HSF_DOMAIN domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HK64_LEIBR

TriTrypDb:

LbrM.32.0920 , LBRM2903_320014400

Length:

466

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HK64

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK64

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	292	296	PF00656	0.561
CLV_C14_Caspase3-7	373	377	PF00656	0.713
CLV_C14_Caspase3-7	403	407	PF00656	0.698
CLV_NRD_NRD_1	114	116	PF00675	0.488
CLV_NRD_NRD_1	177	179	PF00675	0.515
CLV_NRD_NRD_1	188	190	PF00675	0.520
CLV_NRD_NRD_1	193	195	PF00675	0.484
CLV_NRD_NRD_1	261	263	PF00675	0.547
CLV_NRD_NRD_1	268	270	PF00675	0.567
CLV_PCSK_FUR_1	266	270	PF00082	0.431
CLV_PCSK_KEX2_1	114	116	PF00082	0.488
CLV_PCSK_KEX2_1	170	172	PF00082	0.605
CLV_PCSK_KEX2_1	177	179	PF00082	0.518
CLV_PCSK_KEX2_1	187	189	PF00082	0.445
CLV_PCSK_KEX2_1	192	194	PF00082	0.483
CLV_PCSK_KEX2_1	268	270	PF00082	0.430
CLV_PCSK_PC1ET2_1	170	172	PF00082	0.388
CLV_PCSK_PC7_1	188	194	PF00082	0.469
CLV_PCSK_SKI1_1	114	118	PF00082	0.595
CLV_PCSK_SKI1_1	170	174	PF00082	0.398
CLV_PCSK_SKI1_1	194	198	PF00082	0.627
CLV_PCSK_SKI1_1	450	454	PF00082	0.637
CLV_PCSK_SKI1_1	67	71	PF00082	0.536
DEG_SCF_FBW7_1	33	39	PF00400	0.496
DEG_SCF_FBW7_1	5	12	PF00400	0.564
DEG_SPOP_SBC_1	202	206	PF00917	0.603
DOC_CKS1_1	33	38	PF01111	0.502
DOC_CYCLIN_yClb5_NLxxxL_5	216	222	PF00134	0.371
DOC_MAPK_gen_1	114	121	PF00069	0.484
DOC_MAPK_gen_1	177	185	PF00069	0.506
DOC_MAPK_gen_1	187	197	PF00069	0.480
DOC_MAPK_MEF2A_6	114	121	PF00069	0.484
DOC_MAPK_MEF2A_6	42	51	PF00069	0.401
DOC_PP1_RVXF_1	124	131	PF00149	0.586
DOC_PP2B_LxvP_1	334	337	PF13499	0.534
DOC_PP4_FxxP_1	284	287	PF00568	0.651
DOC_PP4_FxxP_1	456	459	PF00568	0.664
DOC_PP4_FxxP_1	77	80	PF00568	0.577
DOC_USP7_MATH_1	120	124	PF00917	0.386
DOC_USP7_MATH_1	18	22	PF00917	0.708
DOC_USP7_MATH_1	203	207	PF00917	0.658
DOC_USP7_MATH_1	280	284	PF00917	0.593
DOC_USP7_MATH_1	322	326	PF00917	0.684
DOC_USP7_MATH_1	327	331	PF00917	0.691
DOC_USP7_MATH_1	337	341	PF00917	0.707
DOC_USP7_MATH_1	36	40	PF00917	0.719
DOC_USP7_MATH_1	95	99	PF00917	0.540
DOC_WW_Pin1_4	171	176	PF00397	0.524
DOC_WW_Pin1_4	178	183	PF00397	0.426
DOC_WW_Pin1_4	32	37	PF00397	0.572
DOC_WW_Pin1_4	338	343	PF00397	0.788
DOC_WW_Pin1_4	417	422	PF00397	0.661
DOC_WW_Pin1_4	5	10	PF00397	0.774
LIG_14-3-3_CanoR_1	114	120	PF00244	0.550
LIG_14-3-3_CanoR_1	22	29	PF00244	0.668
LIG_14-3-3_CanoR_1	268	272	PF00244	0.552
LIG_14-3-3_CanoR_1	276	284	PF00244	0.611
LIG_14-3-3_CanoR_1	415	424	PF00244	0.531
LIG_14-3-3_CanoR_1	450	459	PF00244	0.650
LIG_14-3-3_CanoR_1	67	75	PF00244	0.563
LIG_Actin_WH2_2	26	44	PF00022	0.500
LIG_BIR_III_2	304	308	PF00653	0.543
LIG_BIR_III_4	293	297	PF00653	0.548
LIG_deltaCOP1_diTrp_1	124	131	PF00928	0.319
LIG_deltaCOP1_diTrp_1	50	57	PF00928	0.413
LIG_EH_1	285	289	PF12763	0.653
LIG_FHA_1	116	122	PF00498	0.522
LIG_FHA_1	44	50	PF00498	0.451
LIG_FHA_2	306	312	PF00498	0.544
LIG_FHA_2	33	39	PF00498	0.542
LIG_FHA_2	383	389	PF00498	0.808
LIG_FHA_2	426	432	PF00498	0.735
LIG_LIR_Apic_2	283	287	PF02991	0.651
LIG_LIR_Apic_2	454	459	PF02991	0.661
LIG_LIR_Gen_1	46	53	PF02991	0.410
LIG_LIR_Nem_3	123	128	PF02991	0.566
LIG_LYPXL_yS_3	58	61	PF13949	0.631
LIG_Pex14_2	284	288	PF04695	0.685
LIG_Pex14_2	449	453	PF04695	0.630
LIG_Pex14_2	92	96	PF04695	0.610
LIG_PTB_Apo_2	278	285	PF02174	0.641
LIG_PTB_Apo_2	71	78	PF02174	0.275
LIG_SH2_STAP1	362	366	PF00017	0.749
LIG_SH2_STAP1	37	41	PF00017	0.479
LIG_SH2_STAT3	148	151	PF00017	0.503
LIG_SH2_STAT5	221	224	PF00017	0.522
LIG_SH3_2	109	114	PF14604	0.529
LIG_SH3_3	106	112	PF00018	0.535
LIG_SH3_3	116	122	PF00018	0.474
LIG_SH3_3	169	175	PF00018	0.639
LIG_SH3_3	336	342	PF00018	0.783
LIG_SUMO_SIM_par_1	117	124	PF11976	0.357
LIG_TRAF2_1	257	260	PF00917	0.514
LIG_TRAF2_1	385	388	PF00917	0.766
LIG_WW_1	79	82	PF00397	0.462
MOD_CDC14_SPxK_1	174	177	PF00782	0.326
MOD_CDK_SPxK_1	171	177	PF00069	0.336
MOD_CDK_SPxxK_3	171	178	PF00069	0.338
MOD_CK1_1	104	110	PF00069	0.523
MOD_CK1_1	220	226	PF00069	0.625
MOD_CK1_1	25	31	PF00069	0.704
MOD_CK1_1	270	276	PF00069	0.429
MOD_CK2_1	20	26	PF00069	0.626
MOD_CK2_1	209	215	PF00069	0.551
MOD_CK2_1	305	311	PF00069	0.545
MOD_CK2_1	32	38	PF00069	0.468
MOD_CK2_1	381	387	PF00069	0.746
MOD_DYRK1A_RPxSP_1	171	175	PF00069	0.346
MOD_GlcNHglycan	11	14	PF01048	0.626
MOD_GlcNHglycan	272	275	PF01048	0.545
MOD_GlcNHglycan	278	281	PF01048	0.607
MOD_GlcNHglycan	317	320	PF01048	0.678
MOD_GlcNHglycan	367	370	PF01048	0.570
MOD_GlcNHglycan	38	41	PF01048	0.640
MOD_GlcNHglycan	417	420	PF01048	0.644
MOD_GlcNHglycan	443	447	PF01048	0.508
MOD_GlcNHglycan	458	462	PF01048	0.616
MOD_GlcNHglycan	97	100	PF01048	0.448
MOD_GSK3_1	100	107	PF00069	0.401
MOD_GSK3_1	16	23	PF00069	0.753
MOD_GSK3_1	24	31	PF00069	0.645
MOD_GSK3_1	272	279	PF00069	0.616
MOD_GSK3_1	32	39	PF00069	0.523
MOD_GSK3_1	390	397	PF00069	0.635
MOD_GSK3_1	415	422	PF00069	0.563
MOD_GSK3_1	5	12	PF00069	0.720
MOD_GSK3_1	63	70	PF00069	0.576
MOD_LATS_1	20	26	PF00433	0.558
MOD_N-GLC_1	178	183	PF02516	0.354
MOD_N-GLC_1	31	36	PF02516	0.580
MOD_N-GLC_1	353	358	PF02516	0.546
MOD_N-GLC_2	74	76	PF02516	0.266
MOD_NEK2_1	364	369	PF00069	0.754
MOD_NEK2_1	381	386	PF00069	0.780
MOD_NEK2_1	389	394	PF00069	0.787
MOD_PIKK_1	247	253	PF00454	0.648
MOD_PIKK_1	354	360	PF00454	0.544
MOD_PIKK_1	451	457	PF00454	0.649
MOD_PKA_2	267	273	PF00069	0.579
MOD_PKA_2	315	321	PF00069	0.703
MOD_PKB_1	22	30	PF00069	0.546
MOD_Plk_1	25	31	PF00069	0.565
MOD_Plk_1	347	353	PF00069	0.605
MOD_Plk_1	381	387	PF00069	0.539
MOD_Plk_2-3	267	273	PF00069	0.410
MOD_Plk_2-3	382	388	PF00069	0.540
MOD_Plk_4	217	223	PF00069	0.637
MOD_Plk_4	43	49	PF00069	0.530
MOD_ProDKin_1	171	177	PF00069	0.523
MOD_ProDKin_1	178	184	PF00069	0.416
MOD_ProDKin_1	32	38	PF00069	0.569
MOD_ProDKin_1	338	344	PF00069	0.787
MOD_ProDKin_1	417	423	PF00069	0.665
MOD_ProDKin_1	5	11	PF00069	0.776
MOD_SUMO_for_1	235	238	PF00179	0.364
MOD_SUMO_rev_2	458	466	PF00179	0.652
TRG_ENDOCYTIC_2	125	128	PF00928	0.474
TRG_ENDOCYTIC_2	58	61	PF00928	0.631
TRG_ER_diArg_1	114	116	PF00400	0.488
TRG_ER_diArg_1	176	178	PF00400	0.505
TRG_ER_diArg_1	186	189	PF00400	0.447
TRG_ER_diArg_1	191	194	PF00400	0.471
TRG_Pf-PMV_PEXEL_1	67	71	PF00026	0.583

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P801	Leptomonas seymouri	46%	97%
A0A3Q8IKU6	Leishmania donovani	68%	100%
A4I7P9	Leishmania infantum	69%	100%
E9B2K7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	65%	99%
Q4Q5J9	Leishmania major	65%	100%