Ethanolamine-phosphate cytidylyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ethanolamine-phosphate cytidylyltransferase

Species:

Leishmania braziliensis

UniProt:

A4HK70_LEIBR

TriTrypDb:

LbrM.32.0980 , LBRM2903_320015000

Length:

403

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HK70

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK70

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	12
GO:0006644	phospholipid metabolic process	4	12
GO:0006646	phosphatidylethanolamine biosynthetic process	6	12
GO:0006650	glycerophospholipid metabolic process	5	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0008152	metabolic process	1	12
GO:0008610	lipid biosynthetic process	4	12
GO:0008654	phospholipid biosynthetic process	5	12
GO:0009058	biosynthetic process	2	12
GO:0009987	cellular process	1	12
GO:0019637	organophosphate metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044255	cellular lipid metabolic process	3	12
GO:0045017	glycerolipid biosynthetic process	4	12
GO:0046337	phosphatidylethanolamine metabolic process	6	12
GO:0046474	glycerophospholipid biosynthetic process	5	12
GO:0046486	glycerolipid metabolic process	4	12
GO:0071704	organic substance metabolic process	2	12
GO:0090407	organophosphate biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004306	ethanolamine-phosphate cytidylyltransferase activity	6	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016779	nucleotidyltransferase activity	4	12
GO:0070567	cytidylyltransferase activity	5	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	157	161	PF00656	0.418
CLV_C14_Caspase3-7	391	395	PF00656	0.399
CLV_NRD_NRD_1	216	218	PF00675	0.366
CLV_NRD_NRD_1	252	254	PF00675	0.263
CLV_NRD_NRD_1	75	77	PF00675	0.308
CLV_PCSK_KEX2_1	132	134	PF00082	0.227
CLV_PCSK_KEX2_1	168	170	PF00082	0.207
CLV_PCSK_KEX2_1	376	378	PF00082	0.450
CLV_PCSK_KEX2_1	381	383	PF00082	0.494
CLV_PCSK_KEX2_1	75	77	PF00082	0.308
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.227
CLV_PCSK_PC1ET2_1	168	170	PF00082	0.218
CLV_PCSK_PC1ET2_1	376	378	PF00082	0.471
CLV_PCSK_PC1ET2_1	381	383	PF00082	0.501
CLV_PCSK_PC7_1	377	383	PF00082	0.403
CLV_PCSK_SKI1_1	129	133	PF00082	0.318
CLV_PCSK_SKI1_1	165	169	PF00082	0.215
CLV_PCSK_SKI1_1	181	185	PF00082	0.282
CLV_PCSK_SKI1_1	371	375	PF00082	0.447
CLV_PCSK_SKI1_1	377	381	PF00082	0.539
CLV_Separin_Metazoa	90	94	PF03568	0.511
DEG_SCF_TRCP1_1	353	359	PF00400	0.364
DEG_SPOP_SBC_1	4	8	PF00917	0.651
DOC_ANK_TNKS_1	52	59	PF00023	0.273
DOC_CYCLIN_RxL_1	178	188	PF00134	0.488
DOC_CYCLIN_yClb1_LxF_4	369	374	PF00134	0.430
DOC_MAPK_gen_1	276	285	PF00069	0.474
DOC_MAPK_gen_1	75	83	PF00069	0.508
DOC_MAPK_MEF2A_6	47	56	PF00069	0.304
DOC_PP1_RVXF_1	216	223	PF00149	0.421
DOC_PP1_RVXF_1	369	375	PF00149	0.455
DOC_PP4_FxxP_1	94	97	PF00568	0.511
DOC_SPAK_OSR1_1	133	137	PF12202	0.422
DOC_USP7_MATH_1	3	7	PF00917	0.619
DOC_USP7_MATH_1	334	338	PF00917	0.450
DOC_USP7_UBL2_3	376	380	PF12436	0.484
DOC_WW_Pin1_4	12	17	PF00397	0.534
DOC_WW_Pin1_4	224	229	PF00397	0.450
DOC_WW_Pin1_4	6	11	PF00397	0.612
LIG_Actin_WH2_2	176	194	PF00022	0.543
LIG_Actin_WH2_2	239	255	PF00022	0.367
LIG_Actin_WH2_2	56	74	PF00022	0.418
LIG_APCC_ABBA_1	264	269	PF00400	0.388
LIG_APCC_ABBA_1	346	351	PF00400	0.427
LIG_BIR_II_1	1	5	PF00653	0.452
LIG_FHA_1	15	21	PF00498	0.428
LIG_FHA_1	168	174	PF00498	0.424
LIG_FHA_1	358	364	PF00498	0.315
LIG_FHA_1	39	45	PF00498	0.364
LIG_FHA_1	49	55	PF00498	0.295
LIG_FHA_2	336	342	PF00498	0.442
LIG_LIR_Apic_2	337	343	PF02991	0.353
LIG_LIR_Gen_1	103	111	PF02991	0.464
LIG_LIR_Gen_1	154	161	PF02991	0.407
LIG_LIR_Gen_1	238	249	PF02991	0.407
LIG_LIR_Gen_1	260	267	PF02991	0.500
LIG_LIR_Gen_1	34	44	PF02991	0.388
LIG_LIR_Gen_1	57	68	PF02991	0.407
LIG_LIR_Nem_3	103	109	PF02991	0.415
LIG_LIR_Nem_3	154	158	PF02991	0.407
LIG_LIR_Nem_3	238	244	PF02991	0.407
LIG_LIR_Nem_3	260	264	PF02991	0.442
LIG_LIR_Nem_3	34	39	PF02991	0.331
LIG_LIR_Nem_3	394	399	PF02991	0.520
LIG_LIR_Nem_3	57	63	PF02991	0.414
LIG_LYPXL_yS_3	280	283	PF13949	0.474
LIG_OCRL_FandH_1	59	71	PF00620	0.407
LIG_PCNA_yPIPBox_3	286	296	PF02747	0.418
LIG_PTB_Apo_2	118	125	PF02174	0.449
LIG_PTB_Apo_2	198	205	PF02174	0.330
LIG_PTB_Phospho_1	118	124	PF10480	0.449
LIG_Rb_LxCxE_1	34	51	PF01857	0.393
LIG_SH2_PTP2	261	264	PF00017	0.352
LIG_SH2_SRC	155	158	PF00017	0.418
LIG_SH2_SRC	236	239	PF00017	0.407
LIG_SH2_SRC	261	264	PF00017	0.407
LIG_SH2_STAP1	267	271	PF00017	0.511
LIG_SH2_STAT3	267	270	PF00017	0.453
LIG_SH2_STAT5	117	120	PF00017	0.421
LIG_SH2_STAT5	124	127	PF00017	0.395
LIG_SH2_STAT5	138	141	PF00017	0.407
LIG_SH2_STAT5	236	239	PF00017	0.407
LIG_SH2_STAT5	261	264	PF00017	0.407
LIG_SH2_STAT5	297	300	PF00017	0.426
LIG_SH3_3	10	16	PF00018	0.612
LIG_SH3_3	43	49	PF00018	0.363
LIG_SUMO_SIM_par_1	14	22	PF11976	0.340
LIG_TRAF2_1	154	157	PF00917	0.418
LIG_TRAF2_1	87	90	PF00917	0.431
MOD_CDK_SPK_2	224	229	PF00069	0.459
MOD_CK1_1	223	229	PF00069	0.455
MOD_CK1_1	354	360	PF00069	0.381
MOD_CK1_1	388	394	PF00069	0.388
MOD_CK1_1	6	12	PF00069	0.660
MOD_CK2_1	151	157	PF00069	0.418
MOD_CK2_1	190	196	PF00069	0.513
MOD_CK2_1	325	331	PF00069	0.518
MOD_CK2_1	335	341	PF00069	0.459
MOD_CK2_1	84	90	PF00069	0.407
MOD_GlcNHglycan	1	4	PF01048	0.492
MOD_GlcNHglycan	21	24	PF01048	0.465
MOD_GlcNHglycan	229	232	PF01048	0.408
MOD_GlcNHglycan	353	356	PF01048	0.339
MOD_GSK3_1	167	174	PF00069	0.424
MOD_GSK3_1	220	227	PF00069	0.477
MOD_GSK3_1	4	11	PF00069	0.619
MOD_N-GLC_1	151	156	PF02516	0.152
MOD_N-GLC_1	223	228	PF02516	0.420
MOD_NEK2_1	213	218	PF00069	0.303
MOD_NEK2_2	291	296	PF00069	0.418
MOD_PIKK_1	385	391	PF00454	0.518
MOD_PKA_2	325	331	PF00069	0.531
MOD_Plk_1	143	149	PF00069	0.407
MOD_Plk_1	151	157	PF00069	0.407
MOD_Plk_2-3	143	149	PF00069	0.418
MOD_Plk_4	359	365	PF00069	0.487
MOD_ProDKin_1	224	230	PF00069	0.454
MOD_ProDKin_1	6	12	PF00069	0.612
MOD_SUMO_rev_2	200	209	PF00179	0.478
MOD_SUMO_rev_2	385	393	PF00179	0.521
TRG_ENDOCYTIC_2	106	109	PF00928	0.407
TRG_ENDOCYTIC_2	155	158	PF00928	0.407
TRG_ENDOCYTIC_2	261	264	PF00928	0.374
TRG_ENDOCYTIC_2	280	283	PF00928	0.474
TRG_ENDOCYTIC_2	349	352	PF00928	0.417
TRG_ENDOCYTIC_2	36	39	PF00928	0.395
TRG_ER_diArg_1	75	77	PF00400	0.508
TRG_NES_CRM1_1	188	200	PF08389	0.339
TRG_NLS_MonoExtC_3	379	384	PF00514	0.346
TRG_NLS_MonoExtN_4	377	384	PF00514	0.332
TRG_Pf-PMV_PEXEL_1	217	221	PF00026	0.346
TRG_Pf-PMV_PEXEL_1	256	260	PF00026	0.249
TRG_Pf-PMV_PEXEL_1	75	80	PF00026	0.311

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P9A3	Leptomonas seymouri	80%	100%
A0A0S4KIJ8	Bodo saltans	68%	97%
A0A1X0NUM2	Trypanosomatidae	68%	100%
A0A3S7X5B3	Leishmania donovani	88%	100%
A0A422N8Y0	Trypanosoma rangeli	65%	100%
A4I7Q5	Leishmania infantum	88%	100%
A9N9S2	Coxiella burnetii (strain RSA 331 / Henzerling II)	25%	85%
D0A9W0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
E9B2L3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
O88637	Rattus norvegicus	43%	100%
P33412	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	100%
Q4Q5J3	Leishmania major	85%	100%
Q55BZ4	Dictyostelium discoideum	54%	100%
Q5EA75	Bos taurus	46%	100%
Q83B60	Coxiella burnetii (strain RSA 493 / Nine Mile phase I)	25%	85%
Q8SQW6	Encephalitozoon cuniculi (strain GB-M1)	37%	100%
Q922E4	Mus musculus	43%	100%
Q99447	Homo sapiens	44%	100%
Q9UTI6	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	100%
Q9ZVI9	Arabidopsis thaliana	44%	96%
V5DHH9	Trypanosoma cruzi	64%	100%