LeishMANIAdb
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CUPID domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
CUPID domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HK71_LEIBR
TriTrypDb:
LbrM.32.0990 , LBRM2903_320015200 *
Length:
133

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HK71
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK71

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 87 89 PF00675 0.443
CLV_PCSK_KEX2_1 85 87 PF00082 0.449
CLV_PCSK_PC1ET2_1 85 87 PF00082 0.449
CLV_PCSK_PC7_1 82 88 PF00082 0.443
DEG_SCF_FBW7_1 5 12 PF00400 0.498
DOC_ANK_TNKS_1 118 125 PF00023 0.390
DOC_USP7_MATH_1 14 18 PF00917 0.449
DOC_USP7_UBL2_3 97 101 PF12436 0.449
DOC_WW_Pin1_4 1 6 PF00397 0.715
LIG_14-3-3_CanoR_1 77 84 PF00244 0.333
LIG_BIR_II_1 1 5 PF00653 0.605
LIG_FHA_1 111 117 PF00498 0.411
LIG_FHA_1 6 12 PF00498 0.573
LIG_SH2_GRB2like 72 75 PF00017 0.407
LIG_SH2_SRC 72 75 PF00017 0.314
LIG_SH2_STAT5 72 75 PF00017 0.530
LIG_SH3_3 8 14 PF00018 0.593
LIG_TRAF2_1 44 47 PF00917 0.448
LIG_TRAF2_1 52 55 PF00917 0.347
MOD_CAAXbox 130 133 PF01239 0.470
MOD_CK1_1 17 23 PF00069 0.418
MOD_CK1_1 3 9 PF00069 0.592
MOD_CK1_1 76 82 PF00069 0.323
MOD_CK2_1 100 106 PF00069 0.377
MOD_CK2_1 114 120 PF00069 0.467
MOD_GlcNHglycan 102 105 PF01048 0.361
MOD_GlcNHglycan 116 119 PF01048 0.419
MOD_GSK3_1 1 8 PF00069 0.600
MOD_GSK3_1 110 117 PF00069 0.456
MOD_N-GLC_1 73 78 PF02516 0.403
MOD_NEK2_1 38 43 PF00069 0.488
MOD_NEK2_1 73 78 PF00069 0.403
MOD_PIKK_1 28 34 PF00454 0.334
MOD_PIKK_1 9 15 PF00454 0.582
MOD_PIKK_1 90 96 PF00454 0.455
MOD_PKA_2 76 82 PF00069 0.323
MOD_ProDKin_1 1 7 PF00069 0.713
TRG_DiLeu_BaEn_4 54 60 PF01217 0.422
TRG_ER_diArg_1 86 88 PF00400 0.450

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8ID08 Leishmania donovani 80% 100%
A4I7Q6 Leishmania infantum 81% 100%
E9B2L4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 100%
Q4Q5J2 Leishmania major 83% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS