RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

polypyrimidine tract-binding protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HK66_LEIBR

TriTrypDb:

LbrM.32.0940 , LBRM2903_320014600

Length:

751

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0010494	cytoplasmic stress granule	5	1
GO:0035770	ribonucleoprotein granule	3	1
GO:0036464	cytoplasmic ribonucleoprotein granule	4	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0099080	supramolecular complex	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HK66

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK66

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	235	239	PF00656	0.571
CLV_C14_Caspase3-7	625	629	PF00656	0.597
CLV_C14_Caspase3-7	668	672	PF00656	0.803
CLV_NRD_NRD_1	190	192	PF00675	0.668
CLV_NRD_NRD_1	56	58	PF00675	0.678
CLV_NRD_NRD_1	610	612	PF00675	0.598
CLV_PCSK_FUR_1	525	529	PF00082	0.519
CLV_PCSK_KEX2_1	190	192	PF00082	0.668
CLV_PCSK_KEX2_1	488	490	PF00082	0.444
CLV_PCSK_KEX2_1	527	529	PF00082	0.476
CLV_PCSK_KEX2_1	56	58	PF00082	0.678
CLV_PCSK_KEX2_1	610	612	PF00082	0.598
CLV_PCSK_PC1ET2_1	488	490	PF00082	0.503
CLV_PCSK_PC1ET2_1	527	529	PF00082	0.476
CLV_PCSK_SKI1_1	20	24	PF00082	0.531
CLV_PCSK_SKI1_1	205	209	PF00082	0.517
CLV_PCSK_SKI1_1	542	546	PF00082	0.656
CLV_PCSK_SKI1_1	747	751	PF00082	0.705
DEG_APCC_DBOX_1	204	212	PF00400	0.518
DOC_ANK_TNKS_1	385	392	PF00023	0.704
DOC_ANK_TNKS_1	394	401	PF00023	0.811
DOC_ANK_TNKS_1	416	423	PF00023	0.564
DOC_ANK_TNKS_1	440	447	PF00023	0.570
DOC_CKS1_1	182	187	PF01111	0.553
DOC_CKS1_1	679	684	PF01111	0.605
DOC_CYCLIN_RxL_1	17	27	PF00134	0.516
DOC_MAPK_gen_1	190	196	PF00069	0.648
DOC_MAPK_gen_1	573	582	PF00069	0.368
DOC_MAPK_gen_1	610	618	PF00069	0.404
DOC_MAPK_gen_1	636	645	PF00069	0.639
DOC_MAPK_MEF2A_6	639	647	PF00069	0.641
DOC_PP1_RVXF_1	260	266	PF00149	0.490
DOC_PP1_RVXF_1	597	604	PF00149	0.390
DOC_PP1_RVXF_1	642	648	PF00149	0.625
DOC_PP4_FxxP_1	501	504	PF00568	0.633
DOC_USP7_MATH_1	155	159	PF00917	0.675
DOC_USP7_MATH_1	186	190	PF00917	0.532
DOC_USP7_MATH_1	219	223	PF00917	0.405
DOC_USP7_MATH_1	297	301	PF00917	0.702
DOC_USP7_MATH_1	356	360	PF00917	0.622
DOC_USP7_MATH_1	431	435	PF00917	0.728
DOC_USP7_MATH_1	696	700	PF00917	0.818
DOC_USP7_MATH_1	730	734	PF00917	0.713
DOC_USP7_UBL2_3	595	599	PF12436	0.628
DOC_WW_Pin1_4	181	186	PF00397	0.747
DOC_WW_Pin1_4	301	306	PF00397	0.566
DOC_WW_Pin1_4	340	345	PF00397	0.604
DOC_WW_Pin1_4	427	432	PF00397	0.753
DOC_WW_Pin1_4	453	458	PF00397	0.474
DOC_WW_Pin1_4	559	564	PF00397	0.438
DOC_WW_Pin1_4	678	683	PF00397	0.646
DOC_WW_Pin1_4	735	740	PF00397	0.583
DOC_WW_Pin1_4	90	95	PF00397	0.578
LIG_14-3-3_CanoR_1	337	344	PF00244	0.565
LIG_14-3-3_CanoR_1	56	60	PF00244	0.660
LIG_14-3-3_CanoR_1	644	648	PF00244	0.627
LIG_Actin_WH2_2	582	597	PF00022	0.630
LIG_APCC_ABBA_1	261	266	PF00400	0.593
LIG_BIR_II_1	1	5	PF00653	0.522
LIG_BIR_III_4	324	328	PF00653	0.729
LIG_deltaCOP1_diTrp_1	266	272	PF00928	0.493
LIG_deltaCOP1_diTrp_1	473	481	PF00928	0.557
LIG_eIF4E_1	472	478	PF01652	0.439
LIG_FHA_1	1	7	PF00498	0.507
LIG_FHA_1	202	208	PF00498	0.501
LIG_FHA_1	229	235	PF00498	0.520
LIG_FHA_1	493	499	PF00498	0.513
LIG_FHA_1	584	590	PF00498	0.539
LIG_FHA_1	612	618	PF00498	0.386
LIG_FHA_2	44	50	PF00498	0.561
LIG_FHA_2	623	629	PF00498	0.607
LIG_IBAR_NPY_1	311	313	PF08397	0.833
LIG_LIR_Apic_2	292	297	PF02991	0.728
LIG_LIR_Gen_1	266	277	PF02991	0.713
LIG_LIR_Gen_1	473	481	PF02991	0.440
LIG_LIR_Gen_1	646	654	PF02991	0.570
LIG_LIR_Nem_3	266	272	PF02991	0.686
LIG_LIR_Nem_3	427	432	PF02991	0.731
LIG_LIR_Nem_3	473	478	PF02991	0.436
LIG_LIR_Nem_3	479	484	PF02991	0.405
LIG_LIR_Nem_3	646	650	PF02991	0.550
LIG_MYND_1	75	79	PF01753	0.585
LIG_NRBOX	473	479	PF00104	0.451
LIG_NRP_CendR_1	750	751	PF00754	0.836
LIG_Pex14_2	265	269	PF04695	0.585
LIG_PTB_Apo_2	254	261	PF02174	0.610
LIG_PTB_Phospho_1	254	260	PF10480	0.618
LIG_SH2_CRK	294	298	PF00017	0.753
LIG_SH2_GRB2like	120	123	PF00017	0.581
LIG_SH2_PTP2	260	263	PF00017	0.471
LIG_SH2_STAP1	120	124	PF00017	0.676
LIG_SH2_STAP1	472	476	PF00017	0.443
LIG_SH2_STAT3	147	150	PF00017	0.833
LIG_SH2_STAT3	296	299	PF00017	0.724
LIG_SH2_STAT5	166	169	PF00017	0.712
LIG_SH2_STAT5	260	263	PF00017	0.471
LIG_SH2_STAT5	264	267	PF00017	0.542
LIG_SH2_STAT5	513	516	PF00017	0.508
LIG_SH2_STAT5	581	584	PF00017	0.596
LIG_SH3_1	561	567	PF00018	0.627
LIG_SH3_2	185	190	PF14604	0.743
LIG_SH3_2	712	717	PF14604	0.609
LIG_SH3_3	145	151	PF00018	0.806
LIG_SH3_3	180	186	PF00018	0.717
LIG_SH3_3	222	228	PF00018	0.605
LIG_SH3_3	271	277	PF00018	0.657
LIG_SH3_3	317	323	PF00018	0.711
LIG_SH3_3	444	450	PF00018	0.642
LIG_SH3_3	561	567	PF00018	0.627
LIG_SH3_3	648	654	PF00018	0.586
LIG_SH3_3	65	71	PF00018	0.584
LIG_SH3_3	707	713	PF00018	0.663
LIG_SH3_3	73	79	PF00018	0.709
LIG_SH3_3	88	94	PF00018	0.800
LIG_SUMO_SIM_par_1	2	7	PF11976	0.592
LIG_SUMO_SIM_par_1	458	463	PF11976	0.592
LIG_TRAF2_1	46	49	PF00917	0.578
LIG_TRAF2_1	695	698	PF00917	0.752
LIG_WW_3	562	566	PF00397	0.480
MOD_CDK_SPK_2	735	740	PF00069	0.583
MOD_CDK_SPxK_1	559	565	PF00069	0.460
MOD_CK1_1	162	168	PF00069	0.842
MOD_CK1_1	301	307	PF00069	0.569
MOD_CK1_1	340	346	PF00069	0.756
MOD_CK1_1	35	41	PF00069	0.681
MOD_CK1_1	453	459	PF00069	0.466
MOD_CK1_1	738	744	PF00069	0.593
MOD_CK2_1	43	49	PF00069	0.565
MOD_CK2_1	730	736	PF00069	0.692
MOD_GlcNHglycan	108	111	PF01048	0.821
MOD_GlcNHglycan	176	179	PF01048	0.728
MOD_GlcNHglycan	291	294	PF01048	0.784
MOD_GlcNHglycan	306	309	PF01048	0.617
MOD_GlcNHglycan	334	337	PF01048	0.689
MOD_GlcNHglycan	374	377	PF01048	0.688
MOD_GlcNHglycan	382	385	PF01048	0.661
MOD_GlcNHglycan	418	421	PF01048	0.797
MOD_GlcNHglycan	422	425	PF01048	0.747
MOD_GlcNHglycan	433	437	PF01048	0.798
MOD_GlcNHglycan	462	465	PF01048	0.378
MOD_GlcNHglycan	467	470	PF01048	0.390
MOD_GlcNHglycan	529	532	PF01048	0.575
MOD_GlcNHglycan	542	545	PF01048	0.683
MOD_GlcNHglycan	731	735	PF01048	0.702
MOD_GSK3_1	155	162	PF00069	0.783
MOD_GSK3_1	226	233	PF00069	0.430
MOD_GSK3_1	295	302	PF00069	0.675
MOD_GSK3_1	416	423	PF00069	0.564
MOD_GSK3_1	427	434	PF00069	0.530
MOD_GSK3_1	538	545	PF00069	0.624
MOD_GSK3_1	735	742	PF00069	0.586
MOD_N-GLC_1	168	173	PF02516	0.739
MOD_N-GLC_1	465	470	PF02516	0.592
MOD_N-GLC_1	583	588	PF02516	0.541
MOD_N-GLC_2	257	259	PF02516	0.615
MOD_NEK2_1	24	29	PF00069	0.631
MOD_NEK2_1	580	585	PF00069	0.441
MOD_NEK2_1	643	648	PF00069	0.521
MOD_NEK2_2	40	45	PF00069	0.537
MOD_NEK2_2	406	411	PF00069	0.557
MOD_PIKK_1	155	161	PF00454	0.572
MOD_PIKK_1	295	301	PF00454	0.573
MOD_PIKK_1	348	354	PF00454	0.746
MOD_PIKK_1	35	41	PF00454	0.581
MOD_PIKK_1	450	456	PF00454	0.487
MOD_PIKK_1	81	87	PF00454	0.613
MOD_PKA_1	527	533	PF00069	0.628
MOD_PKA_2	406	412	PF00069	0.647
MOD_PKA_2	416	422	PF00069	0.777
MOD_PKA_2	527	533	PF00069	0.577
MOD_PKA_2	55	61	PF00069	0.654
MOD_PKA_2	643	649	PF00069	0.633
MOD_Plk_4	162	168	PF00069	0.745
MOD_Plk_4	604	610	PF00069	0.420
MOD_ProDKin_1	181	187	PF00069	0.742
MOD_ProDKin_1	301	307	PF00069	0.569
MOD_ProDKin_1	340	346	PF00069	0.607
MOD_ProDKin_1	427	433	PF00069	0.751
MOD_ProDKin_1	453	459	PF00069	0.460
MOD_ProDKin_1	559	565	PF00069	0.448
MOD_ProDKin_1	678	684	PF00069	0.644
MOD_ProDKin_1	735	741	PF00069	0.585
MOD_ProDKin_1	90	96	PF00069	0.576
MOD_SUMO_rev_2	536	544	PF00179	0.705
MOD_SUMO_rev_2	587	597	PF00179	0.638
TRG_DiLeu_BaEn_1	49	54	PF01217	0.538
TRG_ENDOCYTIC_2	120	123	PF00928	0.805
TRG_ENDOCYTIC_2	260	263	PF00928	0.471
TRG_ER_diArg_1	190	193	PF00400	0.671
TRG_ER_diArg_1	570	573	PF00400	0.732
TRG_ER_diArg_1	609	611	PF00400	0.588
TRG_ER_diArg_1	638	641	PF00400	0.401
TRG_Pf-PMV_PEXEL_1	193	197	PF00026	0.638
TRG_Pf-PMV_PEXEL_1	655	659	PF00026	0.553

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1I1	Leptomonas seymouri	44%	100%
A0A3Q8IJ43	Leishmania donovani	73%	99%
A4I7Q1	Leishmania infantum	74%	99%
E9B2K9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	98%
Q4Q5J7	Leishmania major	75%	100%