RRM_8 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HK65_LEIBR

TriTrypDb:

LbrM.32.0930 , LBRM2903_320014500

Length:

509

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 4
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HK65

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK65

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0005488	binding	1	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	25	31	PF00089	0.421
CLV_NRD_NRD_1	334	336	PF00675	0.439
CLV_NRD_NRD_1	42	44	PF00675	0.421
CLV_PCSK_KEX2_1	334	336	PF00082	0.439
CLV_PCSK_KEX2_1	42	44	PF00082	0.421
CLV_PCSK_SKI1_1	340	344	PF00082	0.466
CLV_PCSK_SKI1_1	418	422	PF00082	0.530
CLV_PCSK_SKI1_1	42	46	PF00082	0.421
CLV_PCSK_SKI1_1	467	471	PF00082	0.506
CLV_PCSK_SKI1_1	88	92	PF00082	0.348
DEG_Nend_UBRbox_1	1	4	PF02207	0.751
DOC_CKS1_1	56	61	PF01111	0.421
DOC_MAPK_gen_1	339	345	PF00069	0.465
DOC_MAPK_gen_1	42	50	PF00069	0.421
DOC_PP4_FxxP_1	203	206	PF00568	0.718
DOC_PP4_FxxP_1	298	301	PF00568	0.615
DOC_USP7_MATH_1	112	116	PF00917	0.727
DOC_USP7_MATH_1	414	418	PF00917	0.577
DOC_WW_Pin1_4	106	111	PF00397	0.700
DOC_WW_Pin1_4	346	351	PF00397	0.519
DOC_WW_Pin1_4	404	409	PF00397	0.538
DOC_WW_Pin1_4	55	60	PF00397	0.502
LIG_14-3-3_CanoR_1	28	36	PF00244	0.352
LIG_14-3-3_CanoR_1	381	391	PF00244	0.502
LIG_14-3-3_CanoR_1	43	49	PF00244	0.429
LIG_14-3-3_CanoR_1	446	455	PF00244	0.608
LIG_14-3-3_CanoR_1	80	86	PF00244	0.421
LIG_AP2alpha_1	72	76	PF02296	0.421
LIG_BRCT_BRCA1_1	122	126	PF00533	0.574
LIG_EVH1_2	301	305	PF00568	0.526
LIG_FHA_1	100	106	PF00498	0.582
LIG_FHA_1	187	193	PF00498	0.671
LIG_FHA_1	20	26	PF00498	0.353
LIG_FHA_1	202	208	PF00498	0.567
LIG_FHA_1	301	307	PF00498	0.452
LIG_FHA_1	312	318	PF00498	0.348
LIG_FHA_1	35	41	PF00498	0.353
LIG_FHA_1	452	458	PF00498	0.433
LIG_FHA_1	64	70	PF00498	0.488
LIG_FHA_2	320	326	PF00498	0.401
LIG_FHA_2	425	431	PF00498	0.578
LIG_FHA_2	446	452	PF00498	0.579
LIG_LIR_Apic_2	201	206	PF02991	0.717
LIG_LIR_Gen_1	303	313	PF02991	0.429
LIG_LIR_Nem_3	13	17	PF02991	0.733
LIG_LIR_Nem_3	303	308	PF02991	0.417
LIG_LIR_Nem_3	325	330	PF02991	0.435
LIG_Pex14_2	72	76	PF04695	0.421
LIG_SH2_GRB2like	436	439	PF00017	0.540
LIG_SH2_SRC	436	439	PF00017	0.540
LIG_SH2_STAP1	101	105	PF00017	0.577
LIG_SH2_STAP1	398	402	PF00017	0.560
LIG_SH2_STAT5	101	104	PF00017	0.608
LIG_SH2_STAT5	292	295	PF00017	0.682
LIG_SH2_STAT5	365	368	PF00017	0.542
LIG_SH2_STAT5	378	381	PF00017	0.560
LIG_SH2_STAT5	436	439	PF00017	0.467
LIG_SH3_3	135	141	PF00018	0.752
LIG_SH3_3	144	150	PF00018	0.791
LIG_SH3_3	153	159	PF00018	0.608
LIG_SH3_3	162	168	PF00018	0.568
LIG_SH3_3	171	177	PF00018	0.586
LIG_SH3_3	185	191	PF00018	0.594
LIG_SH3_3	230	236	PF00018	0.817
LIG_SH3_3	310	316	PF00018	0.488
LIG_SH3_3	387	393	PF00018	0.570
LIG_SH3_3	454	460	PF00018	0.472
LIG_SH3_3	484	490	PF00018	0.680
LIG_SUMO_SIM_anti_2	307	312	PF11976	0.434
LIG_SUMO_SIM_anti_2	351	358	PF11976	0.503
LIG_WRC_WIRS_1	324	329	PF05994	0.321
MOD_CDK_SPxxK_3	404	411	PF00069	0.506
MOD_CK1_1	186	192	PF00069	0.572
MOD_CK1_1	201	207	PF00069	0.566
MOD_CK1_1	51	57	PF00069	0.403
MOD_CK2_1	121	127	PF00069	0.623
MOD_CK2_1	319	325	PF00069	0.404
MOD_CK2_1	445	451	PF00069	0.567
MOD_GlcNHglycan	106	109	PF01048	0.707
MOD_GlcNHglycan	123	126	PF01048	0.549
MOD_GlcNHglycan	207	210	PF01048	0.557
MOD_GlcNHglycan	370	373	PF01048	0.418
MOD_GSK3_1	15	22	PF00069	0.668
MOD_GSK3_1	201	208	PF00069	0.566
MOD_GSK3_1	23	30	PF00069	0.320
MOD_GSK3_1	300	307	PF00069	0.483
MOD_GSK3_1	319	326	PF00069	0.320
MOD_GSK3_1	400	407	PF00069	0.599
MOD_GSK3_1	420	427	PF00069	0.427
MOD_GSK3_1	428	435	PF00069	0.484
MOD_GSK3_1	44	51	PF00069	0.532
MOD_GSK3_1	447	454	PF00069	0.504
MOD_GSK3_1	95	102	PF00069	0.489
MOD_NEK2_1	121	126	PF00069	0.726
MOD_NEK2_1	229	234	PF00069	0.704
MOD_NEK2_1	323	328	PF00069	0.319
MOD_NEK2_1	400	405	PF00069	0.705
MOD_NEK2_1	99	104	PF00069	0.407
MOD_PIKK_1	15	21	PF00454	0.687
MOD_PIKK_1	186	192	PF00454	0.669
MOD_PKA_2	239	245	PF00069	0.598
MOD_PKA_2	27	33	PF00069	0.348
MOD_PKA_2	445	451	PF00069	0.567
MOD_Plk_1	64	70	PF00069	0.356
MOD_Plk_2-3	451	457	PF00069	0.549
MOD_Plk_4	100	106	PF00069	0.482
MOD_Plk_4	198	204	PF00069	0.719
MOD_Plk_4	300	306	PF00069	0.456
MOD_Plk_4	355	361	PF00069	0.521
MOD_Plk_4	432	438	PF00069	0.457
MOD_Plk_4	64	70	PF00069	0.383
MOD_ProDKin_1	106	112	PF00069	0.701
MOD_ProDKin_1	346	352	PF00069	0.515
MOD_ProDKin_1	404	410	PF00069	0.537
MOD_ProDKin_1	55	61	PF00069	0.502
MOD_SUMO_rev_2	475	482	PF00179	0.603
MOD_SUMO_rev_2	492	502	PF00179	0.536
TRG_ENDOCYTIC_2	270	273	PF00928	0.619
TRG_ENDOCYTIC_2	295	298	PF00928	0.663
TRG_ER_diArg_1	1	4	PF00400	0.838
TRG_ER_diArg_1	333	335	PF00400	0.419
TRG_ER_diArg_1	41	43	PF00400	0.421
TRG_Pf-PMV_PEXEL_1	467	471	PF00026	0.506

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IFS5	Leishmania donovani	82%	100%
A0A422N8U4	Trypanosoma rangeli	42%	100%
A4I7Q0	Leishmania infantum	82%	100%
E9B2K8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4Q5J8	Leishmania major	79%	100%
V5B118	Trypanosoma cruzi	43%	100%