Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HK67_LEIBR

TriTrypDb:

LbrM.32.0950 , LBRM2903_320014700

Length:

669

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HK67

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK67

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	459	463	PF00656	0.460
CLV_C14_Caspase3-7	617	621	PF00656	0.480
CLV_NRD_NRD_1	205	207	PF00675	0.697
CLV_NRD_NRD_1	312	314	PF00675	0.521
CLV_NRD_NRD_1	650	652	PF00675	0.592
CLV_NRD_NRD_1	653	655	PF00675	0.579
CLV_PCSK_FUR_1	203	207	PF00082	0.696
CLV_PCSK_FUR_1	651	655	PF00082	0.529
CLV_PCSK_KEX2_1	205	207	PF00082	0.815
CLV_PCSK_KEX2_1	311	313	PF00082	0.449
CLV_PCSK_KEX2_1	381	383	PF00082	0.581
CLV_PCSK_KEX2_1	526	528	PF00082	0.539
CLV_PCSK_KEX2_1	611	613	PF00082	0.630
CLV_PCSK_KEX2_1	650	652	PF00082	0.587
CLV_PCSK_KEX2_1	653	655	PF00082	0.583
CLV_PCSK_PC1ET2_1	381	383	PF00082	0.581
CLV_PCSK_PC1ET2_1	526	528	PF00082	0.480
CLV_PCSK_PC1ET2_1	611	613	PF00082	0.630
CLV_PCSK_PC7_1	377	383	PF00082	0.602
CLV_PCSK_SKI1_1	11	15	PF00082	0.480
CLV_PCSK_SKI1_1	224	228	PF00082	0.476
CLV_PCSK_SKI1_1	236	240	PF00082	0.488
CLV_PCSK_SKI1_1	345	349	PF00082	0.455
CLV_PCSK_SKI1_1	429	433	PF00082	0.356
CLV_PCSK_SKI1_1	523	527	PF00082	0.474
CLV_PCSK_SKI1_1	614	618	PF00082	0.727
CLV_PCSK_SKI1_1	622	626	PF00082	0.512
DEG_APCC_DBOX_1	163	171	PF00400	0.469
DOC_ANK_TNKS_1	204	211	PF00023	0.541
DOC_CDC14_PxL_1	316	324	PF14671	0.293
DOC_CKS1_1	104	109	PF01111	0.357
DOC_CYCLIN_RxL_1	233	240	PF00134	0.294
DOC_CYCLIN_RxL_1	426	435	PF00134	0.349
DOC_CYCLIN_yCln2_LP_2	372	375	PF00134	0.566
DOC_MAPK_gen_1	342	352	PF00069	0.386
DOC_MAPK_gen_1	364	372	PF00069	0.588
DOC_MAPK_gen_1	495	504	PF00069	0.452
DOC_MAPK_HePTP_8	74	86	PF00069	0.469
DOC_MAPK_MEF2A_6	345	354	PF00069	0.382
DOC_MAPK_MEF2A_6	497	506	PF00069	0.537
DOC_MAPK_MEF2A_6	77	86	PF00069	0.473
DOC_MAPK_NFAT4_5	345	353	PF00069	0.382
DOC_PP1_RVXF_1	160	166	PF00149	0.399
DOC_PP2B_LxvP_1	372	375	PF13499	0.566
DOC_PP4_FxxP_1	26	29	PF00568	0.464
DOC_PP4_MxPP_1	529	532	PF00568	0.457
DOC_USP7_MATH_1	396	400	PF00917	0.620
DOC_USP7_MATH_1	458	462	PF00917	0.499
DOC_USP7_MATH_1	550	554	PF00917	0.537
DOC_USP7_MATH_1	595	599	PF00917	0.658
DOC_USP7_MATH_1	600	604	PF00917	0.616
DOC_USP7_MATH_1	605	609	PF00917	0.577
DOC_WW_Pin1_4	103	108	PF00397	0.366
DOC_WW_Pin1_4	25	30	PF00397	0.463
DOC_WW_Pin1_4	3	8	PF00397	0.480
DOC_WW_Pin1_4	388	393	PF00397	0.486
DOC_WW_Pin1_4	548	553	PF00397	0.516
DOC_WW_Pin1_4	78	83	PF00397	0.468
LIG_14-3-3_CanoR_1	113	121	PF00244	0.358
LIG_14-3-3_CanoR_1	123	130	PF00244	0.400
LIG_14-3-3_CanoR_1	175	181	PF00244	0.436
LIG_14-3-3_CanoR_1	236	246	PF00244	0.374
LIG_14-3-3_CanoR_1	456	461	PF00244	0.337
LIG_14-3-3_CanoR_1	481	488	PF00244	0.501
LIG_14-3-3_CanoR_1	497	503	PF00244	0.543
LIG_14-3-3_CanoR_1	505	512	PF00244	0.501
LIG_14-3-3_CanoR_1	535	543	PF00244	0.546
LIG_14-3-3_CanoR_1	627	632	PF00244	0.542
LIG_Actin_WH2_2	522	537	PF00022	0.476
LIG_Actin_WH2_2	637	652	PF00022	0.485
LIG_AP2alpha_2	439	441	PF02296	0.410
LIG_BIR_II_1	1	5	PF00653	0.563
LIG_BRCT_BRCA1_1	324	328	PF00533	0.331
LIG_BRCT_BRCA1_1	453	457	PF00533	0.480
LIG_BRCT_BRCA1_1	61	65	PF00533	0.420
LIG_deltaCOP1_diTrp_1	569	578	PF00928	0.673
LIG_FHA_1	129	135	PF00498	0.366
LIG_FHA_1	18	24	PF00498	0.463
LIG_FHA_1	233	239	PF00498	0.359
LIG_FHA_1	51	57	PF00498	0.416
LIG_FHA_1	535	541	PF00498	0.518
LIG_FHA_2	146	152	PF00498	0.367
LIG_FHA_2	35	41	PF00498	0.430
LIG_FHA_2	472	478	PF00498	0.413
LIG_FHA_2	615	621	PF00498	0.483
LIG_FHA_2	653	659	PF00498	0.539
LIG_FHA_2	83	89	PF00498	0.479
LIG_LIR_Apic_2	24	29	PF02991	0.461
LIG_LIR_Apic_2	546	552	PF02991	0.511
LIG_LIR_Gen_1	269	280	PF02991	0.489
LIG_LIR_Gen_1	301	310	PF02991	0.370
LIG_LIR_Gen_1	454	464	PF02991	0.442
LIG_LIR_Gen_1	62	69	PF02991	0.429
LIG_LIR_Gen_1	639	649	PF02991	0.564
LIG_LIR_Gen_1	88	95	PF02991	0.517
LIG_LIR_LC3C_4	131	135	PF02991	0.430
LIG_LIR_Nem_3	217	223	PF02991	0.321
LIG_LIR_Nem_3	269	275	PF02991	0.479
LIG_LIR_Nem_3	301	306	PF02991	0.410
LIG_LIR_Nem_3	325	330	PF02991	0.373
LIG_LIR_Nem_3	454	460	PF02991	0.421
LIG_LIR_Nem_3	576	581	PF02991	0.514
LIG_LIR_Nem_3	62	68	PF02991	0.429
LIG_LIR_Nem_3	639	644	PF02991	0.550
LIG_LIR_Nem_3	85	89	PF02991	0.516
LIG_MLH1_MIPbox_1	324	328	PF16413	0.331
LIG_NRBOX	427	433	PF00104	0.353
LIG_PDZ_Class_1	664	669	PF00595	0.528
LIG_PTB_Apo_2	635	642	PF02174	0.443
LIG_SH2_CRK	549	553	PF00017	0.516
LIG_SH2_GRB2like	220	223	PF00017	0.455
LIG_SH2_GRB2like	636	639	PF00017	0.428
LIG_SH2_NCK_1	231	235	PF00017	0.289
LIG_SH2_NCK_1	549	553	PF00017	0.601
LIG_SH2_PTP2	303	306	PF00017	0.365
LIG_SH2_SRC	231	234	PF00017	0.361
LIG_SH2_SRC	251	254	PF00017	0.486
LIG_SH2_SRC	303	306	PF00017	0.365
LIG_SH2_STAP1	272	276	PF00017	0.499
LIG_SH2_STAP1	44	48	PF00017	0.418
LIG_SH2_STAP1	453	457	PF00017	0.323
LIG_SH2_STAT5	121	124	PF00017	0.367
LIG_SH2_STAT5	155	158	PF00017	0.405
LIG_SH2_STAT5	220	223	PF00017	0.455
LIG_SH2_STAT5	251	254	PF00017	0.488
LIG_SH2_STAT5	303	306	PF00017	0.485
LIG_SH2_STAT5	327	330	PF00017	0.391
LIG_SH2_STAT5	89	92	PF00017	0.590
LIG_SH3_3	1	7	PF00018	0.484
LIG_SH3_3	101	107	PF00018	0.492
LIG_SH3_3	52	58	PF00018	0.500
LIG_SH3_3	641	647	PF00018	0.562
LIG_Sin3_3	448	455	PF02671	0.305
LIG_SUMO_SIM_anti_2	131	137	PF11976	0.354
LIG_SUMO_SIM_anti_2	367	374	PF11976	0.580
LIG_SUMO_SIM_par_1	130	137	PF11976	0.357
LIG_SUMO_SIM_par_1	19	24	PF11976	0.461
LIG_SUMO_SIM_par_1	465	471	PF11976	0.420
LIG_TRAF2_1	148	151	PF00917	0.377
LIG_TYR_ITIM	153	158	PF00017	0.407
LIG_TYR_ITIM	229	234	PF00017	0.319
LIG_WRC_WIRS_1	65	70	PF05994	0.432
LIG_WRC_WIRS_1	83	88	PF05994	0.445
MOD_CDC14_SPxK_1	6	9	PF00782	0.479
MOD_CDK_SPxK_1	3	9	PF00069	0.482
MOD_CK1_1	17	23	PF00069	0.502
MOD_CK1_1	183	189	PF00069	0.627
MOD_CK1_1	214	220	PF00069	0.455
MOD_CK1_1	28	34	PF00069	0.451
MOD_CK1_1	3	9	PF00069	0.482
MOD_CK1_1	399	405	PF00069	0.618
MOD_CK1_1	484	490	PF00069	0.427
MOD_CK1_1	551	557	PF00069	0.521
MOD_CK1_1	59	65	PF00069	0.419
MOD_CK1_1	630	636	PF00069	0.396
MOD_CK2_1	145	151	PF00069	0.382
MOD_CK2_1	471	477	PF00069	0.442
MOD_CK2_1	505	511	PF00069	0.595
MOD_CK2_1	652	658	PF00069	0.537
MOD_CK2_1	82	88	PF00069	0.476
MOD_GlcNHglycan	16	19	PF01048	0.578
MOD_GlcNHglycan	239	242	PF01048	0.483
MOD_GlcNHglycan	276	279	PF01048	0.586
MOD_GlcNHglycan	289	292	PF01048	0.727
MOD_GlcNHglycan	295	298	PF01048	0.609
MOD_GlcNHglycan	30	33	PF01048	0.452
MOD_GlcNHglycan	392	395	PF01048	0.599
MOD_GlcNHglycan	419	422	PF01048	0.556
MOD_GlcNHglycan	453	456	PF01048	0.323
MOD_GlcNHglycan	553	556	PF01048	0.596
MOD_GlcNHglycan	607	610	PF01048	0.556
MOD_GSK3_1	17	24	PF00069	0.524
MOD_GSK3_1	237	244	PF00069	0.564
MOD_GSK3_1	386	393	PF00069	0.612
MOD_GSK3_1	395	402	PF00069	0.756
MOD_GSK3_1	410	417	PF00069	0.753
MOD_GSK3_1	458	465	PF00069	0.499
MOD_GSK3_1	551	558	PF00069	0.522
MOD_GSK3_1	591	598	PF00069	0.636
MOD_GSK3_1	600	607	PF00069	0.611
MOD_GSK3_1	623	630	PF00069	0.564
MOD_GSK3_1	78	85	PF00069	0.471
MOD_LATS_1	503	509	PF00433	0.524
MOD_NEK2_1	112	117	PF00069	0.374
MOD_NEK2_1	122	127	PF00069	0.391
MOD_NEK2_1	174	179	PF00069	0.385
MOD_NEK2_1	237	242	PF00069	0.366
MOD_NEK2_1	266	271	PF00069	0.618
MOD_NEK2_1	274	279	PF00069	0.640
MOD_NEK2_1	322	327	PF00069	0.377
MOD_NEK2_1	333	338	PF00069	0.400
MOD_NEK2_1	354	359	PF00069	0.321
MOD_NEK2_1	432	437	PF00069	0.410
MOD_NEK2_1	451	456	PF00069	0.331
MOD_NEK2_1	534	539	PF00069	0.524
MOD_NEK2_1	543	548	PF00069	0.572
MOD_NEK2_1	625	630	PF00069	0.541
MOD_NEK2_2	251	256	PF00069	0.326
MOD_NEK2_2	82	87	PF00069	0.476
MOD_OFUCOSY	321	326	PF10250	0.412
MOD_PIKK_1	386	392	PF00454	0.708
MOD_PIKK_1	505	511	PF00454	0.519
MOD_PIKK_1	556	562	PF00454	0.753
MOD_PK_1	456	462	PF00069	0.346
MOD_PK_1	657	663	PF00069	0.536
MOD_PKA_2	112	118	PF00069	0.370
MOD_PKA_2	122	128	PF00069	0.393
MOD_PKA_2	174	180	PF00069	0.423
MOD_PKA_2	204	210	PF00069	0.542
MOD_PKA_2	534	540	PF00069	0.528
MOD_PKA_2	652	658	PF00069	0.537
MOD_PKB_1	612	620	PF00069	0.597
MOD_Plk_1	432	438	PF00069	0.353
MOD_Plk_1	87	93	PF00069	0.470
MOD_Plk_2-3	145	151	PF00069	0.382
MOD_Plk_2-3	462	468	PF00069	0.496
MOD_Plk_2-3	471	477	PF00069	0.463
MOD_Plk_2-3	88	94	PF00069	0.465
MOD_Plk_4	128	134	PF00069	0.376
MOD_Plk_4	17	23	PF00069	0.488
MOD_Plk_4	183	189	PF00069	0.627
MOD_Plk_4	365	371	PF00069	0.602
MOD_Plk_4	396	402	PF00069	0.519
MOD_Plk_4	462	468	PF00069	0.405
MOD_Plk_4	50	56	PF00069	0.400
MOD_Plk_4	627	633	PF00069	0.543
MOD_Plk_4	64	70	PF00069	0.398
MOD_ProDKin_1	103	109	PF00069	0.359
MOD_ProDKin_1	25	31	PF00069	0.460
MOD_ProDKin_1	3	9	PF00069	0.482
MOD_ProDKin_1	388	394	PF00069	0.489
MOD_ProDKin_1	548	554	PF00069	0.516
MOD_ProDKin_1	78	84	PF00069	0.470
MOD_SUMO_rev_2	618	624	PF00179	0.529
TRG_DiLeu_BaEn_1	365	370	PF01217	0.595
TRG_DiLeu_BaEn_1	664	669	PF01217	0.528
TRG_DiLeu_BaLyEn_6	233	238	PF01217	0.429
TRG_DiLeu_BaLyEn_6	423	428	PF01217	0.388
TRG_DiLeu_BaLyEn_6	502	507	PF01217	0.447
TRG_DiLeu_BaLyEn_6	79	84	PF01217	0.483
TRG_ENDOCYTIC_2	121	124	PF00928	0.367
TRG_ENDOCYTIC_2	155	158	PF00928	0.405
TRG_ENDOCYTIC_2	223	226	PF00928	0.391
TRG_ENDOCYTIC_2	231	234	PF00928	0.361
TRG_ENDOCYTIC_2	263	266	PF00928	0.426
TRG_ENDOCYTIC_2	272	275	PF00928	0.474
TRG_ENDOCYTIC_2	303	306	PF00928	0.387
TRG_ENDOCYTIC_2	327	330	PF00928	0.365
TRG_ENDOCYTIC_2	89	92	PF00928	0.590
TRG_ER_diArg_1	162	165	PF00400	0.403
TRG_ER_diArg_1	310	313	PF00400	0.507
TRG_ER_diArg_1	492	495	PF00400	0.629
TRG_ER_diArg_1	649	651	PF00400	0.606
TRG_ER_diArg_1	652	654	PF00400	0.617
TRG_Pf-PMV_PEXEL_1	179	184	PF00026	0.572
TRG_Pf-PMV_PEXEL_1	298	302	PF00026	0.485
TRG_Pf-PMV_PEXEL_1	429	433	PF00026	0.356
TRG_Pf-PMV_PEXEL_1	505	509	PF00026	0.430

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I873	Leptomonas seymouri	55%	100%
A0A3S7X5C7	Leishmania donovani	78%	100%
A4I7Q2	Leishmania infantum	78%	100%
E9B2L0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4Q5J6	Leishmania major	77%	100%