3_1	386	393	PF00069	0.311
MOD_GSK3_1	485	492	PF00069	0.382
MOD_GSK3_1	499	506	PF00069	0.356
MOD_GSK3_1	558	565	PF00069	0.286
MOD_GSK3_1	600	607	PF00069	0.332
MOD_GSK3_1	680	687	PF00069	0.373
MOD_GSK3_1	709	716	PF00069	0.402
MOD_GSK3_1	724	731	PF00069	0.375
MOD_GSK3_1	792	799	PF00069	0.309
MOD_N-GLC_1	165	170	PF02516	0.467
MOD_N-GLC_1	357	362	PF02516	0.399
MOD_N-GLC_1	499	504	PF02516	0.224
MOD_N-GLC_1	831	836	PF02516	0.422
MOD_N-GLC_1	93	98	PF02516	0.336
MOD_N-GLC_2	323	325	PF02516	0.324
MOD_NEK2_1	102	107	PF00069	0.369
MOD_NEK2_1	240	245	PF00069	0.233
MOD_NEK2_1	274	279	PF00069	0.330
MOD_NEK2_1	29	34	PF00069	0.325
MOD_NEK2_1	307	312	PF00069	0.343
MOD_NEK2_1	327	332	PF00069	0.275
MOD_NEK2_1	377	382	PF00069	0.343
MOD_NEK2_1	383	388	PF00069	0.340
MOD_NEK2_1	463	468	PF00069	0.346
MOD_NEK2_1	480	485	PF00069	0.182
MOD_NEK2_1	486	491	PF00069	0.345
MOD_NEK2_1	537	542	PF00069	0.315
MOD_NEK2_1	558	563	PF00069	0.386
MOD_NEK2_1	585	590	PF00069	0.265
MOD_NEK2_1	846	851	PF00069	0.315
MOD_OFUCOSY	325	332	PF10250	0.325
MOD_PIKK_1	106	112	PF00454	0.159
MOD_PIKK_1	296	302	PF00454	0.456
MOD_PIKK_1	680	686	PF00454	0.159
MOD_PK_1	609	615	PF00069	0.286
MOD_PKA_2	182	188	PF00069	0.251
MOD_PKA_2	204	210	PF00069	0.295
MOD_PKA_2	381	387	PF00069	0.372
MOD_PKA_2	684	690	PF00069	0.297
MOD_Plk_1	118	124	PF00069	0.363
MOD_Plk_1	143	149	PF00069	0.435
MOD_Plk_1	165	171	PF00069	0.353
MOD_Plk_1	191	197	PF00069	0.159
MOD_Plk_1	283	289	PF00069	0.436
MOD_Plk_1	378	384	PF00069	0.159
MOD_Plk_1	742	748	PF00069	0.390
MOD_Plk_1	75	81	PF00069	0.405
MOD_Plk_4	102	108	PF00069	0.316
MOD_Plk_4	143	149	PF00069	0.275
MOD_Plk_4	183	189	PF00069	0.418
MOD_Plk_4	233	239	PF00069	0.378
MOD_Plk_4	242	248	PF00069	0.357
MOD_Plk_4	29	35	PF00069	0.324
MOD_Plk_4	307	313	PF00069	0.324
MOD_Plk_4	360	366	PF00069	0.309
MOD_Plk_4	373	379	PF00069	0.273
MOD_Plk_4	386	392	PF00069	0.273
MOD_Plk_4	463	469	PF00069	0.380
MOD_Plk_4	562	568	PF00069	0.362
MOD_Plk_4	590	596	PF00069	0.362
MOD_Plk_4	609	615	PF00069	0.261
MOD_Plk_4	684	690	PF00069	0.383
MOD_Plk_4	798	804	PF00069	0.298
MOD_ProDKin_1	155	161	PF00069	0.418
MOD_ProDKin_1	504	510	PF00069	0.322
MOD_SUMO_for_1	312	315	PF00179	0.418
MOD_SUMO_rev_2	530	535	PF00179	0.299
TRG_DiLeu_BaEn_1	581	586	PF01217	0.338
TRG_DiLeu_BaEn_2	217	223	PF01217	0.286
TRG_DiLeu_BaEn_4	197	203	PF01217	0.418
TRG_ENDOCYTIC_2	152	155	PF00928	0.418
TRG_ENDOCYTIC_2	311	314	PF00928	0.318
TRG_ENDOCYTIC_2	399	402	PF00928	0.254
TRG_ENDOCYTIC_2	420	423	PF00928	0.298
TRG_ENDOCYTIC_2	460	463	PF00928	0.298
TRG_ENDOCYTIC_2	471	474	PF00928	0.298
TRG_ENDOCYTIC_2	476	479	PF00928	0.298
TRG_ENDOCYTIC_2	538	541	PF00928	0.298
TRG_ENDOCYTIC_2	591	594	PF00928	0.323
TRG_ENDOCYTIC_2	659	662	PF00928	0.432
TRG_ENDOCYTIC_2	802	805	PF00928	0.298
TRG_ER_diArg_1	346	348	PF00400	0.424
TRG_ER_diArg_1	62	64	PF00400	0.306
TRG_NES_CRM1_1	857	872	PF08389	0.298
TRG_NLS_MonoCore_2	290	295	PF00514	0.169
TRG_NLS_MonoExtC_3	290	296	PF00514	0.169
TRG_NLS_MonoExtN_4	663	670	PF00514	0.216
TRG_Pf-PMV_PEXEL_1	348	352	PF00026	0.360
TRG_Pf-PMV_PEXEL_1	723	728	PF00026	0.286

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P622	Leptomonas seymouri	42%	100%
A0A0N1PFQ1	Leptomonas seymouri	69%	98%
A0A0S4JG87	Bodo saltans	39%	99%
A0A0S4JMR5	Bodo saltans	44%	100%
A0A1X0NV83	Trypanosomatidae	48%	100%
A0A1X0NWN0	Trypanosomatidae	43%	100%
A0A3Q8IB62	Leishmania donovani	43%	100%
A0A3Q8IGN1	Leishmania donovani	86%	100%
A0A3R7KUW1	Trypanosoma rangeli	49%	100%
A0A422NJD7	Trypanosoma rangeli	42%	100%
A1A5G6	Xenopus tropicalis	32%	100%
A4HD35	Leishmania braziliensis	42%	100%
A4I0M2	Leishmania infantum	43%	100%
A4I7Q8	Leishmania infantum	86%	100%
B2MZD0	Caenorhabditis elegans	29%	74%
C9ZNR3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AWI3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9B2L6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
G5EEK9	Caenorhabditis elegans	30%	100%
G5EGP4	Caenorhabditis elegans	27%	100%
O13742	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%
O97681	Bos taurus	31%	100%
P15920	Mus musculus	31%	100%
P25286	Rattus norvegicus	33%	100%
P30628	Caenorhabditis elegans	31%	99%
P32563	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	100%
P37296	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	100%
Q01290	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	31%	100%
Q13488	Homo sapiens	30%	100%
Q29466	Bos taurus	33%	100%
Q4Q5J0	Leishmania major	85%	100%
Q4QAY7	Leishmania major	44%	100%
Q54E04	Dictyostelium discoideum	34%	100%
Q5R422	Pongo abelii	33%	100%
Q8AVM5	Xenopus laevis	33%	100%
Q8RWZ7	Arabidopsis thaliana	31%	100%
Q8W4S4	Arabidopsis thaliana	32%	100%
Q920R6	Mus musculus	32%	100%
Q93050	Homo sapiens	33%	100%
Q9HBG4	Homo sapiens	34%	100%
Q9I8D0	Gallus gallus	32%	100%
Q9SJT7	Arabidopsis thaliana	31%	100%
Q9Y487	Homo sapiens	31%	100%
Q9Z1G4	Mus musculus	30%	100%
V5BQN9	Trypanosoma cruzi	50%	100%
V5D763	Trypanosoma cruzi	41%	100%